LOCUS       NM_025179              11508 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens plexin A2 (PLXNA2), mRNA.
ACCESSION   NM_025179 NM_153014 XM_372810
VERSION     NM_025179.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11508)
  AUTHORS   Toledano,S., Sabag,A.D., Ilan,N., Liburkin-Dan,T., Kessler,O. and
            Neufeld,G.
  TITLE     Plexin-A2 enables the proliferation and the development of tumors
            from glioblastoma derived cells
  JOURNAL   Cell Death Dis 14 (1), 41 (2023)
   PUBMED   36658114
  REMARK    GeneRIF: Plexin-A2 enables the proliferation and the development of
            tumors from glioblastoma derived cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11508)
  AUTHORS   Altuame,F.D., Shamseldin,H.E., Albatti,T.H., Hashem,M., Ewida,N.,
            Abdulwahab,F. and Alkuraya,F.S.
  TITLE     PLXNA2 as a candidate gene in patients with intellectual disability
  JOURNAL   Am J Med Genet A 185 (12), 3859-3865 (2021)
   PUBMED   34327814
  REMARK    GeneRIF: PLXNA2 as a candidate gene in patients with intellectual
            disability.
REFERENCE   3  (bases 1 to 11508)
  AUTHORS   Pijuan,J., Ortigoza-Escobar,J.D., Ortiz,J., Alcala,A., Calvo,M.J.,
            Cubells,M., Hernando-Davalillo,C., Palau,F. and Hoenicka,J.
  TITLE     PLXNA2 and LRRC40 as candidate genes in autism spectrum disorder
  JOURNAL   Autism Res 14 (6), 1088-1100 (2021)
   PUBMED   33749153
  REMARK    GeneRIF: PLXNA2 and LRRC40 as candidate genes in autism spectrum
            disorder.
REFERENCE   4  (bases 1 to 11508)
  AUTHORS   St Clair,R.M., Emerson,S.E., D'Elia,K.P., Weir,M.E., Schmoker,A.M.,
            Ebert,A.M. and Ballif,B.A.
  TITLE     Fyn-dependent phosphorylation of PlexinA1 and PlexinA2 at conserved
            tyrosines is essential for zebrafish eye development
  JOURNAL   FEBS J 285 (1), 72-86 (2018)
   PUBMED   29091353
  REMARK    GeneRIF: Data suggest that Fyn tyrosine kinase (Fyn)-dependent
            phosphorylation at two critical tyrosines is a key feature of
            vertebrate plexin A1 (PlxnA1) and plexin A2 (PlxnA2) signal
            transduction.
REFERENCE   5  (bases 1 to 11508)
  AUTHORS   Belyk,M., Kraft,S.J. and Brown,S.
  CONSRTM   Pediatric Imaging, Neurocognition and Genetics Study
  TITLE     PlexinA polymorphisms mediate the developmental trajectory of human
            corpus callosum microstructure
  JOURNAL   J Hum Genet 60 (3), 147-150 (2015)
   PUBMED   25518740
  REMARK    GeneRIF: Data indicate that plexin A1-4 (PLXNA1-4) mediation of
            neuroanatomical traits can be detected using in vivo neuroimaging
            techniques.
REFERENCE   6  (bases 1 to 11508)
  AUTHORS   Negishi,M., Oinuma,I. and Katoh,H.
  TITLE     Plexins: axon guidance and signal transduction
  JOURNAL   Cell Mol Life Sci 62 (12), 1363-1371 (2005)
   PUBMED   15818466
  REMARK    Review article
REFERENCE   7  (bases 1 to 11508)
  AUTHORS   Sasaki,Y., Cheng,C., Uchida,Y., Nakajima,O., Ohshima,T., Yagi,T.,
            Taniguchi,M., Nakayama,T., Kishida,R., Kudo,Y., Ohno,S.,
            Nakamura,F. and Goshima,Y.
  TITLE     Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in
            regulation of dendrite orientation in cerebral cortex
  JOURNAL   Neuron 35 (5), 907-920 (2002)
   PUBMED   12372285
REFERENCE   8  (bases 1 to 11508)
  AUTHORS   Whitford,K.L. and Ghosh,A.
