LOCUS       NM_001354452            2080 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens phospholipid phosphatase 5 (PLPP5), transcript variant
            4, mRNA.
ACCESSION   NM_001354452
VERSION     NM_001354452.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2080)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2080)
  AUTHORS   Wu,J.C., Jia,H.L., Li,Z.R., Zhou,K.L., Qin,L.X., Dong,Q.Z. and
            Ren,N.
  TITLE     Genomic aberrations in the HTPAP promoter affect tumor metastasis
            and clinical prognosis of hepatocellular carcinoma
  JOURNAL   PLoS One 9 (3), e90528 (2014)
   PUBMED   24603412
  REMARK    GeneRIF: genetic variants at loci -1053 and +64 of the HTPAP
            promoter affect the expression of HTPAP, which might be a novel
            determinant and target for HCC prognosis
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2080)
  AUTHORS   Mahmood,S.F., Gruel,N., Nicolle,R., Chapeaublanc,E., Delattre,O.,
            Radvanyi,F. and Bernard-Pierrot,I.
  TITLE     PPAPDC1B and WHSC1L1 are common drivers of the 8p11-12 amplicon,
            not only in breast tumors but also in pancreatic adenocarcinomas
            and lung tumors
  JOURNAL   Am J Pathol 183 (5), 1634-1644 (2013)
   PUBMED   24051013
  REMARK    GeneRIF: PPAPDC1B and WHSC1L1 played a major role in regulating the
            survival of breast cancer, pancreatic adenocarcinoma and small-cell
            lung cancer-derived cell lines.
REFERENCE   4  (bases 1 to 2080)
  AUTHORS   Ren,N., Wu,J.C., Dong,Q.Z., Sun,H.J., Jia,H.L., Li,G.C., Sun,B.S.,
            Dai,C., Shi,J., Wei,J.W., Sheng,Y.Y., Zhou,H.J., Ye,Q.H. and
            Qin,L.X.
  TITLE     Association of specific genotypes in metastatic suppressor HTPAP
            with tumor metastasis and clinical prognosis in hepatocellular
            carcinoma
  JOURNAL   Cancer Res 71 (9), 3278-3286 (2011)
   PUBMED   21531764
  REMARK    GeneRIF: Findings identify an HTPAP genotype and associated gene
            expression pattern that favors metastasis progression and that
            could be used to predict tumor metastasis and prognosis in HCC
            patients.
            Erratum:[Cancer Res. 2011 Jun 15;71(12):4325]
REFERENCE   5  (bases 1 to 2080)
  AUTHORS   Dai,C., Dong,Q.Z., Ren,N., Zhu,J.J., Zhou,H.J., Sun,H.J., Wang,G.,
            Zhang,X.F., Xue,Y.H., Jia,H.L., Ye,Q.H. and Qin,L.X.
  TITLE     Downregulation of HTPAP transcript variant 1 correlates with tumor
            metastasis and poor survival in patients with hepatocellular
            carcinoma
  JOURNAL   Cancer Sci 102 (3), 583-590 (2011)
   PUBMED   21219541
  REMARK    GeneRIF: HTPAP-1 may be the transcript of HTPAP to exhibit a
            suppressive role on hepatocellular cancer(HCC) metastasis, and can
            be a prognostic marker for HCC.
REFERENCE   6  (bases 1 to 2080)
  AUTHORS   Bernard-Pierrot,I., Gruel,N., Stransky,N., Vincent-Salomon,A.,
            Reyal,F., Raynal,V., Vallot,C., Pierron,G., Radvanyi,F. and
            Delattre,O.
  TITLE     Characterization of the recurrent 8p11-12 amplicon identifies
            PPAPDC1B, a phosphatase protein, as a new therapeutic target in
            breast cancer
  JOURNAL   Cancer Res 68 (17), 7165-7175 (2008)
   PUBMED   18757432
  REMARK    GeneRIF: microarray experiments on PPAPDC1B knockdown indicated
            this gene interfered with cell signaling pathways, including
            Janus-activated kinase-signal transducer and activator of
            transcription, mitogen-activated protein kinase, and protein kinase
            C pathways
REFERENCE   7  (bases 1 to 2080)
  AUTHORS   Takeuchi,M., Harigai,M., Momohara,S., Ball,E., Abe,J., Furuichi,K.
            and Kamatani,N.
  TITLE     Cloning and characterization of DPPL1 and DPPL2, representatives of
            a novel type of mammalian phosphatidate phosphatase
  JOURNAL   Gene 399 (2), 174-180 (2007)
   PUBMED   17590538
  REMARK    GeneRIF: DPPL1 and DPPL2 represent a novel type of mammalian
            phosphatidate phosphatase.
REFERENCE   8  (bases 1 to 2080)
  AUTHORS   Wu,X., Jia,H.L., Wang,Y.F., Ren,N., Ye,Q.H., Sun,H.C., Wang,L.,
            Liu,Y.K., Tang,Z.Y. and Qin,L.X.
  TITLE     HTPAP gene on chromosome 8p is a candidate metastasis suppressor
            for human hepatocellular carcinoma
  JOURNAL   Oncogene 25 (12), 1832-1840 (2006)
   PUBMED   16261160
  REMARK    GeneRIF: HTPAP is a novel metastatic suppressor gene for
            hepatocellular carcinoma
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087362.13.
