LOCUS       NM_001354458            2043 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens phospholipid phosphatase 5 (PLPP5), transcript variant
            8, mRNA.
ACCESSION   NM_001354458
VERSION     NM_001354458.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2043)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2043)
  AUTHORS   Wu,J.C., Jia,H.L., Li,Z.R., Zhou,K.L., Qin,L.X., Dong,Q.Z. and
            Ren,N.
  TITLE     Genomic aberrations in the HTPAP promoter affect tumor metastasis
            and clinical prognosis of hepatocellular carcinoma
  JOURNAL   PLoS One 9 (3), e90528 (2014)
   PUBMED   24603412
  REMARK    GeneRIF: genetic variants at loci -1053 and +64 of the HTPAP
            promoter affect the expression of HTPAP, which might be a novel
            determinant and target for HCC prognosis
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2043)
  AUTHORS   Mahmood,S.F., Gruel,N., Nicolle,R., Chapeaublanc,E., Delattre,O.,
            Radvanyi,F. and Bernard-Pierrot,I.
  TITLE     PPAPDC1B and WHSC1L1 are common drivers of the 8p11-12 amplicon,
            not only in breast tumors but also in pancreatic adenocarcinomas
            and lung tumors
  JOURNAL   Am J Pathol 183 (5), 1634-1644 (2013)
   PUBMED   24051013
  REMARK    GeneRIF: PPAPDC1B and WHSC1L1 played a major role in regulating the
            survival of breast cancer, pancreatic adenocarcinoma and small-cell
            lung cancer-derived cell lines.
REFERENCE   4  (bases 1 to 2043)
  AUTHORS   Ren,N., Wu,J.C., Dong,Q.Z., Sun,H.J., Jia,H.L., Li,G.C., Sun,B.S.,
            Dai,C., Shi,J., Wei,J.W., Sheng,Y.Y., Zhou,H.J., Ye,Q.H. and
            Qin,L.X.
  TITLE     Association of specific genotypes in metastatic suppressor HTPAP
            with tumor metastasis and clinical prognosis in hepatocellular
            carcinoma
  JOURNAL   Cancer Res 71 (9), 3278-3286 (2011)
   PUBMED   21531764
  REMARK    GeneRIF: Findings identify an HTPAP genotype and associated gene
            expression pattern that favors metastasis progression and that
            could be used to predict tumor metastasis and prognosis in HCC
            patients.
            Erratum:[Cancer Res. 2011 Jun 15;71(12):4325]
REFERENCE   5  (bases 1 to 2043)
  AUTHORS   Dai,C., Dong,Q.Z., Ren,N., Zhu,J.J., Zhou,H.J., Sun,H.J., Wang,G.,
            Zhang,X.F., Xue,Y.H., Jia,H.L., Ye,Q.H. and Qin,L.X.
  TITLE     Downregulation of HTPAP transcript variant 1 correlates with tumor
            metastasis and poor survival in patients with hepatocellular
            carcinoma
  JOURNAL   Cancer Sci 102 (3), 583-590 (2011)
   PUBMED   21219541
  REMARK    GeneRIF: HTPAP-1 may be the transcript of HTPAP to exhibit a
            suppressive role on hepatocellular cancer(HCC) metastasis, and can
            be a prognostic marker for HCC.
REFERENCE   6  (bases 1 to 2043)
  AUTHORS   Bernard-Pierrot,I., Gruel,N., Stransky,N., Vincent-Salomon,A.,
            Reyal,F., Raynal,V., Vallot,C., Pierron,G., Radvanyi,F. and
            Delattre,O.
  TITLE     Characterization of the recurrent 8p11-12 amplicon identifies
            PPAPDC1B, a phosphatase protein, as a new therapeutic target in
            breast cancer
  JOURNAL   Cancer Res 68 (17), 7165-7175 (2008)
   PUBMED   18757432
  REMARK    GeneRIF: microarray experiments on PPAPDC1B knockdown indicated
            this gene interfered with cell signaling pathways, including
            Janus-activated kinase-signal transducer and activator of
            transcription, mitogen-activated protein kinase, and protein kinase
            C pathways
REFERENCE   7  (bases 1 to 2043)
  AUTHORS   Takeuchi,M., Harigai,M., Momohara,S., Ball,E., Abe,J., Furuichi,K.
            and Kamatani,N.
  TITLE     Cloning and characterization of DPPL1 and DPPL2, representatives of
            a novel type of mammalian phosphatidate phosphatase
  JOURNAL   Gene 399 (2), 174-180 (2007)
   PUBMED   17590538
  REMARK    GeneRIF: DPPL1 and DPPL2 represent a novel type of mammalian
            phosphatidate phosphatase.
REFERENCE   8  (bases 1 to 2043)
  AUTHORS   Wu,X., Jia,H.L., Wang,Y.F., Ren,N., Ye,Q.H., Sun,H.C., Wang,L.,
            Liu,Y.K., Tang,Z.Y. and Qin,L.X.
  TITLE     HTPAP gene on chromosome 8p is a candidate metastasis suppressor
            for human hepatocellular carcinoma
  JOURNAL   Oncogene 25 (12), 1832-1840 (2006)
   PUBMED   16261160
  REMARK    GeneRIF: HTPAP is a novel metastatic suppressor gene for
            hepatocellular carcinoma
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087362.13.
