LOCUS       NM_020911              12959 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens plexin A4 (PLXNA4), transcript variant 1, mRNA.
ACCESSION   NM_020911
VERSION     NM_020911.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12959)
  AUTHORS   Cho,H., Park,H.J. and Seo,Y.K.
  TITLE     Induction of PLXNA4 Gene during Neural Differentiation in Human
            Umbilical-Cord-Derived Mesenchymal Stem Cells by Low-Intensity
            Sub-Sonic Vibration
  JOURNAL   Int J Mol Sci 23 (3), 1522 (2022)
   PUBMED   35163445
  REMARK    GeneRIF: Induction of PLXNA4 Gene during Neural Differentiation in
            Human Umbilical-Cord-Derived Mesenchymal Stem Cells by
            Low-Intensity Sub-Sonic Vibration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12959)
  AUTHORS   Razzaq,M., Iglesias,M.J., Ibrahim-Kosta,M., Goumidi,L.,
            Soukarieh,O., Proust,C., Roux,M., Suchon,P., Boland,A., Daiain,D.,
            Olaso,R., Havervall,S., Thalin,C., Butler,L., Deleuze,J.F.,
            Odeberg,J., Morange,P.E. and Tregouet,D.A.
  TITLE     An artificial neural network approach integrating plasma proteomics
            and genetic data identifies PLXNA4 as a new susceptibility locus
            for pulmonary embolism
  JOURNAL   Sci Rep 11 (1), 14015 (2021)
   PUBMED   34234248
  REMARK    GeneRIF: An artificial neural network approach integrating plasma
            proteomics and genetic data identifies PLXNA4 as a new
            susceptibility locus for pulmonary embolism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12959)
  AUTHORS   Kim,S.K., Roche,M.D., Fredericson,M., Dragoo,J.L., Horton,B.H.,
            Avins,A.L., Belanger,H.G., Ioannidis,J.P.A. and Abrams,G.D.
  TITLE     A Genome-wide Association Study for Concussion Risk
  JOURNAL   Med Sci Sports Exerc 53 (4), 704-711 (2021)
   PUBMED   33017352
  REMARK    GeneRIF: A Genome-wide Association Study for Concussion Risk.
REFERENCE   4  (bases 1 to 12959)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 12959)
  AUTHORS   Podojil,J.R., Chiang,M.Y., Ifergan,I., Copeland,R., Liu,L.N.,
            Maloveste,S., Langermann,S., Liebenson,D., Balabanov,R., Chi,H.,
            Chen,L., Vignali,D.A.A. and Miller,S.D.
  TITLE     B7-H4 Modulates Regulatory CD4+ T Cell Induction and Function via
            Ligation of a Semaphorin 3a/Plexin A4/Neuropilin-1 Complex
  JOURNAL   J Immunol 201 (3), 897-907 (2018)
   PUBMED   29898965
  REMARK    GeneRIF: B7-H4Ig binds to Sema3a, which acts as a functional bridge
            to stimulate an Nrp-1/Plexin A4 heterodimer.
REFERENCE   6  (bases 1 to 12959)
  AUTHORS   Maestrini,E., Pagnamenta,A.T., Lamb,J.A., Bacchelli,E., Sykes,N.H.,
            Sousa,I., Toma,C., Barnby,G., Butler,H., Winchester,L.,
            Scerri,T.S., Minopoli,F., Reichert,J., Cai,G., Buxbaum,J.D.,
            Korvatska,O., Schellenberg,G.D., Dawson,G., de Bildt,A.,
            Minderaa,R.B., Mulder,E.J., Morris,A.P., Bailey,A.J. and
            Monaco,A.P.
  CONSRTM   IMGSAC
  TITLE     High-density SNP association study and copy number variation
            analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4
            gene region in autism susceptibility
  JOURNAL   Mol Psychiatry 15 (9), 954-968 (2010)
   PUBMED   19401682
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 12959)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 12959)
  AUTHORS   Whitford,K.L. and Ghosh,A.
  TITLE     Plexin signaling via off-track and rho family GTPases
  JOURNAL   Neuron 32 (1), 1-3 (2001)
   PUBMED   11604131
  REMARK    Review article
REFERENCE   9  (bases 1 to 12959)
  AUTHORS   Tamagnone,L., Artigiani,S., Chen,H., He,Z., Ming,G.I., Song,H.,
            Chedotal,A., Winberg,M.L., Goodman,C.S., Poo,M., Tessier-Lavigne,M.
            and Comoglio,P.M.