  TITLE     Plexin signaling via off-track and rho family GTPases
  JOURNAL   Neuron 32 (1), 1-3 (2001)
   PUBMED   11604131
  REMARK    Review article
REFERENCE   9  (bases 1 to 11508)
  AUTHORS   Tamagnone,L., Artigiani,S., Chen,H., He,Z., Ming,G.I., Song,H.,
            Chedotal,A., Winberg,M.L., Goodman,C.S., Poo,M., Tessier-Lavigne,M.
            and Comoglio,P.M.
  TITLE     Plexins are a large family of receptors for transmembrane,
            secreted, and GPI-anchored semaphorins in vertebrates
  JOURNAL   Cell 99 (1), 71-80 (1999)
   PUBMED   10520995
  REMARK    Erratum:[Cell 2001 Jan 26;104(2):following 320]
REFERENCE   10 (bases 1 to 11508)
  AUTHORS   Maestrini,E., Tamagnone,L., Longati,P., Cremona,O., Gulisano,M.,
            Bione,S., Tamanini,F., Neel,B.G., Toniolo,D. and Comoglio,P.M.
  TITLE     A family of transmembrane proteins with homology to the
            MET-hepatocyte growth factor receptor
  JOURNAL   Proc Natl Acad Sci U S A 93 (2), 674-678 (1996)
   PUBMED   8570614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL606753.12, AL544219.3,
            AB007932.1, DA500239.1, X87831.2, AL356275.20 and H11743.1.
            
            On Nov 23, 2018 this sequence version replaced NM_025179.3.
            
            Summary: This gene encodes a member of the plexin-A family of
            semaphorin co-receptors. Semaphorins are a large family of secreted
            or membrane-bound proteins that mediate repulsive effects on axon
            pathfinding during nervous system development. A subset of
            semaphorins are recognized by plexin-A/neuropilin transmembrane
            receptor complexes, triggering a cellular signal transduction
            cascade that leads to axon repulsion. This plexin-A family member
            is thought to transduce signals from semaphorin-3A and -3C.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.267831.1,
                                           SRR1660805.204651.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000367033.4/
                                                ENSP00000356000.3
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AL606753.12        24806-24869         c
            65-247              AL544219.3         1-183
            248-613             AL606753.12        24257-24622         c
            614-1927            AB007932.1         1-1314
            1928-1935           DA500239.1         215-222
            1936-5684           AB007932.1         1323-5071
            5685-6144           X87831.2           3526-3985
            6145-6876           AB007932.1         5532-6263
            6877-11213          AL356275.20        161985-166321       c
            11214-11508         H11743.1           14-308              c
FEATURES             Location/Qualifiers
     source          1..11508
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.2"
     gene            1..11508
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /note="plexin A2"
                     /db_xref="GeneID:5362"
                     /db_xref="HGNC:HGNC:9100"
                     /db_xref="MIM:601054"
     exon            1..742
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            743..2010
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2193
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2328
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2429
