LOCUS       NM_207299               2477 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens phospholipid phosphatase related 1 (PLPPR1),
            transcript variant 1, mRNA.
ACCESSION   NM_207299
VERSION     NM_207299.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2477)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2477)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2477)
  AUTHORS   Savaskan,N.E., Brauer,A.U. and Nitsch,R.
  TITLE     Molecular cloning and expression regulation of PRG-3, a new member
            of the plasticity-related gene family
  JOURNAL   Eur J Neurosci 19 (1), 212-220 (2004)
   PUBMED   14750979
REFERENCE   4  (bases 1 to 2477)
  AUTHORS   Brauer,A.U., Savaskan,N.E., Kuhn,H., Prehn,S., Ninnemann,O. and
            Nitsch,R.
  TITLE     A new phospholipid phosphatase, PRG-1, is involved in axon growth
            and regenerative sprouting
  JOURNAL   Nat Neurosci 6 (6), 572-578 (2003)
   PUBMED   12730698
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL357935.14, BI914341.1,
            BI601921.1, BC022465.1 and AK000307.1.
            
            On Nov 22, 2018 this sequence version replaced NM_207299.1.
            
            Summary: This gene encodes a member of the plasticity-related gene
            (PRG) family. Members of the PRG family mediate lipid phosphate
            phosphatase activity in neurons and are known to be involved in
            neuronal plasticity. The protein encoded by this gene does not
            perform its function through enzymatic phospholipid degradation.
            This gene is strongly expressed in brain. It shows dynamic
            expression regulation during brain development and neuronal
            excitation. Alternatively spliced transcript variants encoding the
            same protein have been observed. [provided by RefSeq, Jul 2008].
            
