LOCUS       NM_001030059            3458 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens phospholipid phosphatase 4 (PLPP4), transcript variant
            1, mRNA.
ACCESSION   NM_001030059 XM_113641
VERSION     NM_001030059.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3458)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3458)
  AUTHORS   Yang,H., Hong,D., Cho,S.Y., Park,Y.S., Ko,W.R., Kim,J.H., Hur,H.,
            Lee,J., Kim,S.J., Kwon,S.Y., Lee,J.H., Park,D.Y., Song,K.S.,
            Chang,H., Ryu,M.H., Cho,K.S., Kang,J.W., Kook,M.C., Thiessen,N.,
            He,A., Mungall,A., Han,S.U. and Kim,H.K.
  TITLE     RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent
            and prognostic in diffuse gastric cancer
  JOURNAL   Nat Commun 9 (1), 4439 (2018)
   PUBMED   30361512
  REMARK    GeneRIF: PPAPDC1A fusions and in-frame fusions containing a RhoGAP
            domain clearly define the aggressive subset (7.5%) of diffuse
            gastric cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3458)
  AUTHORS   Zhang,X., Zhang,L., Lin,B., Chai,X., Li,R., Liao,Y., Deng,X.,
            Liu,Q., Yang,W., Cai,Y., Zhou,W., Lin,Z., Huang,W., Zhong,M.,
            Lei,F., Wu,J., Yu,S., Li,X., Li,S., Li,Y., Zeng,J., Long,W., Ren,D.
            and Huang,Y.
  TITLE     Phospholipid Phosphatase 4 promotes proliferation and
            tumorigenesis, and activates Ca2+-permeable Cationic Channel in
            lung carcinoma cells
  JOURNAL   Mol Cancer 16 (1), 147 (2017)
   PUBMED   28851360
  REMARK    GeneRIF: Studied the clinical significance and biological roles of
            PLPP4 in lung carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3458)
  AUTHORS   Sherva,R., Tripodis,Y., Bennett,D.A., Chibnik,L.B., Crane,P.K., de
            Jager,P.L., Farrer,L.A., Saykin,A.J., Shulman,J.M., Naj,A. and
            Green,R.C.
  CONSRTM   GENAROAD Consortium; Alzheimer's Disease Neuroimaging Initiative;
            Alzheimer's Disease Genetics Consortium
  TITLE     Genome-wide association study of the rate of cognitive decline in
            Alzheimer's disease
  JOURNAL   Alzheimers Dement 10 (1), 45-52 (2014)
   PUBMED   23535033
REFERENCE   5  (bases 1 to 3458)
  AUTHORS   Takeuchi,M., Harigai,M., Momohara,S., Ball,E., Abe,J., Furuichi,K.
            and Kamatani,N.
  TITLE     Cloning and characterization of DPPL1 and DPPL2, representatives of
            a novel type of mammalian phosphatidate phosphatase
  JOURNAL   Gene 399 (2), 174-180 (2007)
   PUBMED   17590538
  REMARK    GeneRIF: DPPL1 and DPPL2 represent a novel type of mammalian
            phosphatidate phosphatase.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DR000933.1, BC132787.1, HY340365.1 and AC023282.8.
