LOCUS       NM_001037317            3983 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens phospholipid phosphatase related 5 (PLPPR5),
            transcript variant 1, mRNA.
ACCESSION   NM_001037317
VERSION     NM_001037317.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3983)
  AUTHORS   Kim,Y.K., Kim,Y., Hwang,M.Y., Shimokawa,K., Won,S., Kato,N.,
            Tabara,Y., Yokota,M., Han,B.G., Lee,J.H. and Kim,B.J.
  TITLE     Identification of a genetic variant at 2q12.1 associated with blood
            pressure in East Asians by genome-wide scan including
            gene-environment interactions
  JOURNAL   BMC Med Genet 15, 65 (2014)
   PUBMED   24903457
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3983)
  AUTHORS   Shaffer,J.R., Feingold,E., Wang,X., Lee,M., Tcuenco,K., Weeks,D.E.,
            Weyant,R.J., Crout,R., McNeil,D.W. and Marazita,M.L.
  TITLE     GWAS of dental caries patterns in the permanent dentition
  JOURNAL   J Dent Res 92 (1), 38-44 (2013)
   PUBMED   23064961
REFERENCE   3  (bases 1 to 3983)
  AUTHORS   Wang,X., Shaffer,J.R., Zeng,Z., Begum,F., Vieira,A.R., Noel,J.,
            Anjomshoaa,I., Cuenco,K.T., Lee,M.K., Beck,J., Boerwinkle,E.,
            Cornelis,M.C., Hu,F.B., Crosslin,D.R., Laurie,C.C., Nelson,S.C.,
            Doheny,K.F., Pugh,E.W., Polk,D.E., Weyant,R.J., Crout,R.,
            McNeil,D.W., Weeks,D.E., Feingold,E. and Marazita,M.L.
  TITLE     Genome-wide association scan of dental caries in the permanent
            dentition
  JOURNAL   BMC Oral Health 12, 57 (2012)
   PUBMED   23259602
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3983)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 3983)
  AUTHORS   Broggini,T., Nitsch,R. and Savaskan,N.E.
  TITLE     Plasticity-related gene 5 (PRG5) induces filopodia and neurite
            growth and impedes lysophosphatidic acid- and nogo-A-mediated
            axonal retraction
  JOURNAL   Mol Biol Cell 21 (4), 521-537 (2010)
   PUBMED   20032306
REFERENCE   6  (bases 1 to 3983)
  AUTHORS   Sun,L., Gu,S., Sun,Y., Zheng,D., Wu,Q., Li,X., Dai,J., Dai,J.,
            Ji,C., Xie,Y. and Mao,Y.
  TITLE     Cloning and characterization of a novel human phosphatidic acid
            phosphatase type 2, PAP2d, with two different transcripts PAP2d_v1
            and PAP2d_v2
  JOURNAL   Mol Cell Biochem 272 (1-2), 91-96 (2005)
   PUBMED   16010976
  REMARK    GeneRIF: A novel human phosphatidic acid phosphatase type 2 isoform
            cDNAs (PAP2d) from the fetal brain cDNA library was cloned and
            characterized.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR001828.1, AY574039.1,
            BC040174.1, AF131783.1 and R37934.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001037317.1.
            
            Summary: The protein encoded by this gene is a type 2 member of the
            phosphatidic acid phosphatase (PAP) family. All type 2 members of
            this protein family contain 6 transmembrane regions, and a
            consensus N-glycosylation site. PAPs convert phosphatidic acid to
            diacylglycerol, and function in de novo synthesis of glycerolipids
            as well as in receptor-activated signal transduction mediated by
            phospholipase D. Alternate transcriptional splice variants,
            encoding different isoforms, have been characterized. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), also known as PAP2d_v1,
            represents the longer transcript and encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.18547.1,
                                           SRR1803612.25856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149178, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263177.5/ ENSP00000263177.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DR001828.1         37-49
            14-789              AY574039.1         1-776
            790-1108            BC040174.1         559-877
            1109-1622           AY574039.1         1096-1609
            1623-2698           BC040174.1         1377-2452
            2699-2825           AF131783.1         243-369
            2826-3165           BC040174.1         2580-2919
            3166-3974           AF131783.1         710-1518
            3975-3983           R37934.1           10-18               c
