LOCUS       NM_032242               9309 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens plexin A1 (PLXNA1), mRNA.
ACCESSION   NM_032242 XM_011512908 XM_497933
VERSION     NM_032242.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9309)
  AUTHORS   Hu,J., Zhang,J., Han,B., Qu,Y., Zhang,Q., Yu,Z., Zhang,L., Han,J.,
            Liu,H., Gao,L., Feng,T., Dou,B., Chen,W. and Sun,F.
  TITLE     PLXNA1 confers enzalutamide resistance in prostate cancer via AKT
            signaling pathway
  JOURNAL   Neoplasia 57, 101047 (2024)
   PUBMED   39226661
  REMARK    GeneRIF: PLXNA1 confers enzalutamide resistance in prostate cancer
            via AKT signaling pathway.
REFERENCE   2  (bases 1 to 9309)
  AUTHORS   Ye,F., Xia,T., Zhao,M., Zhao,W., Min,P., Wang,Y., Wang,Q., Zhang,Y.
            and Du,J.
  TITLE     PlexinA1 promotes gastric cancer migration through preventing
            MICAL1 protein ubiquitin/proteasome-mediated degradation in a
            Rac1-dependent manner
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (4), 167124 (2024)
   PUBMED   38508474
  REMARK    GeneRIF: PlexinA1 promotes gastric cancer migration through
            preventing MICAL1 protein ubiquitin/proteasome-mediated degradation
            in a Rac1-dependent manner.
REFERENCE   3  (bases 1 to 9309)
  AUTHORS   Lu,Y., Cheng,D., Pang,J., Peng,Y., Jin,S., Zhang,X., Li,Y. and
            Zuo,Y.
  TITLE     Chronic stress promotes gastric cancer progression via the
            adrenoceptor beta 2/PlexinA1 pathway
  JOURNAL   Cell Stress Chaperones 29 (1), 201-215 (2024)
   PUBMED   38331165
  REMARK    GeneRIF: Chronic stress promotes gastric cancer progression via the
            adrenoceptor beta 2/PlexinA1 pathway.
REFERENCE   4  (bases 1 to 9309)
  AUTHORS   Su,L., Liang,W., Lu,Z. and Han,X.
  TITLE     [PLXNA1 is highly expressed in hepatocellular carcinoma and affects
            patients' survival and immune microenvironment]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (11), 1909-1918 (2023)
   PUBMED   38081609
  REMARK    GeneRIF: [PLXNA1 is highly expressed in hepatocellular carcinoma
            and affects patients' survival and immune microenvironment].
REFERENCE   5  (bases 1 to 9309)
  AUTHORS   Li,C., Lin,J., Jiang,Q. and Shang,H.
  TITLE     Rare variant screening and burden analysis of PLXNA1 in Parkinson's
            disease
  JOURNAL   Eur J Neurol 29 (12), 3737-3741 (2022)
   PUBMED   35852441
  REMARK    GeneRIF: Rare variant screening and burden analysis of PLXNA1 in
            Parkinson's disease.
REFERENCE   6  (bases 1 to 9309)
  AUTHORS   Takahashi,T. and Strittmatter,S.M.
  TITLE     Plexina1 autoinhibition by the plexin sema domain
  JOURNAL   Neuron 29 (2), 429-439 (2001)
   PUBMED   11239433
REFERENCE   7  (bases 1 to 9309)
  AUTHORS   Rohm,B., Rahim,B., Kleiber,B., Hovatta,I. and Puschel,A.W.
  TITLE     The semaphorin 3A receptor may directly regulate the activity of
            small GTPases
  JOURNAL   FEBS Lett 486 (1), 68-72 (2000)
   PUBMED   11108845
REFERENCE   8  (bases 1 to 9309)
  AUTHORS   Tamagnone,L., Artigiani,S., Chen,H., He,Z., Ming,G.I., Song,H.,
            Chedotal,A., Winberg,M.L., Goodman,C.S., Poo,M., Tessier-Lavigne,M.
            and Comoglio,P.M.
  TITLE     Plexins are a large family of receptors for transmembrane,
            secreted, and GPI-anchored semaphorins in vertebrates
  JOURNAL   Cell 99 (1), 71-80 (1999)
   PUBMED   10520995
  REMARK    Erratum:[Cell 2001 Jan 26;104(2):following 320]
REFERENCE   9  (bases 1 to 9309)
  AUTHORS   Takahashi,T., Fournier,A., Nakamura,F., Wang,L.H., Murakami,Y.,
            Kalb,R.G., Fujisawa,H. and Strittmatter,S.M.
