LOCUS       NM_032728               2065 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens phospholipid phosphatase 7 (inactive) (PLPP7),
            transcript variant 1, mRNA.
ACCESSION   NM_032728
VERSION     NM_032728.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2065)
  AUTHORS   Ramirez-Martinez,A., Zhang,Y., Chen,K., Kim,J., Cenik,B.K.,
            McAnally,J.R., Cai,C., Shelton,J.M., Huang,J., Brennan,A.,
            Evers,B.M., Mammen,P.P.A., Xu,L., Bassel-Duby,R., Liu,N. and
            Olson,E.N.
  TITLE     The nuclear envelope protein Net39 is essential for muscle nuclear
            integrity and chromatin organization
  JOURNAL   Nat Commun 12 (1), 690 (2021)
   PUBMED   33514739
  REMARK    GeneRIF: The nuclear envelope protein Net39 is essential for muscle
            nuclear integrity and chromatin organization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2065)
  AUTHORS   Liu,G.H., Guan,T., Datta,K., Coppinger,J., Yates,J. 3rd and
            Gerace,L.
  TITLE     Regulation of myoblast differentiation by the nuclear envelope
            protein NET39
  JOURNAL   Mol Cell Biol 29 (21), 5800-5812 (2009)
   PUBMED   19704009
  REMARK    GeneRIF: NET39 is a muscle-enriched nuclear envelope transmembrane
            protein, which regulates initiation of myogenic differentiation via
            affecting mTOR-IGF-II pathway.
REFERENCE   3  (bases 1 to 2065)
  AUTHORS   Schirmer,E.C., Florens,L., Guan,T., Yates,J.R. 3rd and Gerace,L.
  TITLE     Nuclear membrane proteins with potential disease links found by
            subtractive proteomics
  JOURNAL   Science 301 (5638), 1380-1382 (2003)
   PUBMED   12958361
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK075207.1, BC006362.2 and AL354855.26.
            
            On Nov 23, 2018 this sequence version replaced NM_032728.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075207.1, SRR3476690.202186.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372264.4/ ENSP00000361338.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AK075207.1         30-167
            139-795             BC006362.2         125-781
            796-2065            AL354855.26        23107-24376
FEATURES             Location/Qualifiers
     source          1..2065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.13"
     gene            1..2065
                     /gene="PLPP7"
                     /gene_synonym="C9orf67; NET39; PPAPDC3"
                     /note="phospholipid phosphatase 7 (inactive)"
                     /db_xref="GeneID:84814"
                     /db_xref="HGNC:HGNC:28174"
                     /db_xref="MIM:618743"
     exon            1..726
                     /gene="PLPP7"
                     /gene_synonym="C9orf67; NET39; PPAPDC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1091
                     /gene="PLPP7"
                     /gene_synonym="C9orf67; NET39; PPAPDC3"
                     /EC_number="3.1.3.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable lipid phosphate phosphatase PPAPDC3; phosphatidic
                     acid phosphatase type 2 domain-containing protein 3;
                     phosphatidic acid phosphatase type 2 domain containing 3;
                     inactive phospholipid phosphatase 7; nuclear envelope
                     transmembrane protein NET39; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="inactive phospholipid phosphatase 7 isoform 1"
                     /protein_id="NP_116117.3"
                     /db_xref="CCDS:CCDS6942.1"
                     /db_xref="GeneID:84814"
