LOCUS       NM_017514              10885 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens plexin A3 (PLXNA3), mRNA.
ACCESSION   NM_017514
VERSION     NM_017514.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10885)
  AUTHORS   Steele,J.L., Morrow,M.M., Sarnat,H.B., Alkhunaizi,E., Brandt,T.,
            Chitayat,D.A., DeFilippo,C.P., Douglas,G.V., Dubbs,H.A.,
            Elloumi,H.Z., Glassford,M.R., Hannibal,M.C., Heron,B., Kim,L.E.,
            Marco,E.J., Mignot,C., Monaghan,K.G., Myers,K.A., Parikh,S.,
            Quinonez,S.C., Rajabi,F., Shankar,S.P., Shinawi,M.S., van de
            Kamp,J.J.P., Veerapandiyan,A., Waldman,A.T. and Graf,W.D.
  TITLE     Semaphorin-Plexin Signaling: From Axonal Guidance to a New X-Linked
            Intellectual Disability Syndrome
  JOURNAL   Pediatr Neurol 126, 65-73 (2022)
   PUBMED   34740135
  REMARK    GeneRIF: Semaphorin-Plexin Signaling: From Axonal Guidance to a New
            X-Linked Intellectual Disability Syndrome.
REFERENCE   2  (bases 1 to 10885)
  AUTHORS   Qureshi,M., Hatem,M., Alroughani,R., Jacob,S.P. and Al-Temaimi,R.A.
  TITLE     PLXNA3 Variant rs5945430 is Associated with Severe Clinical Course
            in Male Multiple Sclerosis Patients
  JOURNAL   Neuromolecular Med 19 (2-3), 286-292 (2017)
   PUBMED   28536997
  REMARK    GeneRIF: Exome analysis of Kuwaiti multiple sclerosis patients
            revealed a missense variant (rs5945430) in Plexin A3 (PLXNA3) gene
            (Xq28) associated with male-specific MS severity and disability.
REFERENCE   3  (bases 1 to 10885)
  AUTHORS   Belyk,M., Kraft,S.J. and Brown,S.
  CONSRTM   Pediatric Imaging, Neurocognition and Genetics Study
  TITLE     PlexinA polymorphisms mediate the developmental trajectory of human
            corpus callosum microstructure
  JOURNAL   J Hum Genet 60 (3), 147-150 (2015)
   PUBMED   25518740
  REMARK    GeneRIF: Data indicate that plexin A1-4 (PLXNA1-4) mediation of
            neuroanatomical traits can be detected using in vivo neuroimaging
            techniques.
REFERENCE   4  (bases 1 to 10885)
  AUTHORS   Gabrovska,P.N., Smith,R.A., Tiang,T., Weinstein,S.R., Haupt,L.M.
            and Griffiths,L.R.
  TITLE     Semaphorin-plexin signalling genes associated with human breast
            tumourigenesis
  JOURNAL   Gene 489 (2), 63-69 (2011)
   PUBMED   21925246
  REMARK    GeneRIF: in vitro analysis on PLXNA3 also suggest that this gene
            may have some form of growth suppressive role in breast cancer, in
            addition to a similar role for the gene previously reported in
            ovarian cancer.
REFERENCE   5  (bases 1 to 10885)
  AUTHORS   Fiedler,S.E., Schillace,R.V., Daniels,C.J., Andrews,S.F. and
            Carr,D.W.
  TITLE     Myeloid translocation gene 16b is a dual A-kinase anchoring protein
            that interacts selectively with plexins in a phospho-regulated
            manner
  JOURNAL   FEBS Lett 584 (5), 873-877 (2010)
   PUBMED   20138877
REFERENCE   6  (bases 1 to 10885)
  AUTHORS   Tamagnone,L., Artigiani,S., Chen,H., He,Z., Ming,G.I., Song,H.,
            Chedotal,A., Winberg,M.L., Goodman,C.S., Poo,M., Tessier-Lavigne,M.
            and Comoglio,P.M.