  TITLE     Plexins are a large family of receptors for transmembrane,
            secreted, and GPI-anchored semaphorins in vertebrates
  JOURNAL   Cell 99 (1), 71-80 (1999)
   PUBMED   10520995
  REMARK    Erratum:[Cell 2001 Jan 26;104(2):following 320]
REFERENCE   10 (bases 1 to 12959)
  AUTHORS   Touchman,J.W., Bouffard,G.G., Weintraub,L.A., Idol,J.R., Wang,L.,
            Robbins,C.M., Nussbaum,J.C., Lovett,M. and Green,E.D.
  TITLE     2006 expressed-sequence tags derived from human chromosome
            7-enriched cDNA libraries
  JOURNAL   Genome Res 7 (3), 281-292 (1997)
   PUBMED   9074931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DR003088.1, AK123428.1, AB046770.3, AC018643.3, CD243425.1 and
            AA253415.1.
            
            On Aug 14, 2020 this sequence version replaced NM_020911.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no quality transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.3328725.1,
                                           SRR14038197.2394179.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321063.9/ ENSP00000323194.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               DR003088.1         393-544
            153-1429            AK123428.1         153-1429
            1430-5747           AB046770.3         1-4318
            5748-5749           AC018643.3         31946-31947         c
            5750-5817           AB046770.3         4321-4388
            5818-6488           CD243425.1         26-696
            6489-12958          AC018643.3         24737-31206         c
            12959-12959         AA253415.1         9-9                 c
FEATURES             Location/Qualifiers
     source          1..12959
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.3"
     gene            1..12959
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /note="plexin A4"
                     /db_xref="GeneID:91584"
                     /db_xref="HGNC:HGNC:9102"
                     /db_xref="MIM:604280"
     exon            1..49
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            50..1323
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..5820
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="plexin-A4 isoform 1 precursor"
                     /protein_id="NP_065962.1"
                     /db_xref="CCDS:CCDS43646.1"
                     /db_xref="GeneID:91584"
                     /db_xref="HGNC:HGNC:9102"
                     /db_xref="MIM:604280"
                     /translation="MKAMPWNWTCLLSHLLMVGMGSSTLLTRQPAPLSQKQRSFVTFR
                     GEPAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQ
                     TCNEPLTTTNNVNKMLLIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYL
                     SGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPTISSRKLTKNSEADGMFAYVF
                     HDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVY
                     TSKLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDL
                     LFTVFSKGQKRKMKSLDESALCIFILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIP
                     CSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAYVYKNHSLAFVGT
                     KSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVE
                     SCGQYQSCGECLGSGDPHCGWCVLHNTCTRKERCERSKEPRRFASEMKQCVRLTVHPN
                     NISVSQYNVLLVLETYNVPELSAGVNCTFEDLSEMDGLVVGNQIQCYSPAAKEVPRII
                     TENGDHHVVQLQLKSKETGMTFASTSFVFYNCSVHNSCLSCVESPYRCHWCKYRHVCT
