LOCUS       NM_182676               1733 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens phospholipid transfer protein (PLTP), transcript
            variant 2, mRNA.
ACCESSION   NM_182676
VERSION     NM_182676.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1733)
  AUTHORS   Andreasson,J., Boden,E., Fakhro,M., von Wachter,C., Olm,F.,
            Malmsjo,M., Hallgren,O. and Lindstedt,S.
  TITLE     Exhaled phospholipid transfer protein and hepatocyte growth factor
            receptor in lung adenocarcinoma
  JOURNAL   Respir Res 23 (1), 369 (2022)
   PUBMED   36544145
  REMARK    GeneRIF: Exhaled phospholipid transfer protein and hepatocyte
            growth factor receptor in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1733)
  AUTHORS   Gnanapradeepan,K., Indeglia,A., Stieg,D.C., Clarke,N., Shao,C.,
            Dougherty,J.F., Murali,N. and Murphy,M.E.
  TITLE     PLTP is a p53 target gene with roles in cancer growth suppression
            and ferroptosis
  JOURNAL   J Biol Chem 298 (12), 102637 (2022)
   PUBMED   36309086
  REMARK    GeneRIF: PLTP is a p53 target gene with roles in cancer growth
            suppression and ferroptosis.
REFERENCE   3  (bases 1 to 1733)
  AUTHORS   Jiang,C. and Jiang,W.
  TITLE     AGTR1, PLTP, and SCG2 associated with immune genes and immune cell
            infiltration in calcific aortic valve stenosis: analysis from
            integrated bioinformatics and machine learning
  JOURNAL   Math Biosci Eng 19 (4), 3787-3802 (2022)
   PUBMED   35341274
  REMARK    GeneRIF: AGTR1, PLTP, and SCG2 associated with immune genes and
            immune cell infiltration in calcific aortic valve stenosis:
            analysis from integrated bioinformatics and machine learning.
REFERENCE   4  (bases 1 to 1733)
  AUTHORS   Zhang,F.H., Yin,R.X., Yao,L.M., Lin,W.X., Wu,J.Z. and Yang,D.Z.
  TITLE     Association between the PLTP rs4810479 SNP and Serum Lipid Traits
            in the Chinese Maonan and Han Populations
  JOURNAL   Genet Res (Camb) 2021, 9925272 (2021)
   PUBMED   34385888
  REMARK    GeneRIF: Association between the PLTP rs4810479 SNP and Serum Lipid
            Traits in the Chinese Maonan and Han Populations.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1733)
  AUTHORS   Glasgow,B.J. and Abduragimov,A.R.
  TITLE     Lipocalin-1 is the acceptor protein for phospholipid transfer
            protein in tears
  JOURNAL   Biochem Biophys Res Commun 548, 35-38 (2021)
   PUBMED   33631671
  REMARK    GeneRIF: Lipocalin-1 is the acceptor protein for phospholipid
            transfer protein in tears.
REFERENCE   6  (bases 1 to 1733)
  AUTHORS   Hailman,E., Albers,J.J., Wolfbauer,G., Tu,A.Y. and Wright,S.D.
  TITLE     Neutralization and transfer of lipopolysaccharide by phospholipid
            transfer protein
  JOURNAL   J Biol Chem 271 (21), 12172-12178 (1996)
   PUBMED   8647810
REFERENCE   7  (bases 1 to 1733)
  AUTHORS   Tu,A.Y., Wolfbauer,G. and Albers,J.J.
  TITLE     Functional characterization of the promoter region of the human
            phospholipid transfer protein gene
  JOURNAL   Biochem Biophys Res Commun 217 (3), 705-711 (1995)
   PUBMED   8554588
REFERENCE   8  (bases 1 to 1733)
  AUTHORS   Albers,J.J., Wolfbauer,G., Cheung,M.C., Day,J.R., Ching,A.F.,
            Lok,S. and Tu,A.Y.
  TITLE     Functional expression of human and mouse plasma phospholipid
            transfer protein: effect of recombinant and plasma PLTP on HDL
            subspecies
  JOURNAL   Biochim Biophys Acta 1258 (1), 27-34 (1995)
   PUBMED   7654777
REFERENCE   9  (bases 1 to 1733)
  AUTHORS   Whitmore,T.E., Day,J.R. and Albers,J.J.
  TITLE     Localization of the human phospholipid transfer protein gene to
            chromosome 20q12-q13.1
  JOURNAL   Genomics 28 (3), 599-600 (1995)
   PUBMED   7490104
REFERENCE   10 (bases 1 to 1733)
  AUTHORS   Day,J.R., Albers,J.J., Lofton-Day,C.E., Gilbert,T.L., Ching,A.F.,
            Grant,F.J., O'Hara,P.J., Marcovina,S.M. and Adolphson,J.L.
  TITLE     Complete cDNA encoding human phospholipid transfer protein from
            human endothelial cells
  JOURNAL   J Biol Chem 269 (12), 9388-9391 (1994)
   PUBMED   8132678
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL008726.3 and BC005045.1.
            
            On Aug 13, 2020 this sequence version replaced NM_182676.2.
