LOCUS       NM_021105               1976 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens phospholipid scramblase 1 (PLSCR1), transcript variant
            1, mRNA.
ACCESSION   NM_021105
VERSION     NM_021105.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1976)
  AUTHORS   Zhou,S., Xu,J. and Zhu,Y.
  TITLE     Phospholipid scramblase 1 acts through the IL-6/JAK/STAT3 pathway
            to promote the malignant progression of glioma
  JOURNAL   Arch Biochem Biophys 756, 110002 (2024)
   PUBMED   38636689
  REMARK    GeneRIF: Phospholipid scramblase 1 acts through the IL-6/JAK/STAT3
            pathway to promote the malignant progression of glioma.
REFERENCE   2  (bases 1 to 1976)
  AUTHORS   Hayashi,Y., Suzuki,T., Horioka,N., Dohmae,N. and Tanikawa,T.
  TITLE     Phospholipid Scramblase 1 Localizes Proximal to Sphingomyelin
            Synthase Isoforms but Is Not Involved in Sphingomyelin Synthesis
  JOURNAL   Biol Pharm Bull 47 (6), 1136-1143 (2024)
   PUBMED   38866522
  REMARK    GeneRIF: Phospholipid Scramblase 1 Localizes Proximal to
            Sphingomyelin Synthase Isoforms but Is Not Involved in
            Sphingomyelin Synthesis.
REFERENCE   3  (bases 1 to 1976)
  AUTHORS   Xu,D., Jiang,W., Wu,L., Gaudet,R.G., Park,E.S., Su,M.,
            Cheppali,S.K., Cheemarla,N.R., Kumar,P., Uchil,P.D., Grover,J.R.,
            Foxman,E.F., Brown,C.M., Stansfeld,P.J., Bewersdorf,J., Mothes,W.,
            Karatekin,E., Wilen,C.B. and MacMicking,J.D.
  TITLE     PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2
            infection
  JOURNAL   Nature 619 (7971), 819-827 (2023)
   PUBMED   37438530
  REMARK    GeneRIF: PLSCR1 is a cell-autonomous defence factor against
            SARS-CoV-2 infection.
REFERENCE   4  (bases 1 to 1976)
  AUTHORS   Rayala,S., Sivagnanam,U. and Gummadi,S.N.
  TITLE     Biophysical characterization of the DNA binding motif of human
            phospholipid scramblase 1
  JOURNAL   Eur Biophys J 51 (7-8), 579-593 (2022)
   PUBMED   36260146
  REMARK    GeneRIF: Biophysical characterization of the DNA binding motif of
            human phospholipid scramblase 1.
REFERENCE   5  (bases 1 to 1976)
  AUTHORS   Koyiloth,M. and Gummadi,S.N.
  TITLE     Interaction of human phospholipid scramblase 1 with cholesterol via
            CRAC motif is essential for functional regulation and subcellular
            localization
  JOURNAL   Int J Biol Macromol 209 (Pt A), 850-857 (2022)
   PUBMED   35439477
  REMARK    GeneRIF: Interaction of human phospholipid scramblase 1 with
            cholesterol via CRAC motif is essential for functional regulation
            and subcellular localization.
REFERENCE   6  (bases 1 to 1976)
  AUTHORS   Kasukabe,T., Kobayashi,H., Kaneko,Y., Okabe-Kado,J. and Honma,Y.
  TITLE     Identity of human normal counterpart (MmTRA1b) of mouse
            leukemogenesis-associated gene (MmTRA1a) product as plasma membrane
            phospholipid scramblase and chromosome mapping of the human
            MmTRA1b/phospholipid scramblase gene
  JOURNAL   Biochem Biophys Res Commun 249 (2), 449-455 (1998)
   PUBMED   9712717
REFERENCE   7  (bases 1 to 1976)
  AUTHORS   Zhao,J., Zhou,Q., Wiedmer,T. and Sims,P.J.
  TITLE     Palmitoylation of phospholipid scramblase is required for normal
            function in promoting Ca2+-activated transbilayer movement of
            membrane phospholipids
  JOURNAL   Biochemistry 37 (18), 6361-6366 (1998)
   PUBMED   9572851
REFERENCE   8  (bases 1 to 1976)
  AUTHORS   Zhou,Q., Sims,P.J. and Wiedmer,T.
  TITLE     Identity of a conserved motif in phospholipid scramblase that is
            required for Ca2+-accelerated transbilayer movement of membrane
            phospholipids
  JOURNAL   Biochemistry 37 (8), 2356-2360 (1998)
   PUBMED   9485382
REFERENCE   9  (bases 1 to 1976)
  AUTHORS   Zhou,Q., Zhao,J., Stout,J.G., Luhm,R.A., Wiedmer,T. and Sims,P.J.
  TITLE     Molecular cloning of human plasma membrane phospholipid scramblase.
            A protein mediating transbilayer movement of plasma membrane
            phospholipids
  JOURNAL   J Biol Chem 272 (29), 18240-18244 (1997)
   PUBMED   9218461
REFERENCE   10 (bases 1 to 1976)
  AUTHORS   Basse,F., Stout,J.G., Sims,P.J. and Wiedmer,T.
  TITLE     Isolation of an erythrocyte membrane protein that mediates
            Ca2+-dependent transbilayer movement of phospholipid
  JOURNAL   J Biol Chem 271 (29), 17205-17210 (1996)
   PUBMED   8663431
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF098642.1 and BC032718.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021105.2.
            
            Summary: This gene encodes a phospholipid scramblase family member.