                     HDPKTCSFQEGRVKLPEDCPQLLRVDKILVPVEVIKPITLKAKNLPQPQSGQRGYECI
                     LNIQGSEQRVPALRFNSSSVQCQNTSYSYEGMEINNLPVELTVVWNGHFNIDNPAQNK
                     VHLYKCGAMRESCGLCLKADPDFACGWCQGPGQCTLRQHCPAQESQWLELSGAKSKCT
                     NPRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQI
                     VCEMGEAKPSQHAGFVEICVAVCRPEFMARSSQLYYFMTLTLSDLKPSRGPMSGGTQV
                     TITGTNLNAGSNVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRAKIHQ
                     DLVFQYVEDPTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHINICEV
                     LNATEMTCQAPALALGPDHQSDLTERPEEFGFILDNVQSLLILNKTNFTYYPNPVFEA
                     FGPSGILELKPGTPIILKGKNLIPPVAGGNVKLNYTVLVGEKPCTVTVSDVQLLCESP
                     NLIGRHKVMARVGGMEYSPGMVYIAPDSPLSLPAIVSIAVAGGLLIIFIVAVLIAYKR
                     KSRESDLTLKRLQMQMDNLESRVALECKEAFAELQTDIHELTSDLDGAGIPFLDYRTY
                     TMRVLFPGIEDHPVLRDLEVPGYRQERVEKGLKLFAQLINNKVFLLSFIRTLESQRSF
                     SMRDRGNVASLIMTVLQSKLEYATDVLKQLLADLIDKNLESKNHPKLLLRRTESVAEK
                     MLTNWFTFLLYKFLKECAGEPLFSLFCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQ
                     IDYKTLVLSCVSPDNANSPEVPVKILNCDTITQVKEKILDAIFKNVPCSHRPKAADMD
                     LEWRQGSGARMILQDEDITTKIENDWKRLNTLAHYQVPDGSVVALVSKQVTAYNAVNN
                     STVSRTSASKYENMIRYTGSPDSLRSRTPMITPDLESGVKMWHLVKNHEHGDQKEGDR
                     GSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADK
                     HGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCST
                     SEHRLGKDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMN
                     EFNTMSALSEIFSYVGKYSEEILGPLDHDDQCGKQKLAYKLEQVITLMSLDS"
     exon            1324..1506
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1638
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1739
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1863
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2017
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2117
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2232
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2433
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2530
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2721
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2873
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..2991
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            2992..3128
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..3293
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            3294..3387
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            3388..3627
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            3628..3774
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            3775..4009
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            4010..4152
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            4153..4421
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            4422..4488
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            4489..4635
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            4636..4795
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            4796..4899
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            4900..4999
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            5000..5190
