LOCUS       NM_001130082            7178 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens plexin B1 (PLXNB1), transcript variant 2, mRNA.
ACCESSION   NM_001130082
VERSION     NM_001130082.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7178)
  AUTHORS   Xuan,Z., Zhang,Y., Li,D., Wang,K., Huang,P. and Shi,J.
  TITLE     PLXNB1/SEMA4D signals mediate interactions between malignant
            epithelial and immune cells to promote colorectal cancer liver
            metastasis
  JOURNAL   J Cell Mol Med 28 (20), e70142 (2024)
   PUBMED   39443302
  REMARK    GeneRIF: PLXNB1/SEMA4D signals mediate interactions between
            malignant epithelial and immune cells to promote colorectal cancer
            liver metastasis.
REFERENCE   2  (bases 1 to 7178)
  AUTHORS   Wei,X., Liu,Z., Shen,Y., Dong,H., Chen,K., Shi,X., Chen,Y., Wang,B.
            and Dong,S.
  TITLE     Semaphorin4A promotes lung cancer by activation of NF-kappaB
            pathway mediated by PlexinB1
  JOURNAL   PeerJ 11, e16292 (2023)
   PUBMED   37901456
  REMARK    GeneRIF: Semaphorin4A promotes lung cancer by activation of
            NF-kappaB pathway mediated by PlexinB1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7178)
  AUTHORS   Yang,G., Ullah,H.M.A., Parker,E., Gorsi,B., Libowitz,M.,
            Maguire,C., King,J.B., Coon,H., Lopez-Larson,M., Anderson,J.S.,
            Yandell,M. and Shcheglovitov,A.
  TITLE     Neurite outgrowth deficits caused by rare PLXNB1 mutation in
            pediatric bipolar disorder
  JOURNAL   Mol Psychiatry 28 (6), 2525-2539 (2023)
   PUBMED   37032361
  REMARK    GeneRIF: Neurite outgrowth deficits caused by rare PLXNB1 mutation
            in pediatric bipolar disorder.
REFERENCE   4  (bases 1 to 7178)
  AUTHORS   Welch,B.A., Cho,H.J., Ucakturk,S.A., Farmer,S.M., Cetinkaya,S.,
            Abaci,A., Akkus,G., Simsek,E., Kotan,L.D., Turan,I., Gurbuz,F.,
            Yuksel,B., Wray,S. and Topaloglu,A.K.
  TITLE     PLXNB1 mutations in the etiology of idiopathic hypogonadotropic
            hypogonadism
  JOURNAL   J Neuroendocrinol 34 (4), e13103 (2022)
   PUBMED   35170806
  REMARK    GeneRIF: PLXNB1 mutations in the etiology of idiopathic
            hypogonadotropic hypogonadism.
REFERENCE   5  (bases 1 to 7178)
  AUTHORS   Li,C., Wan,L., Wang,P., Guan,X., Li,C. and Wang,X.
  TITLE     Sema4D/Plexin-B1 promotes the progression of osteosarcoma cells by
            activating Pyk2-PI3K-AKT pathway
  JOURNAL   J Musculoskelet Neuronal Interact 21 (4), 577-583 (2021)
   PUBMED   34854398
  REMARK    GeneRIF: Sema4D/Plexin-B1 promotes the progression of osteosarcoma
            cells by activating Pyk2-PI3K-AKT pathway.
REFERENCE   6  (bases 1 to 7178)
  AUTHORS   Swiercz,J.M., Kuner,R., Behrens,J. and Offermanns,S.
  TITLE     Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA
            and growth cone morphology
  JOURNAL   Neuron 35 (1), 51-63 (2002)
   PUBMED   12123608
REFERENCE   7  (bases 1 to 7178)
  AUTHORS   Vikis,H.G., Li,W. and Guan,K.L.
  TITLE     The plexin-B1/Rac interaction inhibits PAK activation and enhances
            Sema4D ligand binding
  JOURNAL   Genes Dev 16 (7), 836-845 (2002)
   PUBMED   11937491
  REMARK    GeneRIF: The plexin-B1/Rac interaction inhibits PAK activation and
            enhances Sema4D ligand binding
REFERENCE   8  (bases 1 to 7178)
  AUTHORS   Vikis,H.G., Li,W., He,Z. and Guan,K.L.
