LOCUS       NM_032812              12275 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens plexin domain containing 2 (PLXDC2), transcript
            variant 1, mRNA.
ACCESSION   NM_032812
VERSION     NM_032812.9
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12275)
  AUTHORS   Lang,L., Chen,F., Li,Y., Shay,C., Yang,F., Dan,H., Chen,Z.G.,
            Saba,N.F. and Teng,Y.
  TITLE     Adaptive c-Met-PLXDC2 Signaling Axis Mediates Cancer Stem Cell
            Plasticity to Confer Radioresistance-associated Aggressiveness in
            Head and Neck Cancer
  JOURNAL   Cancer Res Commun 3 (4), 659-671 (2023)
   PUBMED   37089864
  REMARK    GeneRIF: Adaptive c-Met-PLXDC2 Signaling Axis Mediates Cancer Stem
            Cell Plasticity to Confer Radioresistance-associated Aggressiveness
            in Head and Neck Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12275)
  AUTHORS   Li,Y., Li,J.Q., Jiang,H.P. and Li,X.
  TITLE     The Upregulation of PLXDC2 Correlates with Immune Microenvironment
            Characteristics and Predicts Prognosis in Gastric Cancer
  JOURNAL   Dis Markers 2021, 5669635 (2021)
   PUBMED   34777633
  REMARK    GeneRIF: The Upregulation of PLXDC2 Correlates with Immune
            Microenvironment Characteristics and Predicts Prognosis in Gastric
            Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12275)
  AUTHORS   Hamada,Y., Eguchi,A., Tanaka,K., Katsurahara,M., Horiki,N.,
            Nakamura,M., Tenpaku,M., Iwasa,M., Ichishi,M., Watanabe,M. and
            Takei,Y.
  TITLE     Plexin domain containing protein 2 is more expressed within the
            invasive area of human colorectal cancer tissues
  JOURNAL   Hum Cell 34 (5), 1580-1583 (2021)
   PUBMED   34146255
  REMARK    GeneRIF: Plexin domain containing protein 2 is more expressed
            within the invasive area of human colorectal cancer tissues.
REFERENCE   4  (bases 1 to 12275)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 12275)
  AUTHORS   Grosskopf,A.K., Schlagowski,S., Fricke,T., Ensser,A.,
            Desrosiers,R.C. and Hahn,A.S.
  TITLE     Plxdc family members are novel receptors for the rhesus monkey
            rhadinovirus (RRV)
  JOURNAL   PLoS Pathog 17 (3), e1008979 (2021)
   PUBMED   33657166
  REMARK    GeneRIF: Plxdc family members are novel receptors for the rhesus
            monkey rhadinovirus (RRV).
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 12275)
  AUTHORS   Liu,T., Qian,W.J., Gritsenko,M.A., Camp,D.G. 2nd, Monroe,M.E.,
            Moore,R.J. and Smith,R.D.
  TITLE     Human plasma N-glycoproteome analysis by immunoaffinity
            subtraction, hydrazide chemistry, and mass spectrometry
  JOURNAL   J Proteome Res 4 (6), 2070-2080 (2005)
   PUBMED   16335952
REFERENCE   7  (bases 1 to 12275)
  AUTHORS   Nanda,A., Buckhaults,P., Seaman,S., Agrawal,N., Boutin,P.,
            Shankara,S., Nacht,M., Teicher,B., Stampfl,J., Singh,S.,
            Vogelstein,B., Kinzler,K.W. and St Croix,B.
  TITLE     Identification of a binding partner for the endothelial cell
            surface proteins TEM7 and TEM7R
  JOURNAL   Cancer Res 64 (23), 8507-8511 (2004)
   PUBMED   15574754
REFERENCE   8  (bases 1 to 12275)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   9  (bases 1 to 12275)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 12275)
  AUTHORS   Carson-Walter,E.B., Watkins,D.N., Nanda,A., Vogelstein,B.,
            Kinzler,K.W. and St Croix,B.
