LOCUS       NM_001102559            2134 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens phospholipid phosphatase 5 (PLPP5), transcript variant
            1, mRNA.
ACCESSION   NM_001102559
VERSION     NM_001102559.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2134)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2134)
  AUTHORS   Wu,J.C., Jia,H.L., Li,Z.R., Zhou,K.L., Qin,L.X., Dong,Q.Z. and
            Ren,N.
  TITLE     Genomic aberrations in the HTPAP promoter affect tumor metastasis
            and clinical prognosis of hepatocellular carcinoma
  JOURNAL   PLoS One 9 (3), e90528 (2014)
   PUBMED   24603412
  REMARK    GeneRIF: genetic variants at loci -1053 and +64 of the HTPAP
            promoter affect the expression of HTPAP, which might be a novel
            determinant and target for HCC prognosis
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2134)
  AUTHORS   Mahmood,S.F., Gruel,N., Nicolle,R., Chapeaublanc,E., Delattre,O.,
            Radvanyi,F. and Bernard-Pierrot,I.
  TITLE     PPAPDC1B and WHSC1L1 are common drivers of the 8p11-12 amplicon,
            not only in breast tumors but also in pancreatic adenocarcinomas
            and lung tumors
  JOURNAL   Am J Pathol 183 (5), 1634-1644 (2013)
   PUBMED   24051013
  REMARK    GeneRIF: PPAPDC1B and WHSC1L1 played a major role in regulating the
            survival of breast cancer, pancreatic adenocarcinoma and small-cell
            lung cancer-derived cell lines.
REFERENCE   4  (bases 1 to 2134)
  AUTHORS   Ren,N., Wu,J.C., Dong,Q.Z., Sun,H.J., Jia,H.L., Li,G.C., Sun,B.S.,
            Dai,C., Shi,J., Wei,J.W., Sheng,Y.Y., Zhou,H.J., Ye,Q.H. and
            Qin,L.X.
  TITLE     Association of specific genotypes in metastatic suppressor HTPAP
            with tumor metastasis and clinical prognosis in hepatocellular
            carcinoma
  JOURNAL   Cancer Res 71 (9), 3278-3286 (2011)
   PUBMED   21531764
  REMARK    GeneRIF: Findings identify an HTPAP genotype and associated gene
            expression pattern that favors metastasis progression and that
            could be used to predict tumor metastasis and prognosis in HCC
            patients.
            Erratum:[Cancer Res. 2011 Jun 15;71(12):4325]
REFERENCE   5  (bases 1 to 2134)
  AUTHORS   Dai,C., Dong,Q.Z., Ren,N., Zhu,J.J., Zhou,H.J., Sun,H.J., Wang,G.,
            Zhang,X.F., Xue,Y.H., Jia,H.L., Ye,Q.H. and Qin,L.X.
  TITLE     Downregulation of HTPAP transcript variant 1 correlates with tumor
            metastasis and poor survival in patients with hepatocellular
            carcinoma
  JOURNAL   Cancer Sci 102 (3), 583-590 (2011)
   PUBMED   21219541
  REMARK    GeneRIF: HTPAP-1 may be the transcript of HTPAP to exhibit a
            suppressive role on hepatocellular cancer(HCC) metastasis, and can
            be a prognostic marker for HCC.
REFERENCE   6  (bases 1 to 2134)
  AUTHORS   Bernard-Pierrot,I., Gruel,N., Stransky,N., Vincent-Salomon,A.,
            Reyal,F., Raynal,V., Vallot,C., Pierron,G., Radvanyi,F. and
            Delattre,O.