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2553
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2707
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2804
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2919
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3120
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3121..3217
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3408
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3560
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..3678
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..3815
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3816..3983
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3984..4077
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4078..4317
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4318..4461
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4462..4696
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4697..4839
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4840..5108
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            5109..5175
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            5176..5322
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            5323..5482
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            5483..5586
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            5587..5686
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            5687..5877
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            5878..6047
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            6048..6260
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            6261..6411
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     exon            6412..11508
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6904..6909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /note="hexamer: AACAAA"
     polyA_site      6924
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
     regulatory      11465..11470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /note="hexamer: AATAAA"
     regulatory      11480..11485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /note="hexamer: ATTAAA"
     polyA_site      11489
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
                     /note="major polyA site"
     polyA_site      11508
                     /gene="PLXNA2"
                     /gene_synonym="OCT; PLXN2"
ORIGIN      
        1 gataatgagc tgcatggtga aatagggagg ccggcgctca gggctcctcc gccgccgccg
       61 ccgccgccgc cgccgccgcc accgcgggag ccagagctgc cgggaggagc ggcatccgcg
      121 ccagactgga gcgggagggc ggcggagggc agttgctggg aatttttcag ccgagagggc
      181 gagcgatccg gagagagacc ccgagagctt gggagcggta gggcgtgcga gcgccgcagc
      241 cagcggagca aacctcgaaa tagatctgga aagccaggct cccggaggaa atgggactgt
      301 gaacgaaccg gagagcaaga agggaaggaa gcgccgggat tgctgatgtc agaggagccc
      361 ggaaagtcgc gctggaaaaa tctgaagaca gccggggctc tgcttcttcc tcaggagaga
      421 caccgccggc cgcccccaca cgccccctcg gcgcctccgg gtgccccctg agagccggcg
      481 acagcgccca gccgggctgc tgcggggcga cggaggactg aggggcgcgc ggagcggaga
      541 ccgaggagcg acttcaggaa tacagataag tgtctggtgg cttgacgtgg attttaatga
      601 atttggactc catgtggatt tggtcgtctc cctgattccg agctgcgggc agggagaggg
      661 gcctcgcgcc gccctcagca gccggcggcg gccgaggtag accgagcggg gacggaagga
