LOCUS       NP_006218                493 aa            linear   PRI 28-APR-2025
DEFINITION  phospholipid transfer protein isoform a precursor [Homo sapiens].
ACCESSION   NP_006218
VERSION     NP_006218.1
DBSOURCE    REFSEQ: accession NM_006227.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 493)
  AUTHORS   Andreasson,J., Boden,E., Fakhro,M., von Wachter,C., Olm,F.,
            Malmsjo,M., Hallgren,O. and Lindstedt,S.
  TITLE     Exhaled phospholipid transfer protein and hepatocyte growth factor
            receptor in lung adenocarcinoma
  JOURNAL   Respir Res 23 (1), 369 (2022)
   PUBMED   36544145
  REMARK    GeneRIF: Exhaled phospholipid transfer protein and hepatocyte
            growth factor receptor in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 493)
  AUTHORS   Gnanapradeepan,K., Indeglia,A., Stieg,D.C., Clarke,N., Shao,C.,
            Dougherty,J.F., Murali,N. and Murphy,M.E.
  TITLE     PLTP is a p53 target gene with roles in cancer growth suppression
            and ferroptosis
  JOURNAL   J Biol Chem 298 (12), 102637 (2022)
   PUBMED   36309086
  REMARK    GeneRIF: PLTP is a p53 target gene with roles in cancer growth
            suppression and ferroptosis.
REFERENCE   3  (residues 1 to 493)
  AUTHORS   Jiang,C. and Jiang,W.
  TITLE     AGTR1, PLTP, and SCG2 associated with immune genes and immune cell
            infiltration in calcific aortic valve stenosis: analysis from
            integrated bioinformatics and machine learning
  JOURNAL   Math Biosci Eng 19 (4), 3787-3802 (2022)
   PUBMED   35341274
  REMARK    GeneRIF: AGTR1, PLTP, and SCG2 associated with immune genes and
            immune cell infiltration in calcific aortic valve stenosis:
            analysis from integrated bioinformatics and machine learning.
REFERENCE   4  (residues 1 to 493)
  AUTHORS   Zhang,F.H., Yin,R.X., Yao,L.M., Lin,W.X., Wu,J.Z. and Yang,D.Z.
  TITLE     Association between the PLTP rs4810479 SNP and Serum Lipid Traits
            in the Chinese Maonan and Han Populations
  JOURNAL   Genet Res (Camb) 2021, 9925272 (2021)
   PUBMED   34385888
  REMARK    GeneRIF: Association between the PLTP rs4810479 SNP and Serum Lipid
            Traits in the Chinese Maonan and Han Populations.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 493)
  AUTHORS   Glasgow,B.J. and Abduragimov,A.R.
  TITLE     Lipocalin-1 is the acceptor protein for phospholipid transfer
            protein in tears
  JOURNAL   Biochem Biophys Res Commun 548, 35-38 (2021)
   PUBMED   33631671
  REMARK    GeneRIF: Lipocalin-1 is the acceptor protein for phospholipid
            transfer protein in tears.
REFERENCE   6  (residues 1 to 493)
  AUTHORS   Hailman,E., Albers,J.J., Wolfbauer,G., Tu,A.Y. and Wright,S.D.
  TITLE     Neutralization and transfer of lipopolysaccharide by phospholipid
            transfer protein
  JOURNAL   J Biol Chem 271 (21), 12172-12178 (1996)
   PUBMED   8647810
REFERENCE   7  (residues 1 to 493)
  AUTHORS   Tu,A.Y., Wolfbauer,G. and Albers,J.J.
  TITLE     Functional characterization of the promoter region of the human
            phospholipid transfer protein gene
  JOURNAL   Biochem Biophys Res Commun 217 (3), 705-711 (1995)
   PUBMED   8554588
REFERENCE   8  (residues 1 to 493)
  AUTHORS   Albers,J.J., Wolfbauer,G., Cheung,M.C., Day,J.R., Ching,A.F.,
            Lok,S. and Tu,A.Y.
  TITLE     Functional expression of human and mouse plasma phospholipid
            transfer protein: effect of recombinant and plasma PLTP on HDL
            subspecies
  JOURNAL   Biochim Biophys Acta 1258 (1), 27-34 (1995)
   PUBMED   7654777
REFERENCE   9  (residues 1 to 493)
  AUTHORS   Whitmore,T.E., Day,J.R. and Albers,J.J.
  TITLE     Localization of the human phospholipid transfer protein gene to
            chromosome 20q12-q13.1
  JOURNAL   Genomics 28 (3), 599-600 (1995)
   PUBMED   7490104
REFERENCE   10 (residues 1 to 493)
  AUTHORS   Day,J.R., Albers,J.J., Lofton-Day,C.E., Gilbert,T.L., Ching,A.F.,
            Grant,F.J., O'Hara,P.J., Marcovina,S.M. and Adolphson,J.L.