FEATURES             Location/Qualifiers
     source          1..3983
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.3"
     gene            1..3983
                     /gene="PLPPR5"
                     /gene_synonym="LPPR5; PAP2; PAP2D; PRG5"
                     /note="phospholipid phosphatase related 5"
                     /db_xref="GeneID:163404"
                     /db_xref="HGNC:HGNC:31703"
                     /db_xref="MIM:617287"
     exon            1..427
                     /gene="PLPPR5"
                     /gene_synonym="LPPR5; PAP2; PAP2D; PRG5"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1156
                     /gene="PLPPR5"
                     /gene_synonym="LPPR5; PAP2; PAP2D; PRG5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidic acid phosphatase type 2; plasticity-related
                     protein 5; PRG-5; phosphatidic acid phosphatase 2d;
                     plasticity-related gene 5 protein; lipid phosphate
                     phosphatase-related protein type 5; phosphatidic acid
                     phosphatase type 2d; phospholipid phosphatase-related
                     protein type 5"
                     /codon_start=1
                     /product="phospholipid phosphatase-related protein type 5
                     isoform 1"
                     /protein_id="NP_001032394.1"
                     /db_xref="CCDS:CCDS30778.1"
                     /db_xref="GeneID:163404"
                     /db_xref="HGNC:HGNC:31703"
                     /db_xref="MIM:617287"
                     /translation="MPLLPAALTSSMLYFQMVIMAGTVMLAYYFEYTDTFTVNVQGFF
                     CHDSAYRKPYPGPEDSSAVPPVLLYSLAAGVPVLVIIVGETAVFCLQLATRDFENQEK
                     TILTGDCCYINPLVRRTVRFLGIYTFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYT
                     ALGCQQYTQFISGEEACTGNPDLIMRARKTFPSKEAALSVYAAMYLTMYITNTIKAKG
                     TRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLVVCVVNNFKG
                     RQAENEHIHMDNLAQMPMISIPRVESPLEKVTSVQNHITAFAEVT"
     exon            428..560
                     /gene="PLPPR5"
                     /gene_synonym="LPPR5; PAP2; PAP2D; PRG5"
                     /inference="alignment:Splign:2.1.0"
     exon            561..811
                     /gene="PLPPR5"
                     /gene_synonym="LPPR5; PAP2; PAP2D; PRG5"
                     /inference="alignment:Splign:2.1.0"
     exon            812..988
                     /gene="PLPPR5"
                     /gene_synonym="LPPR5; PAP2; PAP2D; PRG5"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1123
                     /gene="PLPPR5"
                     /gene_synonym="LPPR5; PAP2; PAP2D; PRG5"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..3983
                     /gene="PLPPR5"
                     /gene_synonym="LPPR5; PAP2; PAP2D; PRG5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1840..1845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPPR5"
                     /gene_synonym="LPPR5; PAP2; PAP2D; PRG5"
                     /note="hexamer: ATTAAA"
     polyA_site      1860
                     /gene="PLPPR5"
                     /gene_synonym="LPPR5; PAP2; PAP2D; PRG5"
                     /note="major polyA site"
     regulatory      3951..3956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPPR5"
                     /gene_synonym="LPPR5; PAP2; PAP2D; PRG5"
                     /note="hexamer: AATAAA"
     polyA_site      3983
                     /gene="PLPPR5"
                     /gene_synonym="LPPR5; PAP2; PAP2D; PRG5"
ORIGIN      
        1 agcctgccgg cgcctcgaag cccggacctg cctccgcctc ttcctccagc ggctccatcc
       61 cgcctcccgt gcctcgtcct cccgccgcct ccgccgccgc gcccccggtg gctgcctcgg
      121 cggaccgggg agggggccca ccgcgtcgac cgcccgctcg gctcggctcg gcccggcccg
      181 ggaggcgtgc atgcccctgc tgcccgcggc gctcaccagc agcatgctct atttccagat
      241 ggtgatcatg gcagggacgg tgatgctggc gtactacttc gagtatacgg acacgttcac
      301 cgtgaacgtg cagggcttct tctgccacga cagcgcctac cgcaaaccct acccgggccc
      361 ggaggacagc agcgccgtgc cccccgtgct cctctactcg ctggccgccg gggtccccgt
      421 gctcgtgata atagttggag aaactgctgt cttttgccta caactagcca caagggattt
      481 tgaaaaccag gaaaaaacta ttttaactgg agactgttgc tatataaacc cgctggtgcg
      541 ccgaactgtc cgatttcttg gaatttatac atttggactg tttgctacag atatctttgt
