LOCUS       NM_001145319            3700 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens plastin 1 (PLS1), transcript variant 1, mRNA.
ACCESSION   NM_001145319
VERSION     NM_001145319.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3700)
  AUTHORS   Teng,Y.S., Chen,W.Y., Yan,Z.B., Lv,Y.P., Liu,Y.G., Mao,F.Y.,
            Zhao,Y.L., Peng,L.S., Cheng,P., Duan,M.B., Chen,W., Wang,Y.,
            Luo,P., Zou,Q.M., Chen,J. and Zhuang,Y.
  TITLE     L-Plastin Promotes Gastric Cancer Growth and Metastasis in a
            Helicobacter pylori cagA-ERK-SP1-Dependent Manner
  JOURNAL   Mol Cancer Res 19 (6), 968-978 (2021)
   PUBMED   33771880
  REMARK    GeneRIF: L-Plastin Promotes Gastric Cancer Growth and Metastasis in
            a Helicobacter pylori cagA-ERK-SP1-Dependent Manner.
REFERENCE   2  (bases 1 to 3700)
  AUTHORS   Machado,R.A.C., Stojevski,D., De Landtsheer,S., Lucarelli,P.,
            Baron,A., Sauter,T. and Schaffner-Reckinger,E.
  TITLE     L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway
            and promotes breast cancer cell invasiveness
  JOURNAL   Cell Commun Signal 19 (1), 22 (2021)
   PUBMED   33618712
  REMARK    GeneRIF: L-plastin Ser5 phosphorylation is modulated by the
            PI3K/SGK pathway and promotes breast cancer cell invasiveness.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3700)
  AUTHORS   Zhang,T., Wang,Z., Liu,Y., Huo,Y., Liu,H., Xu,C., Mao,R., Zhu,Y.,
            Liu,L., Wei,D., Liu,G., Pan,B., Tang,Y., Zhou,Z., Yang,C. and
            Guo,Y.
  TITLE     Plastin 1 drives metastasis of colorectal cancer through the
            IQGAP1/Rac1/ERK pathway
  JOURNAL   Cancer Sci 111 (8), 2861-2871 (2020)
   PUBMED   32350953
  REMARK    GeneRIF: Plastin 1 drives metastasis of colorectal cancer through
            the IQGAP1/Rac1/ERK pathway.
REFERENCE   4  (bases 1 to 3700)
  AUTHORS   Wang,L., Lan,Y., Du,Y., Xiang,X., Tian,W., Yang,B., Li,T. and
            Zhai,Q.
  TITLE     Plastin 1 promotes osteoblast differentiation by regulating
            intracellular Ca2
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 52 (5), 563-569 (2020)
   PUBMED   32318696
  REMARK    GeneRIF: Plastin 1 promotes osteoblast differentiation by
            regulating intracellular Ca2.
REFERENCE   5  (bases 1 to 3700)
  AUTHORS   Diaz-Horta,O., Bademci,G., Tokgoz-Yilmaz,S., Guo,S., Zafeer,F.,
            Sineni,C.J., Duman,D., Farooq,A. and Tekin,M.
  TITLE     Novel variant p.E269K confirms causative role of PLS1 mutations in
            autosomal dominant hearing loss
  JOURNAL   Clin Genet 96 (6), 575-578 (2019)
   PUBMED   31432506
  REMARK    GeneRIF: Novel variant p.E269K confirms causative role of PLS1
            mutations in autosomal dominant hearing loss.
REFERENCE   6  (bases 1 to 3700)
  AUTHORS   Chafel,M.M., Shen,W. and Matsudaira,P.
  TITLE     Sequential expression and differential localization of I-, L-, and
            T-fimbrin during differentiation of the mouse intestine and yolk
            sac
  JOURNAL   Dev Dyn 203 (2), 141-151 (1995)
   PUBMED   7655078
REFERENCE   7  (bases 1 to 3700)
  AUTHORS   Lin,C.S., Shen,W., Chen,Z.P., Tu,Y.H. and Matsudaira,P.
