LOCUS       NM_020405               6230 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens plexin domain containing 1 (PLXDC1), mRNA.
ACCESSION   NM_020405
VERSION     NM_020405.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6230)
  AUTHORS   Fu,Y., Zhang,X. and Qiao,Q.
  TITLE     PLXDC1 serves as a potential prognostic marker and involves in
            malignant progression and macrophage polarization in colon cancer
  JOURNAL   J Biochem Mol Toxicol 38 (10), e23832 (2024)
   PUBMED   39267413
  REMARK    GeneRIF: PLXDC1 serves as a potential prognostic marker and
            involves in malignant progression and macrophage polarization in
            colon cancer.
REFERENCE   2  (bases 1 to 6230)
  AUTHORS   Grosskopf,A.K., Schlagowski,S., Fricke,T., Ensser,A.,
            Desrosiers,R.C. and Hahn,A.S.
  TITLE     Plxdc family members are novel receptors for the rhesus monkey
            rhadinovirus (RRV)
  JOURNAL   PLoS Pathog 17 (3), e1008979 (2021)
   PUBMED   33657166
  REMARK    GeneRIF: Plxdc family members are novel receptors for the rhesus
            monkey rhadinovirus (RRV).
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6230)
  AUTHORS   Pietrzyk,L. and Wdowiak,P.
  TITLE     Serum TEM5 and TEM7 concentrations correlate with clinicopathologic
            features and poor prognosis of colorectal cancer patients
  JOURNAL   Adv Med Sci 64 (2), 402-408 (2019)
   PUBMED   31352222
  REMARK    GeneRIF: Serum TEM5 and TEM7 concentrations correlate with
            clinicopathologic features and poor prognosis of colorectal cancer
            patients
REFERENCE   4  (bases 1 to 6230)
  AUTHORS   Falchetti,M.L., D'Alessandris,Q.G., Pacioni,S., Buccarelli,M.,
            Morgante,L., Giannetti,S., Lulli,V., Martini,M., Larocca,L.M.,
            Vakana,E., Stancato,L., Ricci-Vitiani,L. and Pallini,R.
  TITLE     Glioblastoma endothelium drives bevacizumab-induced infiltrative
            growth via modulation of PLXDC1
  JOURNAL   Int J Cancer 144 (6), 1331-1344 (2019)
   PUBMED   30414187
  REMARK    GeneRIF: Study revealed that over-expression of PLXDC1 per se was
            able to change partly the growth features of U87MG glioblastoma
            cells. Molecularly, PLXDC1 regulated the epithelial to mesenchymal
            transition program of tumor cells, whereby its silencing increased
            the mRNA levels of epithelial transcripts, whereas those of
            mesenchymal marker genes were reduced.
REFERENCE   5  (bases 1 to 6230)
  AUTHORS   Kim,G.H., Won,J.E., Byeon,Y., Kim,M.G., Wi,T.I., Lee,J.M.,
            Park,Y.Y., Lee,J.W., Kang,T.H., Jung,I.D., Shin,B.C., Ahn,H.J.,
            Lee,Y.J., Sood,A.K., Han,H.D. and Park,Y.M.
  TITLE     Selective delivery of PLXDC1 small interfering RNA to endothelial
            cells for anti-angiogenesis tumor therapy using CD44-targeted
            chitosan nanoparticles for epithelial ovarian cancer
  JOURNAL   Drug Deliv 25 (1), 1394-1402 (2018)
   PUBMED   29890852
  REMARK    GeneRIF: PLXDC1 silencing by the HA-CH-NP/siRNA significantly
            inhibited tumor growth in A2780 tumor-bearing mice.
REFERENCE   6  (bases 1 to 6230)
  AUTHORS   Yamaji,Y., Yoshida,S., Ishikawa,K., Sengoku,A., Sato,K.,
            Yoshida,A., Kuwahara,R., Ohuchida,K., Oki,E., Enaida,H.,
            Fujisawa,K., Kono,T. and Ishibashi,T.
  TITLE     TEM7 (PLXDC1) in neovascular endothelial cells of fibrovascular
            membranes from patients with proliferative diabetic retinopathy
  JOURNAL   Invest Ophthalmol Vis Sci 49 (7), 3151-3157 (2008)
   PUBMED   18316703
  REMARK    GeneRIF: TEM7 may play significant role in proliferation and
            maintenance of neovascular endothelial cells in fibrovascular
            membranes. TEM7 may be molecular target for new diagnostic and
            therapeutic strategies for proliferative diabetic retinopathy.
