LOCUS       NM_003712               1279 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens phospholipid phosphatase 2 (PLPP2), transcript variant
            1, mRNA.
ACCESSION   NM_003712
VERSION     NM_003712.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1279)
  AUTHORS   Wang,Y., Miao,Z., Qin,X., Yang,Y., Wu,S., Miao,Q., Li,B., Zhang,M.,
            Wu,P., Han,Y. and Li,B.
  TITLE     Transcriptomic landscape based on annotated clinical features
            reveals PLPP2 involvement in lipid raft-mediated proliferation
            signature of early-stage lung adenocarcinoma
  JOURNAL   J Exp Clin Cancer Res 42 (1), 315 (2023)
   PUBMED   37996944
  REMARK    GeneRIF: Transcriptomic landscape based on annotated clinical
            features reveals PLPP2 involvement in lipid raft-mediated
            proliferation signature of early-stage lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1279)
  AUTHORS   Wang,Z., Qi,H., Zhang,Y., Sun,H., Dong,J. and Wang,H.
  TITLE     PLPP2: Potential therapeutic target of breast cancer in PLPP family
  JOURNAL   Immunobiology 227 (6), 152298 (2022)
   PUBMED   36332491
  REMARK    GeneRIF: PLPP2: Potential therapeutic target of breast cancer in
            PLPP family.
REFERENCE   3  (bases 1 to 1279)
  AUTHORS   Tang,X., Cromwell,C.R., Liu,R., Godbout,R., Hubbard,B.P.,
            McMullen,T.P.W. and Brindley,D.N.
  TITLE     Lipid phosphate phosphatase-2 promotes tumor growth through
            increased c-Myc expression
  JOURNAL   Theranostics 12 (13), 5675-5690 (2022)
   PUBMED   35966578
  REMARK    GeneRIF: Lipid phosphate phosphatase-2 promotes tumor growth
            through increased c-Myc expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1279)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1279)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   6  (bases 1 to 1279)
  AUTHORS   Nanjundan,M. and Possmayer,F.
  TITLE     Pulmonary phosphatidic acid phosphatase and lipid phosphate
            phosphohydrolase
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 284 (1), L1-L23 (2003)
   PUBMED   12471011
  REMARK    Review article
REFERENCE   7  (bases 1 to 1279)
  AUTHORS   Zhang,N., Sundberg,J.P. and Gridley,T.
  TITLE     Mice mutant for Ppap2c, a homolog of the germ cell migration
            regulator wunen, are viable and fertile
  JOURNAL   Genesis 27 (4), 137-140 (2000)
   PUBMED   10992322
  REMARK    GeneRIF: Functional study of the mouse homolog
REFERENCE   8  (bases 1 to 1279)
  AUTHORS   Roberts,R., Sciorra,V.A. and Morris,A.J.
  TITLE     Human type 2 phosphatidic acid phosphohydrolases. Substrate
            specificity of the type 2a, 2b, and 2c enzymes and cell surface
            activity of the 2a isoform
  JOURNAL   J Biol Chem 273 (34), 22059-22067 (1998)
   PUBMED   9705349
REFERENCE   9  (bases 1 to 1279)
  AUTHORS   Hooks,S.B., Ragan,S.P. and Lynch,K.R.
  TITLE     Identification of a novel human phosphatidic acid phosphatase type
            2 isoform
  JOURNAL   FEBS Lett 427 (2), 188-192 (1998)
   PUBMED   9607309
REFERENCE   10 (bases 1 to 1279)
  AUTHORS   Leung,D.W., Tompkins,C.K. and White,T.
  TITLE     Molecular cloning of two alternatively spliced forms of human
            phosphatidic acid phosphatase cDNAs that are differentially
            expressed in normal and tumor cells
  JOURNAL   DNA Cell Biol 17 (4), 377-385 (1998)
   PUBMED   9570154
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM050291.1, AF047760.1,
            BM982485.1 and AA428937.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003712.3.