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            5191..5360
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            5361..5573
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            5574..5724
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     exon            5725..12959
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8691..8696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /note="hexamer: TATAAA"
     polyA_site      8722
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /note="major polyA site"
     regulatory      12928..12933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /note="hexamer: AATAAA"
     regulatory      12938..12943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /note="hexamer: ATTAAA"
     polyA_site      12946
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /note="major polyA site"
     polyA_site      12959
                     /gene="PLXNA4"
                     /gene_synonym="FAYV2820; PLEXA4; PLXNA4A; PLXNA4B;
                     PRO34003"
                     /note="major polyA site"
ORIGIN      
        1 agtgtcaatg cggcgctccc gctgaaggag ggaaacgcgg cgcgtccagt aggggagact
       61 gcattgctga gtcctggccc tctgagggga cgactgtgcc tgagtgctgc tgtgccactg
      121 ggacccgcct ctgccatgaa agccatgccc tggaactgga cctgccttct ctcccacctc
      181 ctcatggtgg gcatgggctc ctccactttg ctcacccggc agccagcccc gctgtcccag
      241 aagcagcggt catttgtcac attccgagga gagcccgccg agggtttcaa tcacctggtg
      301 gtggatgaga ggacaggaca catttacttg ggggccgtca atcggattta caagctctcc
      361 agcgacctga aggtcttggt gacgcatgag acagggccgg acgaggacaa ccccaagtgt
      421 tacccacccc gcatcgtcca gacctgcaat gagcccctga ccaccaccaa caatgtcaac
      481 aagatgctcc tcatagacta caaggagaac aggctgattg cctgtgggag cctgtaccaa
      541 ggcatctgca agctgctgag gctggaggac ctcttcaagc tgggggagcc ttatcataag
      601 aaggagcact atctgtcagg tgtcaacgag agcggctcag tctttggagt gatcgtctcc
      661 tacagcaacc tggatgacaa gctgttcatt gccacggcag tggatgggaa gcccgagtat
      721 tttcccacca tctccagccg gaaactgacc aagaactctg aggcggatgg catgttcgcg
      781 tacgtcttcc atgatgagtt cgtggcctcg atgattaaga tcccttcgga caccttcacc
      841 atcatccctg actttgatat ctactatgtc tatggtttta gcagtggcaa ctttgtctac
      901 tttttgaccc tccaacctga gatggtgtct ccaccaggct ccaccaccaa ggagcaggtg
      961 tatacatcca agctcgtgag gctttgcaag gaggacacag ccttcaactc ctatgtagag
     1021 gtgcccattg gctgtgagcg cagtggggtg gagtaccgcc tgctgcaggc tgcctacctg
     1081 tccaaagcgg gggccgtgct tggcaggacc cttggagtcc atccagatga tgacctgctc
     1141 ttcaccgtct tctccaaggg ccagaagcgg aaaatgaaat ccctggatga gtcggccctg
     1201 tgcatcttca tcttgaagca gataaatgac cgcattaagg agcggctgca gtcttgttac
     1261 cggggcgagg gcacgctgga cctggcctgg ctcaaggtga aggacatccc ctgcagcagt
     1321 gcgctcttaa ccattgacga taacttctgt ggcctggaca tgaatgctcc cctgggagtg
     1381 tccgacatgg tgcgtggaat tcccgtcttc acggaggaca gggaccgcat gacgtctgtc
     1441 atcgcatatg tctacaagaa ccactctctg gcctttgtgg gcaccaaaag tggcaagctg
     1501 aagaagatcc gggtggatgg acccaggggc aacgccctcc agtatgagac ggtgcaggtg
     1561 gtggaccccg gcccagtcct ccgggatatg gccttctcca aggaccacga gcaactctac
     1621 atcatgtcag agaggcagct caccagagtc cctgtggagt cctgtggtca gtatcagagc
     1681 tgcggcgagt gccttggctc aggcgacccc cactgtggct ggtgtgtgct gcacaacact
     1741 tgcacccgga aggagcggtg tgagcggtcc aaggagcccc gcaggtttgc ctcggagatg
     1801 aagcagtgtg tccggctgac ggtccatccc aacaatatct ccgtctctca gtacaacgtg
     1861 ctgctggtcc tggagacgta caatgtcccg gagctgtcag ctggcgtcaa ctgcaccttt
