LOCUS       NM_014839               4824 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens phospholipid phosphatase related 4 (PLPPR4),
            transcript variant 1, mRNA.
ACCESSION   NM_014839
VERSION     NM_014839.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4824)
  AUTHORS   Li,H., Zhang,Q., Wan,R., Zhou,L., Xu,X., Xu,C., Yu,Y., Xu,Y.,
            Xiang,Y. and Tang,S.
  TITLE     PLPPR4 haploinsufficiency causes neurodevelopmental disorders by
            disrupting synaptic plasticity via mTOR signalling
  JOURNAL   J Cell Mol Med 27 (21), 3286-3295 (2023)
   PUBMED   37550884
  REMARK    GeneRIF: PLPPR4 haploinsufficiency causes neurodevelopmental
            disorders by disrupting synaptic plasticity via mTOR signalling.
REFERENCE   2  (bases 1 to 4824)
  AUTHORS   Vogt,J., Yang,J.W., Mobascher,A., Cheng,J., Li,Y., Liu,X.,
            Baumgart,J., Thalman,C., Kirischuk,S., Unichenko,P., Horta,G.,
            Radyushkin,K., Stroh,A., Richers,S., Sahragard,N., Distler,U.,
            Tenzer,S., Qiao,L., Lieb,K., Tuscher,O., Binder,H., Ferreiros,N.,
            Tegeder,I., Morris,A.J., Gropa,S., Nurnberg,P., Toliat,M.R.,
            Winterer,G., Luhmann,H.J., Huai,J. and Nitsch,R.
  TITLE     Molecular cause and functional impact of altered synaptic lipid
            signaling due to a prg-1 gene SNP
  JOURNAL   EMBO Mol Med 8 (1), 25-38 (2016)
   PUBMED   26671989
  REMARK    GeneRIF: Glycosylation as a critical mechanism for PRG-1 function
            was significantly reduced by the PRG-1R346T SNP glycosylation as a
            critical mechanism
REFERENCE   3  (bases 1 to 4824)
  AUTHORS   Adams,L.A., White,S.W., Marsh,J.A., Lye,S.J., Connor,K.L.,
            Maganga,R., Ayonrinde,O.T., Olynyk,J.K., Mori,T.A., Beilin,L.J.,
            Palmer,L.J., Hamdorf,J.M. and Pennell,C.E.
  TITLE     Association between liver-specific gene polymorphisms and their
            expression levels with nonalcoholic fatty liver disease
  JOURNAL   Hepatology 57 (2), 590-600 (2013)
   PUBMED   23213074
REFERENCE   4  (bases 1 to 4824)
  AUTHORS   Trimbuch,T., Beed,P., Vogt,J., Schuchmann,S., Maier,N.,
            Kintscher,M., Breustedt,J., Schuelke,M., Streu,N., Kieselmann,O.,
            Brunk,I., Laube,G., Strauss,U., Battefeld,A., Wende,H.,
            Birchmeier,C., Wiese,S., Sendtner,M., Kawabe,H., Kishimoto-Suga,M.,
            Brose,N., Baumgart,J., Geist,B., Aoki,J., Savaskan,N.E.,
            Brauer,A.U., Chun,J., Ninnemann,O., Schmitz,D. and Nitsch,R.
  TITLE     Synaptic PRG-1 modulates excitatory transmission via lipid
            phosphate-mediated signaling
  JOURNAL   Cell 138 (6), 1222-1235 (2009)
   PUBMED   19766573
  REMARK    Erratum:[Cell. 2011 Sep 16;146(6):1043]
REFERENCE   5  (bases 1 to 4824)
  AUTHORS   McDermott,M.I., Sigal,Y.J., Sciorra,V.A. and Morris,A.J.
  TITLE     Is PRG-1 a new lipid phosphatase?
  JOURNAL   Nat Neurosci 7 (8), 789 (2004)
   PUBMED   15280885
REFERENCE   6  (bases 1 to 4824)
  AUTHORS   Brauer,A.U., Savaskan,N.E., Kuhn,H., Prehn,S., Ninnemann,O. and
            Nitsch,R.
  TITLE     A new phospholipid phosphatase, PRG-1, is involved in axon growth
            and regenerative sprouting
  JOURNAL   Nat Neurosci 6 (6), 572-578 (2003)
   PUBMED   12730698
REFERENCE   7  (bases 1 to 4824)
  AUTHORS   Sciorra,V.A. and Morris,A.J.
  TITLE     Roles for lipid phosphate phosphatases in regulation of cellular
            signaling
  JOURNAL   Biochim Biophys Acta 1582 (1-3), 45-51 (2002)
   PUBMED   12069809
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136147.10 and AL139425.8.
            
            On Jul 14, 2020 this sequence version replaced NM_014839.4.