  TITLE     Plexin-neuropilin-1 complexes form functional semaphorin-3A
            receptors
  JOURNAL   Cell 99 (1), 59-69 (1999)
   PUBMED   10520994
REFERENCE   10 (bases 1 to 9309)
  AUTHORS   Maestrini,E., Tamagnone,L., Longati,P., Cremona,O., Gulisano,M.,
            Bione,S., Tamanini,F., Neel,B.G., Toniolo,D. and Comoglio,P.M.
  TITLE     A family of transmembrane proteins with homology to the
            MET-hepatocyte growth factor receptor
  JOURNAL   Proc Natl Acad Sci U S A 93 (2), 674-678 (1996)
   PUBMED   8570614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011199.22.
            
            On or before Sep 21, 2020 this sequence version replaced
            XM_011512908.2, NM_032242.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1485018.1,
                                           SRR11853565.20928.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000393409.3/
                                                ENSP00000377061.2
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AC011199.22        75930-76102         c
            174-1440            AC011199.22        69430-70696         c
            1441-1623           AC011199.22        67651-67833         c
            1624-1764           AC011199.22        55747-55887         c
            1765-1865           AC011199.22        54506-54606         c
            1866-1989           AC011199.22        54209-54332         c
            1990-2143           AC011199.22        53974-54127         c
            2144-2243           AC011199.22        53039-53138         c
            2244-2358           AC011199.22        51304-51418         c
            2359-2559           AC011199.22        47059-47259         c
            2560-2656           AC011199.22        45101-45197         c
            2657-2850           AC011199.22        44842-45035         c
            2851-3002           AC011199.22        44588-44739         c
            3003-3123           AC011199.22        44386-44506         c
            3124-3260           AC011199.22        43897-44033         c
            3261-3428           AC011199.22        42533-42700         c
            3429-3522           AC011199.22        42180-42273         c
            3523-3762           AC011199.22        41553-41792         c
            3763-3906           AC011199.22        41325-41468         c
            3907-4141           AC011199.22        40689-40923         c
            4142-4284           AC011199.22        38873-39015         c
            4285-4541           AC011199.22        36876-37132         c
            4542-4608           AC011199.22        36399-36465         c
            4609-4755           AC011199.22        31131-31277         c
            4756-4915           AC011199.22        30877-31036         c
            4916-5019           AC011199.22        30121-30224         c
            5020-5116           AC011199.22        29681-29777         c
            5117-5307           AC011199.22        29153-29343         c
            5308-5477           AC011199.22        28805-28974         c
            5478-5690           AC011199.22        26618-26830         c
            5691-5841           AC011199.22        26381-26531         c
            5842-9309           AC011199.22        21828-25295         c
FEATURES             Location/Qualifiers
     source          1..9309
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.3"
     gene            1..9309