REFERENCE   7  (bases 1 to 6230)
  AUTHORS   Fuchs,B., Mahlum,E., Halder,C., Maran,A., Yaszemski,M., Bode,B.,
            Bolander,M. and Sarkar,G.
  TITLE     High expression of tumor endothelial marker 7 is associated with
            metastasis and poor survival of patients with osteogenic sarcoma
  JOURNAL   Gene 399 (2), 137-143 (2007)
   PUBMED   17560052
  REMARK    GeneRIF: TEM7 expression level closely parallels histology-based
            prognostication of OGS metastasis and, therefore, it is a
            therapeutic target.
REFERENCE   8  (bases 1 to 6230)
  AUTHORS   Nanda,A., Buckhaults,P., Seaman,S., Agrawal,N., Boutin,P.,
            Shankara,S., Nacht,M., Teicher,B., Stampfl,J., Singh,S.,
            Vogelstein,B., Kinzler,K.W. and St Croix,B.
  TITLE     Identification of a binding partner for the endothelial cell
            surface proteins TEM7 and TEM7R
  JOURNAL   Cancer Res 64 (23), 8507-8511 (2004)
   PUBMED   15574754
REFERENCE   9  (bases 1 to 6230)
  AUTHORS   Carson-Walter,E.B., Watkins,D.N., Nanda,A., Vogelstein,B.,
            Kinzler,K.W. and St Croix,B.
  TITLE     Cell surface tumor endothelial markers are conserved in mice and
            humans
  JOURNAL   Cancer Res 61 (18), 6649-6655 (2001)
   PUBMED   11559528
REFERENCE   10 (bases 1 to 6230)
  AUTHORS   St Croix,B., Rago,C., Velculescu,V., Traverso,G., Romans,K.E.,
            Montgomery,E., Lal,A., Riggins,G.J., Lengauer,C., Vogelstein,B. and
            Kinzler,K.W.
  TITLE     Genes expressed in human tumor endothelium
  JOURNAL   Science 289 (5482), 1197-1202 (2000)
   PUBMED   10947988
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA205327.1, BC036059.1, AK312999.1, AC091178.7 and AF378753.1.
            
            On Nov 24, 2018 this sequence version replaced NM_020405.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this RefSeq
            transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF378753.1, SRR14038197.766731.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315392.9/ ENSP00000323927.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DA205327.1         13-34
            23-658              BC036059.1         1-636
            659-1584            AK312999.1         493-1418
            1585-4147           AC091178.7         46604-49166         c
            4148-6230           AF378753.1         4029-6111
FEATURES             Location/Qualifiers
     source          1..6230
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..6230
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
                     /note="plexin domain containing 1"
                     /db_xref="GeneID:57125"
                     /db_xref="HGNC:HGNC:20945"
                     /db_xref="MIM:606826"
     exon            1..276
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1703
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
                     /note="2410003I07Rik; plexin domain-containing protein 1;
                     tumor endothelial marker 7; tumor endothelial marker 3"
                     /codon_start=1
                     /product="plexin domain-containing protein 1 precursor"
                     /protein_id="NP_065138.2"
                     /db_xref="CCDS:CCDS11333.1"
                     /db_xref="GeneID:57125"
                     /db_xref="HGNC:HGNC:20945"
                     /db_xref="MIM:606826"