            
            On Jun 1, 2019 this sequence version replaced NM_001354458.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.221569.1,
                                           SRR1803614.60698.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC087362.13        29125-29223         c
            100-208             AC087362.13        28881-28989         c
            209-272             AC087362.13        27896-27959         c
            273-397             AC087362.13        27266-27390         c
            398-568             AC087362.13        26140-26310         c
            569-2043            AC087362.13        23129-24603         c
FEATURES             Location/Qualifiers
     source          1..2043
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.23"
     gene            1..2043
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /note="phospholipid phosphatase 5"
                     /db_xref="GeneID:84513"
                     /db_xref="HGNC:HGNC:25026"
                     /db_xref="MIM:610626"
     exon            1..99
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            100..208
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            209..272
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            273..397
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..729
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /EC_number="3.1.3.4"
                     /EC_number="3.6.1.75"
                     /note="isoform 8 is encoded by transcript variant 8;
                     diacylglycerol pyrophosphate like 1; phosphatidate
                     phosphatase PPAPDC1B; phosphatidic acid phosphatase type 2
                     domain-containing protein 1B; phosphatidic acid
                     phosphatase type 2 domain containing 1B; diacylglycerol
                     pyrophosphate phosphatase-like 1; testicular secretory
                     protein Li 38"
                     /codon_start=1
                     /product="phospholipid phosphatase 5 isoform 8"
                     /protein_id="NP_001341387.1"
                     /db_xref="CCDS:CCDS87598.1"
                     /db_xref="GeneID:84513"
                     /db_xref="HGNC:HGNC:25026"
                     /db_xref="MIM:610626"
                     /translation="MCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTP
                     QGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYYPP
                     LTDAECHKPFQDKLVLSTAQKPGDSYCFDI"
     exon            398..568
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            569..2043
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2020..2025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /note="hexamer: AGTAAA"
     polyA_site      2043
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /note="major polyA site"
ORIGIN      
        1 agcgtcgctc ggagctcgcg gccggatggg gaaggcggcg gcggcggtgg cctttggggc
       61 cgaagtgggc gtgcggctcg cgctgttcgc ggccttcctg gtgacggagc tgctcccccc
      121 gttccagaga ctcatccagc cggaggagat gtggctctac cggaacccct acgtggaggc
      181 ggagtatttc cccaccaagc cgatgtttct gccagccttg ccctggctct gaatggcgtc
      241 tttaccaaca caataaaact gatcgtaggg aggccacgcc cagatttctt ctaccgctgc
      301 ttccctgatg ggctagccca ttctgacttg atgtgtacag gggataagga cgtggtgaat
      361 gagggccgaa agagcttccc cagtggacat tcttcctttg catttgctgg tctggccttt
      421 gcgtccttct acctggcagg gaagttacac tgcttcacac cacaaggccg tgggaaatct
      481 tggaggttct gtgcctttct gtcacctcta ctttttgcag ctgtgattgc actgtcccgc
      541 acatgtgact acaagcatca ctggcaagat gtactagttg gatccatgat tggaatgaca
      601 tttgcctatg tctgctatcg gcagtattat cctcctctga ctgatgcaga atgccataaa
      661 ccatttcaag acaaacttgt actttccact gcacagaagc ctggggattc ttattgtttt
      721 gatatttaaa aattgaatct ggccgggcgt ggtggctcat gcctgtaatc ccaacacttt
      781 gggaggctga ggagggtgga tcacctgagg tcaggaccag cctggccaac atggtgaacc
      841 ctgtctctac taaaaataca aaaattagcc aggagttgtg tgccgtaatc ccagctacct
      901 gggaggctga ggtaggagaa ttgcttgaac ctgggagctg gaggttccag tgagccgaga
      961 tcgcaccact gcactccagc ctaggcaaca gagtgagacc ccatctcaaa aaaaaaaaaa
     1021 attgaatcta tctcaataga gaacaggtga actagccctc ctaaccggac catgcacaag
     1081 acaagaaatt ctagcctttt tttccccttc caaggtgcaa gtgaggacat aagccacact
     1141 gtattctgcc tccaaatgat tacacacttt tgcccctgct catctatctt gaggagttac
     1201 ggttcttttc cactactgta tgccacatgt tctagtaaaa ggatctttca aaggtgtcca
     1261 acaccttatg aatctggtct atcagattaa tatctgaaga tctacagtgt ttttacattt
     1321 aatttaaatg ccattcttag aaggatcttg tcacaaagaa gcctttacat agccccacct
     1381 tgtctcagaa gctagagttc attatcaaaa cttaatttcc atttcatata gctcaaaatc
     1441 ttaaaatcta gggcatggcc aactaaatta ctttgattct gtttaccttc tctgatgaca
     1501 attccatcaa gccttaaata ggaaaatgtc gaatctaggg taatttatca cttttgtgtg
     1561 catcttatct gagtccagcc atctggtact gctgtgcatt ttgaacaccg tgggcataaa
     1621 caatttgttg aattactaag tgaaaacaat aataaagaag aaaatggtca ggagtgtggt
     1681 ttcagcacta ctaacagatg actgtttcta cctcatttga ccataactgt acttgtgagc
     1741 ttctttcctt ccattcatga ctgaagatct gctcaaatgc accaacactg ccaagtgact
     1801 aaggtagaaa agaaaaatga caggtatcgt catctgaagg acagatgaat ctttttctgc
     1861 cccttcttca caatggaata taaggaacaa ttatgggatg tcatcagaat ggatgccata
     1921 ggacctacag ctccctttct ctttattgtg attatacttt aaatatgaca ttgtctttta
     1981 tgtgtatgtt cctatatttt caatgtatct ttttccttca gtaaacctga tattcaaata
     2041 aaa
//
