LOCUS       NM_003713               3273 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens phospholipid phosphatase 3 (PLPP3), mRNA.
ACCESSION   NM_003713
VERSION     NM_003713.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3273)
  AUTHORS   Chabowski,D.S., Hughes,W.E., Hockenberry,J.C., LoGiudice,J.,
            Beyer,A.M. and Gutterman,D.D.
  TITLE     Lipid phosphate phosphatase 3 maintains NO-mediated flow-mediated
            dilatation in human adipose resistance arterioles
  JOURNAL   J Physiol 601 (3), 469-481 (2023)
   PUBMED   36575638
  REMARK    GeneRIF: Lipid phosphate phosphatase 3 maintains NO-mediated
            flow-mediated dilatation in human adipose resistance arterioles.
REFERENCE   2  (bases 1 to 3273)
  AUTHORS   Jose,A. and Kienesberger,P.C.
  TITLE     Autotaxin-LPA-LPP3 Axis in Energy Metabolism and Metabolic Disease
  JOURNAL   Int J Mol Sci 22 (17), 9575 (2021)
   PUBMED   34502491
  REMARK    GeneRIF: Autotaxin-LPA-LPP3 Axis in Energy Metabolism and Metabolic
            Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3273)
  AUTHORS   Smyth,S.S., Kraemer,M., Yang,L., Van Hoose,P. and Morris,A.J.
  TITLE     Roles for lysophosphatidic acid signaling in vascular development
            and disease
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1865 (8), 158734 (2020)
   PUBMED   32376340
  REMARK    GeneRIF: Roles for lysophosphatidic acid signaling in vascular
            development and disease.
            Review article
REFERENCE   4  (bases 1 to 3273)
  AUTHORS   Mao,G., Smyth,S.S. and Morris,A.J.
  TITLE     Regulation of PLPP3 gene expression by NF-kappaB family
            transcription factors
  JOURNAL   J Biol Chem 294 (38), 14009-14019 (2019)
   PUBMED   31362988
  REMARK    GeneRIF: Findings indicate that up-regulation of PLPP3 during
            inflammation and atherosclerosis results from canonical activation
            of the NF-kappaB signaling cascade to increase PLPP3 expression
            through nuclear import and binding of RelA and RelB transcription
            factors to the PLPP3 promoter and suggest a mechanism by which the
            LPP3 substrate, LPA, can regulate PLPP3 expression.
REFERENCE   5  (bases 1 to 3273)
  AUTHORS   Mkannez,G., Gagne-Ouellet,V., Jalloul Nsaibia,M., Boulanger,M.C.,
            Rosa,M., Argaud,D., Hadji,F., Gaudreault,N., Rheaume,G.,
            Bouchard,L., Bosse,Y. and Mathieu,P.
  TITLE     DNA methylation of a PLPP3 MIR transposon-based enhancer promotes
            an osteogenic programme in calcific aortic valve disease
  JOURNAL   Cardiovasc Res 114 (11), 1525-1535 (2018)
   PUBMED   29726894
  REMARK    GeneRIF: DNA methylation of a MIR-based enhancer downregulates the
            expression of PLPP3 and promotes the mineralization of the aortic
            valve in calcific aortic valve disease.
REFERENCE   6  (bases 1 to 3273)
  AUTHORS   Nanjundan,M. and Possmayer,F.
  TITLE     Pulmonary phosphatidic acid phosphatase and lipid phosphate
            phosphohydrolase
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 284 (1), L1-L23 (2003)
   PUBMED   12471011
  REMARK    Review article
REFERENCE   7  (bases 1 to 3273)
  AUTHORS   Ishikawa,T., Kai,M., Wada,I. and Kanoh,H.
  TITLE     Cell surface activities of the human type 2b phosphatidic acid
            phosphatase
  JOURNAL   J Biochem 127 (4), 645-651 (2000)
   PUBMED   10739957
REFERENCE   8  (bases 1 to 3273)
  AUTHORS   Sciorra,V.A. and Morris,A.J.
  TITLE     Sequential actions of phospholipase D and phosphatidic acid
            phosphohydrolase 2b generate diglyceride in mammalian cells
  JOURNAL   Mol Biol Cell 10 (11), 3863-3876 (1999)
   PUBMED   10564277
REFERENCE   9  (bases 1 to 3273)
  AUTHORS   Roberts,R., Sciorra,V.A. and Morris,A.J.
  TITLE     Human type 2 phosphatidic acid phosphohydrolases. Substrate
            specificity of the type 2a, 2b, and 2c enzymes and cell surface
            activity of the 2a isoform
  JOURNAL   J Biol Chem 273 (34), 22059-22067 (1998)
   PUBMED   9705349
REFERENCE   10 (bases 1 to 3273)
  AUTHORS   Kai,M., Wada,I., Imai,Si., Sakane,F. and Kanoh,H.
  TITLE     Cloning and characterization of two human isozymes of
            Mg2+-independent phosphatidic acid phosphatase
  JOURNAL   J Biol Chem 272 (39), 24572-24578 (1997)
   PUBMED   9305923
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA580891.1, AF043329.1,
            AC099562.2 and BQ027458.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003713.4.