  TITLE     Cell surface tumor endothelial markers are conserved in mice and
            humans
  JOURNAL   Cancer Res 61 (18), 6649-6655 (2001)
   PUBMED   11559528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353147.10, AY358486.1, AC067743.10, AL353790.15 and AI311457.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032812.8.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.148716.1,
                                           SRR1803612.166865.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377252.5/ ENSP00000366460.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL353147.10        82367-82377
            12-2605             AY358486.1         1-2594
            2606-4653           AC067743.10        1-2048              c
            4654-12159          AL353790.15        2001-9506
            12160-12275         AI311457.1         19-134              c
FEATURES             Location/Qualifiers
     source          1..12275
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.31"
     gene            1..12275
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
                     /note="plexin domain containing 2"
                     /db_xref="GeneID:84898"
                     /db_xref="HGNC:HGNC:21013"
                     /db_xref="MIM:606827"
     exon            1..760
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
                     /inference="alignment:Splign:2.1.0"
     CDS             649..2238
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; 1200007L24Rik; plexin domain-containing protein
                     2; tumor endothelial marker 7-related protein"
                     /codon_start=1
                     /product="plexin domain-containing protein 2 isoform 1
                     precursor"
                     /protein_id="NP_116201.7"
                     /db_xref="CCDS:CCDS7132.1"
                     /db_xref="GeneID:84898"
                     /db_xref="HGNC:HGNC:21013"
                     /db_xref="MIM:606827"
                     /translation="MARFPKADLAAAGVMLLCHFFTDQFQFADGKPGDQILDWQYGVT
                     QAFPHTEEEVEVDSHAYSHRWKRNLDFLKAVDTNRASVGQDSPEPRSFTDLLLDDGQD
                     NNTQIEEDTDHNYYISRIYGPSDSASRDLWVNIDQMEKDKVKIHGILSNTHRQAARVN
                     LSFDFPFYGHFLREITVATGGFIYTGEVVHRMLTATQYIAPLMANFDPSVSRNSTVRY
                     FDNGTALVVQWDHVHLQDNYNLGSFTFQATLLMDGRIIFGYKEIPVLVTQISSTNHPV
                     KVGLSDAFVVVHRIQQIPNVRRRTIYEYHRVELQMSKITNISAVEMTPLPTCLQFNRC
                     GPCVSSQIGFNCSWCSKLQRCSSGFDRHRQDWVDSGCPEESKEKMCENTEPVETSSRT
                     TTTVGATTTQFRVLTTTRRAVTSQFPTSLPTEDDTKIALHLKDNGASTDDSAAEKKGG
                     TLHAGLIIGILILVLIVATAILVTVYMYHHPTSAASIFFIERRPSRWPAMKFRRGSGH
                     PAYAEVEPVGEKEGFIVSEQC"
     exon            761..972
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1119
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1189
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1312
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1431
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1531
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1627
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1709
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1770
