LOCUS       NM_001393892            2697 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens phospholipid phosphatase related 2 (PLPPR2),
            transcript variant 3, mRNA.
ACCESSION   NM_001393892 XM_005260017
VERSION     NM_001393892.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2697)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2697)
  AUTHORS   Savaskan,N.E., Brauer,A.U. and Nitsch,R.
  TITLE     Molecular cloning and expression regulation of PRG-3, a new member
            of the plasticity-related gene family
  JOURNAL   Eur J Neurosci 19 (1), 212-220 (2004)
   PUBMED   14750979
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024575.6.
            
            On Mar 22, 2021 this sequence version replaced XM_005260017.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138524.789008.1,
                                           SRR9304715.734222.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000688289.1/ ENSP00000510269.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AC024575.6         30713-30853
            142-316             AC024575.6         32083-32257
            317-396             AC024575.6         32941-33020
            397-585             AC024575.6         34813-35001
            586-721             AC024575.6         35102-35237
            722-993             AC024575.6         36498-36769
            994-1170            AC024575.6         37794-37970
            1171-1293           AC024575.6         38994-39116
            1294-1345           AC024575.6         39442-39493
            1346-2697           AC024575.6         39628-40979
FEATURES             Location/Qualifiers
     source          1..2697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2697
                     /gene="PLPPR2"
                     /gene_synonym="LPPR2; PRG4"
                     /note="phospholipid phosphatase related 2"
                     /db_xref="GeneID:64748"
                     /db_xref="HGNC:HGNC:29566"
                     /db_xref="MIM:619591"
     exon            1..141
                     /gene="PLPPR2"
                     /gene_synonym="LPPR2; PRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            142..316
                     /gene="PLPPR2"
                     /gene_synonym="LPPR2; PRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            317..396
                     /gene="PLPPR2"
                     /gene_synonym="LPPR2; PRG4"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..1689
                     /gene="PLPPR2"
                     /gene_synonym="LPPR2; PRG4"
                     /EC_number="3.1.3.4"
                     /note="isoform 3 is encoded by transcript variant 3;
                     plasticity related gene 4; plasticity-related gene 4
                     protein; lipid phosphate phosphatase-related protein type
                     2; phospholipid phosphatase-related protein type 2;
                     inactive phospholipid phosphatase PLPPR2"
                     /codon_start=1
                     /product="phospholipid phosphatase-related protein type 2
                     isoform 3"
                     /protein_id="NP_001380821.1"
                     /db_xref="CCDS:CCDS92519.1"
                     /db_xref="GeneID:64748"
                     /db_xref="HGNC:HGNC:29566"
                     /db_xref="MIM:619591"
                     /translation="MAGGRPHLKRSFSIIPCFVFVESVLLGIVILLAYRLEFTDTFPV
                     HTQGFFCYDSTYAKPYPGPEAASRVPPALVYALVTAGPTLTILLGELARAFFPAPPSA
                     VPVIGESTIVSGACCRFSPPVRRLVRFLGVYSFGLFTTTIFANAGQVVTGNPTPHFLS
                     VCRPNYTALGCLPPSPDRPGPDRFVTDQGACAGSPSLVAAARRAFPCKDAALCAYAVT
                     YTAMYVTLVFRVKGSRLVKPSLCLALLCPAFLVGVVRVAEYRNHWSDVLAGFLTGAAI
                     ATFLVTCVVHNFQSRPPSGRRLSPWEDLGQAPTMDSPLEKLSVAQEPEVCRPHSTPAR
                     LTPSKSQNCARRGHLIPSCVSSRAPAMCSSPRVPRPRLRSEPTPLPLPLPLPAPTPSQ
                     GPSPSSPGPGGPGGGGGRGRKLLLPTPLLRDLYTLSGLYPSPFHRDNFSPYLFASRDH
                     LL"
     exon            397..585
                     /gene="PLPPR2"
                     /gene_synonym="LPPR2; PRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            586..721
                     /gene="PLPPR2"
                     /gene_synonym="LPPR2; PRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            722..993
                     /gene="PLPPR2"