  TITLE     Identification of I-plastin, a human fimbrin isoform expressed in
            intestine and kidney
  JOURNAL   Mol Cell Biol 14 (4), 2457-2467 (1994)
   PUBMED   8139549
REFERENCE   8  (bases 1 to 3700)
  AUTHORS   Shibata,M., Yamakawa,Y., Ohoka,T., Mizuno,S. and Suzuki,K.
  TITLE     Characterization of a 64-kd protein phosphorylated during
            chemotactic activation with IL-8 and fMLP of human
            polymorphonuclear leukocytes. II. Purification and amino acid
            analysis of phosphorylated 64-kd protein
  JOURNAL   J Leukoc Biol 54 (1), 10-16 (1993)
   PUBMED   8336074
REFERENCE   9  (bases 1 to 3700)
  AUTHORS   Zu,Y., Kohno,M., Kubota,I., Nishida,E., Hanaoka,M. and Namba,Y.
  TITLE     Characterization of interleukin 2 stimulated 65-kilodalton
            phosphoprotein in human T cells
  JOURNAL   Biochemistry 29 (4), 1055-1062 (1990)
   PUBMED   2111166
REFERENCE   10 (bases 1 to 3700)
  AUTHORS   Lin,C.S., Aebersold,R.H., Kent,S.B., Varma,M. and Leavitt,J.
  TITLE     Molecular cloning and characterization of plastin, a human
            leukocyte protein expressed in transformed human fibroblasts
  JOURNAL   Mol Cell Biol 8 (11), 4659-4668 (1988)
   PUBMED   3211125
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA427212.1, L20826.1,
            AK290316.1, BM263745.1 and AA933088.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001145319.1.
            
            Summary: Plastins are a family of actin-binding proteins that are
            conserved throughout eukaryote evolution and expressed in most
            tissues of higher eukaryotes. In humans, two ubiquitous plastin
            isoforms (L and T) have been identified. The protein encoded by
            this gene is a third distinct plastin isoform, which is
            specifically expressed at high levels in the small intestine.
            Alternatively spliced transcript variants varying in the 5' UTR,
            but encoding the same protein, have been found for this gene. A
            pseudogene of this gene is found on chromosome 11.[provided by
            RefSeq, Feb 2010].
            
            Transcript Variant: This variant (1) represents the more
            predominant transcript. Transcript variants 1, 2 and 3 encode the
            same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.100827.1,
                                           SRR1660809.39829.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000457734.7/ ENSP00000387890.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-556               DA427212.1         7-562
            557-1611            L20826.1           501-1555
            1612-2146           AK290316.1         1591-2125
            2147-2855           L20826.1           2091-2799
            2856-3349           BM263745.1         115-608
            3350-3700           AA933088.1         15-365              c
FEATURES             Location/Qualifiers
     source          1..3700
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..3700
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /note="plastin 1"
                     /db_xref="GeneID:5357"
                     /db_xref="HGNC:HGNC:9090"
                     /db_xref="MIM:602734"
     exon            1..117
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /inference="alignment:Splign:2.1.0"
     exon            118..223
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..2043
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /note="I plastin; fimbrin; intestine specific plastin"
                     /codon_start=1
                     /product="plastin-1"