            
            Summary: The protein encoded by this gene is a member of the
            phosphatidic acid phosphatase (PAP) family. PAPs convert
            phosphatidic acid to diacylglycerol, and function in de novo
            synthesis of glycerolipids as well as in receptor-activated signal
            transduction mediated by phospholipase D. This protein is a
            membrane glycoprotein localized at the cell plasma membrane. It has
            been shown to actively hydrolyze extracellular lysophosphatidic
            acid and short-chain phosphatidic acid. The expression of this gene
            is found to be enhanced by epidermal growth factor in Hela cells.
            [provided by RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.265923.1,
                                           SRR1660807.251446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398, SAMEA2162568
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371250.4/ ENSP00000360296.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               DA580891.1         30-284
            256-1605            AF043329.1         2-1351
            1606-3252           AC099562.2         78897-80543         c
            3253-3273           BQ027458.1         31-51               c
FEATURES             Location/Qualifiers
     source          1..3273
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.2"
     gene            1..3273
                     /gene="PLPP3"
                     /gene_synonym="Dri42; LPP3; PAP2B; PPAP2B; VCIP"
                     /note="phospholipid phosphatase 3"
                     /db_xref="GeneID:8613"
                     /db_xref="HGNC:HGNC:9229"
                     /db_xref="MIM:607125"
     exon            1..686
                     /gene="PLPP3"
                     /gene_synonym="Dri42; LPP3; PAP2B; PPAP2B; VCIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             548..1483
                     /gene="PLPP3"
                     /gene_synonym="Dri42; LPP3; PAP2B; PPAP2B; VCIP"
                     /EC_number="3.1.3.4"
                     /note="lipid phosphate phosphohydrolase 3; type-2
                     phosphatidic acid phosphatase-beta; vascular endothelial
                     growth factor and type I collagen inducible; PAP2 beta;
                     phosphatidate phosphohydrolase type 2b; phosphatidic acid
                     phosphatase type 2B"
                     /codon_start=1
                     /product="phospholipid phosphatase 3"
                     /protein_id="NP_003704.3"
                     /db_xref="CCDS:CCDS604.1"
                     /db_xref="GeneID:8613"
                     /db_xref="HGNC:HGNC:9229"
                     /db_xref="MIM:607125"
                     /translation="MQNYKYDKAIVPESKNGGSPALNNNPRRSGSKRVLLICLDLFCL
                     FMAGLPFLIIETSTIKPYHRGFYCNDESIKYPLKTGETINDAVLCAVGIVIAILAIIT
                     GEFYRIYYLKKSRSTIQNPYVAALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLS
                     VCNPDFSQINCSEGYIQNYRCRGDDSKVQEARKSFFSGHASFSMYTMLYLVLYLQARF
                     TWRGARLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIVFFVSD
                     LFKTKTTLSLPAPAIRKEILSPVDIIDRNNHHNMM"
     exon            687..844
                     /gene="PLPP3"
                     /gene_synonym="Dri42; LPP3; PAP2B; PPAP2B; VCIP"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1122
                     /gene="PLPP3"
                     /gene_synonym="Dri42; LPP3; PAP2B; PPAP2B; VCIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1180
                     /gene="PLPP3"
                     /gene_synonym="Dri42; LPP3; PAP2B; PPAP2B; VCIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1357
                     /gene="PLPP3"
                     /gene_synonym="Dri42; LPP3; PAP2B; PPAP2B; VCIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..3273
                     /gene="PLPP3"
                     /gene_synonym="Dri42; LPP3; PAP2B; PPAP2B; VCIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3250..3255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPP3"
                     /gene_synonym="Dri42; LPP3; PAP2B; PPAP2B; VCIP"
                     /note="hexamer: AATAAA"
     polyA_site      3273