            
            Summary: The protein encoded by this gene belongs to the lipid
            phosphate phosphatase (LPP) family. LPPs catalyze the
            dephosphorylation of a number of bioactive lipid mediators that
            regulate a variety of cell functions. This protein is specifically
            expressed in neurons. It is located in the membranes of outgrowing
            axons and has been shown to be important for axonal outgrowth
            during development and regenerative sprouting. Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene.[provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) is the longer transcript and
            encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF357013.1, AF541281.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370185.9/ ENSP00000359204.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AL136147.10        121156-121335
            181-366             AL136147.10        144629-144814
            367-496             AL139425.8         4263-4392
            497-692             AL139425.8         6560-6755
            693-750             AL139425.8         8434-8491
            751-924             AL139425.8         9249-9422
            925-4824            AL139425.8         13210-17109
FEATURES             Location/Qualifiers
     source          1..4824
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.3-p21.2"
     gene            1..4824
                     /gene="PLPPR4"
                     /gene_synonym="LPPR4; LPR4; PHP1; PRG-1; PRG1"
                     /note="phospholipid phosphatase related 4"
                     /db_xref="GeneID:9890"
                     /db_xref="HGNC:HGNC:23496"
                     /db_xref="MIM:607813"
     exon            1..180
                     /gene="PLPPR4"
                     /gene_synonym="LPPR4; LPR4; PHP1; PRG-1; PRG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..2250
                     /gene="PLPPR4"
                     /gene_synonym="LPPR4; LPR4; PHP1; PRG-1; PRG1"
                     /EC_number="3.1.3.106"
                     /note="isoform 1 is encoded by transcript variant 1;
                     brain-specific phosphatidic acid phosphatase-like protein
                     1; plasticity related gene 1; plasticity-related gene 1
                     protein; lipid phosphate phosphatase-related protein type
                     4; phospholipid phosphatase-related protein type 4;
                     2-lysophosphatidate phosphatase PLPPR4; inactive
                     2-lysophosphatidate phosphatase PLPPR4"
                     /codon_start=1
                     /product="phospholipid phosphatase-related protein type 4
                     isoform 1"
                     /protein_id="NP_055654.3"
                     /db_xref="CCDS:CCDS757.2"
                     /db_xref="GeneID:9890"
                     /db_xref="HGNC:HGNC:23496"
                     /db_xref="MIM:607813"
                     /translation="MSAKERPKGKVIKDSVTLLPCFYFVELPILASSVVSLYFLELTD
                     VFKPVHSGFSCYDRSLSMPYIEPTQEAIPFLMLLSLAFAGPAITIMVGEGILYCCLSK
                     RRNGVGLEPNINAGGCNFNSFLRRAVRFVGVHVFGLCSTALITDIIQLSTGYQAPYFL
                     TVCKPNYTSLNVSCKENSYIVEDICSGSDLTVINSGRKSFPSQHATLAAFAAVYVSMY
                     FNSTLTDSSKLLKPLLVFTFIICGIICGLTRITQYKNHPVDVYCGFLIGGGIALYLGL
                     YAVGNFLPSDESMFQHRDALRSLTDLNQDPNRLLSAKNGSSSDGIAHTEGILNRNHRD
                     ASSLTNLKRANADVEIITPRSPMGKENMVTFSNTLPRANTPSVEDPVRRNASIHASMD
                     SARSKQLLTQWKNKNESRKLSLQVIEPEPGQSPPRSIEMRSSSEPSRVGVNGDHHGPG
                     NQYLKIQPGAVPGCNNSMPGGPRVSIQSRPGSSQLVHIPEETQENISTSPKSSSARAK
                     WLKAAEKTVACNRSNSQPRIMQVIAMSKQQGVLQSSPKNTEGSTVSCTGSIRYKTLTD
                     HEPSGIVRVEAHPENNRPIIQIPSTEGEGSGSWKWKAPEKGSLRQTYELNDLNRDSES