  TITLE     Complete cDNA encoding human phospholipid transfer protein from
            human endothelial cells
  JOURNAL   J Biol Chem 269 (12), 9388-9391 (1994)
   PUBMED   8132678
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL008726.3 and L26232.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene is one of at least two
            lipid transfer proteins found in human plasma. The encoded protein
            transfers phospholipids from triglyceride-rich lipoproteins to high
            density lipoprotein (HDL). In addition to regulating the size of
            HDL particles, this protein may be involved in cholesterol
            metabolism. At least two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) encodes the predominant
            isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.276112.1,
                                           SRR3476690.757448.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372431.8/ ENSP00000361508.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     Protein         1..493
                     /product="phospholipid transfer protein isoform a
                     precursor"
                     /note="lipid transfer protein II; BPI fold containing
                     family E"
                     /calculated_mol_wt=53071
     sig_peptide     1..17
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1687
     mat_peptide     18..493
                     /product="phospholipid transfer protein isoform a"
                     /calculated_mol_wt=53071
     Region          21..239
                     /region_name="BPI1"
                     /note="BPI/LBP/CETP N-terminal domain; Bactericidal
                     permeability-increasing protein (BPI) /
                     Lipopolysaccharide-binding protein (LBP) / Cholesteryl
                     ester transfer protein (CETP) N-terminal domain; binds to
                     and neutralizes lipopolysaccharides from the outer...;
                     cd00025"
                     /db_xref="CDD:237992"
     Site            21..27
                     /site_type="other"
                     /note="BPI dimerizatation interface [polypeptide binding]"
                     /db_xref="CDD:237992"
     Site            order(26,31,34,38,41,88,129,131,141,188,192,196,230)
                     /site_type="active"
                     /note="apolar binding pocket [active]"
                     /db_xref="CDD:237992"
     Site            64
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) (complex) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952,
                     ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218,
                     ECO:0000269|PubMed:21515415; propagated from
                     UniProtKB/Swiss-Prot (P55058.1)"
     Site            94
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952,
                     ECO:0000269|PubMed:21515415; propagated from
                     UniProtKB/Swiss-Prot (P55058.1)"
     Site            117
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) (complex) asparagine.
                     /evidence=ECO:0000269|PubMed:21515415; propagated from
                     UniProtKB/Swiss-Prot (P55058.1)"
     Site            143
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952,
                     ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:21515415;
                     propagated from UniProtKB/Swiss-Prot (P55058.1)"
     Region          228..464
                     /region_name="LBP_BPI_CETP_C"
                     /note="LBP / BPI / CETP family, C-terminal domain;
                     pfam02886"
                     /db_xref="CDD:397154"
     Site            245
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) (complex) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952,
                     ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:21515415;
                     propagated from UniProtKB/Swiss-Prot (P55058.1)"
     Site            order(264..268,447..452,458..463)
                     /site_type="other"
                     /note="BPI dimerization interface [polypeptide binding]"
                     /db_xref="CDD:237993"
     Site            order(268,273,276,280,283,342,375,377,386,422,426,430,434,
                     456)
                     /site_type="active"
                     /note="apolar binding pocket [active]"
                     /db_xref="CDD:237993"
     Site            398
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952; propagated from
                     UniProtKB/Swiss-Prot (P55058.1)"
     CDS             1..493
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /coded_by="NM_006227.4:89..1570"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS13386.1"
                     /db_xref="GeneID:5360"
                     /db_xref="HGNC:HGNC:9093"
                     /db_xref="MIM:172425"
ORIGIN      
        1 malfgalfla llagahaefp gckirvtska lelvkqeglr fleqeletit ipdlrgkegh
       61 fyynisevkv telqltssel dfqpqqelml qitnaslglr frrqllywff ydggyinasa
      121 egvsirtgle lsrdpagrmk vsnvscqasv srmhaafggt fkkvydflst fitsgmrfll
      181 nqqicpvlyh agtvllnsll dtvpvrssvd elvgidyslm kdpvastsnl dmdfrgaffp
      241 lternwslpn ravepqlqee ermvyvafse fffdsamesy fragalqlll vgdkvphdld
      301 mllratyfgs ivllspavid splklelrvl apprctikps gttisvtasv tialvppdqp
      361 evqlssmtmd arlsakmalr gkalrtqldl rrfriysnhs aleslalipl qaplktmlqi
      421 gvmpmlnert wrgvqiplpe ginfvhevvt nhagfltiga dlhfakglre vieknrpadv
      481 rastaptpst aav
//
