LOCUS       NM_001270366            2306 bp    mRNA    linear   PRI 15-FEB-2024
DEFINITION  Homo sapiens phospholipid phosphatase related 3 (PLPPR3),
            transcript variant 2, mRNA.
ACCESSION   NM_001270366
VERSION     NM_001270366.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2306)
  AUTHORS   Brauer,A.U., Savaskan,N.E., Kuhn,H., Prehn,S., Ninnemann,O. and
            Nitsch,R.
  TITLE     A new phospholipid phosphatase, PRG-1, is involved in axon growth
            and regenerative sprouting
  JOURNAL   Nat Neurosci 6 (6), 572-578 (2003)
   PUBMED   12730698
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004799.2, AL136596.1, AY436785.1 and BC012339.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001270366.1.
            
            Summary: The proteins in the lipid phosphate phosphatase (LPP)
            family, including PRG2, are integral membrane proteins that
            modulate bioactive lipid phosphates including phosphatidate,
            lysophosphatidate, and sphingosine-1-phosphate in the context of
            cell migration, neurite retraction, and mitogenesis (Brauer et al.,
            2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) lacks an alternate segment in
            the coding region, compared to variant 1. The resulting isoform (2)
            lacks an internal region compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY436785.1, BX420549.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000520876.8/ ENSP00000430297.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC004799.2         2725-2727           c
            4-4                 AL136596.1         1-1
            5-2276              AY436785.1         1-2272
            2277-2306           BC012339.1         1443-1472
FEATURES             Location/Qualifiers
     source          1..2306
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2306
                     /gene="PLPPR3"
                     /gene_synonym="LPPR3; LPR3; PRG-2; PRG2"
                     /note="phospholipid phosphatase related 3"
                     /db_xref="GeneID:79948"
                     /db_xref="HGNC:HGNC:23497"
                     /db_xref="MIM:610391"
     exon            1..41
                     /gene="PLPPR3"
                     /gene_synonym="LPPR3; LPR3; PRG-2; PRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            42..142
                     /gene="PLPPR3"
                     /gene_synonym="LPPR3; LPR3; PRG-2; PRG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2224
                     /gene="PLPPR3"
                     /gene_synonym="LPPR3; LPR3; PRG-2; PRG2"
                     /EC_number="3.1.3.4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     PAP-2-like protein 2; plasticity-related gene 2 protein;
                     lipid phosphate phosphatase-related protein type 3;
                     phospholipid phosphatase-related protein type 3; inactive
                     phospholipid phosphatase PLPPR3"
                     /codon_start=1
                     /product="phospholipid phosphatase-related protein type 3
                     isoform 2"
                     /protein_id="NP_001257295.1"
                     /db_xref="CCDS:CCDS58636.1"
                     /db_xref="GeneID:79948"
                     /db_xref="HGNC:HGNC:23497"
                     /db_xref="MIM:610391"
                     /translation="MISTKEKNKIPKDSMTLLPCFYFVELPIVASSIVSLYFLELTDL
                     FKPAKVGFQCYDRTLSMPYVETNEELIPLLMLLSLAFAAPAASIMVAEGMLYCLQSRL
                     WGRAGGPAGAEGSINAGGCNFNSFLRRTVRFVGVHVFGLCATALVTDVIQLATGYHTP
                     FFLTVCKPNYTLLGTSCEVNPYITQDICSGHDIHAILSARKTFPSQHATLSAFAAVYV
                     SMYFNSVISDTTKLLKPILVFAFAIAAGVCGLTQITQYRSHPVDVYAGFLIGAGIAAY
                     LACHAVGNFQAPPAEKPAAPAPAKDALRALTQRGHDSVYQQNKSVSTDELGPPGRLEG
                     APRPVAREKTSLGSLKRASVDVDLLAPRSPMAKENMVTFSHTLPRASAPSLDDPARRH
                     MTIHVPLDASRSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEEEDEE
                     EEEEEEEEEDEGPAPPSLYPTVQARPGLGPRVILPPRAGPPPLVHIPEEGAQTGAGLS
                     PKSGAGVRAKWLMMAEKSGAAVANPPRLLQVIAMSKAPGAPGPKAAETASSSSASSDS
                     SQYRSPSDRDSASIVTIDAHAPHHPVVHLSAGGAPWEWKAAGGGAKAEADGGYELGDL
                     ARGFRGGAKPPGVSPGSSVSDVDQEEPRFGAVATVNLATGEGLPPLGAADGALGPGSR