  TITLE     The semaphorin receptor plexin-B1 specifically interacts with
            active Rac in a ligand-dependent manner
  JOURNAL   Proc Natl Acad Sci U S A 97 (23), 12457-12462 (2000)
   PUBMED   11035813
REFERENCE   9  (bases 1 to 7178)
  AUTHORS   Tamagnone,L., Artigiani,S., Chen,H., He,Z., Ming,G.I., Song,H.,
            Chedotal,A., Winberg,M.L., Goodman,C.S., Poo,M., Tessier-Lavigne,M.
            and Comoglio,P.M.
  TITLE     Plexins are a large family of receptors for transmembrane,
            secreted, and GPI-anchored semaphorins in vertebrates
  JOURNAL   Cell 99 (1), 71-80 (1999)
   PUBMED   10520995
  REMARK    Erratum:[Cell 2001 Jan 26;104(2):following 320]
REFERENCE   10 (bases 1 to 7178)
  AUTHORS   Maestrini,E., Tamagnone,L., Longati,P., Cremona,O., Gulisano,M.,
            Bione,S., Tamanini,F., Neel,B.G., Toniolo,D. and Comoglio,P.M.
  TITLE     A family of transmembrane proteins with homology to the
            MET-hepatocyte growth factor receptor
  JOURNAL   Proc Natl Acad Sci U S A 93 (2), 674-678 (1996)
   PUBMED   8570614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134772.2, BC066773.1 and AB007867.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001130082.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066773.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296440.11/ ENSP00000296440.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC134772.2         43730-43764         c
            36-1616             BC066773.1         3-1583
            1617-2519           AB007867.1         1749-2651
            2520-2520           AC134772.2         33582-33582         c
            2521-7176           AB007867.1         2653-7308
            7177-7178           BC066773.1         7143-7144
FEATURES             Location/Qualifiers
     source          1..7178
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..7178
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /note="plexin B1"
                     /db_xref="GeneID:5364"
                     /db_xref="HGNC:HGNC:9103"
                     /db_xref="MIM:601053"
     exon            1..79
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            80..132
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            133..1245
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..6546
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /note="plexin 5; semaphorin receptor SEP"
                     /codon_start=1
                     /product="plexin-B1 precursor"
                     /protein_id="NP_001123554.1"
                     /db_xref="CCDS:CCDS2765.1"
                     /db_xref="GeneID:5364"
                     /db_xref="HGNC:HGNC:9103"
                     /db_xref="MIM:601053"
                     /translation="MPALGPALLQALWAGWVLTLQPLPPTAFTPNGTYLQHLARDPTS
                     GTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLL
                     VSPGALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGL
                     AGEPLLFVGRGYTSRGVGGGIPPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHF
                     VSAFARGASAYFLFLRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPLACEGGRYGLI
                     QAAAVATSREVAHGEVLFAAFSSAAPPTVGRPPSAAAGASGASALCAFPLDEVDRLAN
                     RTRDACYTREGRAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPL
                     EATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQG
                     SAVSRDLTFDGTFEHLYVMTQSTLLKVPVASCAQHLDCASCLAHRDPYCGWCVLLGRC