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1921
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..1960
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2121
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..12275
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11436..11441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
                     /note="hexamer: ATTAAA"
     polyA_site      11456
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
                     /note="major polyA site"
     regulatory      12250..12255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
                     /note="hexamer: AGTAAA"
     polyA_site      12275
                     /gene="PLXDC2"
                     /gene_synonym="PLXDC2-OT; TEM7R"
ORIGIN      
        1 agactgctgc agccctaacc ttcccagggc tcagctcttt ggagctgccc attcctccgg
       61 ctgcgagaaa ggacgcgcgc cctgcgtcgg gcgaagaaaa gaagcaaaac ttgtcgggag
      121 ggtttcgtca tcaacctcct tcccgcaaac ctaaacctcc tgccggggcc atccctagac
      181 agaggaaagt tcctgcagag ccgaccagcc ctagtggatc tggggcaggc agcggcgctg
      241 gctgtggaat tagatctgtt ttgaacccag tggagcgcat cgctggggct cggaagtcac
      301 cgtccgcggg caccgggttg gcgctgcccg agtggaaccg acagtttgcg agcctcggct
      361 gcaagtggcc tctcctcccc gcggttgttg ttcagtgtcg ggtgagggct gcgagtgtgg
      421 caagttgcaa agagagcctc agaggtccga agagcgctgc gctcctactc gcgttcgctt
      481 cttcctcttc tcggttccct actgtgaaat cgcagcgaca tttacaaagg cctccgggtc
      541 ctaccgagac cgatccgcag cgtttggccc ggtcgtgcct attgcatcgg gagcccccga
      601 gcaccggcga aggactggcg ggtggggtag ggaggtggcg gcggcggcat ggcgaggttc
      661 ccgaaggccg acctggccgc tgcaggagtt atgttacttt gccacttctt cacggaccag
      721 tttcagttcg ccgatgggaa acccggagac caaatccttg attggcagta tggagttact
      781 caggccttcc ctcacacaga ggaggaggtg gaagttgatt cacacgcgta cagccacagg
      841 tggaaaagaa acttggactt tctcaaggcg gtagacacga accgagcaag cgtcggccaa
      901 gactctcctg agcccagaag cttcacagac ctgctgctgg atgatgggca ggacaataac
      961 actcagatcg aggaggatac agaccacaat tactatatat ctcgaatata tggtccatct
     1021 gattctgcca gccgggattt atgggtgaac atagaccaaa tggaaaaaga taaagtgaag
     1081 attcatggaa tattgtccaa tactcatcgg caagctgcaa gagtgaatct gtccttcgat
     1141 tttccatttt atggccactt cctacgtgaa atcactgtgg caaccggggg tttcatatac
     1201 actggagaag tcgtacatcg aatgctaaca gccacacagt acatagcacc tttaatggca
     1261 aatttcgatc ccagtgtatc cagaaattca actgtcagat attttgataa tggcacagca
     1321 cttgtggtcc agtgggacca tgtacatctc caggataatt ataacctggg aagcttcaca
     1381 ttccaggcaa ccctgctcat ggatggacga atcatctttg gatacaaaga aattcctgtc
     1441 ttggtcacac agataagttc aaccaatcat ccagtgaaag tcggactgtc cgatgcattt
     1501 gtcgttgtcc acaggatcca acaaattccc aatgttcgaa gaagaacaat ttatgaatac
     1561 caccgagtag agctacaaat gtcaaaaatt accaacattt cggctgtgga gatgacccca
     1621 ttacccacat gcctccagtt taacagatgt ggcccctgtg tatcttctca gattggcttc
     1681 aactgcagtt ggtgtagtaa acttcaaaga tgttccagtg gatttgatcg tcatcggcag
     1741 gactgggtgg acagtggatg ccctgaagag tcaaaagaga agatgtgtga gaatacagaa
     1801 ccagtggaaa cttcttctcg aaccaccaca accgtaggag cgacaaccac ccagttcagg
     1861 gtcctaacta ccaccagaag agcagtgact tctcagtttc ccaccagcct ccctacagaa
     1921 gatgatacca agatagcact acatctaaaa gataatggag cttctacaga tgacagtgca