                     /gene="PLPP3"
                     /gene_synonym="Dri42; LPP3; PAP2B; PPAP2B; VCIP"
                     /note="major polyA site"
ORIGIN      
        1 agaaaacaaa cccaggcgat cacagcagca gccgccgcgg cagcagcacc aacagcagga
       61 ggagcaggag gagccggagg aggaggagga ggaggaggca aagttagagt tggggctggc
      121 gctccggagt tgctgggctc agcgcagctc ccattcatta aggaaccagc tgcggaggaa
      181 ggtggccgag cgcccgcgct gcccactcgc tcgctcgcgc actcagacgc gcgccacaac
      241 agcgcgcccc aagctgcgca gctctgcaaa agtttctgct cgggatctgg ctctcttccc
      301 cttggacttt agaacgattt agggttgaca gaggaaagca gaggcgcgca ggaggagcag
      361 aaaacaccac cttctgcagt tggaggcagg cagccccggc tgcactctag ccgccgcgcc
      421 cggagccggg gccgacccgc cactatccgc agcagcctcg gccaggaggc gacccgggcg
      481 cctgggtgtg tggctgctgt tgcgggacgt cttcgcgggg cgggaggctc gcgccgcagc
      541 cagcgccatg caaaactaca agtacgacaa agcgatcgtc ccggagagca agaacggcgg
      601 cagcccggcg ctcaacaaca acccgaggag gagcggcagc aagcgggtgc tgctcatctg
      661 cctcgacctc ttctgcctct tcatggcggg cctccccttc ctcatcatcg agacaagcac
      721 catcaagcct taccaccgag ggttttactg caatgatgag agcatcaagt acccactgaa
      781 aactggtgag acaataaatg acgctgtgct ctgtgccgtg gggatcgtca ttgccatcct
      841 cgcgatcatc acgggggaat tctaccggat ctattacctg aagaagtcgc ggtcgacgat
      901 tcagaacccc tacgtggcag cactctataa gcaagtgggc tgcttcctct ttggctgtgc
      961 catcagccag tctttcacag acattgccaa agtgtccata gggcgcctgc gtcctcactt
     1021 cttgagtgtc tgcaaccctg atttcagcca gatcaactgc tctgaaggct acattcagaa
     1081 ctacagatgc agaggtgatg acagcaaagt ccaggaagcc aggaagtcct tcttctctgg
     1141 ccatgcctcc ttctccatgt acactatgct gtatttggtg ctatacctgc aggcccgctt
     1201 cacttggcga ggagcccgcc tgctccggcc cctcctgcag ttcaccttga tcatgatggc
     1261 cttctacacg ggactgtctc gcgtatcaga ccacaagcac catcccagtg atgttctggc
     1321 aggatttgct caaggagccc tggtggcctg ctgcatagtt ttcttcgtgt ctgacctctt
     1381 caagactaag acgacgctct ccctgcctgc ccctgctatc cggaaggaaa tcctttcacc
     1441 tgtggacatt attgacagga acaatcacca caacatgatg taggtgccac ccacctcctg
     1501 agctgttttt gtaaaatgac tgctgacagc aagttcttgc tgctctccaa tctcatcaga
     1561 cagtagaatg tagggaaaaa cttttgcccg actgattttt aaaaaggaaa aaaaaaatgt
     1621 tttactatgt ggccttccaa aataggtagt gtttgcctat gtggaaacaa cagcaaacta
     1681 acaccaagtg ccagagtcct ggatgtgcaa ttggtttaag tgttcatgtt ctagtgaaca
     1741 cagcttgttc aggaacaaac actaaaacga tttgagtaga ggctgctggt caccttttgt
     1801 gacctgagga atcccaggcc tgtgagaaaa gcaaaaattc acattgcagc acatgatgcc
     1861 agaaatagca ctgaatcaag aaaatagcca ttgcggagct gccctcttga gtctttctgt
     1921 ccatcccatt ctattctgta ctgtgacttt agttcaggaa gttttgtttt gtgttttaaa
     1981 taaaaggaaa gagcaagttt gctcagtcaa gtgatcagat cccgaatcta gattcccagt
     2041 tctaaggcct tatcacctcc cctgcccata ggccaacaac catagttcct cacattagtg
     2101 attagcagac tctttgtgga cgagtgaatt tcacaaacag cacaatttca gaagaaatcg
     2161 agggcacagg ccctcacttt tcttcttttg acgcatcatc ctgtgatgtt gaaatgtcaa
     2221 ttgcaggatg ctgatgttgt gcacgtcaat caccgggcac ttgcatactc ttagaaacag
     2281 ttcgacttcg gttactgcct tctcccttga aatccttgct gcgtgcccac caggatttcc
     2341 tgtgagggcc caggaatgag caaggcatgg tctgccacca gctgacggaa agcagccttc
     2401 tgtacaacag atgggagggt gaagggggca gaatgaaaat cgaaccaacc ttttagctgt
     2461 tgcaaatcag aaggagccag agaagcaggc agtctcatgc atgagaggtt acccttcagg
     2521 atgacagagc tgagggtctt tgtaggagtt gctcttgctg tgtaaagcac tattgtcttg
     2581 gggttgagcc ctagggcagt tcttggtagg ttctgctggg cagaacatat gggttaaatc
     2641 tcggtagaga gtttccctca tcctctatcc gtaagtgtcc ttccatgcaa ggtcccactc
     2701 taggtgatag acagggaccc cttctactga acctttgagg aaaggaggaa ggaagaaatg
     2761 cgtttagatc ttggatgcag acctttcaaa gggttaaatg taaccatatg gatcaaccac
     2821 atgcacatcc ttactacaga atccgtcctt tcatttcaac ttatagcaag ctatgatttt
     2881 tatatataaa tattatataa ataatgtata aaacattaaa agttaactat gtaagatatt
     2941 atttctgaaa caatttagct atatccacta tgattataaa ctgtgtctcg acctgtgtta
     3001 tttacattag ctgcttaaaa aagcattgag ttaatttttt taaatatcaa ctaaaatatc
     3061 atagttctgt ggtagacatt gttttataat gaaataactg caactagaga aaactgtata
     3121 aaaacattaa attgtcagta tttttgtaag gttccatttt gtaaagagaa taatattcaa
     3181 agacttttgt agcatacaaa gtgaaaactt gtatctgcga aactatactt gtattaaatg
     3241 tgctttttaa ataaaagctc gtaacacaac taa
//