                     SRRSECSRGQGPEQWLWSFQPELGCLQVAAMSPANISREETREVFLSVPDLPPLWPGE
                     SYSCHFGEHQSPALLTGSGVMCPSPDPSEAPVLPRGADYVSVSVELRFGAVVIAKTSL
                     SFYDCVAVTELRPSAQCQACVSSRWGCNWCVWQHLCTHKASCDAGPMVASHQSPLVSP
                     DPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWA
                     GSGSISSPGSTGSPLHEEPSPPSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVA
                     AVPPADPGPEALHPTVPLDLPPATVPATTFPGAMGSVKPALDWLTREGGELPEADEWT
                     GGDAPAFSTSTLLSGDGDSAELEGPPAPLILPSSLDYQYDTPGLWELEEATLGASSCP
                     CVESVQGSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVMELEGLEVVVEARVECEPP
                     PDTQCHVTCQQHQLSYEALQPELRVGLFLRRAGRLRVDSAEGLHVVLYDCSVGHGDCS
                     RCQTAMPQYGCVWCEGERPRCVTREACGEAEAVATQCPAPLIHSVEPLTGPVDGGTRV
                     TIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEVAGATAVEVP
                     GRGRGVSEHDFAYQDPKVHSIFPARGPRAGGTRLTLNGSKLLTGRLEDIRVVVGDQPC
                     HLLPEQQSEQLRCETSPRPTPATLPVAVWFGATERRLQRGQFKYTLDPNITSAGPTKS
                     FLSGGREICVRGQNLDVVQTPRIRVTVVSRMLQPSQGLGRRRRVVPETACSLGPSCSS
                     QQFEEPCHVNSSQLITCRTPALPGLPEDPWVRVEFILDNLVFDFATLNPTPFSYEADP
                     TLQPLNPEDPTMPFRHKPGSVFSVEGENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLY
                     CEPPVEQPLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGLG
                     VGTSLLALGVIIIVLMYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMT
                     DLTSDLLGSGIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQGLGQLSNLL
                     NSKLFLTKFIHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYV
                     AKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSV
                     TGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGAGEAQGVPVKVLDCDTISQAKEKM
                     LDQLYKGVPLTQRPDPRTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVP
                     DGATVALVPCLTKHVLRENQDYVPGERTPMLEDVDEGGIRPWHLVKPSDEPEPPRPRR
                     GSLRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLL
                     DEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTF
                     MDACTLADHKLGRDSPINKLLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAEL
                     SWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLGYRLQQIAAAVENKV
                     TDL"
     exon            1246..1428
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1557
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1658
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1791
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1948
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2057
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2166
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2847
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..2970
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2971..3093
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3187
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3188..3360
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3512
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3513..3618
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3619..3755
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3756..3932
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            3933..4104
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4105..4347
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4348..4524