                     /gene_synonym="LPPR2; PRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1170
                     /gene="PLPPR2"
                     /gene_synonym="LPPR2; PRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1293
                     /gene="PLPPR2"
                     /gene_synonym="LPPR2; PRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1345
                     /gene="PLPPR2"
                     /gene_synonym="LPPR2; PRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..2697
                     /gene="PLPPR2"
                     /gene_synonym="LPPR2; PRG4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2674..2679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPPR2"
                     /gene_synonym="LPPR2; PRG4"
                     /note="hexamer: AATAAA"
     polyA_site      2697
                     /gene="PLPPR2"
                     /gene_synonym="LPPR2; PRG4"
                     /note="major polyA site"
ORIGIN      
        1 gtctgcgcgg cgcggccagg cccggccgac cgcgtctcgg tcttcgcgtc tgccagcctg
       61 gctggcagtc cgtctgtcca tcccgccgcg ccggggcagt ctaggcggag cgggggctca
      121 ggcggcggcg gcctcgacgc gagtgagtgt cgtggttggg gtgctggacc cagagtgcct
      181 accctcgcct gcctgggcct cagtttccac atctgcacaa tgggggtgac catccctgcc
      241 ctgctggctg ccaggagcgg ctgtgagtct tcaggcgtgg atgcagcctg ggggaagcca
      301 tagggcgctt tcacaggcct ggccttcacc atggcgggag ggagaccgca tctgaagagg
      361 agtttctcca tcatcccctg ctttgtcttc gtggagtcgg tgctgctggg cattgtgatc
      421 ctgcttgctt accgcctgga gttcacggac accttccctg tgcacaccca gggattcttc
      481 tgctatgaca gtacctacgc caagccctac ccagggcctg aggctgccag ccgagtgcct
      541 cctgctcttg tctacgcact ggtcactgcc gggcccaccc tcacgatcct gctgggagag
      601 ctggcgcgtg cctttttccc tgcaccacct tcagccgtcc cagtcatcgg ggagagcacc
      661 atcgtgtctg gggcctgctg ccgcttcagc cccccagtgc ggaggctggt ccgcttcctg
      721 ggggtctact ccttcggcct cttcaccacg accatcttcg ccaacgcggg gcaggtggtg
      781 accggcaatc ccacgccaca cttcctgtcc gtgtgccgcc ccaactacac ggccctgggc
      841 tgcctgccac cttctccgga tcggccaggt cccgaccgct ttgtcactga ccagggtgcc
      901 tgcgctggca gtcccagcct cgtggccgcc gcgcgccgcg ccttcccctg caaggatgcg
      961 gccctctgcg cctacgcggt cacctacaca gcgatgtacg tgactctcgt gttccgcgtg
     1021 aagggctccc gcctggtcaa accctcgctc tgcctggcct tgctgtgccc ggccttcctg
     1081 gtgggcgtgg tccgcgtggc cgagtaccga aaccactggt cggacgtgct ggctggcttc
     1141 ctgacagggg cggccatcgc cacctttttg gtcacctgcg ttgtgcataa ctttcagagc
     1201 cggccaccct ctggccgaag gctctctccc tgggaggacc tgggccaagc ccccaccatg
     1261 gatagccccc tcgaaaagtt aagtgtggcg caggaacccg aggtctgcag gccgcattcg
     1321 acaccggcac ggctcacccc atccaagtcg cagaactgcg cccgccgtgg ccacctgatc
     1381 cccagctgtg tctcctccag ggccccagcc atgtgttcgt cgccccgtgt gccccgtcct
     1441 cgattgaggt ctgagccgac gcccttgccc ctgcccctac ccctgccagc gcccaccccc
     1501 agccagggcc cctcgccttc ctcccctgga cctggggggc caggcggggg tggtggacgt
     1561 ggccggaagc tgctgctgcc cacgcccctg ctgcgggacc tgtacaccct gagtggactc
     1621 tatccctccc ccttccaccg ggacaacttc agcccttacc tgtttgccag ccgtgaccac
     1681 ctgctgtgag gcccgaccac ccacccagaa tctgcccagt ccccacttct tccctgccac
     1741 gcgtgtgtgt gcgtgtgcca cgtgagtgcc aaagtcccct gccccccaag ccagccagac
     1801 ccagacatta gaagatggct agaaggacat ttaggagaca tctgcctctc tggccctctg
     1861 agatatcccg atgggcacaa atggaaggtg cgcacttgcc cctactattg cccttttaag
     1921 ggccaaagct tgaccccatt ggccattgcc tggctaatga gaacccctgg ttctcagaat
     1981 tttaaccaaa aggagttggc tccaaccaat gggagccttc ccctcacttc ttagaatcct
     2041 cctgcaagag ggcaactcca gccagtgttc agcgactgaa cagccaatag gagcccttgg
     2101 tttccagaat ttctagagtg ggtgggcatg attccagtca atgggggacc gcccgtgtct
     2161 aagcatgtgc aaaggagagg agggagatga ggtcattgtt tgtcattgag tcttctctca
     2221 gaatcagcga gcccagctgt agggtggggg gcaggctccc ccatggcagg gtccttgggg
     2281 tacccctttt cctctcagcc cctccctgtg tgcggcctct ccacctctca cccactctct
     2341 cctaatcccc tacttaagta gggcttgccc cacttcagag gttttggggt tcagggtgct
     2401 gtgtctcccc ttgcctgtgc ccaggtcatc ccaaaccctt ctgttattta ttagggctgt
     2461 gggaagggtt tttcttcttt ttcttggaac ctgcccctgt tcttcacact gccccccatg
     2521 cctcagcctc atacagatgt gccatcatgg ggggcatggg tggagcagag gggctccctc
     2581 accccgggca ggcaaaggca gtgggtagag gaggcactgc ccccctttcc tgccccctcc
     2641 tcatctttaa taaagacctg gcttctcatc tttaataaag acctgtttgt aacagaa
//
