LOCUS       NM_203453               2965 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens phospholipid phosphatase 6 (PLPP6), mRNA.
ACCESSION   NM_203453
VERSION     NM_203453.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2965)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2965)
  AUTHORS   Carlo,T., Kalwa,H. and Levy,B.D.
  TITLE     15-Epi-lipoxin A4 inhibits human neutrophil superoxide anion
            generation by regulating polyisoprenyl diphosphate phosphatase 1
  JOURNAL   FASEB J 27 (7), 2733-2741 (2013)
   PUBMED   23568778
  REMARK    GeneRIF: Data indicate that polyisoprenyl diphosphate phosphatase 1
            (PDP1) serves an integral signaling role in neutrophil
            proinflammatory responses and as a target for counter-regulatory
            mediators.
REFERENCE   3  (bases 1 to 2965)
  AUTHORS   Miriyala,S., Subramanian,T., Panchatcharam,M., Ren,H.,
            McDermott,M.I., Sunkara,M., Drennan,T., Smyth,S.S., Spielmann,H.P.
            and Morris,A.J.
  TITLE     Functional characterization of the atypical integral membrane lipid
            phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion
            of isoprenols and isoprenoid phosphates in mammalian cells
  JOURNAL   J Biol Chem 285 (18), 13918-13929 (2010)
   PUBMED   20110354
  REMARK    GeneRIF: PDP1/PPAPDC2 is a functional isoprenoid diphosphate
            phosphatase.
REFERENCE   4  (bases 1 to 2965)
  AUTHORS   Carlo,T., Petasis,N.A. and Levy,B.D.
  TITLE     Activation of polyisoprenyl diphosphate phosphatase 1 remodels
            cellular presqualene diphosphate
  JOURNAL   Biochemistry 48 (13), 2997-3004 (2009)
   PUBMED   19220020
  REMARK    GeneRIF: PDP1 can serve as a new checkpoint for polyisoprenyl
            phosphate remodeling during cell activation.[PDP1]
REFERENCE   5  (bases 1 to 2965)
  AUTHORS   Fukunaga,K., Arita,M., Takahashi,M., Morris,A.J., Pfeffer,M. and
            Levy,B.D.
  TITLE     Identification and functional characterization of a presqualene
            diphosphate phosphatase
  JOURNAL   J Biol Chem 281 (14), 9490-9497 (2006)
   PUBMED   16464866
  REMARK    GeneRIF: findings indicate that PPAPDC2 in human PMN is the first
            lipid phosphate phosphohydrolase identified for PSDP; regulation of
            this activity of the enzyme may have important roles for PMN
            activation in innate immunity
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA416947.1, AK128369.1 and BC036833.1.
            
            On Aug 31, 2019 this sequence version replaced NM_203453.4.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC038108.2, SRR1660803.13044.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381883.5/ ENSP00000371307.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                DA416947.1         1-76
            77-2400             AK128369.1         37-2360
            2401-2965           BC036833.1         324-888
FEATURES             Location/Qualifiers
     source          1..2965
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.1"
     gene            1..2965
                     /gene="PLPP6"
                     /gene_synonym="bA6J24.6; LPRP-B; PA-PSP; PDP1; PPAPDC2;
                     PSDP"
                     /note="phospholipid phosphatase 6"
                     /db_xref="GeneID:403313"
                     /db_xref="HGNC:HGNC:23682"
                     /db_xref="MIM:611666"
     exon            1..2965
                     /gene="PLPP6"
                     /gene_synonym="bA6J24.6; LPRP-B; PA-PSP; PDP1; PPAPDC2;
                     PSDP"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..970
                     /gene="PLPP6"
                     /gene_synonym="bA6J24.6; LPRP-B; PA-PSP; PDP1; PPAPDC2;
                     PSDP"
                     /EC_number="3.6.1.68"
                     /note="polyisoprenoid diphosphate phosphatase type 1;
                     presqualene diphosphate phosphatase; lipid
                     phosphatase-related protein-B; type 1 polyisoprenoid
                     diphosphate phosphatase; PPAP2 domain-containing protein
                     2; phosphatidic acid phosphatase type 2 domain-containing
                     protein 2; phosphatidic acid phosphatase type 2 domain
                     containing 2"
                     /codon_start=1
                     /product="polyisoprenoid diphosphate/phosphate
                     phosphohydrolase PLPP6"
                     /protein_id="NP_982278.3"
                     /db_xref="CCDS:CCDS34981.1"
                     /db_xref="GeneID:403313"
                     /db_xref="HGNC:HGNC:23682"