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4525..4673
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4674..4774
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4775..4992
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            4993..5171
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            5172..5238
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            5239..5385
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            5386..5554
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            5555..5658
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            5659..5743
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            5744..5916
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            5917..6077
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            6078..6225
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            6226..6290
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            6291..6366
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            6367..6441
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     exon            6442..7178
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7158..7163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /note="hexamer: ATTAAA"
     polyA_site      7178
                     /gene="PLXNB1"
                     /gene_synonym="PLEXIN-B1; PLXN5; SEP"
                     /note="major polyA site"
ORIGIN      
        1 agtgggagca ggggcggtga gcaggggcgg tgggcagggc caggtgcgca ggggagaaac
       61 aaggcgcctt ggagttcagg tgactcccac acgggtcatg ctgttgtctc ctgatccagc
      121 cggccctgcc aggtgaccat gcctgctctg ggcccagctc ttctccaggc tctctgggcc
      181 gggtgggtcc tcaccctcca gccccttcca ccaactgcat tcactcccaa tggcacgtat
      241 ctgcagcacc tggcaaggga ccccacctca ggcaccctct acctgggggc taccaacttc
      301 ctgttccagc tgagccctgg gctgcagctg gaggccacag tgtccaccgg ccctgtgcta
      361 gacagcaggg actgcctgcc acctgtgatg cctgatgagt gcccccaggc ccagcctacc
      421 aacaacccga atcagctgct cctggtgagc ccaggggccc tggtggtatg cgggagcgtg
      481 caccaggggg tctgtgaaca gcggcgcctg gggcagctcg agcagctgct gctgcggcca
      541 gagcggcctg gggacacaca atatgtggct gccaatgatc ctgcggtcag cacggtgggg
      601 ctggtagccc agggcttggc aggggagccc ctcctgtttg tggggcgagg atacaccagc
      661 aggggtgtgg ggggtggcat tccacccatc acaacccggg ccctgtggcc gcccgacccc
      721 caagctgcct tctcctatga ggagacagcc aagctggcag tgggccgcct ctccgagtac
      781 agccaccact tcgtgagtgc ctttgcacgt ggggccagcg cctacttcct gttcctgcgg
      841 cgggacctgc aggctcagtc tagagctttt cgtgcctatg tatctcgagt gtgtctccgg
      901 gaccagcact actactccta tgtggagttg cctctggcct gcgaaggtgg ccgctacggg
      961 ctgatccagg ctgcagctgt ggccacgtcc agggaggtgg cgcatgggga ggtgctcttt
     1021 gcagctttct cctcggctgc accccccact gtgggccggc ccccatcggc ggctgctggg
     1081 gcatctggag cctctgccct ctgtgccttc cccctggatg aggtggaccg gcttgctaat
     1141 cgcacgcgag atgcctgcta cacccgggag ggtcgtgctg aggatgggac cgaggtggcc
     1201 tacatcgagt atgatgtcaa ttctgactgt gcacagctgc cagtggacac cctggatgct
     1261 tatccctgtg gctcagacca cacgcccagc cccatggcca gccgggtccc gctggaagcc
     1321 acaccaattc tggagtggcc agggattcag ctaacagctg tggcagtcac catggaagat
     1381 ggacacacca tcgctttcct gggtgatagt caagggcagc tgcacagggt ctacttgggc
     1441 ccagggagcg atggccaccc atactccaca cagagcatcc agcaggggtc tgcagtgagc
     1501 agagacctca cctttgatgg gacctttgag cacctgtatg tcatgaccca gagcacactt
