LOCUS       NM_031310               2290 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens plasmalemma vesicle associated protein (PLVAP), mRNA.
ACCESSION   NM_031310
VERSION     NM_031310.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2290)
  AUTHORS   Wen,Y., Wang,Y., Huang,Y., Liu,Z. and Hui,C.
  TITLE     PLVAP protein expression correlated with microbial composition,
            clinicopathological features, and prognosis of patients with
            stomach adenocarcinoma
  JOURNAL   J Cancer Res Clin Oncol 149 (10), 7139-7153 (2023)
   PUBMED   36884119
  REMARK    GeneRIF: PLVAP protein expression correlated with microbial
            composition, clinicopathological features, and prognosis of
            patients with stomach adenocarcinoma.
REFERENCE   2  (bases 1 to 2290)
  AUTHORS   Denzer,L., Muranyi,W., Schroten,H. and Schwerk,C.
  TITLE     The role of PLVAP in endothelial cells
  JOURNAL   Cell Tissue Res 392 (2), 393-412 (2023)
   PUBMED   36781482
  REMARK    GeneRIF: The role of PLVAP in endothelial cells.
            Review article
REFERENCE   3  (bases 1 to 2290)
  AUTHORS   Wang,Y., Yu,H., Xie,X., Deng,T., Ye,L., Wu,L., Ding,X., Yang,Z.,
            Zhu,Q., Li,J., Zheng,Y., Yu,Z. and Chen,G.
  TITLE     Plasmalemma vesicle-associated protein promotes angiogenesis in
            cholangiocarcinoma via the DKK1/CKAP4/PI3K signaling pathway
  JOURNAL   Oncogene 40 (25), 4324-4337 (2021)
   PUBMED   34079085
  REMARK    GeneRIF: Plasmalemma vesicle-associated protein promotes
            angiogenesis in cholangiocarcinoma via the DKK1/CKAP4/PI3K
            signaling pathway.
REFERENCE   4  (bases 1 to 2290)
  AUTHORS   Yokomori,H., Ando,W. and Oda,M.
  TITLE     Plasmalemmal Vesicle-Associated Protein Is Associated with
            Endothelial Cells Sprouting from the Peribiliary Capillary Plexus
            in Human Cirrhotic Liver
  JOURNAL   J Vasc Res 58 (6), 361-369 (2021)
   PUBMED   34280928
  REMARK    GeneRIF: Plasmalemmal Vesicle-Associated Protein Is Associated with
            Endothelial Cells Sprouting from the Peribiliary Capillary Plexus
            in Human Cirrhotic Liver.
REFERENCE   5  (bases 1 to 2290)
  AUTHORS   De Leo,L., Naviglio,S., Vatta,S., Benelli,E., Stera,G., Santon,D.,
            Ziberna,F., Taddio,A., Martelossi,S., Giudici,F., Giuffrida,P., Di
            Sabatino,A., Corazza,G.R., Ventura,A. and Not,T.
  TITLE     Circulating PV-1 as a marker of celiac disease-associated liver
            injury
  JOURNAL   Biomark Med 14 (18), 1675-1681 (2020)
   PUBMED   33346700
  REMARK    GeneRIF: Circulating PV-1 as a marker of celiac disease-associated
            liver injury.
REFERENCE   6  (bases 1 to 2290)
  AUTHORS   Strickland,L.A., Jubb,A.M., Hongo,J.A., Zhong,F., Burwick,J.,
            Fu,L., Frantz,G.D. and Koeppen,H.
  TITLE     Plasmalemmal vesicle-associated protein (PLVAP) is expressed by
            tumour endothelium and is upregulated by vascular endothelial
            growth factor-A (VEGF)
  JOURNAL   J Pathol 206 (4), 466-475 (2005)
   PUBMED   15971170
REFERENCE   7  (bases 1 to 2290)
  AUTHORS   Stan,R.V., Tkachenko,E. and Niesman,I.R.
  TITLE     PV1 is a key structural component for the formation of the stomatal
            and fenestral diaphragms
  JOURNAL   Mol Biol Cell 15 (8), 3615-3630 (2004)
   PUBMED   15155804
  REMARK    GeneRIF: PV1 is a key structural component, necessary for the
            biogenesis of the stomatal and fenestral diaphragms.