     1921 gaggacctgt cagagatgga tgggctggtc gtgggcaatc agatccagtg ctactcccct
     1981 gcagccaagg aggtgccccg gatcatcaca gagaatgggg accaccatgt cgtacagctt
     2041 cagctcaaat caaaggagac cggcatgacc ttcgccagca ccagctttgt cttctacaat
     2101 tgcagcgtcc acaattcgtg cctgtcctgc gtggagagtc cataccgctg ccactggtgt
     2161 aaataccggc atgtctgcac ccatgacccc aagacctgct ccttccagga aggccgagtg
     2221 aagctgcccg aggactgccc ccagctgctg cgagtggaca agatcctggt gcccgtggag
     2281 gtgatcaagc ctatcacgct gaaggccaag aacctccccc agccccagtc tgggcagcgt
     2341 ggctacgaat gcatcctcaa cattcagggc agcgagcagc gagtgcccgc cctgcgcttc
     2401 aacagctcca gcgtacagtg ccagaacacc tcttattcct atgaagggat ggagatcaac
     2461 aacctgcccg tggagttgac agtcgtgtgg aatgggcact tcaacattga caacccagct
     2521 cagaataaag ttcacctcta caagtgtgga gccatgcgtg agagctgcgg gctgtgcctc
     2581 aaggctgacc cagacttcgc atgtggctgg tgccagggcc caggccagtg caccctgcgc
     2641 cagcactgcc ctgcccagga gagccagtgg ctggagctgt ctggtgccaa aagcaagtgc
     2701 acaaaccccc gcatcacaga gataatcccg gtgacaggcc cccgggaagg gggcaccaag
     2761 gtcactatcc gaggggagaa cctgggcctg gaatttcgcg acatcgcctc ccatgtcaag
     2821 gttgctggcg tggagtgcag ccctttagtg gatggttaca tccctgcaga acagatcgtg
     2881 tgtgagatgg gggaggccaa gcccagccag catgcaggct tcgtggagat ctgcgtggct
     2941 gtgtgtcggc ctgaattcat ggcccggtcc tcacagctct attacttcat gacactgact
     3001 ctctcagatc tgaagcccag ccgggggccc atgtccggag ggacccaagt gaccatcaca
     3061 ggcaccaacc tgaatgccgg aagcaacgtg gtggtgatgt ttggaaagca gccctgtctc
     3121 ttccacaggc gatctccatc ctacattgtc tgcaacacca catcctcaga tgaggtgcta
     3181 gagatgaagg tgtcggtgca ggtggacagg gccaagatcc accaggacct ggtctttcag
     3241 tatgtggaag accccaccat cgtgcggatt gagccagaat ggagcattgt cagtggaaac
     3301 acacccatcg ccgtatgggg gacccacctg gacctcatac agaaccccca gatccgtgcc
     3361 aagcatggag ggaaggagca catcaatatc tgtgaggttc tgaacgctac tgagatgacc
     3421 tgtcaggcgc ccgccctcgc tctgggtcct gaccaccagt cagacctgac cgagaggccc
     3481 gaggagtttg gcttcatcct ggacaacgtc cagtccctgc tcatcctcaa caagaccaac
     3541 ttcacctact atcccaaccc ggtgtttgag gcctttggtc cctcaggaat cctggagctc
     3601 aagcctggca cgcccatcat cctaaagggc aagaacctga tcccgcctgt ggctgggggc
     3661 aacgtgaagc tgaactacac tgtgctggtt ggggagaagc cgtgcaccgt gaccgtgtca
     3721 gatgtccagc tgctctgcga gtcccccaac ctcatcggca ggcacaaagt gatggcccgt
     3781 gtcggtggca tggagtactc cccggggatg gtgtacattg ccccggacag cccgctcagc
     3841 ctgcccgcca tcgtcagcat cgcagtggct ggcggcctcc tcatcatttt catcgtggcc
     3901 gtgctcattg cctataaacg caagtcccgc gaaagtgacc tcacgctgaa gcggctgcag
     3961 atgcagatgg acaacctgga gtcccgtgtg gccctggagt gcaaggaagc ctttgccgag
     4021 ctgcagacgg acatccatga gctgaccagt gacctggatg gagccgggat tccgttcctg
     4081 gactatagaa cttacaccat gcgggtgctg ttcccaggaa ttgaagacca ccctgtcctc
     4141 cgggaccttg aggtcccggg ctaccggcag gagcgtgtgg agaaaggcct gaagctcttc
     4201 gcccagctca tcaacaacaa ggtgttcctg ctgtccttca tccgcacgct tgagtcccag
     4261 cgtagcttct ccatgcgcga ccgtggcaac gtggcctcac tcatcatgac cgtgctgcag
     4321 agcaagctgg agtacgccac tgatgtgctg aagcagctgc tggccgacct cattgacaag
     4381 aacctggaga gcaagaacca ccctaagctg ctgctcagga ggactgagtc agtggctgag
     4441 aagatgctga ccaattggtt tactttcctc ctctacaagt tcctcaagga gtgtgctggg
     4501 gagcccctct tctccctgtt ctgtgccatc aagcagcaga tggagaaggg ccccattgac
     4561 gccatcacgg gcgaggcccg ctactccttg agcgaggaca agctcatccg ccagcagatt
     4621 gactacaaaa ccctggtcct gagctgtgtc agcccagaca atgccaacag ccccgaggtc