            
            Summary: The protein encoded by this gene is one of at least two
            lipid transfer proteins found in human plasma. The encoded protein
            transfers phospholipids from triglyceride-rich lipoproteins to high
            density lipoprotein (HDL). In addition to regulating the size of
            HDL particles, this protein may be involved in cholesterol
            metabolism. At least two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1, resulting in an isoform (b) which has
            the same N- and C-termini but which is shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005045.1, AK289371.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AL008726.3         84542-84551         c
            11-1595             BC005045.1         1-1585
            1596-1733           AL008726.3         71018-71155         c
FEATURES             Location/Qualifiers
     source          1..1733
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..1733
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /note="phospholipid transfer protein"
                     /db_xref="GeneID:5360"
                     /db_xref="HGNC:HGNC:9093"
                     /db_xref="MIM:172425"
     exon            1..77
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            78..188
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1414
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; lipid transfer protein II; BPI fold containing
                     family E"
                     /codon_start=1
                     /product="phospholipid transfer protein isoform b
                     precursor"
                     /protein_id="NP_872617.1"
                     /db_xref="CCDS:CCDS13387.1"
                     /db_xref="GeneID:5360"
                     /db_xref="HGNC:HGNC:9093"
                     /db_xref="MIM:172425"
                     /translation="MALFGALFLALLAGAHAEFPGCKIRVTSKALELVKQEGLRFLEQ
                     ELETITIPDLRGKEGHFYYNISEVKVTELQLTSSELDFQPQQELMLQITNASLGLRFR
                     RQLLYWFLKVYDFLSTFITSGMRFLLNQQICPVLYHAGTVLLNSLLDTVPVRSSVDEL
                     VGIDYSLMKDPVASTSNLDMDFRGAFFPLTERNWSLPNRAVEPQLQEEERMVYVAFSE
                     FFFDSAMESYFRAGALQLLLVGDKVPHDLDMLLRATYFGSIVLLSPAVIDSPLKLELR
                     VLAPPRCTIKPSGTTISVTASVTIALVPPDQPEVQLSSMTMDARLSAKMALRGKALRT
                     QLDLRRFRIYSNHSALESLALIPLQAPLKTMLQIGVMPMLNERTWRGVQIPLPEGINF
                     VHEVVTNHAGFLTIGADLHFAKGLREVIEKNRPADVRASTAPTPSTAAV"
     exon            189..288
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            289..417
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            418..481
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            482..545
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            546..637
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            638..814
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            815..874
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1039
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1107
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1150
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1214
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1291
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1733
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1576..1581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /note="hexamer: ATTACA"
     polyA_site      1595
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /note="major polyA site"
     regulatory      1711..1716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /note="hexamer: AATAAA"
     polyA_site      1733
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
ORIGIN      
        1 gccagacccc gtcgcccgga tcccctgagc tgcccgccat cccacgtgac cgcgccgccc
       61 cccagctcca ccgctgagcc cgctcgccat ggccctcttc ggggccctct tcctagcgct
      121 gctggcaggc gcacatgcag agttcccagg ctgcaagatc cgcgtcacct ccaaggcgct
      181 ggagctggtg aagcaggagg ggctgcgctt tctggagcaa gagctggaga ctatcaccat
      241 tccggacctg cggggcaaag aaggccactt ctactacaac atctctgagg tgaaggtcac
      301 agagctgcaa ctgacatctt ccgagctcga tttccagcca cagcaggagc tgatgcttca
      361 aatcaccaat gcctccttgg ggctgcgctt ccggagacag ctgctctact ggttcttgaa
      421 ggtgtatgat tttctctcca cgttcatcac ctcagggatg cgcttcctcc tcaaccagca
      481 gatctgccct gtcctctacc acgcagggac ggtcctgctc aactccctcc tggacaccgt
      541 gcctgtgcgc agttctgtgg acgagcttgt tggcattgac tattccctca tgaaggatcc
      601 tgtggcttcc accagcaacc tggacatgga cttccggggg gccttcttcc ccctgactga
      661 gaggaactgg agcctcccca accgggcagt ggagccccag ctgcaggagg aagagcggat
      721 ggtgtatgtg gccttctctg agttcttctt cgactctgcc atggagagct acttccgggc
      781 gggggccctg cagctgttgc tggtggggga caaggtgccc cacgacctgg acatgctgct
      841 gagggccacc tactttggga gcattgtcct gctgagccca gcagtgattg actccccatt
      901 gaagctggag ctgcgggtcc tggccccacc gcgctgcacc atcaagccct ctggcaccac
      961 catctctgtc actgctagcg tcaccattgc cctggtccca ccagaccagc ctgaggtcca
     1021 gctgtccagc atgactatgg acgcccgtct cagcgccaag atggctctcc gggggaaggc
     1081 cctgcgcacg cagctggacc tgcgcaggtt ccgaatctat tccaaccatt ctgcactgga
     1141 gtcgctggct ctgatcccat tacaggcccc tctgaagacc atgctgcaga ttggggtgat
     1201 gcccatgctc aatgagcgga cctggcgtgg ggtgcagatc ccactacctg agggcatcaa
     1261 ctttgtgcat gaggtggtga cgaaccatgc gggattcctc accatcgggg ctgatctcca
     1321 ctttgccaaa gggctgcgag aggtgattga gaagaaccgg cctgctgatg tcagggcgtc
     1381 cactgccccc acaccgtcca cagcagctgt ctgagccctc aatccccaag ctggcagctg
     1441 tcattcagga ccccaacccc tctcagcccc tcttttccca cattcatagc ctgtagtgcc
     1501 ccctctaacc cccagtgcca cagagaagac gggatttgaa gctgtaccca atttaattcc
     1561 ataatcaatc tatcaattac agtccgtcca ccacctccct gtgggctgtc ctgagctctg
     1621 ttgggttcct gggatggaat cagtgcatca taaagggcat tctttaagca gagaaggggc
     1681 caggccaccc cattcaggaa ctgctgcggg aataaagtgc taacttgccc cca
//