            
            Summary: The protein encoded by this gene is a member of the
            phosphatidic acid phosphatase (PAP) family. PAPs convert
            phosphatidic acid to diacylglycerol, and function in de novo
            synthesis of glycerolipids as well as in receptor-activated signal
            transduction mediated by phospholipase D. This protein is similar
            to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B
            (PPAP2B). All three proteins contain 6 transmembrane regions, and a
            consensus N-glycosylation site. This protein has been shown to
            possess membrane associated PAP activity. Three alternatively
            spliced transcript variants encoding distinct isoforms have been
            reported. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) differs in the 5' region,
            including the 5' UTR and 5' coding region, as compared to variant
            3. The resulting isoform (1) has a distinct and shorter N-terminus,
            as compared to isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF035959.1, SRR5189658.51970.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153946 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000434325.7/ ENSP00000388565.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BM050291.1         34-57
            25-950              AF047760.1         1-926
            951-1275            BM982485.1         18-342              c
            1276-1279           AA428937.1         10-13               c
FEATURES             Location/Qualifiers
     source          1..1279
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1279
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /note="phospholipid phosphatase 2"
                     /db_xref="GeneID:8612"
                     /db_xref="HGNC:HGNC:9230"
                     /db_xref="MIM:607126"
     exon            1..119
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..934
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /EC_number="3.1.3.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidic acid phosphohydrolase type 2c; lipid
                     phosphate phosphohydrolase 2; type-2 phosphatidic acid
                     phosphatase-gamma; PAP2c; PAP2-gamma; phosphatidic acid
                     phosphatase 2c; phosphatidate phosphohydrolase type 2c;
                     phosphatidic acid phosphatase type 2C"
                     /codon_start=1
                     /product="phospholipid phosphatase 2 isoform 1"
                     /protein_id="NP_003703.1"
                     /db_xref="CCDS:CCDS12023.1"
                     /db_xref="GeneID:8612"
                     /db_xref="HGNC:HGNC:9230"
                     /db_xref="MIM:607126"
                     /translation="MQRRWVFVLLDVLCLLVASLPFAILTLVNAPYKRGFYCGDDSIR
                     YPYRPDTITHGLMAGVTITATVILVSAGEAYLVYTDRLYSRSDFNNYVAAVYKVLGTF
                     LFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQLEKVCRGNPADVTEA
                     RLSFYSGHSSFGMYCMVFLALYVQARLCWKWARLLRPTVQFFLVAFALYVGYTRVSDY
                     KHHWSDVLVGLLQGALVAALTVCYISDFFKARPPQHCLKEEELERKPSLSLTLTLGEA
                     DHNHYGYPHSSS"
     exon            120..271
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            272..549
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            550..607
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            608..784
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            785..1279
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1253..1258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /note="hexamer: AGTAAA"
     polyA_site      1279
                     /gene="PLPP2"
                     /gene_synonym="LPP2; PAP-2c; PAP2-g; PPAP2C"
                     /note="major polyA site"
ORIGIN      
        1 gtgactccgc ggccgggccg ggacgcgacg ggacgcgctg ggaccggcgt cgggggtcgc
       61 ggggaccatg cagcggaggt gggtcttcgt gctgctcgac gtgctgtgct tactggtcgc
      121 ctccctgccc ttcgctatcc tgacgctggt gaacgccccg tacaagcgag gattttactg
      181 cggggatgac tccatccggt acccctaccg tccagatacc atcacccacg ggctcatggc
      241 tggggtcacc atcacggcca ccgtcatcct tgtctcggcc ggggaagcct acctggtgta
      301 cacagaccgg ctctattctc gctcggactt caacaactac gtggctgctg tatacaaggt
      361 gctggggacc ttcctgtttg gggctgccgt gagccagtct ctgacagacc tggccaagta
      421 catgattggg cgtctgaggc ccaacttcct agccgtctgc gaccccgact ggagccgggt
      481 caactgctcg gtctatgtgc agctggagaa ggtgtgcagg ggaaaccctg ctgatgtcac
      541 cgaggccagg ttgtctttct actcgggaca ctcttccttt gggatgtact gcatggtgtt
      601 cttggcgctg tatgtgcagg cacgactctg ttggaagtgg gcacggctgc tgcgacccac
      661 agtccagttc ttcctggtgg cctttgccct ctacgtgggc tacacccgcg tgtctgatta
      721 caaacaccac tggagcgatg tccttgttgg cctcctgcag ggggcactgg tggctgccct
      781 cactgtctgc tacatctcag acttcttcaa agcccgaccc ccacagcact gtctgaagga
      841 ggaggagctg gaacggaagc ccagcctgtc actgacgttg accctgggcg aggctgacca
      901 caaccactat ggatacccgc actcctcctc ctgaggccgg accccgccca ggcagggagc
      961 tgctgtgagt ccagctgagg cccacccagg tggtccctcc agccctggtt aggcactgag
     1021 ggctctggac gggctccagg aaccctgggc tgatgggagc agtgagcggg ctccgctgcc
     1081 ccctgccctg cactggacca ggagtctgga gatgcctggg tagccctcag catttggagg
     1141 ggaacctgtt cccgtcggtc cccaaatatc cccttctttt tatggggtta aggaagggac
     1201 cgagagatca gatagttgct gttttgtaaa atgtaatgta tatgtggttt ttagtaaaat
     1261 agggcacctg tttcacaaa
//