     4681 ccagtaaaga tcctcaactg tgacaccatc actcaggtca aggagaagat tctggatgcc
     4741 atcttcaaga atgtgccttg ctcccaccgg cccaaagctg cagatatgga tctggagtgg
     4801 cgacaaggaa gtggggcaag gatgatcttg caggatgaag acatcaccac caagattgag
     4861 aatgattgga agcgactgaa cacactggcc cactaccagg tgccagatgg ttccgtggtg
     4921 gcattagtgt ccaagcaggt gacagcctat aacgcagtga acaactccac cgtctccagg
     4981 acctcagcaa gtaaatatga aaacatgatc cggtacacgg gcagccccga cagcctccgc
     5041 tcacggacac ctatgatcac tcctgacctg gagagtggag tcaagatgtg gcacctagtg
     5101 aagaaccacg agcacggaga ccagaaggag ggggaccggg ggagcaagat ggtgtctgaa
     5161 atctacctga cccgactcct ggccactaag ggcacactgc agaagtttgt ggatgacctc
     5221 tttgagacca tcttcagcac ggcacaccgt ggctctgccc tgcccctggc catcaagtac
     5281 atgtttgact tcctggatga gcaggctgat aaacatggca ttcatgaccc gcacgtccgc
     5341 catacctgga agagcaattg cctgcccctg aggttttggg tcaacatgat caagaacccg
     5401 cagtttgtgt ttgacatcca taagaacagc atcacagacg cctgcctctc tgtggtggct
     5461 cagaccttca tggactcttg ctccacgtca gagcaccggc tgggcaagga ctcgccctcc
     5521 aacaagctgc tgtatgccaa ggacatcccc agctacaaga attgggtgga gaggtattac
     5581 tcagacatag ggaagatgcc agccatcagc gaccaagaca tgaacgcata cctggctgag
     5641 cagtcccgga tgcacatgaa tgagttcaac accatgagtg cactctcaga gatcttctcc
     5701 tatgtgggca aatacagcga ggagatcctt ggacctctgg accacgatga ccagtgtggg
     5761 aagcagaaac tggcctacaa actagaacaa gtcataaccc tcatgagctt agacagctga
     5821 gaaccgtcct tccagggccg ccctggaggg ggacacacca agccgtgcct cagtctagat
     5881 tatcatcttt accaagtgca agttccgact ggcatcagca gcatcccctg agcagcgctg
     5941 tttctctctc tttctctctg cctctttccg tttctccctc cttcctggat ctcttctctt
     6001 ccagttgctc tgccaacacg attggaccaa gccactgacc ctcagttagt ccaagaatgg
     6061 ccaggcccat ggcaagggag ctgaccagaa gatgtcagag aggcctctgt ctcccaggtg
     6121 ctcctgaccc tgtgcatgtc agcagcaggg tgcaaataac gaatgaggag ccagggacag
     6181 gggacatttc tgtgctgcta cttcaccttc cactttggca gcccctgctt tggtctgagc
     6241 cttggcctag ggaagaggca aggaaggact tcagtattat ctttactggg aagacatcac
     6301 ctggctctcc cttcccacag ttccatctcc agtggttcag ccagtggtct gatcgctttg
     6361 cagctgtgag aagaaaggct acacctcctg catgtggctg gagcagggca tgtgtgggca
     6421 gctgggaggt gctccttgag gctccttctc ccccactggg ctggtgtcca gaggcttcct
     6481 gtccttttcc aggtctccag agggacctgc ctgccctgcc tgctcccccg ccagtagaaa
     6541 gccaggcagg agaaagaata gcaattacat tccaccatgg agatgctcct gaccttttca
     6601 tctgaatcct agtagcagaa atgtaacaca gggggagaaa aggaaagaga gttgcatcta
     6661 ccctggaagc agaatttgtt ttccatttac cctcaaattc aaatgagtca caatcatagt
     6721 cataggtcta gtccactacc agagccctga gtgctgtcaa gagaaagcat ctatctccac
     6781 cctcctttgt caaccttcat caagggtcaa cgtgaaatgc agagtgcatc taggagattc
     6841 tacctccagc catctccatg gctccatccc catcatcctt cctgagaact ccatagacgg
     6901 ctggggccaa cagcctagtc cctgttccct ctgcagaatc cggtgccatt gctatgcaga
     6961 tgactttgtc actgggctgt ccagacctct ttgggaatga tttcatcaac atctcagctg
     7021 tctctcatca ttctccttcc tcatctcttc agcagtcatc cttgaaagaa acagacttaa
     7081 gcaaagcctc acggagacag cccaaaatgc cagccaacct cagcctccag cttgtcagat
     7141 ctgggaggga caaagagtcg agctgatggg cctggctgga attaagaaga gggacataca
     7201 aatgaccttg gccttggcat ccatctcccc atctgttctt acatctacag atgcacgatt
     7261 ttagccaggc aggcaaatgt gtgcctagaa attgatacta ggtaagcaga ggctatgggg
     7321 agagatggtc taatggaggg ttctaggaac ctttcatcct aaggagacct taggtgctgt
     7381 ctggtgcagt ctcccatcct aagcaggagt ctctgttggc acctctgctc tggagttgtt