      721 cagaccgacg tcgccgagct ggaatcatgt gagggccaac cggggaaggt ggagcagatg
      781 agcacacaca ggagccgtct cctcaccgcc gcccctctca gcatggaaca gaggcggccc
      841 tggccccggg ccctggaggt ggacagccgc tctgtggtcc tgctctcagt ggtctgggtg
      901 ctgctggccc ccccagcagc cggcatgcct cagttcagca ccttccactc tgagaatcgt
      961 gactggacct tcaaccactt gaccgtccac caagggacgg gggccgtcta tgtgggggcc
     1021 atcaaccggg tctataagct gacaggcaac ctgaccatcc aggtggctca taagacaggg
     1081 ccagaagagg acaacaagtc ttgttacccg cccctcatcg tgcagccctg cagcgaagtg
     1141 ctcaccctca ccaacaatgt caacaagctg ctcatcattg actactctga gaaccgcctg
     1201 ctggcctgtg ggagcctcta ccagggggtc tgcaagctgc tgcggctgga tgacctcttc
     1261 atcctggtgg agccatccca caagaaggag cactacctgt ccagtgtcaa caagacgggc
     1321 accatgtacg gggtgattgt gcgctctgag ggtgaggatg gcaagctctt catcggcacg
     1381 gctgtggatg ggaagcagga ttacttcccg accctgtcca gccggaagct gccccgagac
     1441 cctgagtcct cagccatgct cgactatgag ctacacagcg attttgtctc ctctctcatc
     1501 aagatccctt cagacaccct ggccctggtc tcccactttg acatcttcta catctacggc
     1561 tttgctagtg ggggctttgt ctactttctc actgtccagc ccgagacccc tgagggtgtg
     1621 gccatcaact ccgctggaga cctcttctac acctcacgca tcgtgcggct ctgcaaggat
     1681 gaccccaagt tccactcata cgtgtccctg cccttcggct gcacccgggc cggggtggaa
     1741 taccgcctcc tgcaggctgc ttacctggcc aagcctgggg actcactggc ccaggccttc
     1801 aatatcacca gccaggacga tgtactcttt gccatcttct ccaaagggca gaagcagtat
     1861 caccacccgc ccgatgactc tgccctgtgt gccttcccta tccgggccat caacttgcag
     1921 atcaaggagc gcctgcagtc ctgctaccag ggcgagggca acctggagct caactggctg
     1981 ctggggaagg acgtccagtg caccaaggcg cctgtcccca tcgatgataa cttctgtgga
     2041 ctggacatca accagcccct gggaggctca actccagtgg agggcctgac cctgtacacc
     2101 accagcaggg accgcatgac ctctgtggcc tcctacgttt acaacggcta cagcgtggtt
     2161 tttgtgggga ctaagagtgg caagctgaaa aagattcggg ccgacggtcc cccccatggt
     2221 ggggtccagt acgagatggt ctctgtgctc aaggacggaa gccccatcct ccgggacatg
     2281 gccttctcca ttgatcagcg ctacctgtac gtcatgtctg agagacaggt caccagggtc
     2341 cccgtggagt catgtgagca gtatacgact tgtggggagt gcctgagctc tggggaccct
     2401 cactgtggct ggtgtgccct gcacaacatg tgctcccgca gggacaaatg ccaacaggcc
     2461 tgggaaccta atcgatttgc tgccagcatc agccagtgtg tgagccttgc agtgcatccc
     2521 agcagcatct cagtatctga gcacagccgg ttgcttagcc tggtagtgag tgatgctcct
     2581 gatctatctg cgggtatcgc ctgtgccttt gggaacctga cagaggtgga ggggcaggtg
     2641 tccgggagcc aggtcatctg catctcacct gggcccaagg atgtccctgt catcccgctg
     2701 gatcaagact ggtttgggct ggagctacag ctgaggtcca aggagacagg gaagatattt
     2761 gtcagcaccg agttcaagtt ttacaactgc agtgcccacc aactgtgcct gtcctgtgtc
     2821 aacagcgcct tccgctgcca ttggtgcaag taccgcaacc tctgcactca tgaccccacc
     2881 acctgctcct tccaggaggg ccggatcaat atttcagagg actgtcccca gctggtgccc
     2941 acagaggaga tcttgattcc agtcggggag gtaaagccaa tcacccttaa ggcgcgaaat
     3001 ctgccccagc cgcagtccgg ccagcgaggc tatgagtgtg tcctcaacat acaaggagcc
     3061 atccaccggg tccccgctct gcgcttcaac agctccagcg ttcagtgtca gaacagctcg
     3121 taccagtatg atggcatgga catcagcaat ctggccgtgg atttcgctgt ggtgtggaac
     3181 ggcaatttca tcattgacaa ccctcaggac ctgaaagtcc atctctacaa gtgtgcagcc
     3241 cagcgggaga gctgcggcct ctgcctcaag gccgaccgga agtttgagtg tggctggtgc
     3301 agcggcgagc gcaggtgcac cctccaccag cactgtacca gcccttccag cccctggctc
     3361 gactggtcca gccacaatgt caagtgctcc aaccctcaaa tcaccgagat tttgacggtg