     1981 gctgagaaga aagggggaac cctccacgct ggcctcatca ttggaatcct catcctggtc
     2041 ctcattgtag ccacagccat tcttgtgaca gtctatatgt atcaccaccc aacatcagca
     2101 gccagcatct tctttattga gagacgccca agcagatggc ctgcgatgaa gtttagaaga
     2161 ggctctggac atcctgccta tgctgaagtt gaaccagttg gagagaaaga aggctttatt
     2221 gtatcagagc agtgctaaaa tttctaggac agaacaacac cagtactggt ttacaggtgt
     2281 taagactaaa attttgccta tacctttaag acaaacaaac aaacacacac acaaacaagc
     2341 tctaagctgc tgtagcctga agaagacaag atttctggac aagctcagcc caggaaacaa
     2401 agggtaaaca aaaaactaaa acttatacaa gataccattt acactgaaca tagaattccc
     2461 tagtggaatg tcatctatag ttcactcgga acatctcccg tggacttatc tgaagtatga
     2521 caagattata atgcttttgg cttaggtgca gggttgcaaa gggatcagaa aaaaaaaatc
     2581 ataataaagc tttagttcat gagggatcga cacctttggt tcaaatgttc tctgatgtct
     2641 caaagataac tgttttccaa agcctgaacc ctttcactca aaagagcaat gatgaatgtc
     2701 tcaagattgc taagaaaaac agcccatgca agagtgagaa caaacacaaa ataagagatt
     2761 ttctacattt tcaaaacaga tgtgtggcaa aaggatgttg tttttctggt ctagatccat
     2821 ctgtaccaac aagttcatca ctttacagaa cgaatctttt tatccgtaca ggaggttcaa
     2881 accatgtctg cctcttcctt tgtaatgaat gacctttcta tgagctgtga caaaatttcc
     2941 gaacaattaa ctaaggattt gggaagaggg ggtggcaaac ggggctttct gttttcctgc
     3001 ctcagcatga aaacatctga tttatgcttt atggaagcct tacctccaat ccccaactgt
     3061 taagtcccat gaaaccacag ttgctctggg ctgatggaaa caaaaggaaa cagtatgaag
     3121 agttccttaa tcatttttga aacaaaaatg ttaagggatt ttaaacatat gattattttt
     3181 aattttatgc cttttcagta ctaaacaccc atttcattgc tgattcctgt ctaagaagcc
     3241 attcacgtca gcatggcgat agaaagaatg aaaaaaccct gctgaatcat acagtaattt
     3301 tctttaaagc acatagtagt tacataaata tatatatata aatatatttt tgtttataac
     3361 taacacaagg caggatcttg tgactctaag agtgcgtttt gtcatcaagg caaaacagat
     3421 gcaagatgca tcactgcatt acttccatag agttgtaaaa taatccttaa tattagaata
     3481 tttttctgtc acttagcaaa agtggttcag ttcattgccg cgcccatcat gttcttgact
     3541 atttgatcca ctttttcgtt tatgtcaacc ccttccctct ctggctaaat aaagtggatg
     3601 cagaaagctc cttaaatgga gatatcgatt gccttggaat cacaatcctg attttgaaaa
     3661 ttcctcatga atgaagaaag gaatggcatc ccttgagaag gaaagtggtt aatatacata
     3721 ctgagctcct aaagtttaaa ttcaggtact gagtgtacaa tttcaccaac attctaaccc
     3781 atgaaacttt tacactctgt gccaagaaac tgttggcttt tgtaaggtac agtgctcaac
     3841 atttgcagat tcaggtctca agaagcagag atgtctcata agcagcattt tcccaacagt
     3901 ttagcatctg tacacatctg ccttggtcat cagtccactc acagagtacc atactttatc
     3961 atcacaagtg tctgacgtga acgaatgcca ttttctattc catatatttt gctttacaat
     4021 tttaagtatt tgatgaagat ggtaactttt tcctaactta gttaactatt aaaaaaaatt
     4081 ttgaaaagca aggtgattga aggattgtga tgacaatctc tttgcagcag ctatgtatgg
     4141 tttatgtgaa gtatccccac ttattcttgt ggagcaggtt tggtgagaca gcaataacca
     4201 aatgacatgc caatattact ggtgcaactg gtattctaca aatgcataag gaacacatag
     4261 acgacttcct tttaggataa aatgatgctt ctttcactac cttttgtggt agctgtggct
     4321 tccaatagca actgtttgac agttatataa atcttgcatg tgtattctta gtttgtgtcc
     4381 cttaagtact acttaattct caagtagtaa tgttattctt atacccttca gcgttctatt
     4441 ttgattcaaa acaattgatt caaaacaatt ttgaatcaat tttctatttt gattcaaaac
     4501 aattgataat tctgtaaaaa aacataaaca ctgaattctt cagtgaacca aagcaacaaa