            
            On Jan 2, 2020 this sequence version replaced NM_001030059.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.181555.1,
                                           SRR1660803.225056.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398250.6/ ENSP00000381302.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                DR000933.1         205-256
            53-933              BC132787.1         149-1029
            934-1257            HY340365.1         32-355              c
            1258-3458           AC023282.8         40251-42451
FEATURES             Location/Qualifiers
     source          1..3458
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.12"
     gene            1..3458
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
                     /note="phospholipid phosphatase 4"
                     /db_xref="GeneID:196051"
                     /db_xref="HGNC:HGNC:23531"
     exon            1..135
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..895
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
                     /EC_number="3.1.3.4"
                     /EC_number="3.6.1.75"
                     /note="isoform a is encoded by transcript variant 1;
                     diacylglycerol pyrophosphate like 2; phosphatidate
                     phosphatase PPAPDC1A; phosphatidic acid phosphatase type 2
                     domain-containing protein 1A; phosphatidic acid
                     phosphatase type 2 domain containing 1A; diacylglycerol
                     pyrophosphate phosphatase-like 2"
                     /codon_start=1
                     /product="phospholipid phosphatase 4 isoform a"
                     /protein_id="NP_001025230.1"
                     /db_xref="CCDS:CCDS41573.1"
                     /db_xref="GeneID:196051"
                     /db_xref="HGNC:HGNC:23531"
                     /translation="MRELAIEIGVRALLFGVFVFTEFLDPFQRVIQPEEIWLYKNPLV
                     QSDNIPTRLMFAISFLTPLAVICVVKIIRRTDKTEIKEAFLAVSLALALNGVCTNTIK
                     LIVGRPRPDFFYRCFPDGVMNSEMHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFY
                     LAGKLHCFTESGRGKSWRLCAAILPLYCAMMIALSRMCDYKHHWQDSFVGGVIGLIFA
                     YICYRQHYPPLANTACHKPYVSLRVPASLKKEERPTADSAPSLPLEGITEGPV"
     exon            136..244
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            245..335
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            336..399
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            400..524
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            525..695
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
                     /inference="alignment:Splign:2.1.0"
     exon            696..3458
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1221..1226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
                     /note="hexamer: AATAAA"
     polyA_site      1257
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
                     /note="major polyA site"
     polyA_site      1270
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
     regulatory      1474..1479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
                     /note="hexamer: AATAAA"
     polyA_site      1492
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
     regulatory      3103..3108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
                     /note="hexamer: AATAAA"
     polyA_site      3127
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
     regulatory      3416..3421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
                     /note="hexamer: AATATA"
     regulatory      3438..3443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
                     /note="hexamer: ATTAAA"
     polyA_site      3443
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
     polyA_site      3458
                     /gene="PLPP4"
                     /gene_synonym="DPPL2; PPAPDC1; PPAPDC1A"
ORIGIN      
        1 ctggcgagcc ggcgccggcc gagctgcggg agccgcggag agcaccagct gacgccgcgg
       61 gagctgctcc ggccgcacca tgcgggagct ggccattgag atcggggtgc gagccctgct