                     ESTLRRHAGGLGLAEREAEAEAEGYFRKMQARRFPD"
     exon            143..328
                     /gene="PLPPR3"
                     /gene_synonym="LPPR3; LPR3; PRG-2; PRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            329..470
                     /gene="PLPPR3"
                     /gene_synonym="LPPR3; LPR3; PRG-2; PRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            471..666
                     /gene="PLPPR3"
                     /gene_synonym="LPPR3; LPR3; PRG-2; PRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            667..724
                     /gene="PLPPR3"
                     /gene_synonym="LPPR3; LPR3; PRG-2; PRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            725..898
                     /gene="PLPPR3"
                     /gene_synonym="LPPR3; LPR3; PRG-2; PRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            899..2306
                     /gene="PLPPR3"
                     /gene_synonym="LPPR3; LPR3; PRG-2; PRG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2287..2292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPPR3"
                     /gene_synonym="LPPR3; LPR3; PRG-2; PRG2"
                     /note="hexamer: AATAAA"
     polyA_site      2306
                     /gene="PLPPR3"
                     /gene_synonym="LPPR3; LPR3; PRG-2; PRG2"
                     /note="major polyA site"
ORIGIN      
        1 acggaggaga cgcgctttgt gctgggcgcc ggccgcgcca gccacggcct gcggcgcccg
       61 cggcaccatg atctccacca aggagaagaa caagatcccg aaggacagca tgacgcttct
      121 gccctgcttc tacttcgtgg agctgcccat agtggcttct tccatcgtat ccttgtactt
      181 cctggagctg accgacctct tcaagccggc caaggtgggc ttccagtgct atgaccgcac
      241 tctctccatg ccctacgtgg agaccaacga ggagctcatc ccgctgctga tgctgctcag
      301 cttggccttc gcggcccctg ccgcctcgat catggtggcc gagggcatgt tgtactgtct
      361 gcagtcccgg ctgtggggcc gtgccggggg gcccgccggg gcggagggca gcatcaacgc
      421 cggcggctgc aacttcaact ccttcctgcg gcgtacggtg cggtttgtgg gtgtccacgt
      481 gttcggcctg tgtgccacag ccctggtgac ggacgtgatc cagctggcca cgggttacca
      541 cactcccttc ttcctcaccg tctgcaagcc caactacact ctcctgggca cgtcctgcga
      601 ggtcaacccc tacatcacgc aggacatctg ctccggccac gacatccacg ccatcctgtc
      661 tgcacggaag accttcccgt cccagcacgc cacgctgtca gccttcgccg cggtctatgt
      721 gtcgatgtac ttcaactcgg tcatctcgga caccaccaag ctgctgaagc ccatcctggt
      781 cttcgccttt gccatcgccg cgggcgtatg cgggctcacg cagatcacgc agtaccgcag
      841 ccaccctgtg gacgtgtatg ccggcttcct catcggggcg ggcatcgctg cctacctggc
      901 ctgccacgcg gtgggcaact tccaggcccc acctgcagag aagcccgcgg ccccggcccc
      961 cgccaaggac gcgctgcggg ccctgacgca gcggggccac gactcggttt atcagcagaa
     1021 taagtcggtg agcaccgacg agctggggcc cccagggcgg ctggagggcg cgccccggcc
     1081 cgtggcccgc gagaagacct cgctgggcag cctgaagcgc gccagcgtgg acgtggacct
     1141 gctggccccg cgcagcccca tggccaagga gaacatggtg accttcagcc acacgctgcc
     1201 cagggccagc gcgccctcgc tggacgaccc cgcgcgccgc cacatgacca tccacgtgcc
     1261 gctggacgcc tcgcgctcca agcagctcat cagcgagtgg aagcagaaga gcctggaggg
     1321 ccgcggcctg gggctgcccg acgacgccag ccccgggcac ctgcgcgcgc ccgccgaacc
     1381 catggcggag gaggaggaag aggaggagga cgaagaggaa gaggaggagg aggaagagga
     1441 ggaggacgag ggcccggccc cgccctcgct ctaccccacc gtgcaggcgc ggccggggct
     1501 ggggcctcgg gtcatcctcc caccgcgcgc ggggccgccg ccgctggtgc acatcccgga
     1561 ggagggcgcg cagacggggg ccggcctgtc ccccaaaagc ggcgccgggg tgcgcgccaa
     1621 gtggctcatg atggccgaga agagcggggc ggcagtggcc aaccctccgc ggctgctgca
     1681 ggtcatcgcc atgtccaagg ctccgggcgc gccgggcccc aaggcggccg agacggcgtc
     1741 gtcgtccagc gccagctccg actcctcgca gtaccggtcg ccgtcggacc gcgactccgc
     1801 cagcatcgtg accatcgacg cgcacgcgcc gcaccacccc gtggtgcacc tgtcggccgg
     1861 cggcgcgccc tgggagtgga aggcggcggg cggcggggcc aaggcggagg ccgacggcgg
     1921 ctacgagctg ggggacctgg cgcgcggctt ccgcggcggg gccaagcccc cgggcgtgtc
     1981 ccccggctcg tcggtcagcg acgtggacca ggaggagccg cggttcgggg ccgtggccac
     2041 cgtcaacctg gccacgggcg aggggctgcc cccgctgggc gcggccgatg gggcgctggg
     2101 cccgggcagc cgggagtcca cgctgcggcg ccacgcgggc ggcctggggc tggcggagcg
     2161 cgaggcggag gcggaggccg agggctactt ccgcaagatg caggcgcgcc gcttccccga
     2221 ctagcgcggc ggggccgggg gcgggcgggg ggcgggccga gggcgcgggc ggccgcgcgg
     2281 atgctcaata aagcggcaga aaccga
//
