LOCUS       NM_001395437            1185 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens phospholipid scramblase 2 (PLSCR2), transcript variant
            4, mRNA.
ACCESSION   NM_001395437 XM_017006910
VERSION     NM_001395437.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1185)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1185)
  AUTHORS   Rayala,S., Francis,V.G., Sivagnanam,U. and Gummadi,S.N.
  TITLE     N-terminal proline-rich domain is required for scrambling activity
            of human phospholipid scramblases
  JOURNAL   J Biol Chem 289 (19), 13206-13218 (2014)
   PUBMED   24648509
  REMARK    GeneRIF: hPLSCR1 and PRD-hPLSCR2 showed Ca(2+)-dependent
            aggregation and scrambling activity
REFERENCE   3  (bases 1 to 1185)
  AUTHORS   Sahu,S.K., Aradhyam,G.K. and Gummadi,S.N.
  TITLE     Calcium binding studies of peptides of human phospholipid
            scramblases 1 to 4 suggest that scramblases are new class of
            calcium binding proteins in the cell
  JOURNAL   Biochim Biophys Acta 1790 (10), 1274-1281 (2009)
   PUBMED   19540310
  REMARK    GeneRIF: Results show that binding affinities of the peptides are
            in the order hPLSCR1>hPLSCR3>hPLSCR2>hPLSCR4 for Ca2+ and in the
            order hPLSCR1>hPLSCR2>hPLSCR3>hPLSCR4 for Mg2+.
REFERENCE   4  (bases 1 to 1185)
  AUTHORS   Wiedmer,T., Zhou,Q., Kwoh,D.Y. and Sims,P.J.
  TITLE     Identification of three new members of the phospholipid scramblase
            gene family
  JOURNAL   Biochim Biophys Acta 1467 (1), 244-253 (2000)
   PUBMED   10930526
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC069528.10.
            
            On Jul 6, 2021 this sequence version replaced XM_017006910.2.
            
            Summary: This gene encodes a member of the phospholipid scramblase
            family. Phospholipid scramblases are membrane proteins that mediate
            calcium-dependent, non-specific movement of plasma membrane
            phospholipids and phosphatidylserine exposure. The encoded protein
            contains a low affinity calcium binding motif and may play a role
            in blood coagulation and apoptosis. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Jan 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279865.1139.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000696113.1/ ENSP00000512407.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC069528.10        91888-91954         c
            68-303              AC069528.10        82241-82476         c
            304-346             AC069528.10        80804-80846         c
            347-567             AC069528.10        77632-77852         c
            568-729             AC069528.10        76395-76556         c
            730-891             AC069528.10        71599-71760         c
            892-955             AC069528.10        64151-64214         c
            956-1185            AC069528.10        55681-55910         c
FEATURES             Location/Qualifiers
     source          1..1185
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q24"
     gene            1..1185
                     /gene="PLSCR2"
                     /note="phospholipid scramblase 2"
                     /db_xref="GeneID:57047"
                     /db_xref="HGNC:HGNC:16494"
                     /db_xref="MIM:607610"
     exon            1..67
                     /gene="PLSCR2"
                     /inference="alignment:Splign:2.1.0"
     exon            68..303
                     /gene="PLSCR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..921
                     /gene="PLSCR2"
                     /note="isoform 3 is encoded by transcript variant 4; PL
                     scramblase 2; ca(2+)-dependent phospholipid scramblase 2"
                     /codon_start=1
                     /product="phospholipid scramblase 2 isoform 3"
                     /protein_id="NP_001382366.1"
                     /db_xref="CCDS:CCDS3134.1"
                     /db_xref="GeneID:57047"
                     /db_xref="HGNC:HGNC:16494"
                     /db_xref="MIM:607610"
                     /translation="MPAPPPPLNCPPGLEYLSQIDMILIHQQIELLEVLFSFESSNMY
                     EIKNSFGQRIYFAAEDTNFCIRNCCGRSRPFTLRITDNVGREVITLERPLRCNCCCCP
                     CCLQEIEIQAPPGVPVGYVTQTWHPCLTKFTIKNQKREDVLKISGPCIVCSCIAGVDF
                     EITSLDEQIVVGRISKHWSGFLREAFTDADNFGIQFPRDLDVKMKAVMIGACFLIDYM
                     FFERTR"
     exon            304..346
                     /gene="PLSCR2"
                     /inference="alignment:Splign:2.1.0"
     exon            347..567
                     /gene="PLSCR2"
                     /inference="alignment:Splign:2.1.0"
     exon            568..729
                     /gene="PLSCR2"
                     /inference="alignment:Splign:2.1.0"
     exon            730..891
                     /gene="PLSCR2"
                     /inference="alignment:Splign:2.1.0"
     exon            892..955
                     /gene="PLSCR2"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1185
                     /gene="PLSCR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1158..1163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLSCR2"
                     /note="hexamer: AATAAA"
     polyA_site      1184
                     /gene="PLSCR2"
                     /note="major polyA site"
ORIGIN      
        1 agacgggagg aagccacgct aggacctcgg ctcgctcagg gctgtgcggg agcagctgca
       61 gccacgggac ctcccggaca tattgtctac cctaagcacc aggctggaca cactgggaaa
      121 caggctgacc acctgggctc ccaggccttc tacccaggac gtcagcatga ctacctagtc
      181 ccacctgctg gcacagctgg cattcctgtt caaaatcagc caggtagacc tgaaggggta
      241 ccatggatgc cagcaccacc accaccatta aactgtccgc caggattgga atacttaagt
      301 cagatagata tgatactaat tcatcagcaa attgaacttc tggaagttct attcagtttt
      361 gaaagtagta acatgtatga aatcaagaac agctttgggc agaggattta ttttgcagca
      421 gaagatacta atttctgtat ccgaaattgc tgtgggcggt ctagaccttt taccttgagg
      481 attactgata atgtgggtcg agaagtcata actctggaaa gaccactaag atgtaactgt
      541 tgttgttgcc cctgctgcct tcaggagata gaaatccaag ctcctcctgg tgtaccagta
      601 ggttatgtta ctcagacctg gcacccatgt ctaacaaagt ttacaattaa aaatcagaaa
      661 agagaggatg tactaaaaat tagtggtcca tgtatcgtgt gcagctgtat tgcgggtgtt
      721 gattttgaga ttacatctct tgatgaacaa attgtggttg gcaggatttc taagcactgg
      781 tctgggtttt taagagaggc atttactgat gctgacaact ttggaatcca attccctaga
      841 gaccttgatg ttaaaatgaa agccgtgatg attggtgcct gtttcctcat tgactacatg
      901 ttttttgaaa gaactaggta atgactggaa tgtcagagtg tgggagtgga ttaatgattc
      961 cggatctttg gctaggcaaa atgaaactat aactgatcta aacggttcct tccttcttct
     1021 actgtgcaag gaagatgtaa ggaaaaactc gcacactatc tgtggaactc atttaaattc
     1081 aaatactaga taaacatttc gcattgaata tttacatgga gaaaaatcat caaacatcaa
     1141 caattatcaa gttaattaat aaaaatacta ggtattgcaa aaaag
//
