LOCUS       NM_006227               1889 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens phospholipid transfer protein (PLTP), transcript
            variant 1, mRNA.
ACCESSION   NM_006227
VERSION     NM_006227.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1889)
  AUTHORS   Andreasson,J., Boden,E., Fakhro,M., von Wachter,C., Olm,F.,
            Malmsjo,M., Hallgren,O. and Lindstedt,S.
  TITLE     Exhaled phospholipid transfer protein and hepatocyte growth factor
            receptor in lung adenocarcinoma
  JOURNAL   Respir Res 23 (1), 369 (2022)
   PUBMED   36544145
  REMARK    GeneRIF: Exhaled phospholipid transfer protein and hepatocyte
            growth factor receptor in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1889)
  AUTHORS   Gnanapradeepan,K., Indeglia,A., Stieg,D.C., Clarke,N., Shao,C.,
            Dougherty,J.F., Murali,N. and Murphy,M.E.
  TITLE     PLTP is a p53 target gene with roles in cancer growth suppression
            and ferroptosis
  JOURNAL   J Biol Chem 298 (12), 102637 (2022)
   PUBMED   36309086
  REMARK    GeneRIF: PLTP is a p53 target gene with roles in cancer growth
            suppression and ferroptosis.
REFERENCE   3  (bases 1 to 1889)
  AUTHORS   Jiang,C. and Jiang,W.
  TITLE     AGTR1, PLTP, and SCG2 associated with immune genes and immune cell
            infiltration in calcific aortic valve stenosis: analysis from
            integrated bioinformatics and machine learning
  JOURNAL   Math Biosci Eng 19 (4), 3787-3802 (2022)
   PUBMED   35341274
  REMARK    GeneRIF: AGTR1, PLTP, and SCG2 associated with immune genes and
            immune cell infiltration in calcific aortic valve stenosis:
            analysis from integrated bioinformatics and machine learning.
REFERENCE   4  (bases 1 to 1889)
  AUTHORS   Zhang,F.H., Yin,R.X., Yao,L.M., Lin,W.X., Wu,J.Z. and Yang,D.Z.
  TITLE     Association between the PLTP rs4810479 SNP and Serum Lipid Traits
            in the Chinese Maonan and Han Populations
  JOURNAL   Genet Res (Camb) 2021, 9925272 (2021)
   PUBMED   34385888
  REMARK    GeneRIF: Association between the PLTP rs4810479 SNP and Serum Lipid
            Traits in the Chinese Maonan and Han Populations.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1889)
  AUTHORS   Glasgow,B.J. and Abduragimov,A.R.
  TITLE     Lipocalin-1 is the acceptor protein for phospholipid transfer
            protein in tears
  JOURNAL   Biochem Biophys Res Commun 548, 35-38 (2021)
   PUBMED   33631671
  REMARK    GeneRIF: Lipocalin-1 is the acceptor protein for phospholipid
            transfer protein in tears.
REFERENCE   6  (bases 1 to 1889)
  AUTHORS   Hailman,E., Albers,J.J., Wolfbauer,G., Tu,A.Y. and Wright,S.D.
  TITLE     Neutralization and transfer of lipopolysaccharide by phospholipid
            transfer protein
  JOURNAL   J Biol Chem 271 (21), 12172-12178 (1996)
   PUBMED   8647810
REFERENCE   7  (bases 1 to 1889)
  AUTHORS   Tu,A.Y., Wolfbauer,G. and Albers,J.J.
  TITLE     Functional characterization of the promoter region of the human
            phospholipid transfer protein gene
  JOURNAL   Biochem Biophys Res Commun 217 (3), 705-711 (1995)
   PUBMED   8554588
REFERENCE   8  (bases 1 to 1889)
  AUTHORS   Albers,J.J., Wolfbauer,G., Cheung,M.C., Day,J.R., Ching,A.F.,
            Lok,S. and Tu,A.Y.
  TITLE     Functional expression of human and mouse plasma phospholipid
            transfer protein: effect of recombinant and plasma PLTP on HDL
            subspecies
  JOURNAL   Biochim Biophys Acta 1258 (1), 27-34 (1995)
   PUBMED   7654777
REFERENCE   9  (bases 1 to 1889)
  AUTHORS   Whitmore,T.E., Day,J.R. and Albers,J.J.
  TITLE     Localization of the human phospholipid transfer protein gene to
            chromosome 20q12-q13.1
  JOURNAL   Genomics 28 (3), 599-600 (1995)
   PUBMED   7490104
REFERENCE   10 (bases 1 to 1889)
  AUTHORS   Day,J.R., Albers,J.J., Lofton-Day,C.E., Gilbert,T.L., Ching,A.F.,
            Grant,F.J., O'Hara,P.J., Marcovina,S.M. and Adolphson,J.L.
  TITLE     Complete cDNA encoding human phospholipid transfer protein from
            human endothelial cells
  JOURNAL   J Biol Chem 269 (12), 9388-9391 (1994)
   PUBMED   8132678
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL008726.3 and L26232.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006227.3.