                     /translation="MRGELWLLVLVLREAARALSPQPGAGHDEGPGSGWAAKGTVRGW
                     NRRARESPGHVSEPDRTQLSQDLGGGTLAMDTLPDNRTRVVEDNHSYYVSRLYGPSEP
                     HSRELWVDVAEANRSQVKIHTILSNTHRQASRVVLSFDFPFYGHPLRQITIATGGFIF
                     MGDVIHRMLTATQYVAPLMANFNPGYSDNSTVVYFDNGTVFVVQWDHVYLQGWEDKGS
                     FTFQAALHHDGRIVFAYKEIPMSVPEISSSQHPVKTGLSDAFMILNPSPDVPESRRRS
                     IFEYHRIELDPSKVTSMSAVEFTPLPTCLQHRSCDACMSSDLTFNCSWCHVLQRCSSG
                     FDRYRQEWMDYGCAQEAEGRMCEDFQDEDHDSASPDTSFSPYDGDLTTTSSSLFIDSL
                     TTEDDTKLNPYAGGDGLQNNLSPKTKGTPVHLGTIVGIVLAVLLVAAIILAGIYINGH
                     PTSNAALFFIERRPHHWPAMKFRSHPDHSTYAEVEPSGHEKEGFMEAEQC"
     exon            277..455
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
                     /inference="alignment:Splign:2.1.0"
     exon            456..599
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
                     /inference="alignment:Splign:2.1.0"
     exon            600..669
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
                     /inference="alignment:Splign:2.1.0"
     exon            670..792
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
                     /inference="alignment:Splign:2.1.0"
     exon            793..911
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1011
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1107
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1189
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1250
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1386
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1422
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1583
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..6230
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2389..2394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
                     /note="hexamer: AATAAA"
     polyA_site      2413
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
                     /note="major polyA site"
     regulatory      6213..6218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
                     /note="hexamer: AATAAA"
     polyA_site      6230
                     /gene="PLXDC1"
                     /gene_synonym="TEM3; TEM7"
ORIGIN      
        1 gctcccggag gccgcagcct ccagctccgc tcgcgctctc gccgctcctg ccggctcgcc
       61 cggccccgcg ctccgccgtc tcctcgccgc ccgcccctcc gccagccccg gggaccgcgc
      121 ggccgcagcc tgagccaggg ccccctccct cgtcaggacc ggggcagcaa gcaggccggg
      181 ggcaggtccg ggcacccacc atgcgaggcg agctctggct cctggtgctg gtgctcaggg
      241 aggctgcccg ggcgctgagc ccccagcccg gagcaggtca cgatgagggc ccaggctctg
      301 gatgggctgc caaagggacc gtgcggggct ggaaccggag agcccgagag agccctgggc
      361 atgtgtcaga gccggacagg acccagctga gccaggacct gggtgggggc accctggcca
      421 tggacacgct gccagataac aggaccaggg tggtggagga caaccacagc tattatgtgt
      481 cccgtctcta tggccccagc gagccccaca gccgggaact gtgggtagat gtggccgagg
      541 ccaaccggag ccaagtgaag atccacacaa tactctccaa cacccaccgg caggcttcga
      601 gagtggtctt gtcctttgat ttccctttct acgggcatcc tctgcggcag atcaccatag
      661 caactggagg cttcatcttc atgggggacg tgatccatcg gatgctcaca gctactcagt
      721 atgtggcgcc cctgatggcc aacttcaacc ctggctactc cgacaactcc acagttgttt
      781 actttgacaa tgggacagtc tttgtggttc agtgggacca cgtttatctc caaggctggg