      121 cttcggagtc ttcgttttta cagagttttt ggatccgttc cagagagtca tccagccaga
      181 agagatctgg ctctataaaa atcctttggt gcaatcagat aacataccta cccgcctcat
      241 gtttgcaatt tctttcctca cacccctggc tgttatttgt gtggtgaaaa ttatccggcg
      301 aacagacaag actgaaatta aggaagcctt cttagcggtg tccttggctc ttgctttgaa
      361 tggagtctgc acaaacacta ttaaattaat agtgggaaga cctcgccccg atttctttta
      421 ccgctgcttt ccagatggag tgatgaactc ggaaatgcat tgcacaggtg accccgatct
      481 ggtgtccgag ggccgcaaaa gcttccccag catccattcc tcctttgcct tttcgggcct
      541 tggcttcacg acgttctact tggcgggcaa gctgcactgc ttcaccgaga gtgggcgggg
      601 aaagagctgg cggctctgtg ctgccatcct gcccttgtac tgcgccatga tgattgccct
      661 gtcccgcatg tgcgactaca agcatcactg gcaagattcc tttgtgggtg gagtcatcgg
      721 cctcattttt gcatacattt gctacagaca gcactatcct cctctggcca acacagcttg
      781 ccataaaccc tacgttagtc tgcgagtccc agcctcactg aagaaagagg agaggcccac
      841 agctgacagc gcacccagct tgcctctgga ggggatcacc gaaggcccgg tatgaccagt
      901 gtcctgggag gatggacact aagccctggg cacatctgcc accctgacat cataacacaa
      961 tagaaatggt tttctgtagt gtatttttca tcagttgttt ctcaaagtca tcgtacttct
     1021 gcttctgttt cactgatggt gttcctgcta ctttaaatgt ctacttccaa catccttgaa
     1081 tttgcaagtg aaggacaaca atctctgaga gacgtgtgga agaggctgtg aaggtggggt
     1141 ttggggagct tggccgattc gtctatctga aatgtttgct gtaacagcca ccttcctatg
     1201 ttttcatggt tgtaaaacat aataaaacct cccacgtgga agacttggtg ttggccaccc
     1261 agcgcaacaa gtcatttgga gatgcagcag gtttctcaga gacccaaagc cagctctgtc
     1321 tgtaggtcat tccaggtgct gagcttggaa gcaaaggctc agaacctttc tgagccatca
     1381 gcttctcata gcccacgtct ctaaaataga tttgaaactt ggagtgacag cttgagcatt
     1441 tccagggctt ttgaatcatt gaatctggaa gcaaataaaa ttaataactt catgcacaga
     1501 cttccaccaa acacaatgag catgaagatg catgagtgca tgtgtggggg atgaggtcac
     1561 agcagttgcc tgagggttca tgggcacaat atccttccca tcttccagtc taagtttatg
     1621 gagccacttc tgtagctctg cctcatacag tgaatttttg gggcacgggg gctttacttg
     1681 gctcttctgc aagaagtgat gtgaccgatc tcacagatca gaaaccgcat gcctggggct
     1741 catctcaagg gagtggctga gtggccattg gggataagaa gcaacttcag gctgagaatt
     1801 tttccccttt aggatctgag ttttgcagag ctctgctcta aggattctcc aagtggtggt
     1861 gtgttcctgt tcctatctag ctggcaatat ttcagcatga taggactctg gtagaaggta
     1921 caagaacaga atcaggaatg tgctgtgtct ctcgctcagc tctttgcatt gttgaataca
     1981 gccagtcaat atgaaccttt ttcagtctga gtatagagca cgctgctcct tggccagcta
     2041 gttttttcaa ggcaaggagc atccccttca tccaattctg attggatgta ccatgtggtt
     2101 gttcagattc ctgggcctgg gtgctacgag gtgatgcatc tttgctatcc agagtgtcac
     2161 tttttttttt ttttttttga gatggagtct cgctgtgtcg agactgcact ggagtgcagt
     2221 ggcgtgatct tggctcactg caacctttgc ctctgggttc aagctattct cgtgcctcag
     2281 cctcccaagt agctaggact acaggtgccc gccaccacac ctggctaatt tttgtatttt
     2341 tagtagacac ggggtttcac cacgttggcc aggctggtct cggactccta gcctcaagtg
     2401 atctgcccac ctcggcctcc caaagtgctg ggattataag cgtgagccac tgcacctggc
     2461 caagagtgtt gcttttgggc agttagcata acagactgca ttttgagaga ctcaggtggc
     2521 tgcctaaatg gtcagcttat cagccctggg ctgcgtgtgc aagttagaag catcagaata
     2581 tctttgatca gccatttctg ttaagctcca tgggcttaag cttggagtgc atgtaccact
     2641 gactatgctc catgagcccc agtgcagccc tctccagccc tggtccttcc aaactggctt
     2701 tggcacggtc atgtgattgt cccctggatg gagtgggaga gggggaggct tgaattgact
     2761 ttcatccaaa gtcaagccat tgatttttta aaaattatag cagttacatt ggcaagcaac
     2821 tttgaagatg aatgtgagat attttaagag ataaatcata gcaattgaaa agacataatt
     2881 ttaaattctg agctaaaatt catttaaaat tagaaaatta aacaatactc taatttaact
     2941 aaaaactcta taattttcaa aaataaagcc caaaatagaa atgtaggaaa aagatccttt
     3001 gctactgtta aaaaaaaaaa ccccatcctg atgtggccca cattcttatt tgattctagt
     3061 tttatctgag caagaggaaa ggaaaagggt tgtacttcag ttaataaaga cttaaaattc
     3121 tggaccatca agtgtaaatt taatataaat aattttattt aaagataaat ggccaggaag
     3181 tactctgcaa agtaacaaca gagtattact aatgctgata attacatgga aaatcctaat
     3241 actggccatg taaaagcttt gattaaaata taattcaaat tacagatgat gtaataacat
     3301 gaagctggtg gtaggatcct caggagccat aatgaacagt gtaagccagt tcacaaaagg
     3361 caggcatttt tacagatcct tatgtttcaa tttcatgctc tattcacgtg aagtaaatat
     3421 aacatcacag tgtaccaatt aaatggccat aatgagaa
//