                     /protein_id="NP_001138791.1"
                     /db_xref="CCDS:CCDS3125.1"
                     /db_xref="GeneID:5357"
                     /db_xref="HGNC:HGNC:9090"
                     /db_xref="MIM:602734"
                     /translation="MENSTTTISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEAS
                     LPLPGYKVREIVEKILSVADSNKDGKISFEEFVSLMQELKSKDISKTFRKIINKREGI
                     TAIGGTSTISSEGTQHSYSEEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLA
                     DGILLCKMINLSEPDTIDERAINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDL
                     KEGKPHLVLGLLWQIIKVGLFADIEISRNEALIALLNEGEELEELMKLSPEELLLRWV
                     NYHLTNAGWHTISNFSQDIKDSRAYFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKR
                     AGLMLQEADKLGCKQFVTPADVVSGNPKLNLAFVANLFNTYPCLHKPNNNDIDMNLLE
                     GESKEERTFRNWMNSLGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYPA
                     LGGNMKKIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNVL
                     SDLGEGEKVNDEIIIKWVNQTLKSANKKTSISSFKDKSISTSLPVLDLIDAIAPNAVR
                     QEMIRRENLSDEDKLNNAKYAISVARKIGARIYALPDDLVEVKPKMVMTVFACLMGKG
                     LNRIK"
     exon            224..387
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /inference="alignment:Splign:2.1.0"
     exon            388..517
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /inference="alignment:Splign:2.1.0"
     exon            518..650
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /inference="alignment:Splign:2.1.0"
     exon            651..732
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /inference="alignment:Splign:2.1.0"
     exon            733..898
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1041
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1134
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1330
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1409
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1524
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1658
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1782
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1907
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..3700
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3676..3681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /note="hexamer: AATAAA"
     polyA_site      3700
                     /gene="PLS1"
                     /gene_synonym="DFNA76"
                     /note="major polyA site"
ORIGIN      
        1 agtggcgcga gcgcagcggc tacgcgggcg cggagaggta gccgcagagt ggacctgcag
       61 gtacttggat ctccagtggg agctgccctc tcgaaggcag gacagcggtg gcggcagata
      121 taaagacctg aagatagtct tttctgtcca aagatggaaa acagtactac taccatttct
      181 cgggaggagc ttgaagaact acaagaggca tttaataaaa tagatattga caatagtggg
      241 tatgtcagtg actatgaact tcaagacctg tttaaggaag caagccttcc tctgcctggc
      301 tacaaggtgc gcgagattgt ggagaaaatt ctatcagttg ctgacagcaa caaagatggc
      361 aaaatcagtt ttgaagagtt tgtgtcacta atgcaagaat taaaaagcaa agatatcagc
      421 aaaacattcc gaaaaataat taacaagagg gaagggatta ctgctattgg aggaacttca
      481 actatttcca gtgagggcac acagcattct tattcagagg aagaaaaagt ggcttttgtt
      541 aactggataa acaaagccct ggagaatgac cctgactgta agcatcttat acccatgaat
      601 cccaatgatg atagtctttt caagtcactt gcagatggca tccttctttg caaaatgatc
      661 aacttatctg aaccagatac aattgatgaa agagccatca ataagaaaaa gctcacgcca
      721 ttcactattt ctgaaaattt aaacctagct ctgaattctg cctcagccat tggttgtaca
      781 gtggtcaaca ttggtgcatc agatctcaaa gaaggaaaac ctcacttggt cttgggactt