  TITLE     Plexins are a large family of receptors for transmembrane,
            secreted, and GPI-anchored semaphorins in vertebrates
  JOURNAL   Cell 99 (1), 71-80 (1999)
   PUBMED   10520995
  REMARK    Erratum:[Cell 2001 Jan 26;104(2):following 320]
REFERENCE   7  (bases 1 to 10885)
  AUTHORS   Chen,E.Y., Zollo,M., Mazzarella,R., Ciccodicola,A., Chen,C.N.,
            Zuo,L., Heiner,C., Burough,F., Repetto,M., Schlessinger,D. and
            D'Urso,M.
  TITLE     Long-range sequence analysis in Xq28: thirteen known and six
            candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and
            G6PD loci
  JOURNAL   Hum Mol Genet 5 (5), 659-668 (1996)
   PUBMED   8733135
REFERENCE   8  (bases 1 to 10885)
  AUTHORS   Maestrini,E., Tamagnone,L., Longati,P., Cremona,O., Gulisano,M.,
            Bione,S., Tamanini,F., Neel,B.G., Toniolo,D. and Comoglio,P.M.
  TITLE     A family of transmembrane proteins with homology to the
            MET-hepatocyte growth factor receptor
  JOURNAL   Proc Natl Acad Sci U S A 93 (2), 674-678 (1996)
   PUBMED   8570614
REFERENCE   9  (bases 1 to 10885)
  AUTHORS   Bione,S., Tamanini,F., Maestrini,E., Tribioli,C., Poustka,A.,
            Torri,G., Rivella,S. and Toniolo,D.
  TITLE     Transcriptional organization of a 450-kb region of the human X
            chromosome in Xq28
  JOURNAL   Proc Natl Acad Sci U S A 90 (23), 10977-10981 (1993)
   PUBMED   8248200
REFERENCE   10 (bases 1 to 10885)
  AUTHORS   Sedlacek,Z., Korn,B., Konecki,D.S., Siebenhaar,R., Coy,J.F.,
            Kioschis,P. and Poustka,A.
  TITLE     Construction of a transcription map of a 300 kb region around the
            human G6PD locus by direct cDNA selection
  JOURNAL   Hum Mol Genet 2 (11), 1865-1869 (1993)
   PUBMED   8281148
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY158513.1, HY098587.1,
            X87852.1, CN427844.1, BF798844.1, BQ720233.1, BQ718472.1,
            BG820285.1, CN484803.1, AW001914.1 and AC244090.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_017514.4.
            
            Summary: This gene encodes a member of the plexin class of
            proteins. The encoded protein is a class 3 semaphorin receptor, and
            may be involved in cytoskeletal remodeling and as well as
            apoptosis. Studies of a similar gene in zebrafish suggest that it
            is important for axon pathfinding in the developing nervous system.
            This gene may be associated with tumor progression. [provided by
            RefSeq, Aug 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X87852.1, SRR11853566.30322.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369682.4/ ENSP00000358696.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 HY158513.1         2-2
            2-34                HY098587.1         4-36
            35-838              X87852.1           44-847
            839-839             CN427844.1         567-567
            840-1314            X87852.1           849-1323
            1315-1315           BF798844.1         256-256
            1316-2463           X87852.1           1325-2472
            2464-2464           BQ720233.1         733-733
            2465-3084           X87852.1           2474-3093
            3085-3085           BQ718472.1         280-280
            3086-3636           X87852.1           3095-3645
            3637-3898           BG820285.1         66-327