     4561 taatagagaa aacttcttga aactggagtg tgggaaaact tcttaacaga actaagagtt
     4621 aaaggtagtg agaagtgtgt ggtgtgtgaa ttctttagtg gtaaggggaa atgtgggcta
     4681 aatccttttc tttcatgaaa ctctcattct attttatatt tctggtttgt tcttgttccc
     4741 atgtgagaaa acatacagtt tctgaaaatt caaaatggtc atcaatgctt tggactttac
     4801 ataattatgt attagagaag gtgcaactgt acattactta atatactatg aacataatag
     4861 aataacaaaa aaagataaca aagagatgca aacttctgga taaatcagat aaatggtgct
     4921 acagaggaat ttagttattt cagcttaatt atttgtaaaa ataataatca gtgactaggt
     4981 aaagatactg aaactcaaga aaaatatctt gacccattta tgtctagtgt tccattattg
     5041 gaacgctaag cttatgggag ttatttagag cctactgctc aaggtcatca ccaaggtctg
     5101 gttgcaaaaa ttcaaaaaat tgcaacctca ggcataaatg gcttaagccc aagagatggc
     5161 actgaccata aatggtggct tgtgtgtgaa gggtttggac ttcaagatat actaacacct
     5221 agaaaactaa aagtgcaatt gacccccaat tactatttta gtttgaggta tcaagggcat
     5281 ttgccaatct cttatatgta gcttctagag ttgtgctgtc caatattata tccactagcc
     5341 aacgtggctt ttgaaattaa aattaattaa aattaaatta aaaatgtaat tcttcagtca
     5401 caccagccac atttcaaagg ctcaatagcc acgcctggct tgtggctacc atattggata
     5461 acaagaaaca cttccgtggt tgaagaaaat tttaatggac aatgctgtgt ttcatttgaa
     5521 ttcgttgtcc ttgaagaaaa gggaagaaga ggaaagaaac aagatttggt agctcttggg
     5581 catatccaag catttttgat tttagagagg ccctatggag taatgaaaaa aatacaagct
     5641 gacacagctt taaatcccca ctgtgttatc ttgggaaaat cacttcaacc tccttgagtc
     5701 tcaatttgca attttggaaa agaaaaacaa tttttgtcct gtctttcttg caagattatt
     5761 atgcaacctg attaaatgta cagatgtgca gactcttaaa aaccttatgt taatgtaacc
     5821 catataaagt acgacttttg gtcgagtacc agcacaaatt tgcattcaaa ggaagaatag
     5881 ttcatcagtg caaaaagcgt tcaaaggtaa tcagttcatc acgtatcttg agaaaaagag
     5941 aatgcattca aaacacaaag caaaattgct tcagtttctt ttctgcccat ctgaatattt
     6001 cctttagtat ttgtcccaca tgacatccat cccatgtatt tatccactct ttcacaacat
     6061 tgcctatgaa catccttcaa ctggctcagt tctttattgc atagagccac ttagcttctc
     6121 tagtttctta tgatttccta ttttacactt aacagcaaaa ggaggcttcc atttagaagg
     6181 cactatctca aacataaata atttcatatt tattttatca ctgtaacact aaggagctat
     6241 ggcattaaaa tataaaacta tttggaactt aatgtaaacc tttgcacatg cagactatat
     6301 aaagggaata aaattatttt aaattatgct aatatccaga tacatattct aaggttagta
     6361 tcatttatca gtttttcgca acagattctt atgttacatc ttcatgaggg agtataaatt
     6421 tgatcacgtc cctagtgtct attgcccact tgagaaaggt tttgccagga tccacagatc
     6481 gcttcaagat gctttcgttt atgataggaa attaatattt aaataagact aattgaaaac
     6541 tagattatct ggttctaatt tcttcctcct gtgaaatgtt cttttggttt gtatttcttt
     6601 aggtattttc caagttactg ctgcttttac ttcacgacct ccaaccccac ttttgttatc
     6661 agcgtcatat gccagagtca tggcagatcc agcctggaca acatagtgag acccatctct
     6721 atcaaatata catatatata tatatatata cacacacaca cacacacaca caaatataca
     6781 tatatatcaa atatatatgt atatttgata gagatgatag caattatgtg tgtgtgtgtg
     6841 tgtgtgtgtg tgtgtgtgtt agccaagtgt ggtttctcat gcctgtagtc ccagctactt
     6901 tggaggctga agtgtaagag ttgcttgagc ccatgagtta gaggctgctg tgagctatga
     6961 tcatgccact gcactccagc ctgggcaaca gagcaaaacc ccatctctaa ataaaaaaaa
     7021 agaatcgtga gacatcatgt aatccaacct cttaatgtta cagataagta aactgaggcc
     7081 caaagagata tagtaatagt cccagtgtca gtaaactggg tcttgaactt aaatgtttgt