                     /db_xref="MIM:611666"
                     /translation="MPSPRRSMEGRPLGVSASSSSSSPGSPAHGGGGGGSRFEFQSLL
                     SSRATAVDPTCARLRASESPVHRRGSFPLAAAGPSQSPAPPLPEEDRMDLNPSFLGIA
                     LRSLLAIDLWLSKKLGVCAGESSSWGSVRPLMKLLEISGHGIPWLLGTLYCLCRSDSW
                     AGREVLMNLLFALLLDLLLVALIKGLVRRRRPAHNQMDMFVTLSVDKYSFPSGHATRA
                     ALMSRFILNHLVLAIPLRVLVVLWAFVLGLSRVMLGRHNVTDVAFGFFLGYMQYSIVD
                     YCWLSPHNAPVLFLLWSQR"
     regulatory      2941..2946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPP6"
                     /gene_synonym="bA6J24.6; LPRP-B; PA-PSP; PDP1; PPAPDC2;
                     PSDP"
                     /note="hexamer: AATAAA"
     polyA_site      2965
                     /gene="PLPP6"
                     /gene_synonym="bA6J24.6; LPRP-B; PA-PSP; PDP1; PPAPDC2;
                     PSDP"
                     /note="major polyA site"
ORIGIN      
        1 agtgcggaag cggaagaggc tgcagggccg ggaagcctct gtttggtccg gccaggtccc
       61 gggatccggg ccgccagctg cgatgccaag tccccggagg agcatggagg gacggccgct
      121 gggcgtctcc gcttcgagca gcagcagcag ccccggcagc ccagcccatg gcggcggtgg
      181 cggcggcagc aggtttgagt tccagtccct gctcagcagc cgcgccacgg ccgtggaccc
      241 cacctgcgcc cggctccgtg catcggagag cccagttcac cgccgcggct ccttccccct
      301 ggccgcggcg ggcccctcgc agtcgcccgc gcctccgctg cccgaggagg accgcatgga
      361 cttgaacccg tccttcctgg gcatcgccct gcgctccctg ctggccatcg acctgtggct
      421 gtccaagaag ctgggggtgt gcgcgggaga gagctcgtcg tggggcagcg tgcgacccct
      481 tatgaagctg ctggagatct cgggacacgg catcccctgg ctgctgggca ccctctactg
      541 cctgtgcagg agcgacagct gggccgggcg cgaggtgctg atgaacctgc tcttcgccct
      601 gctgttggac ctgctgctgg tggccttgat caaagggctg gtccgcaggc gccgcccggc
      661 ccacaaccag atggacatgt ttgtcactct ctcggtggac aagtactcct tcccctcggg
      721 ccatgccaca agggccgccc tgatgtcgag gttcatcctg aaccacctgg tgctggccat
      781 tccactgagg gtgctggtgg ttctgtgggc cttcgtcttg ggcctatcca gggtcatgct
      841 ggggcggcac aatgtcaccg acgtagcttt tggctttttt ctgggctaca tgcagtacag
      901 catcgtggac tattgctggc tctcacccca taatgctccg gtcctctttt tactgtggag
      961 tcaacgatga caccatctca ttgattatgg caccaggaag tctgaaggtt tccacattcg
     1021 atgatgtcaa cctaaaccag cagccatccc gcttgtccct cttaggcatt tcaggcttcc
     1081 tttgggattt caggtgtccc atgatcttga tgtgctgcta ggctggagca cacactggcc
     1141 attactgaac acagccatat tagggaaagc aaaaaaaccc aaaaaatcct ctattgtata
     1201 tttattcaac aactgtttat gtttccagga caactgcaaa gaaaacaagc tgaggtggtt
     1261 atactgttgc tgttaaaagt tggtatcagt aagatttgtg ttttgtgata atccctaaat
     1321 caacatacca cttgtaaact gaacttcgag aaagaaacat gatgttcatt ctgtaaatat
     1381 acatgcagac aggtcatgta ctaatcctag tccttttcct gaggtagatt ttaaacagta
     1441 tttttaaagt ccaagacata ggtttttcta gtttattccc tgaagatctg ttgccacagt
     1501 tgggagattt cttcttaatc ctgattttct tggtaagctt ttttacttta ttatctctat
     1561 aatttattat ctctatccat atttgtggat cgggtagtgg gaaaagagat tataatactt
     1621 gtctttctct cctctccctc catccctcaa aagatcttta tgcatttccc actactccct
     1681 tactgtcttt tagcattcag agaaaaagcc aacttgctta aagaggaatc acttaaaagg
     1741 taggcatatc taagatgctc atagaagagg aagaatggga catggcccca tgcttatttt
     1801 tgtttacaac gtaacatggc atgagagagg gcagagaaac taagttgctg gggaaagtta
     1861 gaggaactga aagtttggga ataggctgac cacatattat gccagtgacc agtatgacag
     1921 gagatggggc cctgctgcca gtcatctcca ctgaataaag aataatgctc ctctttcagg
     1981 gtaataaagt ggggaaaagg aacgtcttct caatgcaaga acataagctt tctcgtatat
     2041 acctgtatgc tacagttttt cacatggaat tccgttttct gaggtacagc acattttagg
     2101 taacagtatt taacttgaaa ttcatcatgg gagtctgctg ctataccagg cacaagataa
     2161 aactccaaaa tttctgttta cattgacctt tacatttaaa gctgttcatc catggtgcct
     2221 ccccaaatca taagaccaaa gaccaccaaa cgcagggtgg actctgctca ttattctttg
     2281 acccagaaag actggagaag gtatgtgctt taagtgctgc tctacctgaa aagaaatcct
     2341 ttaaattacc tatggaagtg atgtcctcag ataatcttaa tgactatttt ggcatttata
     2401 aatagaaatg attatggact ttgatctgcc atacggaggt tcggaacctg gagaacggct
     2461 gtgataagta ggttttgatt gagtgaaagc atgagcttgt tcagagtgag gggcatagtg
     2521 aaaaaggaac agccatgcct caaaatcaaa tcatttgcat tcccacagca tcctgaatac
     2581 cgactacctc ttcacttgct aaagcagcta aactgtgaag ctctaagtgg tttgggtttg
     2641 ttgtttaacc ttagcgagat cctttaactg cagcaatatt caagccagat atttggaagc
     2701 aaatgatatt tcctcttgca gtgtccacaa atctgaatat taggggcatg aaattaggct
     2761 taccatctga tttgtaatta caattttgga attctctgtt ttagttgctg aggcctgagt
     2821 tttctggctc ttaaagcata gatcatttca cctgatgttt ttgaagcatc ctaagtacag
     2881 tagagtagaa aactgatttc tttgttaatt gtacactgaa taatgccttt taaaaatcaa
     2941 aataaaatta acaaataatg gtgaa
//