            3899-6028           X87852.1           3908-6037
            6029-6410           CN484803.1         249-630
            6411-6752           AW001914.1         10-351              c
            6753-10885          AC244090.3         100426-104558
FEATURES             Location/Qualifiers
     source          1..10885
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..10885
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /note="plexin A3"
                     /db_xref="GeneID:55558"
                     /db_xref="HGNC:HGNC:9101"
                     /db_xref="MIM:300022"
     exon            1..148
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            149..769
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..5791
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /note="Sex chromosome X transmembrane protein of HGF
                     receptor family 3; plexin-4; semaphorin receptor SEX"
                     /codon_start=1
                     /product="plexin-A3 precursor"
                     /protein_id="NP_059984.3"
                     /db_xref="CCDS:CCDS14752.1"
                     /db_xref="GeneID:55558"
                     /db_xref="HGNC:HGNC:9101"
                     /db_xref="MIM:300022"
                     /translation="MPSVCLLLLLFLAVGGALGNRPFRAFVVTDTTLTHLAVHRVTGE
                     VFVGAVNRVFKLAPNLTELRAHVTGPVEDNARCYPPPSMRVCAHRLAPVDNINKLLLI
                     DYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVEQGQ
                     GPSKLFVGTAVDGKSEYFPTLSSRKLISDEDSADMFSLVYQDEFVSSQIKIPSDTLSL
                     YPAFDIYYIYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEFYSYV
                     EFPIGCSWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQKNRASPPRQ
                     TILCLFTLSNINAHIRRRIQSCYRGEGTLALPWLLNKELPCINTPMQINGNFCGLVLN
                     QPLGGLHVIEGLPLLADSTDGMASVAAYTYRQHSVVFIGTRSGSLKKVRVDGFQDAHL
                     YETVPVVDGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYQSCAACLGSGDPHC
                     GWCVLRHRCCREGACLGASAPHGFAEELSKCVQVRVRPNNVSVTSPGVQLTVTLHNVP
                     DLSAGVSCAFEAAAENEAVLLPSGELLCPSPSLQELRALTRGHGATRTVRLQLLSKET
                     GVRFAGADFVFYNCSVLQSCMSCVGSPYPCHWCKYRHTCTSRPHECSFQEGRVHSPEG
                     CPEILPSGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQQRVPAVRFNSS
                     SVQCQNASYSYEGDEHGDTELDFSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLK
                     ADPRFNCGWCISEHRCQLRTHCPAPKTNWMHLSQKGTRCSHPRITQIHPLVGPKEGGT
                     RVTIVGENLGLLSREVGLRVAGVRCNSIPAEYISAERIVCEMEESLVPSPPPGPVELC
                     VGDCSADFRTQSEQVYSFVTPTFDQVSPSRGPASGGTRLTISGSSLDAGSRVTVTVRD
                     SECQFVRRDAKAIVCISPLSTLGPSQAPITLAIDRANISSPGLIYTYTQDPTVTRLEP
                     TWSIINGSTAITVSGTHLLTVQEPRVRAKYRGIETTNTCQVINDTAMLCKAPGIFLGR
                     PQPRAQGEHPDEFGFLLDHVQTARSLNRSSFTYYPDPSFEPLGPSGVLDVKPGSHVVL
                     KGKNLIPAAAGSSRLNYTVLIGGQPCSLTVSDTQLLCDSPSQTGRQPVMVLVGGLEFW
                     LGTLHISAERALTLPAMMGLAAGGGLLLLAITAVLVAYKRKTQDADRTLKRLQLQMDN
                     LESRVALECKEAFAELQTDINELTNHMDEVQIPFLDYRTYAVRVLFPGIEAHPVLKEL
                     DTPPNVEKALRLFGQLLHSRAFVLTFIHTLEAQSSFSMRDRGTVASLTMVALQSRLDY
                     ATGLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPL
                     FLLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPENEGSAQVP
                     VKVLNCDSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMTRIILQDEDVTTKI
                     ECDWKRLNSLAHYQVTDGSLVALVPKQVSAYNMANSFTFTRSLSRYESLLRTASSPDS
                     LRSRAPMITPDQETGTKLWHLVKNHDHADHREGDRGSKMVSEIYLTRLLATKGTLQKF
                     VDDLFETVFSTAHRGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWV
                     NVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNY
                     KSWVERYYRDIAKMASISDQDMDAYLVEQSRLHASDFSVLSALNELYFYVTKYRQEIL
                     TALDRDASCRKHKLRQKLEQIISLVSSDS"
     exon            770..1309
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1492
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1621
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1722
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1846
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2003
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2103
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2218
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2419
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2516
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2707
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2853
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..2974
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3111
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3282
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3376
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3377..3616
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3617..3760
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3761..3995
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3996..4138
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            4139..4395
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            4396..4462
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            4463..4609
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            4610..4769
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            4770..4873
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            4874..4970
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            4971..5161
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            5162..5331
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            5332..5544
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            5545..5695
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            5696..10885
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6727..6732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /note="hexamer: ATTAAA"
     polyA_site      6748
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /note="major polyA site"
     regulatory      10406..10411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /note="hexamer: AATAAA"
     polyA_site      10428
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
     regulatory      10862..10867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
                     /note="hexamer: AATAAA"
     polyA_site      10885
                     /gene="PLXNA3"
                     /gene_synonym="6.3; HSSEXGENE; PLXN3; PLXN4; XAP-6"
ORIGIN      
        1 agtgtgtggg cggcggcggc ggcggctgcg cgcttggggc ccggggcgcg gggcgaggcc
       61 gtggggacgt gcgagcgggg ccgcggtggg gctcgggggc gcgtccacgt ggccagaggg
