LOCUS       NP_001257295             718 aa            linear   PRI 30-APR-2025
DEFINITION  phospholipid phosphatase-related protein type 3 isoform 2 [Homo
            sapiens].
ACCESSION   NP_001257295
VERSION     NP_001257295.1
DBSOURCE    REFSEQ: accession NM_001270366.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 718)
  AUTHORS   Brauer,A.U., Savaskan,N.E., Kuhn,H., Prehn,S., Ninnemann,O. and
            Nitsch,R.
  TITLE     A new phospholipid phosphatase, PRG-1, is involved in axon growth
            and regenerative sprouting
  JOURNAL   Nat Neurosci 6 (6), 572-578 (2003)
   PUBMED   12730698
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004799.2, AL136596.1, AY436785.1 and BC012339.1.
            
            Summary: The proteins in the lipid phosphate phosphatase (LPP)
            family, including PRG2, are integral membrane proteins that
            modulate bioactive lipid phosphates including phosphatidate,
            lysophosphatidate, and sphingosine-1-phosphate in the context of
            cell migration, neurite retraction, and mitogenesis (Brauer et al.,
            2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) lacks an alternate segment in
            the coding region, compared to variant 1. The resulting isoform (2)
            lacks an internal region compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY436785.1, BX420549.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000520876.8/ ENSP00000430297.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..718
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     Protein         1..718
                     /product="phospholipid phosphatase-related protein type 3
                     isoform 2"
                     /EC_number="3.1.3.4"
                     /note="PAP-2-like protein 2; plasticity-related gene 2
                     protein; lipid phosphate phosphatase-related protein type
                     3; phospholipid phosphatase-related protein type 3;
                     inactive phospholipid phosphatase PLPPR3"
                     /calculated_mol_wt=75906
     Site            18..38
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6T4P5.1)"
     Site            70..90
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6T4P5.1)"
     Region          129..278
                     /region_name="PAP2_wunen"
                     /note="PAP2, wunen subfamily. Most likely a family of
                     membrane associated phosphatidic acid phosphatases. Wunen
                     is a drosophila protein expressed in the central nervous
                     system, which provides repellent activity towards
                     primordial germ cells (PGCs), controls the...; cd03384"
                     /db_xref="CDD:239479"
     Site            133..153
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6T4P5.1)"
     Site            order(152,159,205..207,252,258,262)
                     /site_type="active"
                     /db_xref="CDD:239479"
     Site            169
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6T4P5.1)"
     Site            207..227
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6T4P5.1)"
     Site            233..253
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6T4P5.1)"
     Site            263..283
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6T4P5.1)"
     Region          313..347
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6T4P5.1)"
     Site            318
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6T4P5.1)"
     Site            322
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7TPB0; propagated from
                     UniProtKB/Swiss-Prot (Q6T4P5.1)"
     Site            353
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7TPB0; propagated from
                     UniProtKB/Swiss-Prot (Q6T4P5.1)"
     Site            376
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q7TPB0; propagated from
                     UniProtKB/Swiss-Prot (Q6T4P5.1)"
     Region          416..488
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6T4P5.1)"
     Site            428
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7TPB0; propagated from
                     UniProtKB/Swiss-Prot (Q6T4P5.1)"
     Site            508
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7TPB0; propagated from
                     UniProtKB/Swiss-Prot (Q6T4P5.1)"
     Region          545..577
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6T4P5.1)"
     Site            641
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7TPB0; propagated from
                     UniProtKB/Swiss-Prot (Q6T4P5.1)"
     Region          664..702
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6T4P5.1)"
     CDS             1..718
                     /gene="PLPPR3"
                     /gene_synonym="LPPR3; LPR3; PRG-2; PRG2"
                     /coded_by="NM_001270366.2:68..2224"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS58636.1"
                     /db_xref="GeneID:79948"
                     /db_xref="HGNC:HGNC:23497"
                     /db_xref="MIM:610391"
ORIGIN      
        1 mistkeknki pkdsmtllpc fyfvelpiva ssivslyfle ltdlfkpakv gfqcydrtls
       61 mpyvetneel ipllmllsla faapaasimv aegmlyclqs rlwgraggpa gaegsinagg
      121 cnfnsflrrt vrfvgvhvfg lcatalvtdv iqlatgyhtp ffltvckpny tllgtscevn
      181 pyitqdicsg hdihailsar ktfpsqhatl safaavyvsm yfnsvisdtt kllkpilvfa
      241 faiaagvcgl tqitqyrshp vdvyagflig agiaaylach avgnfqappa ekpaapapak
      301 dalraltqrg hdsvyqqnks vstdelgppg rlegaprpva rektslgslk rasvdvdlla
      361 prspmakenm vtfshtlpra sapslddpar rhmtihvpld asrskqlise wkqkslegrg
      421 lglpddaspg hlrapaepma eeeeeeedee eeeeeeeeed egpappslyp tvqarpglgp
      481 rvilppragp pplvhipeeg aqtgaglspk sgagvrakwl mmaeksgaav anpprllqvi
      541 amskapgapg pkaaetasss sassdssqyr spsdrdsasi vtidahaphh pvvhlsagga
      601 pwewkaaggg akaeadggye lgdlargfrg gakppgvspg ssvsdvdqee prfgavatvn
      661 latgeglppl gaadgalgpg srestlrrha gglglaerea eaeaegyfrk mqarrfpd
//