     3421 tctggaccgc cggaaggagg gacgcgagtg accatccatg gcgtgaacct gggtctggac
     3481 ttctccgaga tcgcccacca tgtgcaggtg gctggggtgc cctgcacgcc cctcccaggg
     3541 gaatacatca tcgctgagca gattgtctgt gagatgggcc atgccctcgt gggaaccacc
     3601 tccgggccag tacgcctgtg tattggcgag tgtaagccag agttcatgac gaagtcccat
     3661 cagcagtaca ccttcgtgaa cccttctgtg ctgtcactca acccaatccg aggtcccgag
     3721 tcaggaggca ctatggtgac cattaccggc cattaccttg gggctgggag cagcgtggca
     3781 gtctacctgg gcaaccagac ctgcgagttc tacgggaggt caatgagtga gatcgtgtgt
     3841 gtctcacccc catcatccaa tggccttggc ccggtccctg tttctgtgag tgtcgaccga
     3901 gcccatgtgg atagcaacct gcagtttgag tacatagatg accctcgggt ccagcgcatc
     3961 gagccagagt ggagcattgc cagtggccac acacccctga ccatcacagg cttcaacctg
     4021 gatgtcattc aggagccaag gatccgagtc aaattcaatg gcaaagaatc tgtcaatgtg
     4081 tgtaaagttg tgaacacaac caccctcacc tgcctggcac cctctctgac cacggactac
     4141 cgccctggcc tggacactgt ggaacgccca gatgagtttg gatttgtctt taacaatgtc
     4201 caatccttgc taatttacaa cgacaccaag tttatctact accccaaccc gacctttgaa
     4261 ctgcttagcc ctactggagt cttggatcaa aagccaggat cgcccatcat tctgaagggc
     4321 aaaaacctct gccctcctgc ctctggaggg gccaaactca actacactgt gctcatcgga
     4381 gagacccctt gtgctgtcac cgtatctgag acccagcttc tctgcgagcc tcccaacctc
     4441 accgggcagc acaaggtcat ggttcacgtg ggcgggatgg tgttctcgcc tggctcggtg
     4501 agtgtcatct cagacagctt gctgaccctg ccagccatcg tcagcatcgc ggccggcggc
     4561 agcctcctcc tcatcatcgt catcatcgtc ctcattgcct acaagcgcaa gtctcgagaa
     4621 aatgacctca ctctcaagcg gctgcaaatg cagatggaca atctggagtc ccgtgtggcc
     4681 ttggagtgca aggaagcttt tgctgagctc cagacggata tcaatgagtt gaccagtgac
     4741 ctggaccgct caggaatccc ttacctggac tatcgtacct acgctatgcg agtcctgttc
     4801 ccgggcatcg aggaccaccc cgtcctgcgg gagctggagg tacaaggaaa cgggcagcag
     4861 cacgtggaga aggccctgaa gctctttgcc cagctcatca acaacaaggt gttcctgctg
     4921 accttcatcc gcaccctgga gctgcagcgc agtttctcca tgcgcgaccg gggcaacgtg
     4981 gcttcgctca tcatgaccgg cctgcagggc cgcctggaat atgccactga tgtcctcaag
     5041 cagctgctct ctgacctcat cgataagaac ctggagaaca agaaccaccc caagctgcta
     5101 ctccggagga cagagtctgt ggctgaaaag atgctgacca attggttcgc cttcctcctg
     5161 cacaagttcc taaaggagtg cgcaggggag ccactcttca tgctatactg tgccatcaag
     5221 cagcagatgg agaagggccc cattgatgcc atcacgggcg aggcccgcta ctccctgagc
     5281 gaggacaagc tcatccggca gcagatcgag tacaagaccc tgatcctgaa ctgcgtcaac
     5341 cctgacaacg agaacagtcc agagatccca gtgaaggtgt taaactgtga caccatcaca
     5401 caggtcaagg agaagattct tgatgccgtg tataagaatg tgccctattc ccagcggccg
     5461 agggcagtgg acatggactt ggagtggcgc caaggccgga tcgcccgggt cgtgctgcaa
     5521 gatgaggaca tcaccaccaa gattgagggt gactggaagc ggctcaacac actgatgcat
     5581 tatcaggtgt cagacaggtc ggtggtggct ctggtcccca aacagacctc ctcctacaac
     5641 atccctgcct ctgccagcat ctcccggacg tccatcagca gatacgactc ctccttcagg
     5701 tatacgggca gccccgacag cctgcggtcc cgggccccga tgatcacccc agacctggaa
     5761 agtggggtca aggtgtggca tctggtgaag aaccatgacc acggtgacca gaaggagggt
     5821 gaccggggca gcaagatggt gtccgagatc tacctgaccc ggctactggc caccaagggc
     5881 accctgcaga agtttgtgga cgacttgttt gagaccttgt tcagcactgt gcaccggggc
     5941 agcgctctcc ccctggccat caagtacatg tttgatttcc tagatgagca ggcagacagg
     6001 cacagcatcc atgacacaga tgtgcggcac acctggaaaa gcaactgcct ccctctgcgc
     6061 ttctgggtga acgtgattaa gaacccccag ttcgtgtttg acatccacaa gggcagcatc