      601 aaatgctgga caagtagtca caggaaatct ggccccacat ttccttgccc tgtgtaagcc
      661 caattataca gcacttggat gtcagcagta tacacaattc atcagtgggg aagaggcctg
      721 tactggcaac ccagatctca tcatgagagc ccgaaaaacc tttccatcca aagaagcagc
      781 tctcagtgtc tatgcagcta tgtatctgac catgtacatc accaacacaa tcaaagccaa
      841 gggaaccaga cttgctaagc cagttctatg cttgggctta atgtgtttgg catttcttac
      901 tggactcaac agagtagcag aatatcgaaa tcattggtca gatgttatag caggctttct
      961 ggttggaata tctatagcag tatttctggt tgtgtgcgtg gtgaataatt tcaaagggag
     1021 acaagcagaa aatgagcata tacacatgga taatctggca cagatgccaa tgatcagcat
     1081 tcctcgagta gaaagtcctt tggaaaaggt aacatctgta cagaaccaca tcactgcctt
     1141 cgcagaagtc acatgatatc gaagcagatg gtttttcact gcattggaca tcatcccttt
     1201 ttaccatcca ttcataacac ccaaagtttg tttgattgca agtgaagttt ataaagttgt
     1261 ttaataattt ttataatttt aaaatcaatg tcaacctatc tgtttccccc actagactgt
     1321 gagctcctcg agggcaggat tgtctttttt tttctgtgtc cccagcactt acaacaaagc
     1381 ctagcacaaa gtaggtgttc aacaaaaatg tgatgaccaa atgaacaaaa ttcttaaata
     1441 aaacattcac tttagtttct cacagaatca ttgcaattat gttaaaagaa atctctacat
     1501 aaatcgtatt tgtgtatgaa aaccttctat tttgggctag ttattttttt aatcttcata
     1561 tatctattca gcagtatgcc atatttaatt tgaagtggac tttgaaagtc atgggggttt
     1621 ttattttgtt attcagcatg acattatttc cattctaaca tttcagtgtg tgaaattact
     1681 ttatttttag aaagtatgtt ctatagtaaa ataatgtttc cacattatat tatgttatat
     1741 ttcacttaaa atactattca tactatacat tctaagactg gtgcttctgc ttttgaaggg
     1801 gaaaatgcca atttttactg taataagtaa tgtatcataa ttaaaaatta tttatttgga
     1861 cttcttctcc tgacaattgt ggcttaattc atgacttgtt tttgaatgca ggcagtattt
     1921 agggtagttt aaatgagtaa attcagcact ggtaccttat tattgagtaa tttcccatgg
     1981 gtagcagtgt ctcaagagtg gtcaaaagct ccactcttag gcttttttac tactaaagat
     2041 tccacataat ttaaatggga aagaactata ccctgacaca taatttaaat tatataaatg
     2101 ctagaaatat ggttaatgta ttttactttg catttgtgta gtactttata gtttacaaag
     2161 catatttaca ccaattattt tatgtaatcc tcataataac ctggtataaa catgaagggt
     2221 atggctttat ttttatagat aagaaaaatg aagccaagac agggtaaata acatgccaaa
     2281 tcacaaacta gtaagagaca tagttgaagc ttaaattcaa gttttctggc cctgaactca
     2341 tattcctttc taatatagca cagctgtcat ctcattttgg acactgaggc ctttcagagc
     2401 tcagtagaat cctgggcaac tacctatggt tcaaaaaata aagaaatgcc agaatacaaa
     2461 tatgaaagct ctgctgtatt ttaaatgttt atgttttaag aatgaacact tttcaaatat
     2521 aaaactatat aataattata atccagtttt aagataatat caagagtcta gatgtgaggc
     2581 tttttgtgaa agagaagcct aaattcagca tctccccttc caccctcacc cccaggtccc
     2641 agcctcccac tcagcagagt gcccaaggga cataccttac atttagcatg tagaattcca
     2701 gattacaatc gccataatat aaggaaggtg agctcctcaa caataacttt gcaataatta
     2761 aaactaccct aagtaacttt ggcttatatg gcaaagtaac tttggcagta attgactgaa
     2821 atgaatcttt ctaaacttta cagtactaaa gaaagcaaac ttttaatttc ctctgtaatt
     2881 tcaacagaga tcagcaaata aatataacca aagattgtcc attactcccc aaatagatgt
     2941 tatttgccca tttctatcac tgtggaagct aaaacacttc tactagggcc aaaaagagaa
     3001 aagaaaagaa aatttctact aatttcagac ctctagagca attcagtcct gttggaaatt
     3061 tagaacatga agaaactttg aatgtcttga ccctttttaa agatttttta ggcaataaca
     3121 gtaataggga attcacttat tgagaatgaa agtgaagggg atgatcctaa tgtcttagaa
     3181 agctagatta ctagtaaggc ttccagactt ctatcagttc tattgattct acatcagact
     3241 tccaagcagc caagcaggaa tgtttttcct gttggaagcc ttagccatat attcttatgt
     3301 caaggttgct tctttgcacc ttgctaaacc tgatacgaat gcaggagttt taaattcttc
     3361 aaaaactcag atttaaccca gaaccagagt aaagtcacct ctactattta cacatcatag
     3421 gctcaagatt gtacagtgag tgatgctgtc atgaagaaaa ttcagatgaa aaaggcaaga
     3481 tacatgtgaa taaggcaaaa gccagaaaat agcccttatt catgatgctg ttactgagaa
     3541 taatgaaaat catatttcag aaaatattac catgtaaata tgtacatatg tagtctagta
     3601 aaagcaggca aacacatatc tttctgataa aaacatctcc tttttattct acttacttgg
     3661 ggcccaggtc agtataattt agtcaacttg aaaatttcgg tagtctctgt ttgcatggca
     3721 gaaattctgc acatgtttta tctgattcct gtgataactt aaaaggctct tttatgttaa
     3781 aagagaggtg aatcttcttt gacagacttt gtattttcca cttctaactg ggcctctctt
     3841 ttctcaggat ctatcctagc caaatatctc agttacattt accatacagt ttcctttgtg
     3901 aaagaacagt aggggaggaa ataattctct gctgtgtatt gtatttttca aataaaaatt
     3961 taaaaattca attgaaaact gaa
//