     7441 caccactatg ggagacaagg agaaacatct taggtgaggt tgaggagaag gattcacagt
     7501 cttgccttca ctccccaaac atcagacatc attccttgtc acccactcag aatgagcccc
     7561 ccttggggaa gaaaccacac catttccagc aaagtccatg gagcatccgg tacttttaag
     7621 aacacttgcc cctttggata tgaatatgtg cacatgtgtg tgagcacatg tatgtgtgtg
     7681 tgtgtgtctg ccccaggtgt aggcggaaag ctcaaaagga tttcttgtcc tttgtaggag
     7741 gatttttgaa gtgttcccct tctctttccc cttgctcatc cattcatcct gcagcttcag
     7801 gacatttcaa cacttacttg ctttctatgc tgagagctgg tgggtggaag gagagggcgc
     7861 ttgtccatag gaaatcaggg tggtcgcctg ccgaggcctg gaccttggaa cagggcatca
     7921 tgtgacatcg cagaggacag atggtggaaa agacatgagc aacctaatgg gaagaggaaa
     7981 atgggaaaca atgcattgga agaggaagaa aaaaaataaa taaccaaagg ttttggcaag
     8041 tgcagtacca ggtggagaag cttgactttt ctatccttga tcattttatt ccctcccaag
     8101 aagtcagtca caggacctgg aaggccagaa agggtacatg tgggagacgg tctgaggaag
     8161 tacctcggtc actacaatat ttttgcacat ataaagggtt ggggaggaaa gagacacaaa
     8221 cgtatttaac acagatttgc tggatggaag ctgcgtgtgt gaacgtgtgt atgagtgagt
     8281 gcattttgat tttttttttt tttttttgca cagttaagag aaaaaatcaa acaagcagaa
     8341 aaaaaaaaga aaaaagactt atcacggttc tgctgaagct tttatttttt actggatgat
     8401 gattattgtt attgttactt tggcggtaca ggactttatt ttattccatg tttttgttat
     8461 aagaaaaatt tcaaacacct cagagaaata gaaaggttag gaagaaagag gagacaagga
     8521 cagacaaatt ttctggctgt ccccatttct cctgggggag gggtttgggg ctggtttgac
     8581 tttaattggt gggtgggttg tttctgccgc tctgtttgct gcagtccccg tggcctgctt
     8641 ggggactgag aaatttgagc caggtatcca gagccacagc ccatcttgct tataaaaatt
     8701 atcttctgct gtttgttttc catttcttcc gtttggattc ttggtgcacg tgtgatatgg
     8761 tatttaaaag caaagacaag caacattgtc aaaaagctgt ccttgccccc catcccccac
     8821 ccaaatcttt tttccaaact cccccaggga tcttccttac cccactggca gagcaaacat
     8881 ccaggggctg tccatgtggc ttgcgggctc ccagagaaag gaattgggcc aactttgtcc
     8941 tgtgggatgg aggccccttc acggcctccc tcgaggcaaa gttaatttgt agggtcacca
     9001 ttatgttgag tcatgagcag acagaaggag agaaaaggcc atcttcctta ccttcccctc
     9061 caacttatcc cgtaccctcc cagggaaaat ggtaccagac tgagccatca aaatcactga
     9121 caaagtttag gtgggaattt tttttgcatg ttggagagag aagggcttaa ggtagcaggg
     9181 aagaaggggg ctttgtgggg tcctaaattt taaggaataa gtagaggaag acaagaaaca
     9241 gagtggtagg ctggtcattt ctcctggcca caagtccccc cagatgcagc ttttacccat
     9301 tctttgtcct tccccataag gagagaccct gacatttctt ggtagctgca aatagtgcca
     9361 ctaagtgaag gtggccatca tgccagttac ttcctcagga aaatattttc ttgccttctt
     9421 ctttcagtat ggttttaaat ttgggaacag tggataaccc aagtgtccca caggccaagg
     9481 tacattccaa tggcagcatg atccctgcac ccaaagccag cccctaaagc ctaccccttg
     9541 tgcacccgca gcctggtaag tgagcttggc tgcttgtgag gagctacaag tgaaagagaa
     9601 gttattttaa ataaatccca aagtttgagg cagactgtcc aggactgttc ccaggaagaa
     9661 gcaggagtta cccacaggaa aagtctctga cctggtcccc tcaggcccag ctacctgcgc
     9721 ccaccagcag tgaaggttga tgtactggcc cagcatctcc acctccccca tgcaaccagg
     9781 tccctggtac cgtgtctccc gttgcatgtc tggcttctgc ctgtgctcct cctgccacga
     9841 gcatcctccc tgtccctcct cattccaccg tgtctctcct gcacacatag cctctgtccc
     9901 agggcgattt atccacttga gtacaggagc tgctcagacc tctcagccca gccctctgtg
     9961 actgccccag ccccatccta ccccacccaa agctgccttc ctggctgtag gagctccctc
    10021 gtctagccaa ggccctatgg gtccccatcc gaggatccac aagcaatgac ttcccaaatg
    10081 acctccactg caagaagaat ccttaccact gtttccagag ccgtgaacga tgctgtgatg
    10141 ggcccaggtc tcagcaccac cctctgtgac ctaaaaagaa aagctcaatt tccatctgtc