            The encoded protein is involved in disruption of the asymmetrical
            distribution of phospholipids between the inner and outer leaflets
            of the plasma membrane, resulting in externalization of
            phosphatidylserine. This cell membrane disruption plays an
            important role in the blood coagulation cascade as well as
            macrophage clearing of apoptotic cells. The encoded protein has
            additionally been implicated in gene regulation and
            interferon-induced antiviral responses. [provided by RefSeq, May
            2022].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021100.1, AK313377.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000342435.9/ ENSP00000345494.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AF098642.1         102-151
            51-1976             BC032718.1         33-1958
FEATURES             Location/Qualifiers
     source          1..1976
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q24"
     gene            1..1976
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /note="phospholipid scramblase 1"
                     /db_xref="GeneID:5359"
                     /db_xref="HGNC:HGNC:9092"
                     /db_xref="MIM:604170"
     exon            1..141
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            142..167
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1111
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /note="isoform 1 is encoded by transcript variant 1; PL
                     scramblase 1; erythrocyte phospholipid scramblase;
                     ca(2+)-dependent phospholipid scramblase 1;
                     mg(2+)-dependent nuclease"
                     /codon_start=1
                     /product="phospholipid scramblase 1 isoform 1"
                     /protein_id="NP_066928.1"
                     /db_xref="CCDS:CCDS3135.1"
                     /db_xref="GeneID:5359"
                     /db_xref="HGNC:HGNC:9092"
                     /db_xref="MIM:604170"
                     /translation="MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQV
                     SYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYL
                     SQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPF
                     TLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFT
                     IQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFTDADN
                     FGIQFPLDLDVKMKAVMIGACFLIDFMFFESTGSQEQKSGVW"
     exon            168..248
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            249..466
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            467..509
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            510..730
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            731..892
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1054
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1976
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1340..1345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /note="hexamer: AATGAA"
     polyA_site      1360
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /note="major polyA site"
     regulatory      1954..1959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /note="hexamer: AATAAA"
     polyA_site      1976
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /note="major polyA site"
ORIGIN      
        1 agaccctttt ccggctgact tctgagaagg ttgcgcagca gctgtgcccg gcagtctaga
       61 ggcgcagaag aggaagccat cgcctggccc cggctctctg gaccttgtct cgctcgggag
      121 cggaaacagc ggcagccaga gaactgtttt aatcatggac aaacaaaact cacagatgaa
      181 tgcttctcac ccggaaacaa acttgccagt tgggtatcct cctcagtatc caccgacagc
      241 attccaagga cctccaggat atagtggcta ccctgggccc caggtcagct acccaccccc
      301 accagccggc cattcaggtc ctggcccagc tggctttcct gtcccaaatc agccagtgta
      361 taatcagcca gtatataatc agccagttgg agctgcaggg gtaccatgga tgccagcgcc
      421 acagcctcca ttaaactgtc cacctggatt agaatattta agtcagatag atcagatact
      481 gattcatcag caaattgaac ttctggaagt tttaacaggt tttgaaacta ataacaaata
      541 tgaaattaag aacagctttg gacagagggt ttactttgca gcggaagata ctgattgctg
      601 tacccgaaat tgctgtgggc catctagacc ttttaccttg aggattattg ataatatggg
      661 tcaagaagtc ataactctgg agagaccact aagatgtagc agctgttgtt gtccctgctg
      721 ccttcaggag atagaaatcc aagctcctcc tggtgtacca ataggttatg ttattcagac
      781 ttggcaccca tgtctaccaa agtttacaat tcaaaatgag aaaagagagg atgtactaaa
      841 aataagtggt ccatgtgttg tgtgcagctg ttgtggagat gttgattttg agattaaatc
      901 tcttgatgaa cagtgtgtgg ttggcaaaat ttccaagcac tggactggaa ttttgagaga
      961 ggcatttaca gacgctgata actttggaat ccagttccct ttagaccttg atgttaaaat
     1021 gaaagctgta atgattggtg cctgtttcct cattgacttc atgttttttg aaagcactgg
     1081 cagccaggaa caaaaatcag gagtgtggta gtggattagt gaaagtctcc tcaggaaatc
     1141 tgaagtctgt atattgattg agactatcta aactcatacc tgtatgaatt aagctgtaag
     1201 gcctgtagct ctggttgtat acttttgctt ttcaaattat agtttatctt ctgtataact
     1261 gatttataaa ggtttttgta cattttttaa tactcattgt caatttgaga aaaaggacat
     1321 atgagttttt gcatttatta atgaaacttc ctttgaaaaa ctgctttgaa ttatgatctc
     1381 tgattcattg tccattttac taccaaatat taactaaggc cttattaatt tttatataaa
     1441 ttatatcttg tcctattaaa tctagttaca atttatttca tgcataagag ctaatgttat
     1501 tttgcaaatg ccatatattc aaaaaagctc aaagataatt ttctttacta ttatgttcaa
     1561 ataatattca atatgcatat tatctttaaa aagttaaatg tttttttaat cttcaagaaa
     1621 tcatgctaca cttaacttct cctagaagct aatctatacc ataatatttt catattcaca
     1681 agatattaaa ttaccaattt tcaaattatt gttagtaaag aacaaaatga ttctctccca
     1741 aagaaagaca cattttaaat actccttcac tctaaaactc tggtattata acttttgaaa
     1801 gttaatattt ctacatgaaa tgtttagctc ttacactcta tccttcctag aaaatggtaa
     1861 ttgagattac tcagatatta attaaataca atatcatata tatattcaca gagtataaac
     1921 ctaaataatg atctattaga ttcaaatatt tgaaataaaa acttgatttt tttgta
//