     1561 ctgaaggttc ctgtggcttc ctgtgctcag cacctggact gtgcatcttg ccttgctcac
     1621 agggacccat actgtgggtg gtgcgtgctc cttggcaggt gcagtcgccg ttctgagtgc
     1681 tcgaggggcc agggcccaga gcagtggcta tggagcttcc agcctgagct gggctgtctg
     1741 caagtggcag ccatgagtcc tgccaacatc agccgagagg agacgaggga ggttttccta
     1801 tcagtgccag acctgccacc cctgtggcca ggggagtcat attcctgcca ctttggggaa
     1861 catcagagtc ctgccctgct gactggttct ggtgtgatgt gcccctcccc agaccctagt
     1921 gaggccccag tgctgccgag aggagccgac tacgtatccg tgagcgtgga gctcagattt
     1981 ggcgctgttg tgatcgccaa aacttccctc tctttctatg actgtgtggc ggtcactgaa
     2041 ctccgcccat ctgcgcagtg ccaggcctgt gtgagcagcc gctgggggtg taactggtgt
     2101 gtctggcagc acctgtgcac ccacaaggcc tcgtgtgatg ctgggcccat ggttgcaagc
     2161 catcagagcc cgcttgtctc cccagaccct cctgcaagag gtggacccag cccctcccca
     2221 cccacagccc ccaaagccct ggccacccct gctcctgaca cccttcccgt ggagcctggg
     2281 gctccctcca cagccacagc ttcggacatc tcacctgggg ctagtccttc cctgctcagc
     2341 ccctgggggc catgggcagg ttctggctcc atatcttccc ctggctccac agggtcgcct
     2401 ctccatgagg agccctcccc tcccagcccc caaaatggac ctggaaccgc tgtccctgcc
     2461 cccactgact tcagaccctc agccacacct gaggacctct tggcctcccc gctgtcaccc
     2521 tcagaggtag cagcagtgcc ccctgcagac cctggccccg aggctcttca tcccacagtg
     2581 cccctggacc tgccccctgc cactgttcct gccaccactt tcccaggggc catgggctcc
     2641 gtgaagcccg ccctggactg gctcacgaga gaaggcggcg agctgcccga ggcggacgag
     2701 tggacggggg gtgacgcacc cgccttctcc acttccaccc tcctctcagg tgatggagac
     2761 tcagcagagc ttgagggccc tcccgccccc ctcatcctcc cgtccagcct cgactaccag
     2821 tatgacaccc ccgggctctg ggagctggaa gaggcgacct tgggggcaag ctcctgcccc
     2881 tgtgtggaga gcgttcaggg ctccacgttg atgccggtcc atgtggagcg ggaaatccgg
     2941 ctgctaggca ggaacctgca ccttttccag gatggcccag gagacaatga gtgtgtgatg
     3001 gagctggagg gcctcgaggt ggtggttgag gcccgggtcg agtgtgagcc acctccagat
     3061 acccagtgcc atgtcacctg ccagcagcac cagctcagct atgaggctct gcagccggag
     3121 ctccgtgtgg ggctgtttct gcgtcgggcc ggccgtctgc gtgtggacag tgctgagggg
     3181 ctgcatgtgg tactgtatga ctgttccgtg ggacatggag actgcagccg ctgccaaact
     3241 gccatgcccc agtatggctg tgtgtggtgt gagggggagc gtccacgttg tgtgacccgg
     3301 gaggcctgtg gtgaggctga ggctgtggcc acccagtgcc cagcgcccct catccactcg
     3361 gtggagccac tgactgggcc tgtagacgga ggcacccgtg tcaccatcag gggctccaac
     3421 ctgggccagc atgtgcagga tgtgctgggc atggtcacgg tggctggagt gccctgtgct
     3481 gtggatgccc aggagtacga ggtctccagc agcctcgtgt gcatcaccgg ggccagtggg
     3541 gaggaggtgg ccggcgccac agcggtggag gtgccgggaa gaggacgtgg tgtctcagaa
     3601 cacgactttg cctaccagga tccgaaggtc cattccatct tcccggcccg cggccccaga
     3661 gctgggggca cccgtctcac cctgaatggc tccaagctcc tgactgggcg gctggaggac
     3721 atccgagtgg tggttggaga ccagccttgt cacttgctgc cggagcagca gtcagaacaa
     3781 ctgcggtgtg agaccagccc acgccccacg cctgccacgc tccctgtggc tgtgtggttt
     3841 ggggccacgg agcggaggct tcaacgcgga cagttcaagt ataccttgga ccccaacatc
     3901 acctctgctg gccccaccaa gagcttcctc agtggaggac gtgagatatg cgtccgtggc
     3961 cagaatctgg acgtggtaca gacgccaaga atccgggtga ccgtggtctc gagaatgctg
     4021 cagcccagcc aggggcttgg acggaggcgt cgcgtggtcc cggagacggc atgttccctt
     4081 ggaccctcct gcagtagcca gcaatttgag gagccgtgcc atgtcaactc ctcccagctc
     4141 atcacgtgcc gcacacctgc cctcccaggc ctgcctgagg acccctgggt ccgggtggaa
     4201 tttatccttg acaacctggt ctttgacttt gcaacactga accccacacc tttctcctat
     4261 gaggccgacc ccaccctgca gccactcaac cctgaggacc ccaccatgcc attccggcac
     4321 aagcctggga gtgtgttctc cgtggagggg gagaacctgg accttgcaat gtccaaggag