                     CESLKDSFGSGDRKRSNIDSNEHHHHGITTIRVTPVEGSEIGSETLSISSSRDSTLRR
                     KGNIILIPERSNSPENTRNIFYKGTSPTRAYKD"
     exon            181..366
                     /gene="PLPPR4"
                     /gene_synonym="LPPR4; LPR4; PHP1; PRG-1; PRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..496
                     /gene="PLPPR4"
                     /gene_synonym="LPPR4; LPR4; PHP1; PRG-1; PRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..692
                     /gene="PLPPR4"
                     /gene_synonym="LPPR4; LPR4; PHP1; PRG-1; PRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..750
                     /gene="PLPPR4"
                     /gene_synonym="LPPR4; LPR4; PHP1; PRG-1; PRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..924
                     /gene="PLPPR4"
                     /gene_synonym="LPPR4; LPR4; PHP1; PRG-1; PRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            925..4824
                     /gene="PLPPR4"
                     /gene_synonym="LPPR4; LPR4; PHP1; PRG-1; PRG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4798..4803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPPR4"
                     /gene_synonym="LPPR4; LPR4; PHP1; PRG-1; PRG1"
                     /note="hexamer: AATAAA"
     polyA_site      4824
                     /gene="PLPPR4"
                     /gene_synonym="LPPR4; LPR4; PHP1; PRG-1; PRG1"
                     /note="major polyA site"
ORIGIN      
        1 atcagcggcg ccgggcgctt ggggctggag gaggcagctc gcctcagctg cgctgtgcac
       61 acctcgcccg ggggaggacg cagacccggg caggcggcag ggatgtcggc gaaggagagg
      121 ccaaagggca aagtgatcaa ggacagcgtc accctcctgc cctgctttta tttcgtcgag
      181 ttgcctatat tggcatcatc ggtggttagc ctctatttcc tcgaactcac agatgtcttc
      241 aaacctgtgc actctggatt tagctgctat gaccggagtc ttagcatgcc gtacattgaa
      301 ccaacccagg aggcaattcc attcctcatg ttgcttagct tggcttttgc tggacctgca
      361 attacgatta tggtaggaga aggaattctc tactgttgcc tctccaaaag aagaaatggg
      421 gtcggactag agcccaacat taatgctgga ggctgcaact tcaattcctt cctcagacga
      481 gctgtcagat tcgttggtgt tcatgtattt ggattatgct ctacagctct cattacagat
      541 atcatacagc tgtccacagg atatcaagca ccttactttc tgactgtgtg caaaccaaac
      601 tatacctctc tgaatgtatc ttgcaaagaa aattcctaca ttgtggaaga tatttgctca
      661 ggatctgacc tcacagttat caacagtggc agaaagtcct tcccttctca acatgcaacc
      721 cttgctgcct ttgcagctgt gtatgtttcg atgtacttca attccacatt aacggattcc
      781 tctaagcttc tgaaacctct cttggtcttc acatttatca tctgtggaat aatctgcggg
      841 ctaacacgga taactcagta taagaaccac ccagttgatg tctattgtgg ctttttaata
      901 ggaggaggaa ttgcactgta cttgggcttg tatgctgtgg ggaatttcct gcccagtgat
      961 gagagtatgt ttcagcacag agacgccctc aggtctctga cagacctcaa tcaagatccc
     1021 aaccgacttt tatctgctaa aaatggtagc agcagtgatg gaattgctca tacagaaggc
     1081 atcctcaacc gaaaccacag agatgctagc tctctgacaa atctcaaaag agcaaatgct
     1141 gatgtggaaa tcattactcc acggagcccc atggggaagg agaacatggt taccttcagc
     1201 aataccttgc cgcgagccaa taccccatct gtagaagacc ctgtcagaag aaatgcgagc
     1261 attcatgcct ctatggattc cgctcgatca aagcagctcc tcacccagtg gaagaataag
     1321 aatgaaagtc gaaagttgtc cttgcaagtt atagagcctg agcctgggca gtcaccaccc
     1381 agatccatag aaatgaggtc aagctcagag ccatcgaggg taggggtgaa tggagaccac
     1441 catggtcctg gcaatcagta cctcaaaatc cagcctggcg ctgtccccgg atgtaacaac
     1501 agcatgcctg gagggccaag agtgtccatt cagtcccgtc ctgggtcctc acagttggtg
     1561 cacatccctg aggagactca ggaaaacata agcacctccc ccaaaagcag ctctgctcgg
     1621 gccaagtggt taaaagctgc tgaaaagact gtggcctgta acagaagcaa cagccagccc
     1681 cgaatcatgc aagtcatagc catgtccaag cagcagggtg tcctccaaag cagccccaag
     1741 aacactgaag gcagcacggt ctcctgcact ggctccatcc gctataaaac cttgacagac