      121 cggccacccg gagccagcgg agggacaggc ctgtccccag gcgcggctgc cggccatgcc
      181 ctctgtctgc ctcctcctgc tgctcttcct tgccgtgggg ggggccctgg gcaacaggcc
      241 cttccgtgcc ttcgtggtga cagacaccac gcttacccac ctggctgtgc accgggtgac
      301 tggggaggtg ttcgtgggcg cagtgaaccg agtctttaag ctggccccca acctgactga
      361 gctgcgggcc catgtcacgg ggcccgtcga ggacaacgct cgctgctacc cgccccccag
      421 catgcgcgtg tgtgcccacc gcctggcccc cgtggacaac atcaacaagc tgctgctcat
      481 agactatgcg gcccgccgcc tggtggcctg cggcagcatc tggcagggca tctgccagtt
      541 cctgcgtctg gacgacctct tcaagctggg tgagccgcac caccgcaagg agcactacct
      601 gtcgggggcc caggagcccg actccatggc tggtgtcatt gtggagcagg gccaggggcc
      661 cagcaagctg tttgtgggca ctgctgtcga cggcaagtcg gagtacttcc ccaccttgag
      721 ctcccgcaag ctcatcagtg atgaagacag cgcggacatg ttcagtctcg tgtaccagga
      781 tgagtttgtg tcctcccaga tcaagatccc ctcagacacg ctgtccttgt accctgcctt
      841 tgacatctac tacatctacg gcttcgtcag cgcctccttc gtgtacttcc tgacgctgca
      901 gctggacacc cagcagacgc tgttggacac agcgggcgag aaatttttca cgtccaagat
      961 cgtgcgcatg tgcgcgggag actcagagtt ctactcatac gtggaattcc ccatcggctg
     1021 ctcctggcgc ggcgtggagt accgcttggt gcagagcgcc cacctggcca agcctggcct
     1081 gctgctggcc caggccctgg gcgtgccggc tgatgaggac gtcctcttca ccatcttctc
     1141 tcagggccag aagaaccggg ccagcccacc ccggcagacc atcctctgcc tcttcaccct
     1201 cagcaacatc aatgcccaca tccggcgccg catccagtcc tgctatcgtg gggagggcac
     1261 tctggctctg ccctggctgc tgaacaagga gctgccctgc atcaacaccc ccatgcagat
     1321 caacggcaac ttctgtgggc tggtgttgaa ccagcctctg ggaggcctgc atgtgatcga
     1381 ggggctgccc ctgctggccg acagcaccga cggcatggcc agcgtggccg cctacaccta
     1441 ccgccagcac tctgtggtct tcattggcac gcgcagcggc agcttgaaga aggtgcgggt
     1501 cgatggcttc caggatgccc acctgtatga gacagtcccc gtggtggatg gcagccccat
     1561 cctccgagac ctgctcttca gcccggacca ccggcacatc tatctcctga gtgagaagca
     1621 ggtgagccag ctcccggtgg agacctgtga gcagtaccag agctgcgcag cctgcctggg
     1681 ctccggggac ccgcactgtg gttggtgtgt gctgcgacac aggtgctgcc gcgaaggggc
     1741 ctgtctgggc gcctctgccc cacacggctt tgctgaggag ctgagcaagt gtgtccaggt
     1801 gcgggtccgg cccaacaatg tgtcagtgac gtcacctggg gtgcagctga ccgtcaccct
     1861 gcacaacgtg ccagacctca gtgcgggcgt gagctgcgcc ttcgaggcgg cggcggagaa
     1921 cgaggcggtc ctgctgccct ccggtgaact gctctgcccc tcaccctccc tccaggagct
     1981 ccgagctctt accagggggc atggggccac ccgcactgtg cggctgcagc ttctctccaa
     2041 ggagacaggc gtgaggtttg ccggtgctga ctttgtcttc tacaactgca gcgtcctcca
     2101 gtcgtgcatg tcctgtgttg gcagccctta cccctgccac tggtgtaagt accgccacac
     2161 gtgtaccagc cgcccccacg agtgctcctt ccaggagggc agggtccaca gccctgaggg
     2221 ctgccctgag atcctgccca gtggggacct cctgatcccc gttggggtca tgcagcctct
     2281 taccttgcgg gctaagaacc tacctcagcc gcagtcgggc cagaagaact atgagtgcgt
     2341 ggtgcgggtg caggggcggc agcagcgggt gcctgccgtg cgcttcaaca gcagcagtgt
     2401 gcagtgccag aacgcctcgt actcctatga aggtgatgag catggtgaca ccgagctgga
     2461 cttttccgtg gtctgggatg gagacttccc catagacaag cctcccagct tccgagccct
     2521 cctgtacaag tgctgggcgc agcggcccag ctgtggcctc tgcctcaagg ctgatccccg
     2581 cttcaactgt ggctggtgca tctcagagca caggtgccag ctgcggaccc actgcccggc
     2641 cccgaagacc aactggatgc acctgagcca gaagggcacc cggtgcagcc acccccgcat
     2701 cacgcagatc caccctctcg tggggcccaa ggaaggaggc acccgggtca ccatcgtggg
     2761 tgagaacctg ggcctcttgt cccgagaggt gggcctgcgg gtggctggcg tgcgttgcaa