     7141 ttcagttctc attgccttca tctcttaatt gtcggcactt aaggccaacc aagcagctta
     7201 gacagcgcag tccactcaac ggtaacttta tttgctatat tgacaatctg ctctgttctg
     7261 taatatagaa cattggatca atctttatct ttttgctgac ttaaggaggc tgctattgtt
     7321 gcaatatcca gagatttcaa gttctagcca ttgcggggtc tttgtggtgt tttcaatttc
     7381 tcctctctcc acccctgccc ccatctgtgg ccatctaagt tagcaataca atttattttg
     7441 gccatttaaa atttttctgc ctttgtttta tttcttccca aatatatttg aaaatgaatg
     7501 atctatatag ctgattttct gaccacatat ataattgcaa tttttatttg ctcttcaaac
     7561 tattacaaca tttttgtcct tataaggttt tttgggcaga taatgcgagg tctgtggtgt
     7621 taccttttat atactcctat taccttatgt ttgtgaagca ttttacattt tacagagcac
     7681 tttgattcat ctccctattt gttcatttat ttaactgttc agttcactga aatatttatt
     7741 gaacacctac tggaaccaag tgactgtgct agtaacttgt gatatacagt agtgagagtc
     7801 caggcatgta accgatcatt ataatacaat aacatcccta aaccagactt tacaagtaga
     7861 taggatcaac aatactctat caattttcaa ctccaatttt ctattctact taaaatggga
     7921 actagaaact gtttgcctga agaatgtgtc tgaaacataa tatatcactg catgtctgtg
     7981 ctgtagacct gttaatttta tctgtgagaa aaaaagttac tcaaaattct ccctgaccta
     8041 agaatacttt ctagttcact gcagtcttac tgaccagatg caacagttga agtttgattt
     8101 ctcgacccaa tatttctatt gggttttgaa ttattaatat cactgttttg aggtattcag
     8161 aaacaccagt gtatcaaaaa agcatttgca ctttaggtgt gtgtggtggt tatgtcattt
     8221 attagaccat cccagacata agacaatcag ggaaatcaga aaactccagc ctcaaatgtg
     8281 tctataattt cctgttctac cattgtcata tcataacatg gtattacttc ttaaggtttt
     8341 gattaagttg atctagcctc aacttaaatt gtaatacatc tgcctaatta ttgtctggaa
     8401 taacttttca accatccaat gcccactgct ctcacaatga ttattgtaga gaagtaaaat
     8461 ggtaattatt caagtaaagt cacataattt ctggagtcag tttttcataa caagtttatg
     8521 gaatacatca tcattggctt cttcataata tatttattat gagtgaccaa attttgcctg
     8581 gaggagcaaa atgctcaaaa cttgttatta taggttaatt tccagctcac tgttgacact
     8641 gaaagattct gtgttacttt aaacccagga taaaaggctg gaaaaaaaat taaatgtaag
     8701 tcataaacta gtactcagct tttcctagtt tctaaggctt attaacattt gcaaattact
     8761 caataaatgt ctttcataat ggaataacat aaaagctttt gatttggcag atagtgatat
     8821 tttatttatt ttcattctgg ttgaaaaaaa tctcagtggc ttctcttcat tccacgagaa
     8881 ttttgatttt taacagcagt ctctcttttt ctcagcattg caaatatata tgtatatata
     8941 cattcatgac caaagtatcg cttactgacc atgcagctgt aaaccttctg tgcctatcaa
     9001 acaaatacat agcatgaaac taattttaga agtttcatgg gggaatttta ggggaaagta
     9061 taaacctaag agtgagtgaa tggagatgat tcatggaaaa aaaaataaaa atctaaatgt
     9121 gctattaggc agagttatta acttctttta gttgttgttt gagatggggt tttgctcttg
     9181 ttacccaggc tggagtgcaa tggcgtgatc tcgtctcact gcaacctccg cctcccaggt
     9241 tcaagcgatt ctcctgcctc agccgcccaa gtagctggga ttacaggcat atgccactac
     9301 agccggctaa ttttgtattt ttagtagaga cggggtttct ccatgctggt caggctggtc
     9361 cccagctccc gacctcaggt gatccgccca cctccgcctc ccaaagtgct ggaattacag
     9421 gcctgagcca ccgtgcctgg ccgagttatt aacttcttaa gagcaatgtg ctaataaata
     9481 ctcattgatg accagctcaa atttaggtca ttcagacatc cagacactgg ggcacatatt
     9541 ctgcaagcaa tgctgagacc cctgacatag agaaagcaaa ggatatgcct atgattagtc
     9601 taaaatgcag ccatcacccc ccatacctct tctatggcat tcatcctaac atcatggagg
     9661 cctttgtcct agagaattat gtgacttgcc ctagagaatt agtgaatgac caaaaagaga
