LOCUS       NM_177543               1348 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens phospholipid phosphatase 2 (PLPP2), transcript variant
            3, mRNA.
ACCESSION   NM_177543
VERSION     NM_177543.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1348)
  AUTHORS   Wang,Y., Miao,Z., Qin,X., Yang,Y., Wu,S., Miao,Q., Li,B., Zhang,M.,
            Wu,P., Han,Y. and Li,B.
  TITLE     Transcriptomic landscape based on annotated clinical features
            reveals PLPP2 involvement in lipid raft-mediated proliferation
            signature of early-stage lung adenocarcinoma
  JOURNAL   J Exp Clin Cancer Res 42 (1), 315 (2023)
   PUBMED   37996944
  REMARK    GeneRIF: Transcriptomic landscape based on annotated clinical
            features reveals PLPP2 involvement in lipid raft-mediated
            proliferation signature of early-stage lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1348)
  AUTHORS   Wang,Z., Qi,H., Zhang,Y., Sun,H., Dong,J. and Wang,H.
  TITLE     PLPP2: Potential therapeutic target of breast cancer in PLPP family
  JOURNAL   Immunobiology 227 (6), 152298 (2022)
   PUBMED   36332491
  REMARK    GeneRIF: PLPP2: Potential therapeutic target of breast cancer in
            PLPP family.
REFERENCE   3  (bases 1 to 1348)
  AUTHORS   Tang,X., Cromwell,C.R., Liu,R., Godbout,R., Hubbard,B.P.,
            McMullen,T.P.W. and Brindley,D.N.
  TITLE     Lipid phosphate phosphatase-2 promotes tumor growth through
            increased c-Myc expression
  JOURNAL   Theranostics 12 (13), 5675-5690 (2022)
   PUBMED   35966578
  REMARK    GeneRIF: Lipid phosphate phosphatase-2 promotes tumor growth
            through increased c-Myc expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1348)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1348)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   6  (bases 1 to 1348)
  AUTHORS   Nanjundan,M. and Possmayer,F.
  TITLE     Pulmonary phosphatidic acid phosphatase and lipid phosphate
            phosphohydrolase
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 284 (1), L1-L23 (2003)
   PUBMED   12471011
  REMARK    Review article
REFERENCE   7  (bases 1 to 1348)
  AUTHORS   Zhang,N., Sundberg,J.P. and Gridley,T.
  TITLE     Mice mutant for Ppap2c, a homolog of the germ cell migration
            regulator wunen, are viable and fertile
  JOURNAL   Genesis 27 (4), 137-140 (2000)
   PUBMED   10992322
  REMARK    GeneRIF: Functional study of the mouse homolog
REFERENCE   8  (bases 1 to 1348)
  AUTHORS   Roberts,R., Sciorra,V.A. and Morris,A.J.
  TITLE     Human type 2 phosphatidic acid phosphohydrolases. Substrate
            specificity of the type 2a, 2b, and 2c enzymes and cell surface
            activity of the 2a isoform
  JOURNAL   J Biol Chem 273 (34), 22059-22067 (1998)
   PUBMED   9705349
REFERENCE   9  (bases 1 to 1348)
  AUTHORS   Hooks,S.B., Ragan,S.P. and Lynch,K.R.
  TITLE     Identification of a novel human phosphatidic acid phosphatase type
            2 isoform
  JOURNAL   FEBS Lett 427 (2), 188-192 (1998)
   PUBMED   9607309
REFERENCE   10 (bases 1 to 1348)
  AUTHORS   Leung,D.W., Tompkins,C.K. and White,T.
  TITLE     Molecular cloning of two alternatively spliced forms of human
            phosphatidic acid phosphatase cDNAs that are differentially
            expressed in normal and tumor cells
  JOURNAL   DNA Cell Biol 17 (4), 377-385 (1998)
   PUBMED   9570154
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG831889.1, BE615792.1,
            AF047760.1, BM982485.1 and AA428937.1.
            
            On May 31, 2019 this sequence version replaced NM_177543.2.