     2821 ctccattccg gccgagtaca tcagtgctga gaggatcgtg tgtgagatgg aggagtcgct
     2881 ggtgcccagc ccgccgccgg ggcccgtgga gctgtgtgtg ggtgactgtt cagccgactt
     2941 ccgcacgcag tcggagcagg tctacagctt tgtgacccca acgtttgacc aagtgagtcc
     3001 cagccgtggc ccggcgtccg ggggcacacg gcttaccatc tcaggcagct ctctggatgc
     3061 tggcagcagg gtcacagtga ctgtgaggga cagcgagtgc cagtttgtaa ggagagatgc
     3121 caaggcgatc gtgtgcatct cacctctctc caccctgggc cccagccagg cccccatcac
     3181 acttgccatt gaccgggcta acatctccag ccccgggctc atctacacct acactcagga
     3241 ccccaccgtc acccgccttg agcccacctg gagcatcatc aatggaagca ctgccatcac
     3301 tgtgagtggg acccacctgc tgacggtcca ggagccccgg gtccgtgcca agtaccgcgg
     3361 cattgagacc accaatacat gccaagtgat caacgacact gccatgctgt gtaaggcccc
     3421 cggcatcttt cttgggcggc cccagcctcg ggcgcaaggc gagcaccctg atgagtttgg
     3481 cttcctgctg gaccacgtgc aaacggcccg ctccctcaac cgctcctcct ttacctacta
     3541 ccctgatccc agctttgagc cgctggggcc ctctggcgtg ctggacgtca aaccgggctc
     3601 ccacgtggtg ctgaagggca agaacctgat tcccgctgca gccggcagct cccgcctcaa
     3661 ctacactgtg ctgataggag gccagccgtg ttcgctcact gtctcggaca cacaactcct
     3721 gtgcgactca cccagccaga ctggccggca gcctgtcatg gtgctggtgg gtggcctgga
     3781 gttctggctg ggcaccctgc acatctcggc agagcgggcg ctgaccctac cggccatgat
     3841 ggggctggcg gcggggggtg ggctcctgct gctggccatc acagccgtgc tggtggccta
     3901 caagcgcaag actcaggacg cggaccgtac cctcaagcgt ctgcagctgc agatggacaa
     3961 cctggagtcc cgtgtggccc tggagtgcaa ggaagctttt gcagagctgc agacggacat
     4021 caatgagctg actaaccaca tggacgaggt gcagatcccc ttcctggact accggactta
     4081 cgccgtgcgc gtgctcttcc cgggcatcga ggcccacccg gtgctcaagg agctggatac
     4141 gccacccaac gtggagaagg ccctgcgcct cttcgggcag ctgctgcaca gccgcgcgtt
     4201 cgtgcttacc ttcatccaca cgctggaggc ccagagcagc ttctccatgc gcgaccgcgg
     4261 caccgtggcc tcgctcacca tggtggccct gcagagccgg ctcgactatg ccacggggct
     4321 gctcaagcaa ctgctggccg acctcatcga gaagaacctc gagagcaaga accaccccaa
     4381 gctgctgcta cgcaggacag agtcagtggc tgagaagatg cttaccaact ggttcacgtt
     4441 cctgctgcat aagtttctga aggagtgtgc tggggagcct ctcttcctgc tttactgtgc
     4501 catcaagcag cagatggaga agggccccat tgatgccatc acgggcgagg cacgatactc
     4561 cctgagcgag gacaagctca tccgtcagca gatcgactac aagacactga cccttcactg
     4621 cgtgtgtccg gagaacgagg gcagcgccca ggtcccagtg aaggttctca actgtgacag
     4681 catcacccag gccaaagata agctgctgga cactgtgtac aagggcattc cgtactccca
     4741 gcgtcccaaa gctgaggaca tggacctgga gtggcgccag ggccgcatga ctcgcatcat
     4801 cctccaggat gaggatgtca ccaccaagat cgagtgtgac tggaagaggc tcaactcact
     4861 ggcccactac caggtgacag acggttcctt ggtggcattg gtgcccaaac aagtgtctgc
     4921 ctataacatg gccaactcct tcaccttcac ccgctccctc agccgctacg agagcttgct
     4981 ccgcacggcc agcagccctg atagcctccg ctcacgggca cccatgatta cgcctgacca
     5041 ggagacaggc accaaattgt ggcacctggt gaaaaaccac gaccatgccg accatcgcga
     5101 gggggaccgt ggcagcaaga tggtctccga gatctacctg acacggctgc tggccaccaa
     5161 gggcacactg cagaagttcg tggatgacct ctttgagaca gtgttcagca cagcccaccg
     5221 gggctcggcc ctgcccctgg ccatcaagta catgttcgac ttcctggatg agcaggcgga
     5281 ccagcgccag atcagcgacc ccgatgtgcg ccacacctgg aagagcaact gcctgccgct
     5341 gcgcttctgg gtgaatgtga tcaagaaccc gcagttcgtg ttcgacatcc acaagaacag
     5401 catcacggat gcctgcctgt cggtggtagc ccagaccttc atggactcct gctctacatc
     5461 cgagcaccgc ctggggaagg actcgccctc caacaaactg ctctacgcca aggacatccc