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /note="plexin A1"
                     /db_xref="GeneID:5361"
                     /db_xref="HGNC:HGNC:9099"
                     /db_xref="MIM:601055"
     exon            1..173
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            174..1440
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..5937
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /note="plexin 1; semaphorin receptor NOV"
                     /codon_start=1
                     /product="plexin-A1 precursor"
                     /protein_id="NP_115618.3"
                     /db_xref="CCDS:CCDS33847.2"
                     /db_xref="GeneID:5361"
                     /db_xref="HGNC:HGNC:9099"
                     /db_xref="MIM:601055"
                     /translation="MPLPPRSLQVLLLLLLLLLLLPGMWAEAGLPRAGGGSQPPFRTF
                     SASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVEDNEKCYPPPSVQ
                     SCPHGLGSTDNVNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYL
                     SSVQEAGSMAGVLIAGPPGQGQAKLFVGTPIDGKSEYFPTLSSRRLMANEEDADMFGF
                     VYQDEFVSSQLKIPSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTSPDAAGEH
                     FFTSKIVRLCVDDPKFYSYVEFPIGCEQAGVEYRLVQDAYLSRPGRALAHQLGLAEDE
                     DVLFTVFAQGQKNRVKPPKESALCLFTLRAIKEKIKERIQSCYRGEGKLSLPWLLNKE
                     LGCINSPLQIDDDFCGQDFNQPLGGTVTIEGTPLFVDKDDGLTAVAAYDYRGRTVVFA
                     GTRSGRIRKILVDLSNPGGRPALAYESVVAQEGSPILRDLVLSPNHQYLYAMTEKQVT
                     RVPVESCVQYTSCELCLGSRDPHCGWCVLHSICSRRDACERADEPQRFAADLLQCVQL
                     TVQPRNVSVTMSQVPLVLQAWNVPDLSAGVNCSFEDFTESESVLEDGRIHCRSPSARE
                     VAPITRGQGDQRVVKLYLKSKETGKKFASVDFVFYNCSVHQSCLSCVNGSFPCHWCKY
                     RHVCTHNVADCAFLEGRVNVSEDCPQILPSTQIYVPVGVVKPITLAARNLPQPQSGQR
                     GYECLFHIPGSPARVTALRFNSSSLQCQNSSYSYEGNDVSDLPVNLSVVWNGNFVIDN
                     PQNIQAHLYKCPALRESCGLCLKADPRFECGWCVAERRCSLRHHCAADTPASWMHARH
                     GSSRCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVRLGVRVGKVLCSPVESEY
                     ISAEQIVCEIGDASSVRAHDALVEVCVRDCSPHYRALSPKRFTFVTPTFYRVSPSRGP
                     LSGGTWIGIEGSHLNAGSDVAVSVGGRPCSFSWRNSREIRCLTPPGQSPGSAPIIINI
                     NRAQLTNPEVKYNYTEDPTILRIDPEWSINSGGTLLTVTGTNLATVREPRIRAKYGGI
                     ERENGCLVYNDTTMVCRAPSVANPVRSPPELGERPDELGFVMDNVRSLLVLNSTSFLY
                     YPDPVLEPLSPTGLLELKPSSPLILKGRNLLPPAPGNSRLNYTVLIGSTPCTLTVSET
                     QLLCEAPNLTGQHKVTVRAGGFEFSPGTLQVYSDSLLTLPAIVGIGGGGGLLLLVIVA
                     VLIAYKRKSRDADRTLKRLQLQMDNLESRVALECKEAFAELQTDIHELTNDLDGAGIP
                     FLDYRTYAMRVLFPGIEDHPVLKEMEVQANVEKSLTLFGQLLTKKHFLLTFIRTLEAQ
                     RSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTESV
                     AEKMLTNWFTFLLYKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLI
                     RQQIDYKTLTLNCVNPENENAPEVPVKGLDCDTVTQAKEKLLDAAYKGVPYSQRPKAA
                     DMDLEWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQTSAYNI
                     SNSSTFTKSLSRYESMLRTASSPDSLRSRTPMITPDLESGTKLWHLVKNHDHLDQREG
                     DRGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQA
                     DKHQIHDADVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSC
                     STSEHKLGKDSPSNKLLYAKDIPNYKSWVERYYADIAKMPAISDQDMSAYLAEQSRLH
                     LSQFNSMSALHEIYSYITKYKDEILAALEKDEQARRQRLRSKLEQVVDTMALSS"
     exon            1441..1623