      841 aagacaaggg cagtttcacc ttccaggcag ctctgcacca tgacggccgc attgtctttg
      901 cctataaaga gatccctatg tctgtcccgg aaatcagctc ctcccagcat cctgtcaaaa
      961 ccggcctatc ggatgccttc atgattctca atccatcccc ggatgtgcca gaatctcggc
     1021 gaaggagcat ctttgaatat caccgcatag agctggaccc cagcaaggtc accagcatgt
     1081 cggccgtgga gttcacccca ttgccgacct gcctgcagca taggagctgt gacgcctgca
     1141 tgtcctcaga cctgaccttc aactgcagct ggtgccatgt cctccagaga tgctccagtg
     1201 gctttgaccg ctatcgccag gagtggatgg actatggctg tgcacaggag gcagagggca
     1261 ggatgtgcga ggacttccag gatgaggacc acgactcagc ctcccctgac acttccttca
     1321 gcccctatga tggagacctc accactacct cctcctccct cttcatcgac agcctcacca
     1381 cagaagatga caccaagttg aatccctatg caggaggaga cggccttcag aacaacctgt
     1441 cccccaagac aaagggcact cctgtgcacc tgggcaccat cgtgggcatc gtgctggcag
     1501 tcctcctcgt ggcggccatc atcctggctg gaatttacat caatggccac cccacatcca
     1561 atgctgcgct cttcttcatc gagcgtagac ctcaccactg gccagccatg aagtttcgca
     1621 gccaccctga ccattccacc tatgcggagg tggagccctc gggccatgag aaggagggct
     1681 tcatggaggc tgagcagtgc tgagaacacc aagtctcccc tttgaagact ttgaggccac
     1741 agaaaagaca gttaaagcaa agaagagaag tgacttttcc tggcctctcc cagcatgccc
     1801 tgggctgaga tgagatggtg gtttatggct ccagagctgc tgctcgcttc gtcagcacac
     1861 cccgaatatt gaagaggggg ccaaaaaaca accacatgga ttttttatag gaacaacaac
     1921 ctaatctcat cctgttttga tgcaagggtt ctcttctgtg tcttgtaacc atgaaacagc
     1981 agaagaacta acataactaa ctccattttt gtttaagggg cctttaccta ttcctgcacc
     2041 taggctagga taactttaga gcactgacat aaaacgcaaa aacaggaatc atgccgtttg
     2101 caaaactaac tctgggatta aaggggaagc atgtaaacag ctaactgttt ttgttaaaga
     2161 tttataggaa tgaggaggtt tggctattgt cacatgacag actgttagcc aaggacaaag
     2221 aagttctgca aacctcccct ggacccttgc tggtgtccag atgtctgcgg ttgtcagccc
     2281 cttcctttcc cccgacctaa acataaaaga caaggcaaag cccgcataat tttaagacgg
     2341 ttctttagga cattagtcca ccatcttctt ggtttgctgg ctctccgaaa taaagtccct
     2401 ttccttgctc caactccttg tctctcaacg tattggctat gacgcagcaa gcagaatgaa
     2461 tttggactca gttacaggct gtcaatggtc tgctctgtag cagtctcaga gcctccccga
     2521 cccactacct ggagatagcc agatagccag atgccctgct cctggccacc tttaaagccc
     2581 ctgcatatga cacaggttaa ctaaagtcaa gattggggct gctgcattcc aggttcccta
     2641 gactcacaag ctggtccttg gccaggtgca gtggctcacg cctgtaatcc cagcactttg
     2701 ggaggctgag gcaggcggat cacctgaagt cagaagtttg agaccagcct ggccaacata
     2761 attaaaatgt ctctactaaa aatacaaaaa attagctggg tgtggtgacg cttgcctgta
     2821 tcccagctac tcaggaagct gagacacgag aatcacttga acctgggagg cagaggttgc
     2881 agtgagctca gatagtgcca ctgcactcca gcctgggtga cagagcgaga ctccgtctca
     2941 aaaaaaaaaa aagaaagcag atcctcatgg ctatagagtt ggcattttag ccccagcttc
     3001 tgtagctctg aaagcctaaa gaaggtattc tctccatctg ttaaacacag tatagtggct
     3061 ctcagccctt ggggcatgtt atcatgggag ggaagtcaaa taagaggaga gaaaagaact
     3121 caagggggaa actgcatttt taggctttgc tctcttacct tgccctttct actcagaacc
     3181 aataacttct gcatcaaaac atgttacagc ctgcatcaag ggctttaccc caacctgcag
     3241 cccagccttc cctgggtgag cttgctatgc gcagccacat ttaccatgtg gggctcccta
     3301 ttctgatggc ctgttcggtg ccgggtttac tcactgccct gttctgatgt cagtgcctgt
     3361 acatacctcc aaaggcagga cttgcctgat aaatattttt cctcctctga actggatttt
     3421 ataggcatta aagacaagtc gggtggctag agggctcctt gagacatacc tagcagggaa
     3481 ctgcaggtgg attctgttga gaggcaaagc acctgagtgg ttgggacaca ggcagctggc