     4381 gaggtggtgg ctatgatagg ggatggcccc tgtgtggtga agacgctgac gcggcaccac
     4441 ctgtactgcg agccccccgt ggagcagccc ctgccacggc accatgccct ccgagaggca
     4501 cctgactctt tgcctgagtt cacggtgcag atggggaact tgcgcttctc cctgggtcac
     4561 gtgcagtatg acggcgagag ccctggggct tttcctgtgg cagcccaggt gggcttgggg
     4621 gtgggcacct ctcttctggc tctgggtgtc atcatcattg tcctcatgta caggaggaag
     4681 agcaagcagg ccctgaggga ctataagaag gttcagatcc agctggagaa tctggagagc
     4741 agtgtgcggg accgctgcaa gaaggaattc acagacctca tgactgagat gaccgatctc
     4801 accagtgacc tcctgggcag cggcatcccc ttcctcgact acaaggtgta tgcggagagg
     4861 atcttcttcc ctgggcaccg cgagtcgccc ttgcaccggg acctgggtgt gcctgagagc
     4921 agacggccca ctgtggagca agggctgggg cagctctcta acctgctcaa cagcaagctc
     4981 ttcctcacca agttcatcca cacgctggag agccagcgca ccttttcagc tcgggaccgt
     5041 gcctacgtgg catctctgct caccgtggca ctgcatggga agcttgagta tttcactgac
     5101 atcctccgca ctctgctcag tgacctggtt gcccagtatg tggccaagaa ccccaagctg
     5161 atgctgcgca ggacagagac tgtggtggag aagctgctca ccaactggat gtccatctgt
     5221 ctgtatacct tcgtgaggga ctccgtaggg gagcctctgt acatgctctt tcgagggatt
     5281 aagcaccaag tggataaggg gccagtggac agtgtgacag gcaaggccaa atacaccttg
     5341 aacgacaacc gcctgctcag agaggatgtg gagtaccgtc ccctgacctt gaatgcacta
     5401 ttggctgtgg ggcctggggc aggagaggcc cagggcgtgc ccgtgaaggt cctagactgt
     5461 gacaccatct cccaggcaaa ggagaagatg ctggaccagc tttataaagg agtgcctctc
     5521 acccagcggc cagaccctcg cacccttgat gttgagtggc ggtctggggt ggccgggcac
     5581 ctcattcttt ctgacgagga tgtcacttct gaggtccagg gtctgtggag gcgcctgaac
     5641 acactgcagc attacaaggt cccagatgga gcaactgtgg ccctcgtccc ctgcctcacc
     5701 aagcatgtgc tccgggaaaa ccaggattat gtccctggag agcggacccc aatgctggag
     5761 gatgtagatg aggggggcat ccggccctgg cacctggtga agccaagtga tgagccggag
     5821 ccgcccaggc ctcggagggg cagccttcgg ggcggggagc gtgagcgcgc caaggccatc
     5881 cctgagatct acctgacccg cctgctgtcc atgaagggca ccctgcagaa gttcgtggat
     5941 gacctgttcc aggtgattct cagcaccagc cgccccgtgc cgctcgctgt gaagtacttc
     6001 tttgacctgc tggatgagca ggcccagcag catggcatct ccgaccagga caccatccac
     6061 atctggaaga ccaacagctt gcctctgagg ttctggatca atataataaa aaacccgcag
     6121 tttgtgttcg acgtgcaaac atctgataac atggatgcgg tgctccttgt cattgcacag
     6181 accttcatgg acgcctgcac cctggccgac cacaagctgg gccgggactc cccgatcaac
     6241 aaacttctgt atgcacggga cattccccgg tacaagcgga tggtggaaag gtactatgca
     6301 gacatcagac agactgtccc agccagcgac caagagatga actctgtcct ggctgaactg
     6361 tcctggaact actccggaga cctcggggcg cgagtggccc tgcatgaact ctacaagtac
     6421 atcaacaagt actatgacca gatcatcact gccctggagg aggatggcac ggcccagaag
     6481 atgcagctgg gctatcggct ccagcagatt gcagctgctg tggaaaacaa ggtcacagat
     6541 ctataggaac ccaggagcca cggcctgctg ttgcttcagc ctggcctggg cagccctgga
     6601 agctcggagg agaggccacc ttcttaggtg cctgtagtga ctgacaagca gagttagtgg
     6661 aaggtgactc ccagtctcct ggtggctctg gcctcggccc tgctggatcc acctcctaga
     6721 cccggggcct caaggctcat ggggtagtac ccagcctgct ccccgagtcc agcgaccctg
     6781 tgacaccggt ctgcagggag ttggggacta agggcttcca gagagtggct ggaagagact
     6841 ccaggcccct ggggagactg tactgttcct gaacactggc cttggccaca ctgggattcg
     6901 gagaggaagg aggagagccc catgcttcct gtctgcctcc tccaccatcc ctgacctcag
     6961 ttgagctgcc tctggccttg ttgctgctgc cacatcctag gtctaagagt tgaacgcctc
     7021 tcctaggcca ctacaaactg acccctcagc agggctggct gccacagggc tgccctgcct
     7081 cataggtagc catggtgagg gctatctgct gcaggggggt cttggggaga gtggtgactc
     7141 cattgaccca gcttttcatt aaaggataac acactgca
//