  TITLE     Characterization of the recurrent 8p11-12 amplicon identifies
            PPAPDC1B, a phosphatase protein, as a new therapeutic target in
            breast cancer
  JOURNAL   Cancer Res 68 (17), 7165-7175 (2008)
   PUBMED   18757432
  REMARK    GeneRIF: microarray experiments on PPAPDC1B knockdown indicated
            this gene interfered with cell signaling pathways, including
            Janus-activated kinase-signal transducer and activator of
            transcription, mitogen-activated protein kinase, and protein kinase
            C pathways
REFERENCE   7  (bases 1 to 2134)
  AUTHORS   Takeuchi,M., Harigai,M., Momohara,S., Ball,E., Abe,J., Furuichi,K.
            and Kamatani,N.
  TITLE     Cloning and characterization of DPPL1 and DPPL2, representatives of
            a novel type of mammalian phosphatidate phosphatase
  JOURNAL   Gene 399 (2), 174-180 (2007)
   PUBMED   17590538
  REMARK    GeneRIF: DPPL1 and DPPL2 represent a novel type of mammalian
            phosphatidate phosphatase.
REFERENCE   8  (bases 1 to 2134)
  AUTHORS   Wu,X., Jia,H.L., Wang,Y.F., Ren,N., Ye,Q.H., Sun,H.C., Wang,L.,
            Liu,Y.K., Tang,Z.Y. and Qin,L.X.
  TITLE     HTPAP gene on chromosome 8p is a candidate metastasis suppressor
            for human hepatocellular carcinoma
  JOURNAL   Oncogene 25 (12), 1832-1840 (2006)
   PUBMED   16261160
  REMARK    GeneRIF: HTPAP is a novel metastatic suppressor gene for
            hepatocellular carcinoma
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087362.13, DB458595.1, BC106014.1, BC033025.1 and AA761242.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001102559.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005578.1, SRR1660803.190383.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000424479.7/ ENSP00000392553.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC087362.13        29220-29223         c
            5-34                DB458595.1         2-31
            35-659              BC106014.1         1-625
            660-1112            BC033025.1         716-1168
            1113-2129           BC033025.1         1171-2187
            2130-2134           AA761242.1         22-26               c
FEATURES             Location/Qualifiers
     source          1..2134
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.23"
     gene            1..2134
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /note="phospholipid phosphatase 5"
                     /db_xref="GeneID:84513"
                     /db_xref="HGNC:HGNC:25026"
                     /db_xref="MIM:610626"
     exon            1..99
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..820
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /EC_number="3.1.3.4"
                     /EC_number="3.6.1.75"
                     /note="isoform 1 is encoded by transcript variant 1;
                     diacylglycerol pyrophosphate like 1; phosphatidate
                     phosphatase PPAPDC1B; phosphatidic acid phosphatase type 2
                     domain-containing protein 1B; phosphatidic acid
                     phosphatase type 2 domain containing 1B; diacylglycerol
                     pyrophosphate phosphatase-like 1; testicular secretory
                     protein Li 38"
                     /codon_start=1
                     /product="phospholipid phosphatase 5 isoform 1"
                     /protein_id="NP_001096029.1"
                     /db_xref="CCDS:CCDS47841.1"
                     /db_xref="GeneID:84513"
                     /db_xref="HGNC:HGNC:25026"
                     /db_xref="MIM:610626"
                     /translation="MGKAAAAVAFGAEVGVRLALFAAFLVTELLPPFQRLIQPEEMWL