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1764
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1865
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1989
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2143
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2243
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2358
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2559
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2656
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2850
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..3002
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3123
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3260
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..3428
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3429..3522
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3523..3762
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3763..3906
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3907..4141
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            4142..4284
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            4285..4541
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            4542..4608
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            4609..4755
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            4756..4915
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            4916..5019
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5020..5116
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5117..5307
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5308..5477
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5478..5690
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5691..5841
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5842..9309
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      7500
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
     regulatory      9290..9295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /note="hexamer: ATTAAA"
     polyA_site      9309
                     /gene="PLXNA1"
                     /gene_synonym="DWOPNED; NOV; NOVP; PLEXIN-A1; PLXN1"
                     /note="major polyA site"
ORIGIN      
        1 attcatgctg ggcatcggct gcgcggccac gcagcggagc ccgggcgcgg cggcggcctc
       61 ggcctgggcg gcctacgcgg cttcggcggc cccgcggcgg ggcggacggc ggcggcggcg
      121 cgggcggctg ggcgcggcga tggccggcgg cggggcgcgc cccggggcgg cggggctgaa
      181 gctcctggca ccatgatgct caccccagca ggaccagagc accgaggccc aaggccccag
      241 cctgccatgc cgctgccacc gcggagcctg caggtgctcc tgctgctgct gctgttgctg
      301 ctgctgctgc cgggcatgtg ggctgaggca ggcttgccca gggcaggcgg gggttcacag
      361 ccccccttcc gcaccttctc ggccagcgac tggggcctca cccacctagt ggtgcatgag
      421 cagacaggcg aggtgtatgt gggcgcagtg aaccgcatct ataagctgtc ggggaacctg
      481 acactgctgc gggcccacgt cacgggccct gtggaggaca acgagaagtg ctacccgccg
      541 cccagcgtgc agtcctgccc ccacggcctg ggcagtactg acaacgtcaa caagctgctg
      601 ctgctggact atgccgctaa ccgcctgctg gcctgtggca gcgcctccca gggcatctgc
      661 cagttcctgc gtctggacga tctcttcaaa ctgggtgagc cacaccaccg taaggagcac
      721 tacctgtcca gcgtgcagga ggcaggcagc atggcgggcg tgctcattgc cgggccaccg
      781 ggccagggcc aggccaagct cttcgtgggc acacccatcg atggcaagtc cgagtacttc
      841 cccacactgt ccagccgtcg gctcatggcc aacgaggagg atgccgacat gttcggcttc
      901 gtgtaccagg atgagtttgt gtcatcacag ctcaagatcc cttcggacac gctgtccaag
