LOCUS       NM_003711               1542 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens phospholipid phosphatase 1 (PLPP1), transcript variant
            1, mRNA.
ACCESSION   NM_003711
VERSION     NM_003711.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1542)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1542)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1542)
  AUTHORS   Wang,J., Chen,J., Enns,C.A. and Mayinger,P.
  TITLE     The first transmembrane domain of lipid phosphatase SAC1 promotes
            Golgi localization
  JOURNAL   PLoS One 8 (8), e71112 (2013)
   PUBMED   23936490
  REMARK    GeneRIF: the first of the two transmembrane regions in human SAC1
            (TM1) functions in Golgi localization
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1542)
  AUTHORS   Eaton,J.M., Mullins,G.R., Brindley,D.N. and Harris,T.E.
  TITLE     Phosphorylation of lipin 1 and charge on the phosphatidic acid head
            group control its phosphatidic acid phosphatase activity and
            membrane association
  JOURNAL   J Biol Chem 288 (14), 9933-9945 (2013)
   PUBMED   23426360
  REMARK    GeneRIF: Phosphorylation of lipin 1 and charge on the phosphatidic
            acid head group control its phosphatidic acid phosphatase activity
            and membrane association
REFERENCE   5  (bases 1 to 1542)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 1542)
  AUTHORS   Roberts,R., Sciorra,V.A. and Morris,A.J.
  TITLE     Human type 2 phosphatidic acid phosphohydrolases. Substrate
            specificity of the type 2a, 2b, and 2c enzymes and cell surface
            activity of the 2a isoform
  JOURNAL   J Biol Chem 273 (34), 22059-22067 (1998)
   PUBMED   9705349
REFERENCE   7  (bases 1 to 1542)
  AUTHORS   Hooks,S.B., Ragan,S.P. and Lynch,K.R.
  TITLE     Identification of a novel human phosphatidic acid phosphatase type
            2 isoform
  JOURNAL   FEBS Lett 427 (2), 188-192 (1998)
   PUBMED   9607309
REFERENCE   8  (bases 1 to 1542)
  AUTHORS   Leung,D.W., Tompkins,C.K. and White,T.
  TITLE     Molecular cloning of two alternatively spliced forms of human
            phosphatidic acid phosphatase cDNAs that are differentially
            expressed in normal and tumor cells
  JOURNAL   DNA Cell Biol 17 (4), 377-385 (1998)
   PUBMED   9570154
REFERENCE   9  (bases 1 to 1542)
  AUTHORS   Ulrix,W., Swinnen,J.V., Heyns,W. and Verhoeven,G.
  TITLE     Identification of the phosphatidic acid phosphatase type 2a isozyme
            as an androgen-regulated gene in the human prostatic adenocarcinoma
            cell line LNCaP
  JOURNAL   J Biol Chem 273 (8), 4660-4665 (1998)
   PUBMED   9468526
REFERENCE   10 (bases 1 to 1542)
  AUTHORS   Kai,M., Wada,I., Imai,Si., Sakane,F. and Kanoh,H.
  TITLE     Cloning and characterization of two human isozymes of
            Mg2+-independent phosphatidic acid phosphatase
  JOURNAL   J Biol Chem 272 (39), 24572-24578 (1997)
   PUBMED   9305923
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC008787.2, BC143281.1,
            BC039847.1 and AF014402.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003711.3.
            
            Summary: The protein encoded by this gene is a member of the
            phosphatidic acid phosphatase (PAP) family. PAPs convert
            phosphatidic acid to diacylglycerol, and function in synthesis of
            glycerolipids and in phospholipase D-mediated signal transduction.
            This enzyme is an integral membrane glycoprotein that plays a role
            in the hydrolysis and uptake of lipids from extracellular space.