                     YRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGV
                     FTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGL
                     AFASFYLAGKLHCFTPQGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSM
                     IGMTFAYVCYRQYYPPLTDAECHKPFQDKLVLSTAQKPGDSYCFDI"
     exon            100..208
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            209..299
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            300..363
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            364..488
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            489..659
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     exon            660..2134
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2111..2116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /note="hexamer: AGTAAA"
     polyA_site      2134
                     /gene="PLPP5"
                     /gene_synonym="DPPL1; HTPAP; PPAPDC1B"
                     /note="major polyA site"
ORIGIN      
        1 agcgtcgctc ggagctcgcg gccggatggg gaaggcggcg gcggcggtgg cctttggggc
       61 cgaagtgggc gtgcggctcg cgctgttcgc ggccttcctg gtgacggagc tgctcccccc
      121 gttccagaga ctcatccagc cggaggagat gtggctctac cggaacccct acgtggaggc
      181 ggagtatttc cccaccaagc cgatgtttgt tattgcattt ctctctccac tgtctctgat
      241 cttcctggcc aaatttctca agaaggcaga cacaagagac agcagacaag cctgcctggc
      301 tgccagcctt gccctggctc tgaatggcgt ctttaccaac acaataaaac tgatcgtagg
      361 gaggccacgc ccagatttct tctaccgctg cttccctgat gggctagccc attctgactt
      421 gatgtgtaca ggggataagg acgtggtgaa tgagggccga aagagcttcc ccagtggaca
      481 ttcttccttt gcatttgctg gtctggcctt tgcgtccttc tacctggcag ggaagttaca
      541 ctgcttcaca ccacaaggcc gtgggaaatc ttggaggttc tgtgcctttc tgtcacctct
      601 actttttgca gctgtgattg cactgtcccg cacatgtgac tacaagcatc actggcaaga
      661 tgtactagtt ggatccatga ttggaatgac atttgcctat gtctgctatc ggcagtatta
      721 tcctcctctg actgatgcag aatgccataa accatttcaa gacaaacttg tactttccac
      781 tgcacagaag cctggggatt cttattgttt tgatatttaa aaattgaatc tggccgggcg
      841 tggtggctca tgcctgtaat cccaacactt tgggaggctg aggagggtgg atcacctgag
      901 gtcaggacca gcctggccaa catggtgaac cctgtctcta ctaaaaatac aaaaattagc
      961 caggagttgt gtgccgtaat cccagctacc tgggaggctg aggtaggaga attgcttgaa
     1021 cctgggagct ggaggttcca gtgagccgag atcgcaccac tgcactccag cctaggcaac
     1081 agagtgagac cccatctcaa aaaaaaaaaa aattgaatct atctcaatag agaacaggtg
     1141 aactagccct cctaaccgga ccatgcacaa gacaagaaat tctagccttt ttttcccctt
     1201 ccaaggtgca agtgaggaca taagccacac tgtattctgc ctccaaatga ttacacactt
     1261 ttgcccctgc tcatctatct tgaggagtta cggttctttt ccactactgt atgccacatg
     1321 ttctagtaaa aggatctttc aaaggtgtcc aacaccttat gaatctggtc tatcagatta
     1381 atatctgaag atctacagtg tttttacatt taatttaaat gccattctta gaaggatctt
     1441 gtcacaaaga agcctttaca tagccccacc ttgtctcaga agctagagtt cattatcaaa
     1501 acttaatttc catttcatat agctcaaaat cttaaaatct agggcatggc caactaaatt
     1561 actttgattc tgtttacctt ctctgatgac aattccatca agccttaaat aggaaaatgt
     1621 cgaatctagg gtaatttatc acttttgtgt gcatcttatc tgagtccagc catctggtac
     1681 tgctgtgcat tttgaacacc gtgggcataa acaatttgtt gaattactaa gtgaaaacaa
     1741 taataaagaa gaaaatggtc aggagtgtgg tttcagcact actaacagat gactgtttct
     1801 acctcatttg accataactg tacttgtgag cttctttcct tccattcatg actgaagatc
     1861 tgctcaaatg caccaacact gccaagtgac taaggtagaa aagaaaaatg acaggtatcg
     1921 tcatctgaag gacagatgaa tctttttctg ccccttcttc acaatggaat ataaggaaca
     1981 attatgggat gtcatcagaa tggatgccat aggacctaca gctccctttc tctttattgt
     2041 gattatactt taaatatgac attgtctttt atgtgtatgt tcctatattt tcaatgtatc
     2101 tttttccttc agtaaacctg atattcaaat aaaa
//