     5521 caactacaag agctgggtgg agaggtatta tcgagacatt gcaaagatgg catccatcag
     5581 cgaccaggac atggatgcct acctggtgga gcagtcccgc ctccacgcca gcgacttcag
     5641 cgtcctgagt gcgctcaacg agctgtattt ctatgtcacc aagtaccgcc aggagattct
     5701 cacggctctg gaccgagatg cctcttgtcg gaagcataag ttgcggcaga aactggaaca
     5761 gatcatcagc ctcgtgtcca gcgacagcta aggtggtgga atcggtgagg agggggcttc
     5821 tcagtcctgt gccgtcctcc catccagggg agtggctggc tcaagcctgg gtccccgggc
     5881 tgagccctgg attgggtatc gtggggcagg tcaccctggc cacgatgccc ccggcacacc
     5941 caggccccct tcattagtgc cttgctttgg gccctgcagg gggaggggtg acagggcgag
     6001 cccccacccc agcagcagca atacccccac cctcctgccc tgtgcccagg tgttgggaca
     6061 gtcccaccct ccctgctatt tatatccctc tgcctattta ttgaatcgaa cttcgcctct
     6121 gtctccatct gtaaatatgt gtccccccac cggatgtcgc caccctcact cacctgcctc
     6181 ttcttgagct gtcctgggcc ctgccacccg tctgggctcc tttgtgtagc attatcagcc
     6241 tcggtctggc ctctggcacc tcacccttgc catggctgac cccacccatt ccaaggcggg
     6301 gtcacggtac cagcagcact tggggtgagg cctccaaagc ttcctcagaa ttgtggctgt
     6361 gccacgctgg accacagggt ccccctcaag catctcgggg ccctattctc tctgagcacc
     6421 tggagggctg gactcaggct tgtgccaggg cctgacttgg gcctgggggc cctagaacgc
     6481 tcctcctcct gagcctactg ccaaacgtcc tcagtgttgt ctgcacctgc tccgactcct
     6541 tcagccgccc cattcagcgc ccgctccgtc cagtgcccgc cctgtggggc caaggcggcc
     6601 gtgccttact actctgtgtc ttctgcctcc tctgaggaat ctggccctgt ctgacagtcc
     6661 cagacccccc gttctctcct ctttagttgc atgagttttt ctttgttcat ggaatgtttt
     6721 ttcctgatta aatgttgggg aaatgccatc catgtggggc tctgtccttg gggcaggtca
     6781 gtagacctgt ggatgctgca tgagctggag ccccattgtg ggagaaagga ccactccttg
     6841 cagggtccca gagggtttgg ggaggttcag ggccataccc gacccatcag caaaccccgg
     6901 tggctctacc ttcaagacag attcaaggta gatagattct cctcccttcc accaccccca
     6961 cccagctctc ctgtgccatc gtctatctct gcctggatgc cagtctccct gcttctgccc
     7021 tggctctctt cagcctgttc tcagcgtggg aggcagagag atcctgttat gatataaggt
     7081 ggatcatgtt gcctcactgt ttagaaccct ccggcggttt cagctgcagc cagctccttc
     7141 aaaacctgac aattgcatac tgtcgaggtt gtggcaccca tcatggtgca cctaccaaag
     7201 tcttactccc aggcctgtta agtaatgcag gtggggagaa ggtgacatgc aatttattta
     7261 tttatttatt ttgagacaga gtgtagctgt gttgcccagg ctggagtgca gtggcaagat
     7321 cacagctcag tgcagtctca aactcctggg ctcaagtgat cctcccacct cagcctcctg
     7381 aatagctggg tgtattagtg cactctacta tgccaggctt tttttttttt tttttttgag
     7441 ataggttgcc gctatgttgt tcaggctggt cttgaattcc tggtctcaag tgatcctcac
     7501 ccctcagcct cccaaagtat tgggattaca ggcatgagcc actgtgcccg gccaggtgag
     7561 atggaatctt atttttactt tttatgtttt tttttttttc tttgacggag tgtcgctctg
     7621 tcgcccaggc tggagtgcag tggcatgatc tcggctcact gcaagctccg cctcccaggt
     7681 tcacgccatt ctcctgcctc agcctcccga atagctggaa ctacaggtgc ccaccaccac
     7741 gcccggctaa ttttttgtat ttttagtaga gacggggttt tactgtgtta gccaggatgg
     7801 tctcgatctc ctgacctcgt gatccacctg cctcagcctc ccaaagtgct gggattacag
     7861 gcgtgagcca ccatgcctga cctttttttt tttttttttt tttttttttt ttggagacgg
     7921 gatcttgccc tgttgcccac gctggagtgc agtggcaaaa tcaactcact gcagccttga
     7981 tgtcctgggc tcaagtgatc ttcctgcctc agccttctga gtagctagga ttacaagtgc
     8041 ttgccaccat acccagctgt tttttgtttt tttttttttt ctttagtaga gatggagtct
     8101 tgctggtttt gaacctcctg ggctcaagtg atcctcctgt tttggcctcc caaaattctg
     8161 ggattacagt tgtgagccac tgtgcccagc caagtgagat gcaatttttt tttttttttt