REFERENCE   8  (bases 1 to 2290)
  AUTHORS   Hnasko,R., McFarland,M. and Ben-Jonathan,N.
  TITLE     Distribution and characterization of plasmalemma vesicle protein-1
            in rat endocrine glands
  JOURNAL   J Endocrinol 175 (3), 649-661 (2002)
   PUBMED   12475376
REFERENCE   9  (bases 1 to 2290)
  AUTHORS   Stan,R.V., Arden,K.C. and Palade,G.E.
  TITLE     cDNA and protein sequence, genomic organization, and analysis of
            cis regulatory elements of mouse and human PLVAP genes
  JOURNAL   Genomics 72 (3), 304-313 (2001)
   PUBMED   11401446
REFERENCE   10 (bases 1 to 2290)
  AUTHORS   Stan,R.V., Ghitescu,L., Jacobson,B.S. and Palade,G.E.
  TITLE     Isolation, cloning, and localization of rat PV-1, a novel
            endothelial caveolar protein
  JOURNAL   J Cell Biol 145 (6), 1189-1198 (1999)
   PUBMED   10366592
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX380375.2, AC010319.10, AL834363.1, AF326591.1 and AW874637.1.
            
            On Nov 23, 2018 this sequence version replaced NM_031310.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096030.1, SRR3476690.471722.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252590.9/ ENSP00000252590.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BX380375.2         8-17
            11-11               AC010319.10        114256-114256
            12-2054             AL834363.1         1-2043
            2055-2289           AF326591.1         2053-2287
            2290-2290           AW874637.1         23-23               c
FEATURES             Location/Qualifiers
     source          1..2290
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..2290
                     /gene="PLVAP"
                     /gene_synonym="DIAR10; FELS; gp68; PV-1; PV1"
                     /note="plasmalemma vesicle associated protein"
                     /db_xref="GeneID:83483"
                     /db_xref="HGNC:HGNC:13635"
                     /db_xref="MIM:607647"
     exon            1..423
                     /gene="PLVAP"
                     /gene_synonym="DIAR10; FELS; gp68; PV-1; PV1"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1383
                     /gene="PLVAP"
                     /gene_synonym="DIAR10; FELS; gp68; PV-1; PV1"
                     /note="fenestrated-endothelial linked structure protein;
                     PV-1 protein; plasmalemma vesicle protein 1; fenestrated
                     endothelial-linked structure protein"
                     /codon_start=1
                     /product="plasmalemma vesicle-associated protein"
                     /protein_id="NP_112600.1"
                     /db_xref="CCDS:CCDS32952.1"
                     /db_xref="GeneID:83483"
                     /db_xref="HGNC:HGNC:13635"
                     /db_xref="MIM:607647"
                     /translation="MGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLIILGLV
                     LFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMW
                     LNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFM
                     LNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQL
                     QKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMP
                     SLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREA
                     KLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKT
                     KSQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG"
     exon            424..520
                     /gene="PLVAP"
                     /gene_synonym="DIAR10; FELS; gp68; PV-1; PV1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..1233
                     /gene="PLVAP"
                     /gene_synonym="DIAR10; FELS; gp68; PV-1; PV1"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1294