                     /db_xref="HGNC:HGNC:28174"
                     /db_xref="MIM:618743"
                     /translation="MPASQSRARARDRNNVLNRAEFLSLNQPPKGGPEPRSSGRKASG
                     PSAQPPPAGDGARERRQSQQLPEEDCMQLNPSFKGIAFNSLLAIDICMSKRLGVCAGR
                     AASWASARSMVKLIGITGHGIPWIGGTILCLVKSSTLAGQEVLMNLLLALLLDIMTVA
                     GVQKLIKRRGPYETSPSLLDYLTMDIYAFPAGHASRAAMVSKFFLSHLVLAVPLRVLL
                     VLWALCVGLSRVMIGRHHVTDVLSGFVIGYLQFRLVELVWMPSSTCQMLISAW"
     exon            727..2065
                     /gene="PLPP7"
                     /gene_synonym="C9orf67; NET39; PPAPDC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2043..2048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPP7"
                     /gene_synonym="C9orf67; NET39; PPAPDC3"
                     /note="hexamer: AATACA"
     polyA_site      2065
                     /gene="PLPP7"
                     /gene_synonym="C9orf67; NET39; PPAPDC3"
                     /note="major polyA site"
ORIGIN      
        1 gcagctgtgg actcctcacc tcccggaggc tctgctggtg caggccccgc attggagggc
       61 tcgattggct gcccggctgg cactgacgtc cccttggagc tgggtggcag aggagataaa
      121 cagccatgtg caactctcca cactatattt aacagctgcg gcggagaagg cagggaggca
      181 gccacggtgg cggctctggg ggcagctctt gtcttcgggg agaaggccct tggagccggg
      241 ctggcatcgg ccttctcggg gtgagcgagg tcaccatgcc agcttcccag agccgggccc
      301 gtgcccggga ccgcaacaac gtcctcaacc gggctgagtt cctgtccctg aaccagcccc
      361 ccaagggggg cccggagccc cgcagctcgg gcagaaaggc ctcgggccca tcagcacagc
      421 ccccacctgc tggtgacggg gccagagagc gacgccagtc acagcagctg ccagaggagg
      481 actgcatgca gctgaacccc tccttcaagg gcatcgcctt caactccctg ctggccatcg
      541 atatctgtat gtccaagcgg ctgggggtgt gcgctggccg ggcggcgtcc tgggccagtg
      601 cccgctccat ggtcaagctc atcggcatca cgggccacgg catcccctgg atcggaggca
      661 ccatcctctg cctggtgaag agcagcacac tggccggcca ggaggtgctc atgaatctgc
      721 tcctggccct gctcctggac atcatgacgg tggccggcgt gcagaagctc atcaagcggc
      781 gcggcccgta cgagacgagc cccagcctcc tggactacct caccatggac atctacgcct
      841 tcccggccgg gcacgccagc cgcgccgcca tggtgtccaa gttcttcctc agccacctgg
      901 tgctggcggt gcccctgcgt gtgctgctgg tgctctgggc cctctgcgtg ggcctgtccc
      961 gcgtgatgat cggccgccac cacgtcacgg acgtcctctc cggctttgtc atcggctacc
     1021 tccagttccg tctggtggag ctggtctgga tgccctccag cacctgccag atgctcatct
     1081 ctgcctggtg aagcgcccgc cggcccacac aagcctctgg gggcagggct ggccctagag
     1141 aaggggcagg gggtggcgag gtggcgggcg tgggtggaac agagcggcca ggagtcagag
     1201 cggccacccc cacctcatct tcccctcctg gctggaggct ggcgaaccca ggccacccct
     1261 cccggagaca agcgtgtttg gcagtgccag gcctcttgcc cctttgcttg gactccaagt
     1321 ctcctctcta ggcagccagg acccacccat ggggacagcc ctatttagct tctgctctgg
     1381 gaacagcaaa aatcaggatg gtgggagggg ccgagtcttg tcttgtcctt tcatcatcat
     1441 gactgttgag ttcttggctg tgcccatcac gccacagcac gacgcctgcc aaaatgcccc
     1501 caacctactg cctgatgcag gtgccattgc cattagcggt catcgacagc ttagggcagc
     1561 actttccaac gggtgcccat gggacaccag cctgcgagat gcttttgggg gaaaggggtt
     1621 ttgtggttca ataactttcg gaagtgctgc acactctgtc cccaagttgg acattcacaa
     1681 aggccgttat tgccgtaaag gctctgacaa gccctataga aaagcttctt gctaaacctt
     1741 ctttaaccca tgttttctaa acttatttga ccacagaacc cttttcttgg ggaacagcta
     1801 ttaaccccca aggaattatt ggttcctcaa gtgcgttttg ggagctgctg ccagagagct
     1861 aaagggcctg gggtgtgagc tgactctcct ctggggaggc cgggtgcaca cgccacagcc
     1921 cgaggaaagt gctggccacc gcccgtgggc atcgatgagg ctttggcccc caggggccgg
     1981 actccgtgtg acctaatagg tcgtttccaa gtcacccgtt ttggatgtgc atttcatgtg
     2041 acaatacaga tgacatgcaa atggc
//