      961 ttcccggcct ttgacatcta ctatgtgtac agcttccgca gcgagcagtt tgtctactac
     1021 ctcacgctgc agctagacac acagctgacc tcgcctgatg ccgccggcga gcacttcttc
     1081 acgtccaaga tcgtgcggct ctgtgtggac gaccccaaat tctactcgta cgttgagttc
     1141 cccattggct gcgagcaggc gggtgtggag taccgcctgg tgcaggatgc ctacctgagc
     1201 cggcccggcc gtgccctggc ccaccagctg ggcctggctg aggacgagga cgtgctgttc
     1261 actgtgttcg cccagggcca gaagaaccgc gtgaagccac caaaggagtc agcactgtgc
     1321 ctgttcacgc tcagggccat caaggagaag attaaggagc gcatccagtc ctgctaccgt
     1381 ggtgagggca agctctccct gccgtggctg ctcaacaagg agctgggctg catcaactcg
     1441 cccctgcaga tcgatgacga cttctgcggg caggacttca accagcccct ggggggcaca
     1501 gtcaccattg aggggacgcc cctgttcgtg gacaaggatg atggcctgac cgccgtggct
     1561 gcctatgact atcggggccg cactgtggta ttcgccggca cgcgaagtgg ccgcatccgc
     1621 aagatcctgg tggacctctc aaaccccggt ggccggcctg ccctggccta cgagagcgtc
     1681 gtggcccagg agggcagccc catcctgcga gacctcgtcc tcagccccaa ccaccagtac
     1741 ctctacgcca tgaccgagaa gcaggtgacg cgggtgcctg tggagagctg tgtgcagtac
     1801 acgtcctgtg agctgtgtct ggggtcacgg gacccccact gtggctggtg tgtcctgcac
     1861 agcatctgct cgcggcggga cgcctgtgag cgagcagacg agccccagcg ctttgctgcg
     1921 gacctgctgc agtgtgtgca gctgactgtg cagccccgca atgtgtctgt caccatgtcc
     1981 caggtcccac ttgtgctgca ggcctggaac gtgcctgacc tctcagctgg cgtcaactgc
     2041 tccttcgagg acttcacgga atctgagagc gtcctggagg atggccggat ccactgccgc
     2101 tcaccctccg cccgggaggt ggcgcccatc acgcggggcc agggagacca gcgggtggtg
     2161 aaactctacc taaagtccaa ggagacaggg aagaagtttg cgtctgtgga cttcgtcttc
     2221 tacaactgca gcgtccacca gtcctgcctg tcctgtgtca acggctcctt tccctgccac
     2281 tggtgcaaat accgccacgt gtgcacacac aacgtggctg actgcgcctt cctggagggc
     2341 cgtgtcaacg tgtctgagga ctgcccacag atcctgccct ccacgcagat ctacgtgcca
     2401 gtgggagtgg taaaacccat caccctggcc gcacggaacc tgccacagcc acagtcaggc
     2461 cagcgtggat atgagtgcct cttccacatc ccgggcagcc cggcccgtgt caccgccctg
     2521 cgcttcaaca gctccagcct gcagtgccag aattcctcgt actcctacga ggggaacgat
     2581 gtcagcgacc tgccagtgaa cctgtcagtc gtgtggaacg gcaactttgt cattgacaac
     2641 ccacagaaca tccaggcgca cctctacaag tgcccggccc tgcgcgagag ctgcggcctc
     2701 tgcctcaagg ccgacccgcg cttcgagtgc ggatggtgcg tggccgagcg ccgctgctcc
     2761 ctgcgacacc actgcgctgc cgacacacct gcatcgtgga tgcacgcgcg tcacggcagc
     2821 agtcgctgca ccgaccccaa gatcctcaag ctgtcccccg agacgggccc gaggcagggc
     2881 ggcacgcggc tcactatcac aggcgagaac ctgggcctgc gattcgaaga cgtgcgtctg
     2941 ggcgtgcgcg tgggcaaggt gctgtgcagc cctgtggaga gcgagtacat cagtgcggag
     3001 cagatcgtct gtgagatcgg ggacgccagc tccgtgcgtg cccatgacgc cctggtggag
     3061 gtgtgtgtgc gggactgctc accacactac cgcgccctgt cacccaagcg cttcaccttc
     3121 gtgacaccaa ccttctaccg tgtgagcccc tcccgtgggc ctctgtcagg gggcacctgg
     3181 attggcatcg agggaagcca cctgaacgca ggcagtgatg tggctgtgtc ggtcggtggc
     3241 cggccctgct ccttctcctg gaggaactcc cgtgagatcc ggtgcctgac accccccggg
     3301 cagagccctg gcagcgctcc catcatcatc aacatcaacc gcgcccagct caccaaccct
     3361 gaggtgaagt acaactacac cgaggacccc accatcctga ggatcgaccc cgagtggagc
     3421 atcaacagcg gtgggaccct cctgacggtc acaggcacca acctggccac tgtccgtgaa
     3481 ccccgaatcc gggccaagta tggaggcatt gagagggaga acggctgcct ggtgtacaat
     3541 gacaccacca tggtatgccg cgccccgtct gtggccaacc ctgtgcgcag cccaccagag
     3601 ctgggggagc ggccggatga gctgggcttc gtcatggaca acgtgcgctc cctgcttgtg
     3661 ctcaactcca cctccttcct ctactaccct gaccccgtac tggagccact cagccccact
     3721 ggcctgctgg agctgaagcc cagctcccca ctcatcctca agggccggaa cctcttgcca