     1801 catgagccca gtgggatagt gagggttgag gctcacccag agaacaacag gcccatcata
     1861 cagatcccgt ccactgaagg tgaaggcagt ggctcctgga agtggaaagc ccctgaaaag
     1921 ggcagccttc gccaaactta cgagctcaac gatctcaaca gggactcaga aagctgtgag
     1981 tctctgaaag acagctttgg ttctggagat cgcaagagaa gcaacattga tagcaatgag
     2041 catcaccacc acggaattac caccatccgc gtcaccccag tagagggcag cgaaattggc
     2101 tcagagacgc tgtccatttc ttcttcccgc gactccaccc tgcggagaaa gggcaatatc
     2161 attctaatcc ctgaaagaag caacagcccc gaaaacacta gaaatatctt ctacaaagga
     2221 acctccccca cacgggctta taaggattga gtgatgtcca ttccatcatt agggctactc
     2281 gcaaaagacc atatgttgat tctacctgtg ttctgttcca gcgaattggg aagtctcacc
     2341 aagctagatt gtctaccatc agcccagaac tctgtaactt ttcagaactg ctatactcaa
     2401 acttgcagat ctcacatcaa ggagagggaa aagcacaatg caagaaccta actaacgtga
     2461 tgatatgaag agttttctta agacctgtcg tcaaacttaa aaggttttgc agagggcagt
     2521 atcaaaagaa agtggttttc ttcaaatgta tactatttta cttcctgaat gtgccaactt
     2581 tggggatttt tctttatagt gagctgtggg aacccagaac acacacgttt tccctacagc
     2641 agaggccatg cagtattata tattcatttt gcagaatctg cacctacagc tcaatacggg
     2701 tggtgctgat tattatagta catataccat gtaaactctc aaactctatt tagctgtgaa
     2761 atagtggtgt gcaattcctt gttaaagaaa tgctacttta ttaagaagat gctggctgct
     2821 ttgtgttaga ataggacacc ccgcagcttc tctgtagtgg ctctgtcaca gtcaaaaaat
     2881 gaaaaggttt ttgtgcgttt cttcaaaatt ctgctttctt caacatcaaa aattgtgtag
     2941 aaatattttc agtgaaaggg aataactagt acttttctgc atagtttttc ttctgcttac
     3001 tttttattta agtataggta ctgctaatga atctgttttc ttagtgagta aatttgcata
     3061 attttataaa tattatttta gagaatcttt tgaaattgtt gtgatcatat tttgctttct
     3121 atggcttctc cttaacttat tgattaattt tttgaagtta tagatatgtt ctcctatttt
     3181 aaaagcaaaa ataacaattg acattccttg agcaaaatat actgctgtga atttgcaaac
     3241 aagaaatctg agccaaaact tgacattgtg ggttacattg ccagaaatgt tggtcaagtt
     3301 tgcccttaga tgtctacaac tagctggcat aggttgccat cttaacaagt aatctaaaag
     3361 tcccattcgg ttctacatta ttaacttttt ttttctatat cctgatgacc agtaaattag
     3421 agccacactg gttaagtttg actcgtctct aaaacgtttt tgttaattgg acaccaagag
     3481 gaagaatctg aaaaaaaaat gcatgttggt aagtaaaagt atctcacggt acaaattaag
     3541 aatgactttc ttcaaaatat ctgaataggt gcagttttag tttaacatgc aaacaaccat
     3601 tgttgctacc tatcctgaat caagccttga gcctaaatca aagcaaacca ataccattga
     3661 taagaagaag ataaaaacaa aatattttgg agtgttttcc aacttaaagt atgaagacat
     3721 actcagttct tggaacttag tattaaacct tttttatgcc atttcataag aattccgata
     3781 tatacttgat gattgccaag gggatgaaag gaaacaacag agatggttga tctgatctta
     3841 gctcactttc caataacaga aggagttgtt tacagatgaa tagtatcaca tcattatcaa
     3901 tttccacatg aaaaaggtgg agctttctag aaaaaccaac ctctaaggca ttaggaattt
     3961 agctgaaacc agcagaattg aaaactctgg caataaaaca tggactcaac catatccctt
     4021 ctggcaattt ccttctcaga gaggggagtg ggaataaaat gttgccttcc ccacttctca
     4081 ccaccaccgc catcatgacg ctcatactgg cttttgcctg tttgtagagg aaaaggtggg
     4141 ctggttttag tactctgaag gacaaaaaca agcaaacaaa aacccctgct gcagcatttc
     4201 aggtgcagta tgatatttcc taatctttcc tatttcttaa caaaagattt taaagtactt
     4261 ctctagtcat tgaagttttt ttttctttac ataaatattg atatattctt tttctactca
     4321 aagtgccaaa ggctacagtt tttaatgact taacaaattg taccacattg ttaaggacat
     4381 ataatgatag acactagaac tcagacctct gcatgtatat ttgataacat gtcttttgta
     4441 aaacaaaaat tacaaaaaaa tttgtttaca ttccactggt accttaattt aaaataaatc
     4501 agactaaaag gtggtatctc ttcttagtgt tctatttatc ttatttgcta atgggagcac
     4561 ttcttccttt gttaggctgt gctttactga taaaaccaag tattgaataa agagagttaa
     4621 ttatcttttt aaagtaaata aaattatgaa aatatatata gtatatataa agtactgtgt
     4681 ttaaaaaaat gttatgcaat gttttccaaa ctgataaagt ttgtaaagtg ctataaatgt
     4741 attttgttaa gtacagataa aagctattgt gtgagtatat tgtgctaaaa tcatagaaat
     4801 aaagattaga tttcttcatc aaaa
//