      841 ctctggcaga tcatcaaagt tggccttttt gctgatattg agatttccag gaatgaagct
      901 ctgattgcat tgttaaatga aggtgaggaa ctagaggagc tgatgaagct ttctcccgag
      961 gaattactgc tgcgatgggt gaactaccat ctgaccaatg caggatggca taccatcagc
     1021 aacttcagcc aagacattaa ggactcgaga gcctattttc atctgcttaa tcagattgcc
     1081 cctaaaggtg gggaagatgg acctgccatt gccattgacc tttcaggaat taatgagaca
     1141 aatgacctga agcgtgctgg actcatgctt caagaagcag ataaactggg ctgcaaacag
     1201 tttgttactc ctgcagatgt ggtttcaggc aatcctaaac ttaatttagc ttttgtagct
     1261 aatttgttta acacataccc gtgcctgcac aagccgaata ataatgacat cgatatgaat
     1321 ttactggaag gagagagcaa ggaagagaga acatttcgga actggatgaa ttccttggga
     1381 gtcaacccat acattaatca tttgtacagt gaccttgcag atgctttagt gatctttcag
     1441 ctctatgaga tgatccgagt gccagtcaac tggagccatg tcaacaaacc tccttatcct
     1501 gcccttggag ggaacatgaa gaagattgaa aactgtaact atgcagtgga acttgggaag
     1561 aacaaggcca aattctcctt ggttggcatt gctgggcagg acctaaatga agggaattca
     1621 acacttaccc tggcattggt atggcagctg atgagaaggt acacattgaa tgtgttatcg
     1681 gatcttggag agggtgaaaa agtaaatgat gaaattataa ttaaatgggt caatcagact
     1741 cttaaaagtg caaacaaaaa gacttctatt tccagcttca aggataaatc tataagcaca
     1801 agtttacctg tcctagattt aatagatgcc attgcaccaa atgcagttcg tcaagaaatg
     1861 atcaggagag aaaacttatc tgatgaggac aagctgaaca atgctaaata cgccatttca
     1921 gttgctcgaa agatcggtgc ccggatatat gcattacctg atgacctcgt agaagtgaaa
     1981 ccaaagatgg ttatgacggt gtttgcatgc ttaatgggaa aaggactgaa cagaataaaa
     2041 taatcatttc atatgatttt ctgccacatt aaacatattg tatgcctcac agtttacagg
     2101 attctgaaat gtagtgggtg taaaaccaga gattatttgt atgctcaaaa tagttatata
     2161 ttcattaatg aattcaatat cctgttcata ctagttagag ctggtcagcc tttttgggta
     2221 acacagttaa tttaccaact gatacagata atagaatata ttcataatca agctgatact
     2281 tcatgattaa attatttttg ttgcttaaaa gtcgtattag acaagactaa atcattcttt
     2341 tttatggttc aaaaaagatg aatacaaacg tttttgcagg ttctgctgtg aaatgtggtt
     2401 tgattttttt ggtgtgttaa ttttgatcat aaatgcattc atactcataa tccagtttaa
     2461 tccttttatt tgcttcctcc aactatttaa agtggtccaa aaacactttt ctgtaagttt
     2521 ctatactgtc taaaacctta tggtgaccag aattgtttat taatatcaaa cttttttata
     2581 tatgagaact aattcttgaa taaaccccaa agttcactct cttgtttaag tagcagcagc
     2641 tttttactta aaatttaatt ttaactacat tgatacttta cacatcctag tttggtaaca
     2701 cagctttaac tatgtcatgc aacatatata tgttggtagg atgttattag agagatatgt
     2761 gtgcatatat atttttttgc acctgaatca cccagctttt cataagtggt atgtttaatt
     2821 ggtcattcag ccaaccatca gtattttccc cccacaacat gtgtaacact tttcagtctg
     2881 tggatatctg atacattaag atttcttttt ataagtattc attttgaatg tgcatatagt
     2941 tatttgaccc cttccaaata cttgtagcca aacattggct agaacatccc aagatatgct
     3001 gacactgtcc tgttagcttc atattatact tgctagttta ggtctctata gaagccctat
     3061 ataatttaga atatgcccac tgaatatctt taatagaaag taacataaag ctagtattca
     3121 atgtagagta ttttcatatg tttttcacag cccgttacaa attggcaatg tttggttaat
     3181 gtttgtatta cttggaaatc gctacagctt ggactatttt tttctaaatt tttagcatta
     3241 gtccatttct gctgctaaca attgaatcca gaaatctact ttctccatct tccactgtta
     3301 gtgccagtga gcaatactgt tgtgcaacaa aaatgtcact ttatctcagt gtgaatgagt
     3361 agtctaaatt ccctttctac cattgattta aatatatata ttggtaagag agactgccca
     3421 tgtgtttaga atagaatttt ttaaatgaaa tgatcaacag gtggaatttg aaatatattc
     3481 ttctacaaaa gagatttctt tcccttttat attttgatga ttgttttctt aagattaaga
     3541 tatgttcttg ctcttttata agattattta aattatgttt ccctctgatt ttttttcacc
     3601 attgtattta ctaagttatt ggatttacat gaaatctggc actttagggt gttctttttc
     3661 tcacagagta tatttaataa aaatgctgtg tatatagaaa
//