    10201 ttctttccca ggaccaaggg gacacagtaa tgtgaagtca aatacttaac cgagcaaagg
    10261 gccagtattg ttatcagtca aggacaaacc tcccacctca cagacagcca agcagtgagg
    10321 gaaagacaga cagacatagg taggaaggtg ctctgcaggc acaaggccca gagaagcccc
    10381 tctccgggaa cttcccctgc tccttccagg aacagtgagc ccagtgagca gccccagcca
    10441 gctcttcaag gccttcaagg ggtctttcca tgactgagtc acctccagga gctcacctga
    10501 cccccagaga agacctaccc caggcagctc cgtgccctgg cttctcccca tgccccaaat
    10561 ccccccccgc catccctcct ggtcctcgtc tacatcaagg gcctcttccc ctcttcctgc
    10621 cagctctcag gacaggtgac tgggaggcct tgaaccctca gcctcttcct ttaaaaaaaa
    10681 caaaacaaaa caaaactgtg ggccatttat ttgggatttt ggagttgttt ggtttttgtt
    10741 tgtatatctt aatagttcga aagtaagaag ggagccctgc tatggatgtt aagtccaaat
    10801 tactcggtta gtgggagcaa aacctatgac ttccaagggg atgaggagag gttcagagga
    10861 caggaggagc ctcccccatt gaaaaaaaaa aatgggtcag gacattccct ggatgaggac
    10921 aatgctaggg gtggcatctc acatggctgc tgctattcct ggtgcttccc cacacttttg
    10981 acagatggag tccttctcct accgcctcct gccacctcac cctacaggca ttctctatgt
    11041 aggaaacaag agccttattt tatagagtgg ggagctgaga cacagcctca ggtaacactg
    11101 acacagctcc cgaatgaggc tgggacactc tgcaaacctc tcctcatggt gctaagggtg
    11161 gcatgctctt gacaggaaac ctaaatgacc actcctctca tttggaaagt aatccactgc
    11221 agtaaaagtt tcagacatgc aagagagagt tttttttttt ttactacaaa tttttgctcc
    11281 cccataaaat tattttatta gagggagtat ccaagtttta aaagtatata gaattttttg
    11341 gttgtaagag aaatacatac tcattaggat cccgattaaa ttccttgagt agactggtgc
    11401 ctaccagaaa gcaaagcaaa gttaaacaaa acgaaacaaa atccttcata tacaaaaaga
    11461 actttctgtt tgtattggca gaggtagtga ggtgattcag gtaggctgaa aatcctgggt
    11521 tgcgggagcc tcactttatt ccattcccac ccgctttgat gtctatgctt ggctctctgg
    11581 gctgcccctg gtactgccga atcctacaca tctcttatca gctttcctca aactttaagg
    11641 aggctctgtg agggatgggt catgggaaga cccaagcttt ccctccgcca ggattgcaaa
    11701 agcaagtaga cttggtctat gcagctcttc ttccagcaat ttctttattt ggaattagaa
    11761 cttcctttgt tagtatcttt gatcttttga ctcaagcaca ttttggaagg gctcccttac
    11821 aaaagtagaa tttaaaacag aggatacagt taaagagcaa cccaaaggac gcttaagaaa
    11881 ccgagaccac ttcaccaaac aggactaagg aacactttcg tgcacagaag tcagccgcaa
    11941 tccaggcaca ggacgaagat gggatacacg tgctcatctg tctgtcctcc tttcctctcc
    12001 ctccccgacg ttctagttag cttgttgact tgttaaacct tctgttctta aaatgaaaag
    12061 ctagcttacc tcaaagaatc ttgtttccat tcggaaacca acgattttgt gttttagaat
    12121 ggacagccct cccctcacca ctccctacct tggcctggtg tccttgagac atacggtctt
    12181 tgcttagtcg tgtgttggct gctttgagca ggaacaaggc ctccaggccc tgaggtggga
    12241 aggaaggatt ggatgccact gccctcctcc ccactttagc atgtaggggc cagcccatct
    12301 cttccagcag ggtcctgctg agttaccata gcaaccagca actccagggt accacaacag
    12361 acaatggctc agcgagccga cgtgtgggga tgatgcaggg gttttggccc agccagagga
    12421 cccagagttg agcttcaaat gctagagaag gggagaaaca ggatggaagg gtggtttaag
    12481 gaaccggcag gggtctttga gtcacataga gaagccgttg aaggaggtag ggcaggttat
    12541 ctctgttcca gtcaccccct tccagcccca tcccacttct gtttcaaact aaagctccca
    12601 cctcgaacat tgaccctttg ttagaacaaa gcaaagcata tctttagaca acagtgttaa
    12661 aatgagcctc aaatgtatgt ggatgagatc tctaagaaga gggtcttctg gttttgattt
    12721 ttaaagaaga gtatcctagt aaaatattaa aaaaaaatta aaaagttttt aaaaaggaaa
    12781 cctgtgctat ttaaattgga gcccagttgt aacttggtaa aggcaagctt ctgtaccttt
    12841 gttataatta attgtatacc tgtgtatgta aatataaggc attcctattt tgcagttcag
    12901 aacaaaaaaa acttatttgt aatatagaat aaagtttatt aaaaaataat aaaaatgca
//