            Alternate splicing results in multiple transcript variants of this
            gene. [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (1, also named PAP2-a1) lacks an
            alternate exon and contains an in-frame alternate exon in the 5'
            coding region, compared to variant 2. The resulting isoform (1)
            contains a distinct internal segment and is shorter, compared to
            isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF014402.1, SRR3476690.245936.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159368 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307259.9/ ENSP00000302229.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               BC008787.2         44-328
            286-1216            BC143281.1         1-931
            1217-1488           BC039847.1         1195-1466
            1489-1542           AF014402.1         1495-1548
FEATURES             Location/Qualifiers
     source          1..1542
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..1542
                     /gene="PLPP1"
                     /gene_synonym="LLP1a; LPP1; PAP-2a; PAP2; PPAP2A"
                     /note="phospholipid phosphatase 1"
                     /db_xref="GeneID:8611"
                     /db_xref="HGNC:HGNC:9228"
                     /db_xref="MIM:607124"
     exon            1..393
                     /gene="PLPP1"
                     /gene_synonym="LLP1a; LPP1; PAP-2a; PAP2; PPAP2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..1190
                     /gene="PLPP1"
                     /gene_synonym="LLP1a; LPP1; PAP-2a; PAP2; PPAP2A"
                     /EC_number="3.1.3.4"
                     /EC_number="3.1.3.106"
                     /EC_number="3.6.1.75"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidic acid phosphohydrolase type 2a; lipid
                     phosphate phosphohydrolase 1a; type-2 phosphatidic acid
                     phosphatase alpha; phosphatidic acid phosphatase type 2A;
                     phosphatidic acid phosphatase 2a; phosphatidate
                     phosphohydrolase type 2a"
                     /codon_start=1
                     /product="phospholipid phosphatase 1 isoform 1"
                     /protein_id="NP_003702.2"
                     /db_xref="CCDS:CCDS34159.1"
                     /db_xref="GeneID:8611"
                     /db_xref="HGNC:HGNC:9228"
                     /db_xref="MIM:607124"
                     /translation="MFDKTRLPYVALDVLCVLLAGLPFAILTSRHTPFQRGVFCNDES
                     IKYPYKEDTIPYALLGGIIIPFSIIVIILGETLSVYCNLLHSNSFIRNNYIATIYKAI
                     GTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSKINCSDGYIEYYICRGNAERV
                     KEGRLSFYSGHSSFSMYCMLFVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRV
                     SDYKHHWSDVLTGLIQGALVAILVAVYVSDFFKERTSFKERKEEDSHTTLHETPTTGN
                     HYPSNHQP"
     exon            394..545
                     /gene="PLPP1"
                     /gene_synonym="LLP1a; LPP1; PAP-2a; PAP2; PPAP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            546..826
                     /gene="PLPP1"
                     /gene_synonym="LLP1a; LPP1; PAP-2a; PAP2; PPAP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            827..884
                     /gene="PLPP1"
                     /gene_synonym="LLP1a; LPP1; PAP-2a; PAP2; PPAP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1061
                     /gene="PLPP1"
                     /gene_synonym="LLP1a; LPP1; PAP-2a; PAP2; PPAP2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1542
                     /gene="PLPP1"
                     /gene_synonym="LLP1a; LPP1; PAP-2a; PAP2; PPAP2A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1519..1524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLPP1"
                     /gene_synonym="LLP1a; LPP1; PAP-2a; PAP2; PPAP2A"
                     /note="hexamer: ATTAAA"
     polyA_site      1542
                     /gene="PLPP1"
                     /gene_synonym="LLP1a; LPP1; PAP-2a; PAP2; PPAP2A"
                     /note="major polyA site"
ORIGIN      
        1 gggagagagc gccgggatcc ggacggggag caaccggggc aggccgtgcc ggctgaggag
       61 gtcctgaggc tacagagctg ccgcggctgg cacacgagcg cctcggcact aaccgagtgt
      121 tcgcgggggc tgtgagggga gggccccggg cgccattgct ggcggtggga gcgccgcccg
      181 gtctcagccc gccctcggct gctctcctcc tccggctggg aggggccgta gctcggggcc
      241 gtcgccagcc ccggcccggg ctcgagaatc aagggcctcg gccgccgtcc cgcagctcag
      301 tccatcgccc ttgccgggca gcccgggcag agaccatgtt tgacaagacg cggctgccgt
      361 acgtggccct cgatgtgctc tgcgtgttgc tggctggatt gccttttgca attcttactt
      421 caaggcatac ccccttccaa cgaggagtat tctgtaatga tgagtccatc aagtaccctt
      481 acaaagaaga caccatacct tatgcgttat taggtggaat aatcattcca ttcagtatta
      541 tcgttattat tcttggagaa accctgtctg tttactgtaa ccttttgcac tcaaattcct
      601 ttatcaggaa taactacata gccactattt acaaagccat tggaaccttt ttatttggtg
      661 cagctgctag tcagtccctg actgacattg ccaagtattc aataggcaga ctgcggcctc
      721 acttcttgga tgtttgtgat ccagattggt caaaaatcaa ctgcagcgat ggttacattg
      781 aatactacat atgtcgaggg aatgcagaaa gagttaagga aggcaggttg tccttctatt
      841 caggccactc ttcgttttcc atgtactgca tgctgtttgt ggcactttat cttcaagcca
      901 ggatgaaggg agactgggca agactcttac gccccacact gcaatttggt cttgttgccg
      961 tatccattta tgtgggcctt tctcgagttt ctgattataa acaccactgg agcgatgtgt
     1021 tgactggact cattcaggga gctctggttg caatattagt tgctgtatat gtatcggatt
     1081 tcttcaaaga aagaacttct tttaaagaaa gaaaagagga ggactctcat acaactctgc
     1141 atgaaacacc aacaactggg aatcactatc cgagcaatca ccagccttga aaggcagcag
     1201 ggtgcccagg tgaagctggc ctgttttcta aaggaaaatg attgccacaa ggcaagagga
     1261 tgcatctttc ttcctggtgt acaagccttt aaagacttct gctgctgcta tgcctcttgg
     1321 atgcacactt tgtgtgtaca tagttacctt taactcagtg gttatctaat agctctaaac
     1381 tcattaaaaa aactccaagc cttccaccaa aacagtgccc cacctgtata catttttatt
     1441 aaaaaaatgt aatgcttatg tataaacatg tatgtaatat gctttctatg aatgatgttt
     1501 gatttaaata taatacatat taaaatgtat gggagaacca aa
//