                     /gene="PLVAP"
                     /gene_synonym="DIAR10; FELS; gp68; PV-1; PV1"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1376
                     /gene="PLVAP"
                     /gene_synonym="DIAR10; FELS; gp68; PV-1; PV1"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..2290
                     /gene="PLVAP"
                     /gene_synonym="DIAR10; FELS; gp68; PV-1; PV1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2270..2275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLVAP"
                     /gene_synonym="DIAR10; FELS; gp68; PV-1; PV1"
                     /note="hexamer: AATAAA"
     polyA_site      2290
                     /gene="PLVAP"
                     /gene_synonym="DIAR10; FELS; gp68; PV-1; PV1"
                     /note="major polyA site"
ORIGIN      
        1 agagcaggcc tggtggtgag cagggacggt gcaccggacg gcgggatcga gcaaatgggt
       61 ctggccatgg agcacggagg gtcctacgct cgggcggggg gcagctctcg gggctgctgg
      121 tattacctgc gctacttctt cctcttcgtc tccctcatcc aattcctcat catcctgggg
      181 ctcgtgctct tcatggtcta tggcaacgtg cacgtgagca cagagtccaa cctgcaggcc
      241 accgagcgcc gagccgaggg cctatacagt cagctcctag ggctcacggc ctcccagtcc
      301 aacttgacca aggagctcaa cttcaccacc cgcgccaagg atgccatcat gcagatgtgg
      361 ctgaatgctc gccgcgacct ggaccgcatc aatgccagct tccgccagtg ccagggtgac
      421 cgggtcatct acacgaacaa tcagaggtac atggctgcca tcatcttgag tgagaagcaa
      481 tgcagagatc aattcaagga catgaacaag agctgcgatg ccttgctctt catgctgaat
      541 cagaaggtga agacgctgga ggtggagata gccaaggaga agaccatttg cactaaggat
      601 aaggaaagcg tgctgctgaa caaacgcgtg gcggaggaac agctggttga atgcgtgaaa
      661 acccgggagc tgcagcacca agagcgccag ctggccaagg agcaactgca aaaggtgcaa
      721 gccctctgcc tgcccctgga caaggacaag tttgagatgg accttcgtaa cctgtggagg
      781 gactccatta tcccacgcag cctggacaac ctgggttaca acctctacca tcccctgggc
      841 tcggaattgg cctccatccg cagagcctgc gaccacatgc ccagcctcat gagctccaag
      901 gtggaggagc tggcccggag cctccgggcg gatatcgaac gcgtggcccg cgagaactca
      961 gacctccaac gccagaagct ggaagcccag cagggcctgc gggccagtca ggaggcgaaa
     1021 cagaaggtgg agaaggaggc tcaggcccgg gaggccaagc tccaagctga atgctcccgg
     1081 cagacccagc tagcgctgga ggagaaggcg gtgctgcgga aggaacgaga caacctggcc
     1141 aaggagctgg aagagaagaa gagggaggcg gagcagctca ggatggagct ggccatcaga
     1201 aactcagccc tggacacctg catcaagacc aagtcgcagc cgatgatgcc agtgtcaagg
     1261 cccatgggcc ctgtccccaa cccccagccc atcgacccag ctagcctgga ggagttcaag
     1321 aggaagatcc tggagtccca gaggccccct gcaggcatcc ctgtagcccc atccagtggc
     1381 tgaggaggct ccaggcctga ggaccaaggg atggcccgac tcggcggttt gcggaggatg
     1441 cagggatatg ctcacagcgc ccgacacaac cccctcccgc cgcccccaac cacccagggc
     1501 caccatcaga caactccctg catgcaaacc cctagtaccc tctcacaccc gcacccgcgc
     1561 ctcacgatcc ctcacccaga gcacacggcc gcggagatga cgtcacgcaa gcaacggcgc
     1621 tgacgtcaca tatcaccgtg gtgatggcgt cacgtggcca tgtagacgtc acgaagagat
     1681 atagcgatgg cgtcgtgcag atgcagcacg tcgcacacag acatggggaa cttggcatga
     1741 cgtcacaccg agatgcagca acgacgtcac gggccatgtc gacgtcacac atattaatgt
     1801 cacacagacg cggcgatggc atcacacaga cggtgatgat gtcacacaca gacacagtga
     1861 caacacacac catgacaacg acacctatag atatggcacc aacatcacat gcacgcatgc
     1921 cctttcacac acactttcta cccaattctc acctagtgtc acgttccccc gaccctggca
     1981 cacgggccaa ggtacccaca ggatcccatc ccctcccgca cagccctggg ccccagcacc
     2041 tcccctcctc cagcctcctg gcctcccagc cacttcctca cccccagtgc ctggacccgg
     2101 aggtgagaac aggaagccat tcacctccgc tccttgagcg tgagtgtttc caggaccccc
     2161 tcggggccct gagccggggg tgagggtcac ctgttgtcgg gaggggagcc actccttctc
     2221 ccccaactcc cagccctgcc tgtggcccgt tgaaatgttg gtggcactta ataaatatta
     2281 gtaaatcctt
//