     3781 cctgcacccg gcaactcccg actcaactac acggtgctca tcggctccac accctgtacc
     3841 ctcaccgtgt cggagacgca actgctgtgc gaggcgccca acctcactgg gcagcacaag
     3901 gtcacggtgc gggcaggtgg cttcgagttc tcgccaggga cactgcaggt gtactcggac
     3961 agcctgctga cgctgcctgc cattgtgggc attggcggag gcgggggtct cctgctgctg
     4021 gtcatcgtgg ctgtgctcat cgcctacaag cgcaagtcac gagatgctga ccgcacactc
     4081 aagcggctgc agctccagat ggacaacctg gagtcccgcg tggccctcga atgcaaggaa
     4141 gcctttgcag agctgcagac agacatccac gagctgacca atgacctgga cggtgccggc
     4201 atccccttcc ttgactaccg gacatatgcc atgcgggtgc tctttcctgg gatcgaggac
     4261 caccctgtgc tcaaggagat ggaggtgcag gccaatgtgg agaagtcgct gacactgttc
     4321 gggcagctgc tgaccaagaa gcacttcctg ctgaccttca tccgcacgct ggaggcacag
     4381 cgcagcttct ccatgcgcga ccgcgggaat gtggcctcgc tcatcatgac ggccctgcag
     4441 ggcgagatgg aatacgccac aggcgtgctc aagcagctgc tttccgacct catcgagaag
     4501 aacctggaga gcaagaacca ccccaagctg ctactgcgcc ggactgagtc ggtggcagag
     4561 aagatgctaa ctaactggtt caccttcctc ttgtataagt tcctcaagga gtgcgctggg
     4621 gagccgctgt tcatgctgta ctgcgccatc aagcagcaga tggagaaggg ccccattgac
     4681 gccatcacgg gtgaggcacg ctactccctg agtgaggaca agctcatccg gcagcagatt
     4741 gactacaaga cactgaccct gaactgtgtg aaccctgaga atgagaatgc acctgaggtg
     4801 ccggtgaagg ggctggactg tgacacggtc acccaggcca aggagaagct gctggacgct
     4861 gcctacaagg gcgtgcccta ctcccagcgg cccaaggccg cggacatgga cctggagtgg
     4921 cgccagggcc gcatggcgcg catcatcctg caggacgagg acgtcaccac caagattgac
     4981 aacgattgga agaggctgaa cacactggct cactaccagg tgacagacgg gtcctcggtg
     5041 gcactggtgc ccaagcagac gtccgcctac aacatctcca actcctccac cttcaccaag
     5101 tccctcagca gatacgagag catgctgcgc acggccagca gccccgacag cctgcgctcg
     5161 cgcacgccca tgatcacgcc cgacctggag agcggcacca agctgtggca cctggtgaag
     5221 aaccacgacc acctggacca gcgtgagggt gaccgcggca gcaagatggt ctcggagatc
     5281 tacttgacac ggctactggc caccaagggc acactgcaga agtttgtgga cgacctgttt
     5341 gagaccatct tcagcacggc acaccggggc tcagccctgc cgctggccat caagtacatg
     5401 ttcgacttcc tggatgagca ggccgacaag caccagatcc acgatgctga cgtgcgccac
     5461 acctggaaga gcaactgcct gcccctgcgc ttctgggtga acgtgatcaa gaacccacag
     5521 tttgtgttcg acattcacaa gaacagcatc acggacgcct gcttgtcggt ggtggcccag
     5581 accttcatgg actcctgctc cacctctgag cacaagctgg gcaaggactc accctccaac
     5641 aagctgctct acgccaagga catccccaac tacaagagct gggtggagag gtactatgca
     5701 gacatcgcca agatgccagc catcagcgac caggacatga gtgcgtatct ggctgagcag
     5761 tcccgcctgc acctgagcca gttcaacagc atgagcgcct tgcacgagat ctactcctac
     5821 atcaccaagt acaaggatga gatcctggca gccctggaga aggatgagca ggcgcggcgg
     5881 cagcggctgc ggagcaagct ggagcaggtg gtggacacga tggccctgag cagctgagcc
     5941 ccagctgtga tcatccagca tgatgcagcg tgaggacagc tgagcaggga ccgggacagc
     6001 cctcaccgca tgcgtgtgga gtgtccggtg gtgctcgggc cgccgcagtg cagcgactgc
     6061 ccggccctcc ctcccctgcc tcacccggtc gggtcccggc tcttcctgtg tggaggtgat
     6121 ggtacctgcc acaccacagc tgcgcacaca gctgcttgct caggggccgg gacagcactg
     6181 ggtgctcagg ctggccaagg accttcattg cctggcaaga gctgcccagt ggccttcatg
     6241 ggagaagggc tgacctctga ggggctgagg ggtgaggcca gggccctcca gggggagggg
     6301 tagccagctt gggctgtccc cttgagacca ggacaagagg ctgggggtgt cagcattccc
     6361 agctttccaa gctgccccca ggcggcagag tctgagggtc ccggggcccg gttggcagct
     6421 ggagaaagag gcaaaaagcc cgtagccggg caagaggagc tcaagtcggt ctgggcccgt
     6481 tgccaccgac tcccacctcc agcacccatg cccgctgcac cgctgccatc ctcagattca