     9721 ctttccattt atcttccttt gacttaaaag gcatgaaaat aaggcaaaaa aatcaataaa
     9781 ataattttcc tgaggaaagg ttaagagatg gcactttcct ttccgggccc agagctggat
     9841 ttctctgaga tttgaccatc tcaggactca gacagactcc agtgctattt tctggacatt
     9901 tgtggtgaag cctcagccac catgttcaag gtggtttgaa tgaaaacata ctcagattgt
     9961 cacatttata gcagggaaat aaaaactcaa attaggcatc ctgcagcagg ctactctgaa
    10021 aataacatta ggcaacatca gagcttcact tgcaaagaaa tgttaaaatc attttaggga
    10081 aatcagtgaa gtctctttag aaacagacat cttgtgtatg gcgtaaccca gtcttggggc
    10141 cctcacggag aagaggggga agtcttttca ttgattggtc aaaacaaatc tctcatttgc
    10201 ctgatttgaa gcatttcaac agtgcctgga gagtacatta ttttcagggg aaaaaaagga
    10261 gagagtcttt tttatatgcc agctgggatc atgggaactt cgaatgccag gaatttacta
    10321 ctgtttctgg taattctgtg tgtagtcatt tgaaatgttg aagtgtgaaa agagaagaaa
    10381 ttgggcactt cttgcggcgg gggagggggg gggggcggtg gctttccaga ttttatgcca
    10441 gttgcaccag catgcagaat atttgtaatg catttcaaag tggatataat ggcacccttt
    10501 gtcagaatca caaagctcac tgcggcactg ctacaagagg acactgagga aaatctggcc
    10561 ctatgaacct agtcaacccc aagcaaaaag aatgactatg tgtgtgagtg cagcacatgg
    10621 ccagttcgtt tctcactgtt ttggaaagcc ctgtgtgcca aaccaaggac gtgtctttca
    10681 gggaaaggtt aattttccga agtttattaa aatagaactt ggaaaaccaa gcattttgaa
    10741 tttattccag tcctctgggc atcattccta tttcttctgc catgtcaagg agaaattcca
    10801 agcctgcatt ctgtcatgct aaaataacca gcccatactt ctcggtgacc ttctgttgaa
    10861 cgtacctgag cctgcaaatg taaaaatgat tgtatctgaa tctgcactaa tggtgtctga
    10921 gagcaaaaag agtgtgacct ctattggaaa cctttgttca aattcaataa ttcagagatg
    10981 ctacatactt ctgcaagctt cctgattatg ttcactgtaa tattaatgac ctaagtttga
    11041 atgtatttcc ttacagtcca ttaatttgac atccatcttt tacctgggga ttattacaat
    11101 tgcaataagt cattaatgtt ttcttcacac agcttcttaa accaagtttc tctgcagctc
    11161 tttcggttct gcttacagtg tgtgggaaat ctgatttttt tcccctagta atagtttgat
    11221 aagaaattta gtgtattgac tgcctcagtg acacaattta tctttaaagg tgtggaagct
    11281 ggtggggacc aaatgttacc tgtgtttttg ctgttgattg ctattttcag aagcaaacca
    11341 tgtttttcac ttacagtagg agtcaacaaa tttgggattt tagaaggggg aggagggagc
    11401 tatttgtgta agactgctgt catatttgac tacatattaa aaacagtaaa tgagcatttt
    11461 gttttaattt cttaaatacc ttgtctttca acatacgttt tgtttccttt cttccattag
    11521 tgttcaaaag gttctaccca ttgtggaaga aattctgtgt gcagaattca gaggcacaag
    11581 gctgatggca agatagaaag ttattttgct tctaaaccca ccccgatgtg gaaactgata
    11641 ctagctagag ggagctgtag aaaacaaaga tttcaggatt gcacagtgtg tgggcaatgg
    11701 gatggagact ttttccccta ttcccagcca cagtgcccaa gcgttcaagt ctcctggatc
    11761 agacagatgg gattttagct gctgctttaa atcctagtgc tggaataagt caaggtactt
    11821 cagttcagct cttgcctctg tcactaatct tgctttatga actcctttga ttttctgaat
    11881 aagttccaga aggttctcta ttattctgtc cttcttccaa actggaaatg gctgtatcta
    11941 attctcagga tattttggat gtgtgcctca ggtaatttat gtggaatgtg taaagcaaga
    12001 tgtctccaat tctgaatatt ccttcccctt ttcccaatcc tccactcttg gactaccttt
    12061 ataacaacac cgagtacgca cagacctgaa cccatgccca agaagcacac acaatgactg
    12121 gagctgtcgg gaattcctgt cagtggcatt ccctgagcac tggctctgta caactcaatt
    12181 ataatttttt aagaatcata cctctgtata gatcttttgg actgtactga ttaaactttg
    12241 atattgtgga gtaaattcag aagtgcaatt ttaaa
//