            
            Summary: The protein encoded by this gene is one of at least two
            lipid transfer proteins found in human plasma. The encoded protein
            transfers phospholipids from triglyceride-rich lipoproteins to high
            density lipoprotein (HDL). In addition to regulating the size of
            HDL particles, this protein may be involved in cholesterol
            metabolism. At least two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) encodes the predominant
            isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.276112.1,
                                           SRR3476690.757448.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372431.8/ ENSP00000361508.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AL008726.3         84544-84551         c
            9-1751              L26232.1           8-1750
            1752-1889           AL008726.3         71018-71155         c
FEATURES             Location/Qualifiers
     source          1..1889
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..1889
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /note="phospholipid transfer protein"
                     /db_xref="GeneID:5360"
                     /db_xref="HGNC:HGNC:9093"
                     /db_xref="MIM:172425"
     exon            1..77
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            78..188
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1570
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; lipid transfer protein II; BPI fold containing
                     family E"
                     /codon_start=1
                     /product="phospholipid transfer protein isoform a
                     precursor"
                     /protein_id="NP_006218.1"
                     /db_xref="CCDS:CCDS13386.1"
                     /db_xref="GeneID:5360"
                     /db_xref="HGNC:HGNC:9093"
                     /db_xref="MIM:172425"
                     /translation="MALFGALFLALLAGAHAEFPGCKIRVTSKALELVKQEGLRFLEQ
                     ELETITIPDLRGKEGHFYYNISEVKVTELQLTSSELDFQPQQELMLQITNASLGLRFR
                     RQLLYWFFYDGGYINASAEGVSIRTGLELSRDPAGRMKVSNVSCQASVSRMHAAFGGT
                     FKKVYDFLSTFITSGMRFLLNQQICPVLYHAGTVLLNSLLDTVPVRSSVDELVGIDYS
                     LMKDPVASTSNLDMDFRGAFFPLTERNWSLPNRAVEPQLQEEERMVYVAFSEFFFDSA
                     MESYFRAGALQLLLVGDKVPHDLDMLLRATYFGSIVLLSPAVIDSPLKLELRVLAPPR
                     CTIKPSGTTISVTASVTIALVPPDQPEVQLSSMTMDARLSAKMALRGKALRTQLDLRR
                     FRIYSNHSALESLALIPLQAPLKTMLQIGVMPMLNERTWRGVQIPLPEGINFVHEVVT
                     NHAGFLTIGADLHFAKGLREVIEKNRPADVRASTAPTPSTAAV"
     exon            189..288
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            289..417
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            418..573
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            574..637
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            638..701
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            702..793
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            794..970
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1030
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1195
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1263
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1306
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1370
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1447
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1889
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1732..1737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /note="hexamer: ATTACA"
     polyA_site      1751
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /note="major polyA site"
     regulatory      1867..1872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /note="hexamer: AATAAA"
     polyA_site      1889
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
ORIGIN      
        1 gccagacccc gtcgcccgga tcccctgagc tgcccgccat cccacgtgac cgcgccgccc
       61 cccagctcca ccgctgagcc cgctcgccat ggccctcttc ggggccctct tcctagcgct
      121 gctggcaggc gcacatgcag agttcccagg ctgcaagatc cgcgtcacct ccaaggcgct
      181 ggagctggtg aagcaggagg ggctgcgctt tctggagcaa gagctggaga ctatcaccat
      241 tccggacctg cggggcaaag aaggccactt ctactacaac atctctgagg tgaaggtcac
      301 agagctgcaa ctgacatctt ccgagctcga tttccagcca cagcaggagc tgatgcttca
      361 aatcaccaat gcctccttgg ggctgcgctt ccggagacag ctgctctact ggttcttcta
      421 tgatgggggc tacatcaacg cctcagctga gggtgtgtcc atccgcactg gtctggagct
      481 ctcccgggat cccgctggac ggatgaaagt gtccaatgtc tcctgccagg cctctgtctc
      541 cagaatgcac gcggccttcg ggggaacctt caagaaggtg tatgattttc tctccacgtt
      601 catcacctca gggatgcgct tcctcctcaa ccagcagatc tgccctgtcc tctaccacgc
      661 agggacggtc ctgctcaact ccctcctgga caccgtgcct gtgcgcagtt ctgtggacga
      721 gcttgttggc attgactatt ccctcatgaa ggatcctgtg gcttccacca gcaacctgga
      781 catggacttc cggggggcct tcttccccct gactgagagg aactggagcc tccccaaccg
      841 ggcagtggag ccccagctgc aggaggaaga gcggatggtg tatgtggcct tctctgagtt
      901 cttcttcgac tctgccatgg agagctactt ccgggcgggg gccctgcagc tgttgctggt
      961 gggggacaag gtgccccacg acctggacat gctgctgagg gccacctact ttgggagcat
     1021 tgtcctgctg agcccagcag tgattgactc cccattgaag ctggagctgc gggtcctggc
     1081 cccaccgcgc tgcaccatca agccctctgg caccaccatc tctgtcactg ctagcgtcac
     1141 cattgccctg gtcccaccag accagcctga ggtccagctg tccagcatga ctatggacgc
     1201 ccgtctcagc gccaagatgg ctctccgggg gaaggccctg cgcacgcagc tggacctgcg
     1261 caggttccga atctattcca accattctgc actggagtcg ctggctctga tcccattaca
     1321 ggcccctctg aagaccatgc tgcagattgg ggtgatgccc atgctcaatg agcggacctg
     1381 gcgtggggtg cagatcccac tacctgaggg catcaacttt gtgcatgagg tggtgacgaa
     1441 ccatgcggga ttcctcacca tcggggctga tctccacttt gccaaagggc tgcgagaggt
     1501 gattgagaag aaccggcctg ctgatgtcag ggcgtccact gcccccacac cgtccacagc
     1561 agctgtctga gccctcaatc cccaagctgg cagctgtcat tcaggacccc aacccctctc
     1621 agcccctctt ttcccacatt catagcctgt agtgccccct ctaaccccca gtgccacaga
     1681 gaagacggga tttgaagctg tacccaattt aattccataa tcaatctatc aattacagtc
     1741 cgtccaccac ctccctgtgg gctgtcctga gctctgttgg gttcctggga tggaatcagt
     1801 gcatcataaa gggcattctt taagcagaga aggggccagg ccaccccatt caggaactgc
     1861 tgcgggaata aagtgctaac ttgccccca
//