     6541 ccgcgtgctc tgcgcggccg aggccggagc accacatcca cctcgcccca gagaggctct
     6601 gctccctcct atggaggggc tgtgggccag gctgctcaga ctcctgggtg gcttccagac
     6661 ggaccgggca gcccctctcc gtcctcaggg ctgtgcctct gggagccact gggccagggg
     6721 ccccgggtcg cagagagcac gttcccgtta tttattcccc tccgcgtcct acacaggctg
     6781 ccctggcagc tgtcttcaag ggtaggctga gctccccacc ctggagcccc tgagggcggc
     6841 ccctgagcac tcctctctct ccactctctc tgtccctgcc ccagcggctt ccagtgtggc
     6901 atctcagcag tgtcctggcc cctccagagc agtgggacat ctggggactg tttttgtgtt
     6961 taggggaaaa aattctgctg cactctgctt gggccttgag gtctgtggca gggctcctct
     7021 ggcccgcagt ggcctggatc tatctgggcc atgagtgacg ggcagtgacc agagggactg
     7081 gaggccagcg gtgtccaccc ttgccctcag caagagagaa tgcattctta aaagaaagct
     7141 gtacatgtat atatatgcat atatatatat gtggctctag cctcaggctc cagccccagt
     7201 ggggtactgt acagttaact gaagaagaat tttaaagacg atttgaacaa gaaaatgaag
     7261 gcagtgggaa agcaatgcca aatggttgtg gagaaagtgg ccggagcctc cctggagtgg
     7321 agcagccctg aagcctgtgc cccccgacct gcgggccgct gttttggttt gacatgacaa
     7381 ggaaaggact tcctgctgac cctgagagcc tctggggtgc cgcggcacca cggggcatgc
     7441 atgattgtgc tagcgtttag tctgagttga tctttttaaa actgcaagtg ttgaatacta
     7501 gaggttgtta gacccttttt tatgtttttt aattaatcag tcacttgtaa aagcaaacaa
     7561 gcggtccatc cccttttcaa ggtcactttt ttgatggtac cgaagatccc atggacatta
     7621 agggacagct aactgtggcc agactcagcc ccatgtcctt ggccaggccc aaggagagga
     7681 ctcggcccca tggggtgtgc cagtcttgca gtccgcccca gctgagtagc gtgagccaga
     7741 tgacgccaca gagacccgcc tcttccctga acgcgggtcg gtgtggagtc agtgactgct
     7801 gactcaggga gctccttggc cccgtgggca ctgtgccagg gctggggcct tctgctgctg
     7861 ccacacccag ctcaggcctg ggccagcccc tgcccccagc ccactgaggg ggtgggctta
     7921 ctccctgggc agtcttgggg gccagagctg aggccagtcc atattacagt ggctgggctg
     7981 tttttttcag tagcccctag cattggctgg gattcctgtt cctgggtgcg cctccacctc
     8041 ccttctgatg tttcctggct atggtggggt gggaacctca gtttccccca aagtcttccc
     8101 tggatgctgg cttcaggttg aagtccctgg ttcttccagt tcctcacggg ttaggtaggg
     8161 gctcctgcat caccttcaga atccagttcc aacccccact ctccttaggc cttgtgctct
     8221 gctctgccct gccaggctgc ccttgtccat gtgagtagca tgggcgggtg gtggggacgg
     8281 cagtggtgat gaagggggtg caccacaggc ctcatgaagc agttcccaca tgggcgtgtg
     8341 gctggggcgt ggccaccaca gagcacatgg ctgtgtctag gcgcaagcac tttagcagta
     8401 tctgtttaca tgcgcaagga tcaagccgac tacctgtgct gtctactggg acagcagtct
     8461 ccgagctact ccgtacctcc ctctgccagg tcgtggagtt aggccccagt ccctacttgt
     8521 cactggttcc cactgtgctc ctaactgtgc agcacctggg agctctggcc tggggctgga
     8581 ggccctggta ggagctgcag ttggaggccg ttctgtgccc agcagcggtg agcggctccc
     8641 atgggccctg tgtctgcagg gagccagggc tgcggcacat gtgctgtgaa actggcaccc
     8701 acctggcgtg ctgctgccgc cacttgcttc ctgcagcacc tcctaccctg ctccgtgtcc
     8761 tccctctccc cgcgcctggc tcaggagtgc tggaaaagct cacgcctcgg cctgggagcc
     8821 tggcctcttg atatacctcg agcttcccct gtgctcccca gccccaggac cactggcccc
     8881 ttggcctgag gggctggggg ccccacgacc tgcagcgtcg agtccgggag agagcccgga
     8941 gcggcgtgcc atctcggctc ggccttgctg agagcctccg ccctggcttt ctccctgtct
     9001 ggattcagtg gctcacgttg gtgctacaca gctagaatag atatatttag agagagagat
     9061 atttttaaga caaagcccac aattagctgt cctttaacac cgcagaaccc cctcccagaa
     9121 gaagagcgat ccctcggacg gtccgggcgg gcaccctcag ccgggctctt tgcagaagca
     9181 gcaccgctga ctgtgggccc ggccctcaga tgtgtacata tacggctatt tcctatttta
     9241 ctgttcttca gatttagtac ttgtaaataa acacacacat taaggagaga ttaaacattt
     9301 ttgctaaaa
//