     6121 acggacgcct gcctctctgt ggtggcccag accttcatgg actcttgttc aacgtcagag
     6181 caccggctgg gcaaggactc cccctccaac aagctgctct atgccaagga catccccagc
     6241 tacaagagct gggtggagag atactacgca gacatcgcca agctcccagc catcagtgac
     6301 caggacatga atgcctacct cgccgagcag tcccgcctgc acgccgtgga gttcaacatg
     6361 ctgagtgccc tcaatgagat ctactcctat gtcagcaagt atagtgagga gctcatcggg
     6421 gccctagagc aggatgagca ggcacggcgg cagcggctgg cttataaggt ggagcagctc
     6481 attaatgcca tgtccattga gagctgagag gaggagcctc gcattcctgg gaagagggac
     6541 ctgtccaagc tgtcacactg ggagtctcag atggaaggac aagtgatggg gatcaggccc
     6601 cagagcttgc tgtcccctga gaccccatcc tggggagagg ggaggactcc tctccctacg
     6661 ccagccaagt ttcgtcatag ccagttccag ctgggagaga cagtgggcgt cgtccatcct
     6721 cagtgagaac accagagaac ccggggccgg gagaaggtgg ttcttcaagc cgagaggcac
     6781 gagctgggga cagttctgcc tctgtgactg ctgctttgca tgaaaactca tttgatgtat
     6841 attggggaaa taatgagaac tttatttaat ttttttaaga aaaagggaaa aaaacagaaa
     6901 taaaacaaaa agccgccctg ttaatcccgt ccaacttttg tttaattctg atttctgtct
     6961 cccttccatc ttttctccca ttcctccttc tttatataat gcctatttcc aaatgccaga
     7021 gaaagcagag atgctgagag acattggaga gaaaatgact gtctcctttt ccttgaaatt
     7081 aaaaaaaaaa aaaaaaagag aaagaggaga agaagaatga tgagcacaag tatgcaccaa
     7141 acacttcgca aaaacagagg ccagtaaaac ctggaattat cccggcagcc agaggagtat
     7201 ggaacttcca gaactttgca caaattgcaa agccatcaag agctcaccct ggctgactgg
     7261 aaactgagct ttatctacca cacacctgta tattctcatc ttttgagagg agatgtgtac
     7321 ctagatagta ccaatgcttt ttgctactgt tttttgtttt gttttattta atcctaaacc
     7381 tcaacaaatg aggagctggt ctttgatatg tttcctttca atttccctaa agttactatg
     7441 agaagtgggg tgaggtgggc ctctcccaga ccagacacct ggcagccctg cctcatatca
     7501 atccctgtca taaaccaggc accctgggga aacggcctgg aggtgtgtgg gccaggcctc
     7561 cacgaggttc catttgaaag ttgatttgga gacataggtg tttgactttg gagttcactc
     7621 caatcatcca gtggtccctg gcaattaaaa agaaaacaaa aatcaaacac tgtttacagc
     7681 aagcaatact tgaagagcat aggttacaga agctgcagta tttattatta tgctttcttt
     7741 ctttcattct ctcgtgcctg gagaggggag accacccttc gctcatatac ggaagctcct
     7801 gaccatctgg gcctacagca cttcctcagt agaaatgact gtggcatgcc cacgttacta
     7861 ccttctgcct ctctttctgc ctctcacgga cttgtgagtg tgaaggacaa gtggatgact
     7921 tctcactgga ctttccttct ctgtctcttc tgatgatgcc taaaactatg gataaccaat
     7981 tctcctgagt gtagattcca aacaaagaga ccaaagctcc atgcccaggt ccaaaggccc
     8041 catagaagcc agtgggagtc atcgagagga aaggcgctct gtgagtgtca ggaccttggt
     8101 ggccaggata gccatcagag tgtccaggcc tcccacatta ccttggatcc gagcagccag
     8161 ctccaactgt tctgcaagca gcactggagt cagggggtag gaggacaagt ggaagcaaag
     8221 gtgtgggact ggggaagaca aagaggaaca agctgccctt cctcactttt caaagggtca
     8281 ggaatcctag gctatgatgc tgggaagcta gaccagctcc tccaagagag actagaccag
     8341 ggtcattttc tctgttatta actctgggct ccagcttctc cgtgccctgc tttacctcca
     8401 agtggttcca atttccaaag gccctgctga ccacatgtga ttcccaggag agggctgggg
     8461 gaggggagcg cagaggtctg gcttccatcc ttggcgtgta gctttggatc gctgtctaac
     8521 cacacagcag acgttgcccg gtctccccag ctctagtttc ttgcctgaat gcggctgaca
     8581 aatgggaaga gaaaagcatt cagcaaaata ctcaggaaac ttgctgtttt cattataatt
     8641 cacaaccagc catgccaagg ccactttctt ttgaaaatcc acttctttaa agtttctcag
     8701 gccctattag tagcctgaag gaaatactaa tgactggcct tccgcactaa gccaaagtgt
     8761 ttgctcttca tagcactcaa agcttatcag cgcagagccc ataatttatg gagataaaag