            
            Summary: The protein encoded by this gene is a member of the
            phosphatidic acid phosphatase (PAP) family. PAPs convert
            phosphatidic acid to diacylglycerol, and function in de novo
            synthesis of glycerolipids as well as in receptor-activated signal
            transduction mediated by phospholipase D. This protein is similar
            to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B
            (PPAP2B). All three proteins contain 6 transmembrane regions, and a
            consensus N-glycosylation site. This protein has been shown to
            possess membrane associated PAP activity. Three alternatively
            spliced transcript variants encoding distinct isoforms have been
            reported. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) encodes the longest isoform
            (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.647648.1, BI160067.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                BG831889.1         32-99
            69-620              BE615792.1         53-604
            621-1019            AF047760.1         528-926
            1020-1344           BM982485.1         18-342              c
            1345-1348           AA428937.1         10-13               c
FEATURES             Location/Qualifiers
     source          1..1348
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1348
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /note="phospholipid phosphatase 2"
                     /db_xref="GeneID:8612"
                     /db_xref="HGNC:HGNC:9230"
                     /db_xref="MIM:607126"
     exon            1..188
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1003
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /EC_number="3.1.3.4"
                     /note="isoform 3 is encoded by transcript variant 3;
                     phosphatidic acid phosphohydrolase type 2c; lipid
                     phosphate phosphohydrolase 2; type-2 phosphatidic acid
                     phosphatase-gamma; PAP2c; PAP2-gamma; phosphatidic acid
                     phosphatase 2c; phosphatidate phosphohydrolase type 2c;
                     phosphatidic acid phosphatase type 2C"
                     /codon_start=1
                     /product="phospholipid phosphatase 2 isoform 3"
                     /protein_id="NP_808211.1"
                     /db_xref="CCDS:CCDS12024.1"
                     /db_xref="GeneID:8612"
                     /db_xref="HGNC:HGNC:9230"
                     /db_xref="MIM:607126"
                     /translation="MGVARGPGSRGQHPPPRQQEVCAEGPRARLHPAPPGLGASLPFA
                     ILTLVNAPYKRGFYCGDDSIRYPYRPDTITHGLMAGVTITATVILVSAGEAYLVYTDR
                     LYSRSDFNNYVAAVYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVN
                     CSVYVQLEKVCRGNPADVTEARLSFYSGHSSFGMYCMVFLALYVQARLCWKWARLLRP
                     TVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTVCYISDFFKARPPQHC
                     LKEEELERKPSLSLTLTLGEADHNHYGYPHSSS"
     exon            189..340
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            341..618
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            619..676
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            677..853
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1348
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1322..1327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /note="hexamer: AGTAAA"
     polyA_site      1348
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /note="major polyA site"
ORIGIN      
        1 agacctccct ccgcgccccg cactgcgcgc gccctcccag gctcgggggt ccccgcgtcc
       61 caggcccagg gggatggggg tcgcgagagg cccggggagc cggggccagc atcccccgcc
      121 ccggcagcag gaagtctgtg cggaggggcc gcgcgcgcgc ctccatcccg ccccgcctgg
      181 cctgggagcc tccctgccct tcgctatcct gacgctggtg aacgccccgt acaagcgagg
      241 attttactgc ggggatgact ccatccggta cccctaccgt ccagatacca tcacccacgg
      301 gctcatggct ggggtcacca tcacggccac cgtcatcctt gtctcggccg gggaagccta
      361 cctggtgtac acagaccggc tctattctcg ctcggacttc aacaactacg tggctgctgt
      421 atacaaggtg ctggggacct tcctgtttgg ggctgccgtg agccagtctc tgacagacct
      481 ggccaagtac atgattgggc gtctgaggcc caacttccta gccgtctgcg accccgactg
      541 gagccgggtc aactgctcgg tctatgtgca gctggagaag gtgtgcaggg gaaaccctgc
      601 tgatgtcacc gaggccaggt tgtctttcta ctcgggacac tcttcctttg ggatgtactg
      661 catggtgttc ttggcgctgt atgtgcaggc acgactctgt tggaagtggg cacggctgct
      721 gcgacccaca gtccagttct tcctggtggc ctttgccctc tacgtgggct acacccgcgt
      781 gtctgattac aaacaccact ggagcgatgt ccttgttggc ctcctgcagg gggcactggt
      841 ggctgccctc actgtctgct acatctcaga cttcttcaaa gcccgacccc cacagcactg
      901 tctgaaggag gaggagctgg aacggaagcc cagcctgtca ctgacgttga ccctgggcga
      961 ggctgaccac aaccactatg gatacccgca ctcctcctcc tgaggccgga ccccgcccag
     1021 gcagggagct gctgtgagtc cagctgaggc ccacccaggt ggtccctcca gccctggtta
     1081 ggcactgagg gctctggacg ggctccagga accctgggct gatgggagca gtgagcgggc
     1141 tccgctgccc cctgccctgc actggaccag gagtctggag atgcctgggt agccctcagc
     1201 atttggaggg gaacctgttc ccgtcggtcc ccaaatatcc ccttcttttt atggggttaa
     1261 ggaagggacc gagagatcag atagttgctg ttttgtaaaa tgtaatgtat atgtggtttt
     1321 tagtaaaata gggcacctgt ttcacaaa
//
