LOCUS       NM_001242920            1604 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens phospholipid transfer protein (PLTP), transcript
            variant 3, mRNA.
ACCESSION   NM_001242920
VERSION     NM_001242920.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1604)
  AUTHORS   Andreasson,J., Boden,E., Fakhro,M., von Wachter,C., Olm,F.,
            Malmsjo,M., Hallgren,O. and Lindstedt,S.
  TITLE     Exhaled phospholipid transfer protein and hepatocyte growth factor
            receptor in lung adenocarcinoma
  JOURNAL   Respir Res 23 (1), 369 (2022)
   PUBMED   36544145
  REMARK    GeneRIF: Exhaled phospholipid transfer protein and hepatocyte
            growth factor receptor in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1604)
  AUTHORS   Gnanapradeepan,K., Indeglia,A., Stieg,D.C., Clarke,N., Shao,C.,
            Dougherty,J.F., Murali,N. and Murphy,M.E.
  TITLE     PLTP is a p53 target gene with roles in cancer growth suppression
            and ferroptosis
  JOURNAL   J Biol Chem 298 (12), 102637 (2022)
   PUBMED   36309086
  REMARK    GeneRIF: PLTP is a p53 target gene with roles in cancer growth
            suppression and ferroptosis.
REFERENCE   3  (bases 1 to 1604)
  AUTHORS   Jiang,C. and Jiang,W.
  TITLE     AGTR1, PLTP, and SCG2 associated with immune genes and immune cell
            infiltration in calcific aortic valve stenosis: analysis from
            integrated bioinformatics and machine learning
  JOURNAL   Math Biosci Eng 19 (4), 3787-3802 (2022)
   PUBMED   35341274
  REMARK    GeneRIF: AGTR1, PLTP, and SCG2 associated with immune genes and
            immune cell infiltration in calcific aortic valve stenosis:
            analysis from integrated bioinformatics and machine learning.
REFERENCE   4  (bases 1 to 1604)
  AUTHORS   Zhang,F.H., Yin,R.X., Yao,L.M., Lin,W.X., Wu,J.Z. and Yang,D.Z.
  TITLE     Association between the PLTP rs4810479 SNP and Serum Lipid Traits
            in the Chinese Maonan and Han Populations
  JOURNAL   Genet Res (Camb) 2021, 9925272 (2021)
   PUBMED   34385888
  REMARK    GeneRIF: Association between the PLTP rs4810479 SNP and Serum Lipid
            Traits in the Chinese Maonan and Han Populations.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1604)
  AUTHORS   Glasgow,B.J. and Abduragimov,A.R.
  TITLE     Lipocalin-1 is the acceptor protein for phospholipid transfer
            protein in tears
  JOURNAL   Biochem Biophys Res Commun 548, 35-38 (2021)
   PUBMED   33631671
  REMARK    GeneRIF: Lipocalin-1 is the acceptor protein for phospholipid
            transfer protein in tears.
REFERENCE   6  (bases 1 to 1604)
  AUTHORS   Hailman,E., Albers,J.J., Wolfbauer,G., Tu,A.Y. and Wright,S.D.
  TITLE     Neutralization and transfer of lipopolysaccharide by phospholipid
            transfer protein
  JOURNAL   J Biol Chem 271 (21), 12172-12178 (1996)
   PUBMED   8647810
REFERENCE   7  (bases 1 to 1604)
  AUTHORS   Tu,A.Y., Wolfbauer,G. and Albers,J.J.
  TITLE     Functional characterization of the promoter region of the human
            phospholipid transfer protein gene
  JOURNAL   Biochem Biophys Res Commun 217 (3), 705-711 (1995)
   PUBMED   8554588
REFERENCE   8  (bases 1 to 1604)
  AUTHORS   Albers,J.J., Wolfbauer,G., Cheung,M.C., Day,J.R., Ching,A.F.,
            Lok,S. and Tu,A.Y.
  TITLE     Functional expression of human and mouse plasma phospholipid
            transfer protein: effect of recombinant and plasma PLTP on HDL
            subspecies
  JOURNAL   Biochim Biophys Acta 1258 (1), 27-34 (1995)
   PUBMED   7654777
REFERENCE   9  (bases 1 to 1604)
  AUTHORS   Whitmore,T.E., Day,J.R. and Albers,J.J.
  TITLE     Localization of the human phospholipid transfer protein gene to
            chromosome 20q12-q13.1
  JOURNAL   Genomics 28 (3), 599-600 (1995)
   PUBMED   7490104
REFERENCE   10 (bases 1 to 1604)
  AUTHORS   Day,J.R., Albers,J.J., Lofton-Day,C.E., Gilbert,T.L., Ching,A.F.,
            Grant,F.J., O'Hara,P.J., Marcovina,S.M. and Adolphson,J.L.
  TITLE     Complete cDNA encoding human phospholipid transfer protein from
            human endothelial cells
  JOURNAL   J Biol Chem 269 (12), 9388-9391 (1994)
   PUBMED   8132678
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK299181.1 and AL008726.3.
            
            On Aug 13, 2020 this sequence version replaced NM_001242920.1.