     8821 gaaaggagat ataggtaaga agagtgtgac caggagacct tatgctacct gtaaaaaagt
     8881 tcagcccacc ccatctaact tctgagctct gtttgggtga agattttctg gccgcatggc
     8941 tgctcagact ggcatccagg ctttgctcca ccaagaagtt aaaggcagtc ggacatctca
     9001 gtagcatctc taccagccct taactcaatg catctacctg gcatctccca gcagttactt
     9061 ttggagacga ttcactgccc ctggggcgtt tccttgaagg tttgtggaga gcgtggagaa
     9121 tgatggggca atggccaatt ggagggtgga gagtgaagag ccggagctgg ctgtgagtgg
     9181 tttggccaca tttctcagga ttccatgaga gacttgggga acttgggctg acaaaggaag
     9241 tagcctgggg catccttaag gaaggaatta agaaaaggga aaaagctgga ctcaagccac
     9301 gccatgaggg tgaaaggtta taaggccctg ccccctttcc agctgcccac ctgttcctcc
     9361 tccacacctc ttcgctttgg gccaccaaga accaatgaag tccacaccct ttggatgaga
     9421 aaaagaggga gttggttggc ctctcttctc cctgttatcc aatttgagga tattttgacc
     9481 ttgggtaagg atgaagtgtt aaagccacag ctcctctcca caagaagcca ttcatcttgg
     9541 gggaggcaga gagggaagtc tctctccaaa gtctatccag cttcgcttcg tttcattgat
     9601 ctgcacaaga gacaatgctc tggaaaagga agaggacccc agaagggtgc ttggcaagac
     9661 agaggatgct aatgggcaat ggagagcact ccctccagct ggcccctgct gctgcctccc
     9721 gtcctctgca tggggtcagg tgcttctgtg cttgctgtcc tacctctctc cacagcaggg
     9781 ctctcaaaac cattttgatc ccccattggc agagggttcc cctctttaca gagttcagtc
     9841 attaaaagca tggatcagct gttaatctca ttggaggagg gaactgtttc ctgcattcat
     9901 tcatctggga accttcttga gtagccactg tctgccagcc actgctctag agatgggaaa
     9961 acagcacgga acaaaaccaa ggtctttctt ccagcgaatt tatatccttc aggaagctgg
    10021 ttcctgccac caacttagca ggcaacagtt ctcctcccct agtggcacag ggtaccagtt
    10081 ttgtaggaaa agtggtccag caaaggaaga aagcagacca acccagctgc cttaccttat
    10141 tctggggcca ttcccccagc gatgagagct gctcttgttt ctactgccac catctcttct
    10201 ggctgcactt cacctgctgc ttgagcttct gaccttcctt cagttccacc aaatgaggac
    10261 aggaaatagc agtcaagacc cctggccctg ctgagcgtga aacagaagca atggatgagt
    10321 gctggacgaa gaatggcctg ggcagaacaa atagggagca tttgaaagct tctggctgat
    10381 aaatctccag gtgcatcccg gttgccacgc ctgcccccat taacctgctc ctggtaaata
    10441 ctgatccagc agctgctcca ggagaggccg tctttttttc ccagccacgc tgtgtcttgc
    10501 atgagactcc tggggcctgg gcacagagag aaaagaattg agactcagga ggctcagtgg
    10561 gtgagaaaat gcaaagtggc ttcacagaca cagggctgtg ggagcagatc gacggggaac
    10621 ttgggagatg aacttcaggg ccttccgacg ccttgtctca ggaacatgct ttgagaaaaa
    10681 tggtagcatc ctttccataa ctcagtctct cttccctagt ttccctgaag tgtgacgttt
    10741 tagtatctgg agctcagtga tccccatgaa tgagggataa agtttcactc ttggtatttt
    10801 ctaactagtg ctagggaaag tcctgagaca cgatcacagc cactgcttgg catacagggc
    10861 ctccacccaa taagcaaact ggagattcct cagcctctcg tggacaccca catctcattc
    10921 ttctcacagc agagaagctc tcccttcagc ctgagctgtc ttctttctgc tgcagtgcag
    10981 cctgctccct cctaccctgg cctcaaggaa ggtaggaaac atcttctgca tttcaaagtc
    11041 ctcactttga cttatttggc cttcatcttg gcatggaagg tggcaggcag aatggaaata
    11101 ctccccccaa acagaacaga tattcttgcg tgtgtaaggg cagaagggac aagctctcta
    11161 tcccatgaga ctaggggccg gagcccacct gcctttcccc acaacttttc ctgctcaaac
    11221 ccactcctct tgacacactg gaatctgtat tatatatatt tttaagaaaa tacaatgatg
    11281 gttgtctggt tttgttgttt ttacaggtgt tgtggaataa aaactgtaag aaaattaagt
    11341 atttaaaatg ttccaataaa gtggggtttt ttgttattct aatatattat tgtgtaccta
    11401 ttgtaaatat gaaacactcc tattttgcaa gctgaggaca caatttgtac tgttgttata
    11461 tataaataaa gtttactgaa ttaaaaaaac cttaaatctt taaataaa
//