            
            On May 31, 2019 this sequence version replaced NM_001354452.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.460939.1,
                                           SRR1163655.144670.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC087362.13        29125-29223         c
            100-208             AC087362.13        28881-28989         c
            209-245             AC087362.13        28370-28406         c
            246-309             AC087362.13        27896-27959         c
            310-434             AC087362.13        27266-27390         c
            435-605             AC087362.13        26140-26310         c
            606-2080            AC087362.13        23129-24603         c
FEATURES             Location/Qualifiers
     source          1..2080
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.23"
     gene            1..2080
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /note="phospholipid phosphatase 5"
                     /db_xref="GeneID:84513"
                     /db_xref="HGNC:HGNC:25026"
                     /db_xref="MIM:610626"
     exon            1..99
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..766
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /EC_number="3.1.3.4"
                     /EC_number="3.6.1.75"
                     /note="isoform 4 is encoded by transcript variant 4;
                     diacylglycerol pyrophosphate like 1; phosphatidate
                     phosphatase PPAPDC1B; phosphatidic acid phosphatase type 2
                     domain-containing protein 1B; phosphatidic acid
                     phosphatase type 2 domain containing 1B; diacylglycerol
                     pyrophosphate phosphatase-like 1; testicular secretory
                     protein Li 38"
                     /codon_start=1
                     /product="phospholipid phosphatase 5 isoform 4"
                     /protein_id="NP_001341381.1"
                     /db_xref="GeneID:84513"
                     /db_xref="HGNC:HGNC:25026"
                     /db_xref="MIM:610626"
                     /translation="MGKAAAAVAFGAEVGVRLALFAAFLVTELLPPFQRLIQPEEMWL
                     YRNPYVEAEYFPTKPMFKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFY
                     RCFPDGLAHSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPQG
                     RGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYYPPLT
                     DAECHKPFQDKLVLSTAQKPGDSYCFDI"
     exon            100..208
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            209..245
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            246..309
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            310..434
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            435..605
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            606..2080
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2057..2062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /note="hexamer: AGTAAA"
     polyA_site      2080
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /note="major polyA site"
ORIGIN      
        1 agcgtcgctc ggagctcgcg gccggatggg gaaggcggcg gcggcggtgg cctttggggc
       61 cgaagtgggc gtgcggctcg cgctgttcgc ggccttcctg gtgacggagc tgctcccccc
      121 gttccagaga ctcatccagc cggaggagat gtggctctac cggaacccct acgtggaggc
      181 ggagtatttc cccaccaagc cgatgtttaa ggcagacaca agagacagca gacaagcctg
      241 cctggctgcc agccttgccc tggctctgaa tggcgtcttt accaacacaa taaaactgat
      301 cgtagggagg ccacgcccag atttcttcta ccgctgcttc cctgatgggc tagcccattc
      361 tgacttgatg tgtacagggg ataaggacgt ggtgaatgag ggccgaaaga gcttccccag
      421 tggacattct tcctttgcat ttgctggtct ggcctttgcg tccttctacc tggcagggaa
      481 gttacactgc ttcacaccac aaggccgtgg gaaatcttgg aggttctgtg cctttctgtc
      541 acctctactt tttgcagctg tgattgcact gtcccgcaca tgtgactaca agcatcactg
      601 gcaagatgta ctagttggat ccatgattgg aatgacattt gcctatgtct gctatcggca
      661 gtattatcct cctctgactg atgcagaatg ccataaacca tttcaagaca aacttgtact
      721 ttccactgca cagaagcctg gggattctta ttgttttgat atttaaaaat tgaatctggc
      781 cgggcgtggt ggctcatgcc tgtaatccca acactttggg aggctgagga gggtggatca
      841 cctgaggtca ggaccagcct ggccaacatg gtgaaccctg tctctactaa aaatacaaaa
      901 attagccagg agttgtgtgc cgtaatccca gctacctggg aggctgaggt aggagaattg
      961 cttgaacctg ggagctggag gttccagtga gccgagatcg caccactgca ctccagccta
     1021 ggcaacagag tgagacccca tctcaaaaaa aaaaaaaatt gaatctatct caatagagaa
     1081 caggtgaact agccctccta accggaccat gcacaagaca agaaattcta gccttttttt
     1141 ccccttccaa ggtgcaagtg aggacataag ccacactgta ttctgcctcc aaatgattac
     1201 acacttttgc ccctgctcat ctatcttgag gagttacggt tcttttccac tactgtatgc
     1261 cacatgttct agtaaaagga tctttcaaag gtgtccaaca ccttatgaat ctggtctatc
     1321 agattaatat ctgaagatct acagtgtttt tacatttaat ttaaatgcca ttcttagaag
     1381 gatcttgtca caaagaagcc tttacatagc cccaccttgt ctcagaagct agagttcatt
     1441 atcaaaactt aatttccatt tcatatagct caaaatctta aaatctaggg catggccaac
     1501 taaattactt tgattctgtt taccttctct gatgacaatt ccatcaagcc ttaaatagga
     1561 aaatgtcgaa tctagggtaa tttatcactt ttgtgtgcat cttatctgag tccagccatc
     1621 tggtactgct gtgcattttg aacaccgtgg gcataaacaa tttgttgaat tactaagtga
     1681 aaacaataat aaagaagaaa atggtcagga gtgtggtttc agcactacta acagatgact
     1741 gtttctacct catttgacca taactgtact tgtgagcttc tttccttcca ttcatgactg
     1801 aagatctgct caaatgcacc aacactgcca agtgactaag gtagaaaaga aaaatgacag
     1861 gtatcgtcat ctgaaggaca gatgaatctt tttctgcccc ttcttcacaa tggaatataa
     1921 ggaacaatta tgggatgtca tcagaatgga tgccatagga cctacagctc cctttctctt
     1981 tattgtgatt atactttaaa tatgacattg tcttttatgt gtatgttcct atattttcaa
     2041 tgtatctttt tccttcagta aacctgatat tcaaataaaa
//