            
            Summary: The protein encoded by this gene is one of at least two
            lipid transfer proteins found in human plasma. The encoded protein
            transfers phospholipids from triglyceride-rich lipoproteins to high
            density lipoprotein (HDL). In addition to regulating the size of
            HDL particles, this protein may be involved in cholesterol
            metabolism. At least two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (3) lacks two alternate in-frame
            exons in the 5' coding region compared to variant 1. The resulting
            protein (isoform c) is shorter compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK299181.1, SRR7410570.664424.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               AK299181.1         2-256
            256-256             AL008726.3         83580-83580         c
            257-794             AK299181.1         258-795
            795-795             AL008726.3         74951-74951         c
            796-1420            AK299181.1         797-1421
            1421-1604           AL008726.3         71018-71201         c
FEATURES             Location/Qualifiers
     source          1..1604
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..1604
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /note="phospholipid transfer protein"
                     /db_xref="GeneID:5360"
                     /db_xref="HGNC:HGNC:9093"
                     /db_xref="MIM:172425"
     exon            1..77
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            78..188
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1285
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /note="isoform c precursor is encoded by transcript
                     variant 3; lipid transfer protein II; BPI fold containing
                     family E"
                     /codon_start=1
                     /product="phospholipid transfer protein isoform c
                     precursor"
                     /protein_id="NP_001229849.1"
                     /db_xref="CCDS:CCDS56197.1"
                     /db_xref="GeneID:5360"
                     /db_xref="HGNC:HGNC:9093"
                     /db_xref="MIM:172425"
                     /translation="MALFGALFLALLAGAHAEFPGCKIRVTSKALELVKQEGLRFLEQ
                     ELETITIPDLRGKEGHFYYNISEKVYDFLSTFITSGMRFLLNQQICPVLYHAGTVLLN
                     SLLDTVPVRSSVDELVGIDYSLMKDPVASTSNLDMDFRGAFFPLTERNWSLPNRAVEP
                     QLQEEERMVYVAFSEFFFDSAMESYFRAGALQLLLVGDKVPHDLDMLLRATYFGSIVL
                     LSPAVIDSPLKLELRVLAPPRCTIKPSGTTISVTASVTIALVPPDQPEVQLSSMTMDA
                     RLSAKMALRGKALRTQLDLRRFRIYSNHSALESLALIPLQAPLKTMLQIGVMPMLNER
                     TWRGVQIPLPEGINFVHEVVTNHAGFLTIGADLHFAKGLREVIEKNRPADVRASTAPT
                     PSTAAV"
     exon            189..288
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            289..352
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            353..416
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            417..508
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            509..685
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            686..745
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            746..910
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            911..978
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1021
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1085
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1162
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1604
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1447..1452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /note="hexamer: ATTACA"
     polyA_site      1466
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /note="major polyA site"
     regulatory      1582..1587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
                     /note="hexamer: AATAAA"
     polyA_site      1604
                     /gene="PLTP"
                     /gene_synonym="BPIFE; HDLCQ9"
ORIGIN      
        1 gccagacccc gtcgcccgga tcccctgagc tgcccgccat cccacgtgac cgcgccgccc
       61 cccagctcca ccgctgagcc cgctcgccat ggccctcttc ggggccctct tcctagcgct
      121 gctggcaggc gcacatgcag agttcccagg ctgcaagatc cgcgtcacct ccaaggcgct
      181 ggagctggtg aagcaggagg ggctgcgctt tctggagcaa gagctggaga ctatcaccat
      241 tccggacctg cggggcaaag aaggccactt ctactacaac atctctgaga aggtgtatga
      301 ttttctctcc acgttcatca cctcagggat gcgcttcctc ctcaaccagc agatctgccc
      361 tgtcctctac cacgcaggga cggtcctgct caactccctc ctggacaccg tgcctgtgcg
      421 cagttctgtg gacgagcttg ttggcattga ctattccctc atgaaggatc ctgtggcttc
      481 caccagcaac ctggacatgg acttccgggg ggccttcttc cccctgactg agaggaactg
      541 gagcctcccc aaccgggcag tggagcccca gctgcaggag gaagagcgga tggtgtatgt
      601 ggccttctct gagttcttct tcgactctgc catggagagc tacttccggg cgggggccct
      661 gcagctgttg ctggtggggg acaaggtgcc ccacgacctg gacatgctgc tgagggccac
      721 ctactttggg agcattgtcc tgctgagccc agcagtgatt gactccccat tgaagctgga
      781 gctgcgggtc ctggccccac cgcgctgcac catcaagccc tctggcacca ccatctctgt
      841 cactgctagc gtcaccattg ccctggtccc accagaccag cctgaggtcc agctgtccag
      901 catgactatg gacgcccgtc tcagcgccaa gatggctctc cgggggaagg ccctgcgcac
      961 gcagctggac ctgcgcaggt tccgaatcta ttccaaccat tctgcactgg agtcgctggc
     1021 tctgatccca ttacaggccc ctctgaagac catgctgcag attggggtga tgcccatgct
     1081 caatgagcgg acctggcgtg gggtgcagat cccactacct gagggcatca actttgtgca
     1141 tgaggtggtg acgaaccatg cgggattcct caccatcggg gctgatctcc actttgccaa
     1201 agggctgcga gaggtgattg agaagaaccg gcctgctgat gtcagggcgt ccactgcccc
     1261 cacaccgtcc acagcagctg tctgagccct caatccccaa gctggcagct gtcattcagg
     1321 accccaaccc ctctcagccc ctcttttccc acattcatag cctgtagtgc cccctctaac
     1381 ccccagtgcc acagagaaga cgggatttga agctgtaccc aatttaattc cataatcaat
     1441 ctatcaatta cagtccgtcc accacctccc tgtgggctgt cctgagctct gttgggttcc
     1501 tgggatggaa tcagtgcatc ataaagggca ttctttaagc agagaagggg ccaggccacc
     1561 ccattcagga actgctgcgg gaataaagtg ctaacttgcc ccca
//