     3541 atgggaggga ctttttttga gacagggtct cactgtgtcg cccagggcaa ggatgcccaa
     3601 agacaccagg ttggagaggc acctgccaac tacttgcttt ccctggagcc tgcatgtgcc
     3661 tgtggggtgg ggaggcgtag gggtctacgg ctgcctgaga tgggtgtgca cagtgtgtga
     3721 agtacctacc tccttgcctt gctggactgt cagccagtcg cagggccggc cacaagaccc
     3781 atgtctccat ctggtcatac tccatagcta ccaagttaac ctgctctaaa ctttggagaa
     3841 ctggatctgt ccaataaacg cttatttggc caagcctgat ggctcgtgcc tgtactccca
     3901 gcactttggg aggctgaggt gggagggttg cttgagccca ggggtttgag accagcttgg
     3961 gcaacaacaa caaaaatgcc aggtgtggtg gggtgcacct gtagtcccag ctactaggga
     4021 ggctgagcca ggaggatcac ttgagcccgg gaggttgagg ctgcagtggg gggtcataat
     4081 catgccactg tactccagcc tgggtgacag agtgagaccc tgtctccgaa aaaaaaaaaa
     4141 aaaaaaagaa cggaaaaaga aatgcttaca ttgtcaggga tcctgtagac aatcattaac
     4201 tctatgagat gcttggttct atttttttgg gagactttgt ccaagtgttt tggcttaaga
     4261 aatccatagg cctctcttgg tgacacatct ctagtacttt ttgtcataaa caaacaggcc
     4321 atctgccgcc aaatacatcc actccccatg ccactgacat cctatgggtc agccaggctt
     4381 gctttgactg aggccgaggc atctggaact ttctctgcct gcaggggcta gcagcagagg
     4441 cttcaccgca tcaccacccc ttcctccact cctgacattc tttcccttca gggatccaaa
     4501 atggttggcc gagctcccag tgggaaaacg tgtgctagag ttggggagtg agatgagtgg
     4561 tgctgtccat ggaatcaggc cacagcagga actgccccac tggccatttg agacacacac
     4621 aggtggtaaa tgctctgctg gtgggctgtg cttccctcat tcagagagct ctgttacagc
     4681 ccactgtgtc ctttagaagc ttgaaaggaa cccaactctt tgctgcactg tcctttttct
     4741 tcctcaaatt cagaccctcc ttccaccggc acccccctac tccaccctca gctcttcctt
     4801 gcctggttta tcaagcagag ctgaggcccc acgtttccaa ctctgattgt cacttgcatc
     4861 ttcacaaagg ataaaccacg gagcaactgg aaaaccatca gccaagcgtt cggatgagtc
     4921 tggttattgg tccacccccg accagattcc cttacactta actcacttct ttctttggca
     4981 atgaccctca tgacatgtat aaatgggtat gactaagaag aggctgtgat ctaacattta
     5041 tttgctgcca ttttttactc tggggagaag cagccccaac tcatcactgg gaaagaactc
     5101 cccctgcaaa ccagctaaat ttgataattt aaaccccctg cccctaaaac ttctcacaga
     5161 gctggggagt tggtggcaac tttccaagtc aaggtcttgc ttagaaagtc cttcactaca
     5221 tggccaggtg cagtggctca cgcctgtagt cccaggtact tgggagcctg aggcaggagg
     5281 attgcttgag ctcaggagtt caaggctgca gagagctatg atcatcccac tgcatttgtt
     5341 taaaaataaa tttttaaaat ttgtgtgttt tatcaggggt ctcctgtaca gtgtatctgt
     5401 gtatgtttgt gtgtgtgttt gtatacagcc ttgtttaatg ttttgagcaa taagatatgc
     5461 acacacaggt attttgttgc taaagagatt ggacaaggtt gtagctgtgc tcaggcttca
     5521 gcttggtttg ttaaattgag agataaacaa tgacaagagc tgccagccaa ccacactatt
     5581 caaaaagcaa agtgttcacc actaaagcta accattcatc tggttgcagg caaggctaag
     5641 gctctctctc ctctagttcc tggaacagac tcacagattg gcatgaagca ctgatcaggg
     5701 gctgcactca gactccctgg ccaagcaaac ctacaccaga agagtcagtg tcacagatat
     5761 gatgcggcca atctctgtct ccaaaaacct acctgaactt aatggtagaa ttcaaagatc
     5821 tggggactga gggcacccag ccttctaaaa cacaatgtat tcatgtgttt agtgtaaact
     5881 ctctgcatgg attctcagtg ttaataataa aaggaagcat tcttttacaa ctcctgctgt
     5941 gtgcaaaaga aagtgcaaag gatttggagt ggcattccga agatcaccac acataccttg
     6001 gttctgatgg ctgctgaact ccgacttctt cgctgagaca tgactgtggg aacagcctcc
     6061 agctatctgc tcatcagagg tgctttcctc aacctcctgc accacctcca agagaaacag
     6121 cctaaaaaga aaccccagct gtttacttat attggtctgt aaatccctgg aagtaaaccc
     6181 catgcatttt tatctactgt ctgaggacat acaataaatc tgagaaagtc
//