            Transcript Variant:  This variant (1) represents the longer
            transcript. Both variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022465.1, SRR3476690.432329.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374874.8/ ENSP00000364008.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL357935.14        81930-81951
            23-659              BI914341.1         41-677
            660-744             BI601921.1         644-728
            745-1583            BC022465.1         456-1294
            1584-2445           AK000307.1         1427-2288
            2446-2477           BC022465.1         2161-2192
FEATURES             Location/Qualifiers
     source          1..2477
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.1"
     gene            1..2477
                     /gene="PLPPR1"
                     /gene_synonym="LPPR1; PRG-3; PRG3"
                     /note="phospholipid phosphatase related 1"
                     /db_xref="GeneID:54886"
                     /db_xref="HGNC:HGNC:25993"
                     /db_xref="MIM:619590"
     exon            1..376
                     /gene="PLPPR1"
                     /gene_synonym="LPPR1; PRG-3; PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            377..484
                     /gene="PLPPR1"
                     /gene_synonym="LPPR1; PRG-3; PRG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             422..1399
                     /gene="PLPPR1"
                     /gene_synonym="LPPR1; PRG-3; PRG3"
                     /note="plasticity related gene 3; plasticity-related gene
                     3 protein; lipid phosphate phosphatase-related protein
                     type 1; inactive 2-lysophosphatidate phosphatase PLPPR1"
                     /codon_start=1
                     /product="phospholipid phosphatase-related protein type 1"
                     /protein_id="NP_997182.1"
                     /db_xref="CCDS:CCDS6751.1"
                     /db_xref="GeneID:54886"
                     /db_xref="HGNC:HGNC:25993"
                     /db_xref="MIM:619590"
                     /translation="MAVGNNTQRSYSIIPCFIFVELVIMAGTVLLAYYFECTDTFQVH
                     IQGFFCQDGDLMKPYPGTEEESFITPLVLYCVLAATPTAIIFIGEISMYFIKSTRESL
                     IAQEKTILTGECCYLNPLLRRIIRFTGVFAFGLFATDIFVNAGQVVTGHLTPYFLTVC
                     KPNYTSADCQAHHQFINNGNICTGDLEVIEKARRSFPSKHAALSIYSALYATMYITST
                     IKTKSSRLAKPVLCLGTLCTAFLTGLNRVSEYRNHCSDVIAGFILGTAVALFLGMCVV
                     HNFKGTQGSPSKPKPEDPRGVPLMAFPRIESPLETLSAQNHSASMTEVT"
     exon            485..673
                     /gene="PLPPR1"
                     /gene_synonym="LPPR1; PRG-3; PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            674..806
                     /gene="PLPPR1"
                     /gene_synonym="LPPR1; PRG-3; PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1057
                     /gene="PLPPR1"
                     /gene_synonym="LPPR1; PRG-3; PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1234
                     /gene="PLPPR1"
                     /gene_synonym="LPPR1; PRG-3; PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1366
                     /gene="PLPPR1"
                     /gene_synonym="LPPR1; PRG-3; PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..2477
                     /gene="PLPPR1"
                     /gene_synonym="LPPR1; PRG-3; PRG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2454..2459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPPR1"
                     /gene_synonym="LPPR1; PRG-3; PRG3"
                     /note="hexamer: AAGAAA"
     polyA_site      2477
                     /gene="PLPPR1"
                     /gene_synonym="LPPR1; PRG-3; PRG3"
                     /note="major polyA site"
ORIGIN      
        1 agccttttgc tctttccttt cattaaacaa acaggagatc ctgaaacctg gaccctgtgc
       61 aagctgcagc gccaggagga ggcagcggag gaagcagagc gcgggatggg cgcccagcgg
      121 catctgtgat cccgcgcacc tccgccccac gggcgcgcgc acaaacacgg acacacacat
      181 acacacactc gcgcacacac tcgcacaaac acacactcgt acacgcccgc gccgctcgct
      241 cgccggcttg ctctcccacg caagcggaat gcagcagcgc ctggagagcg tgtctcggac
      301 cgccgcctga atgtacctcg ctcccgggag ccggacggcc cagtagggcg cactggagga
      361 cgctccgctg cgggagcctg gacagttttt gacggtgcag tcttgctata tggtgtgaga
      421 aatggctgta ggaaacaaca ctcaacgaag ttattccatc atcccgtgtt ttatatttgt
      481 tgagcttgtc atcatggctg ggacagtgct gcttgcctac tacttcgaat gcactgacac
      541 ttttcaggtg catatccaag gattcttctg tcaggacgga gacttaatga agccttaccc
      601 agggacagag gaagaaagct tcatcacccc tctggtgctc tattgtgtgc tggctgccac
      661 cccaactgct attattttta ttggtgagat atccatgtat ttcataaaat caacaagaga
      721 atccctgatt gctcaggaga aaacaattct gaccggagaa tgctgttacc tgaacccctt
      781 acttcgaagg atcataagat tcacaggggt gtttgcattt ggactttttg ctactgacat
      841 ttttgtaaac gccggacaag tggtcactgg gcacttaacg ccatacttcc tgactgtgtg
      901 caagccaaac tacaccagtg cagactgcca agcgcaccac cagtttataa acaatgggaa
      961 catttgtact ggggacctgg aagtgataga aaaggctcgg agatcctttc cctccaaaca
     1021 cgctgctctg agcatttact ccgccttata tgccacgatg tatattacaa gcacaatcaa
     1081 gacgaagagc agtcgactgg ccaagccggt gctgtgcctc ggaactctct gcacagcctt
     1141 cctgacaggc ctcaaccggg tctctgagta tcggaaccac tgctcggacg tgattgctgg
     1201 tttcatcctg ggcactgcag tggccctgtt tctgggaatg tgtgtggttc ataactttaa
     1261 aggaacgcaa ggatctcctt ccaaacccaa gcctgaggat ccccgtggag tacccctaat
     1321 ggctttccca aggatagaaa gccctctgga aaccttaagt gcacagaatc actctgcgtc
     1381 catgaccgaa gttacctgag acgactgatg tgtcacaagc tgttttttaa aatcatcttc
     1441 caattctata cttcaaaaca cacagttgct caatgtcaaa ctgtgatgac aaatattacg
     1501 tttatctagt tagaagctaa tgttttgtac attttttgta tgaggaagtg atgtagcttg
     1561 ccctgatttt tttttttttt ttttggtcag ctttaatata tttatgccag aattttaaaa
     1621 ccaacaaaat tttcttgttc aagcgtgcat tgaagaacca catttattca atggttgacg
     1681 ttgttttgtg atatttgtac acaaattttc ttttctcagt tttataaaca cagaatataa
     1741 caattcactt taaactttta ttaccacagt tgctgcctcc tccagaattt ttgaatttta
     1801 ataaaaggca aacttttgag ctgcaggaag gacaatgttg gttaataata aatctcaaag
     1861 tcaattgtag aaaaaaaatt gtcttcaaaa agaatgttgc actctgatct cttaacaaat
     1921 tgttacgttc aaagtttaaa gtgatatatt aacaaagtca cctagttata caaacaattg
     1981 tcagagaatt ctggatttgg agggtattgg ggttatatga ttctttctta gataatggcc
     2041 tctactaaat aactcaagat ctttctggaa tgtcttctgg caggcaggtg ccactgtcag
     2101 cttttctcca aaaagcagcc aacatcagcc tcccctgtca actcaacagt tttgtatctc
     2161 atattatatg gactttatat gaaaatgaat attttacagt ttgcacagta ttattttaca
     2221 gaaaaggaat cagagaatct acaacatagg gccccagaac aacagtttca ctttgtggct
     2281 tttaattatt ctagaatttt aactgcatct catttttcta gcatggtgag aactaatatg
     2341 taactccttt gattgaagga gctcttttgt ccgtacctat cagaatgttt tcttgacact
     2401 tccatgttgg ctcttctcag ctttttttgt acatattttt tttttctaaa gagaagaaaa
     2461 agttatcaca aaatgta
//