     8221 ttttgagaca gagtttcact cttgttgccc aggctggagt gcaatggtat gatcttggct
     8281 caccgcaacc tccgcctccc gggttcaagt gattctcctg cctcagcctc ctgagtagct
     8341 gagattacag gcatgtgcca ccacgcccag ctaattttgt atttttagta gacacagggt
     8401 ttctccatgt tggtcaggct ggtctcgagc tcccgacctc aggtgatccg cccgcctcag
     8461 cctcccaaag tgctgggatt acaggcatga gccactgttc ctggcctttc ttcttttttt
     8521 gtttttgttt ttttttgaga tgcaatttta aatagggtgg cttggacagc cacctgagtt
     8581 gggtttaaaa gctgccagct ccagccgtcc agctgtgggg ccacggtgcc agacagtggt
     8641 ggtggttata ggaccgtagg tgtttaccaa aactagacaa gtccacataa caaccaactg
     8701 cacaaataag gagtaaaata ataaagagaa ggacgtgtga ggcaggactg gattgtagcc
     8761 caggataaag agaagttgcg ggatgacagc tgtgccgtcg gcccagacag aaccatctgg
     8821 acagaggaca gaggataagg gagatggttg aaaatactac catcatatga taatgacaac
     8881 taagccacag gaaaacaagg cagttttaac ctcaggggaa atccctcaga aatggatgga
     8941 atctaccaga agcatcatga gaggaagagg aagggaaaca gagctaaatt ggggccaggt
     9001 gtggtggctc gcacttgtca tcccagcact tttggaggcc caggcgggaa gatcactgga
     9061 gcccaggagt tcaggaccag cctgggcaac aaagcgagat cccctctcta caaaaaataa
     9121 aaaactagcc aggcatggtg gtgcatgcct gtggtcccag ttactcagga ggctgaggtg
     9181 ctggggaaca aggctgcagt gagctgtgat tgtgccagcc taggtgacag agccagaccc
     9241 tgtatcaaaa aaaataataa taattaaaaa acaaaagatc ggctgggcgc ggtggctcat
     9301 gcctgtaatc ccagcacttt gggaggctga ggtgggtgga ccacctgagg tcgggagttc
     9361 gagaccagcc tcaccaacat ggagaaaccc tgtgtctact aaaaatacaa aattagctgg
     9421 gcgtggtggt gcatgcctgt aattctagct acttgggagg ctgaggcagg agaattcact
     9481 tgaacccggg aagtggaggt tgcggtgagc caagatcgca ccattgcact ccagcctggg
     9541 caacaagagt gaaacactgt ctcaaaaaaa aaaaaaaaaa gtgaaagatc taaattgtca
     9601 actattcgtc aataattaat gtctaaaaaa tattaagaaa ggaagaaagg aatgagagca
     9661 aaagagaggg agagaggaaa gtgtcatctt cataagctga aggccagtgc caccgtcacc
     9721 actggcagag ctccccagat tctacaaagg gaaactgttc ctccatatgg agtaataggg
     9781 actggatatg tcatgccaaa tgaaagaaca cgccaaacca gacaaaatat atggaatgca
     9841 gagtattaaa aaactggctg tgggccagtg agggacagcg acgtgtggga gctgggaaac
     9901 aaggtaagcc atgcgactgg cccagtgtcc tgtgtggagt ttcctggtgg agcctggcag
     9961 acacccggac tttaggagtt gaaactgatt cagagcgtcc cagcagctgg agtttgcagg
    10021 gcggagaacc agagagaaga gagctgcaca gggaaagaac cctggatatc cacagaggct
    10081 cccgttccag tgtgcagcgg actacgacta ctggtgagca caggcgtgtg aggaagctac
    10141 ccaagaccag ggaaggccat caccccagca ggagaggatg aacggtaact ccagtgtgca
    10201 agcaggacag ggactagcag ctgtccccac ccaccaggat agagaagctc atgttcacct
    10261 aggcagcact ggccagggtg cccagaatgg tgtttgttgc ctccatagag ggaaacaagc
    10321 ctacagttaa gagctgctct ggtcccacac agcacatctt caaagcaaga ctcaaaagga
    10381 tcaaaccatt tccttgtttt ctgagaataa aagcagttgt acctcttcct tttcactctc
    10441 agaaaatctg atagaatcta taaaagagcc ctaaggctgg agacactgta ttttccaggg
    10501 agccaactcc ttgccccaga cactagtcaa ttgccccagc actttcttca ctgatcgtta
    10561 gaggaaaaaa gctcatgtta gatttaaaaa tcaggaaaaa aatttaacac taaacttgca
    10621 aatattatgt ggtgtatatt acagttacac atttactatg taagtgcaac tgtaaaactg
    10681 aggaagtatt ccaaaatgtt gacagtagtt aatcctgaat gacagaaccc aattgatttt
    10741 cattttcttc catttcctaa attgtcttca atttccttgt actccttgaa tatctgaatt
    10801 ctagaacccc ccccccagca acccaagcac aacaagaata ttgggaggtg ccccagctgc
    10861 aaataaactc agacttggaa tagta
//
