LOCUS       NM_002668               1103 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens proteolipid protein 2 (PLP2), mRNA.
ACCESSION   NM_002668
VERSION     NM_002668.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1103)
  AUTHORS   Xie,F., Qu,J., Lin,D., Feng,K., Tan,M., Liao,H., Zeng,L., Xiong,Q.,
            Huang,J. and Chen,W.
  TITLE     Reduced Proteolipid Protein 2 promotes endoplasmic reticulum
            stress-related apoptosis and increases drug sensitivity in acute
            myeloid leukemia
  JOURNAL   Mol Biol Rep 51 (1), 10 (2023)
   PUBMED   38085372
  REMARK    GeneRIF: Reduced Proteolipid Protein 2 promotes endoplasmic
            reticulum stress-related apoptosis and increases drug sensitivity
            in acute myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1103)
  AUTHORS   Jin,J.S., Tsai,Y.L., Chang,Y.C. and Tsai,W.C.
  TITLE     Low Expression of A3C and PLP2 Indicating a Favorable Prognosis in
            Human Gliomas
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (7), 71-79 (2023)
   PUBMED   37715423
  REMARK    GeneRIF: Low Expression of A3C and PLP2 Indicating a Favorable
            Prognosis in Human Gliomas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1103)
  AUTHORS   Han,W., Jin,M., Liu,C., Zhao,Q., Wang,S., Wang,Y., Yin,Y., Peng,C.,
            Wang,Y. and Cong,Y.
  TITLE     Structural basis of plp2-mediated cytoskeletal protein folding by
            TRiC/CCT
  JOURNAL   Sci Adv 9 (11), eade1207 (2023)
   PUBMED   36921056
  REMARK    GeneRIF: Structural basis of plp2-mediated cytoskeletal protein
            folding by TRiC/CCT.
REFERENCE   4  (bases 1 to 1103)
  AUTHORS   Maia,V.S.C., Berzaghi,R., Arruda,D.C., Machado,F.C., Loureiro,L.L.,
            Melo,P.M.S., Morais,A.S., Budu,A. and Travassos,L.R.
  TITLE     PLP2-derived peptide Rb4 triggers PARP-1-mediated necrotic death in
            murine melanoma cells
  JOURNAL   Sci Rep 12 (1), 2890 (2022)
   PUBMED   35190586
  REMARK    GeneRIF: PLP2-derived peptide Rb4 triggers PARP-1-mediated necrotic
            death in murine melanoma cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1103)
  AUTHORS   Ghosh,D., Dutta,A., Kashyap,A., Upmanyu,N. and Datta,S.
  TITLE     PLP2 drives collective cell migration via ZO-1-mediated
            cytoskeletal remodeling at the leading edge in human colorectal
            cancer cells
  JOURNAL   J Cell Sci 134 (18) (2021)
   PUBMED   34409455
  REMARK    GeneRIF: PLP2 drives collective cell migration via ZO-1-mediated
            cytoskeletal remodeling at the leading edge in human colorectal
            cancer cells.
REFERENCE   6  (bases 1 to 1103)
  AUTHORS   Zhang,L., Jie,C., Obie,C., Abidi,F., Schwartz,C.E., Stevenson,R.E.,
            Valle,D. and Wang,T.
  TITLE     X chromosome cDNA microarray screening identifies a functional PLP2
            promoter polymorphism enriched in patients with X-linked mental
            retardation
  JOURNAL   Genome Res 17 (5), 641-648 (2007)
   PUBMED   17416750
  REMARK    GeneRIF: PLP2 is expressed abundantly in the pyramidal cells of
            hippocampus and granular cells of the cerebellum in the brains of a
            cohort of males with probable X-linked mental retardation.
REFERENCE   7  (bases 1 to 1103)
  AUTHORS   Lee,S.M., Shin,H., Jang,S.W., Shim,J.J., Song,I.S., Son,K.N.,
            Hwang,J., Shin,Y.H., Kim,H.H., Lee,C.K., Ko,J., Na,D.S., Kwon,B.S.
            and Kim,J.
  TITLE     PLP2/A4 interacts with CCR1 and stimulates migration of
            CCR1-expressing HOS cells
  JOURNAL   Biochem Biophys Res Commun 324 (2), 768-772 (2004)
   PUBMED   15474493
  REMARK    GeneRIF: PLP2/A4 has a role in the chemotactic processes via CCR1
REFERENCE   8  (bases 1 to 1103)
  AUTHORS   Wang,B., Nguyen,M., Breckenridge,D.G., Stojanovic,M., Clemons,P.A.,
            Kuppig,S. and Shore,G.C.
  TITLE     Uncleaved BAP31 in association with A4 protein at the endoplasmic
            reticulum is an inhibitor of Fas-initiated release of cytochrome c
            from mitochondria
  JOURNAL   J Biol Chem 278 (16), 14461-14468 (2003)
   PUBMED   12529377
REFERENCE   9  (bases 1 to 1103)
  AUTHORS   Breitwieser,G.E., McLenithan,J.C., Cortese,J.F., Shields,J.M.,
            Oliva,M.M., Majewski,J.L., Machamer,C.E. and Yang,V.W.
  TITLE     Colonic epithelium-enriched protein A4 is a proteolipid that
            exhibits ion channel characteristics
  JOURNAL   Am J Physiol 272 (3 Pt 1), C957-C965 (1997)
   PUBMED   9124532
REFERENCE   10 (bases 1 to 1103)
  AUTHORS   Oliva,M.M., Cortese,J.F. and Yang,V.W.
  TITLE     Promoter regulation of a differentially expressed gene in the human
            colonic epithelial cell lines HT29-18 and HT29-18-C1
  JOURNAL   Gene 159 (2), 151-157 (1995)
   PUBMED   7622043
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB220888.1, BC109066.2 and
            AC232271.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002668.2.
            
            Summary: This gene encodes an integral membrane protein that
            localizes to the endoplasmic reticulum in colonic epithelial cells.
            The encoded protein can multimerize and may function as an ion
            channel. A polymorphism in the promoter of this gene may be linked
            to an increased risk of X-linked cognitive disability. A pseudogene
            of this gene is found on chromosome 5. [provided by RefSeq, Jan
            2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279848.8144.1,
                                           SRR5189658.107344.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376327.6/ ENSP00000365505.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                DB220888.1         62-99
            39-642              BC109066.2         1-604
            643-1103            AC232271.2         108242-108702       c
FEATURES             Location/Qualifiers
     source          1..1103
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..1103
                     /gene="PLP2"
                     /gene_synonym="A4; A4LSB"
                     /note="proteolipid protein 2"
                     /db_xref="GeneID:5355"
                     /db_xref="HGNC:HGNC:9087"
                     /db_xref="MIM:300112"
     exon            1..199
                     /gene="PLP2"
                     /gene_synonym="A4; A4LSB"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..562
                     /gene="PLP2"
                     /gene_synonym="A4; A4LSB"
                     /note="A4 differentiation-dependent protein;
                     differentiation-dependent protein A4; intestinal membrane
                     A4 protein; proteolipid protein 2 (colonic
                     epithelium-enriched)"
                     /codon_start=1
                     /product="proteolipid protein 2"
                     /protein_id="NP_002659.1"
                     /db_xref="CCDS:CCDS14319.1"
                     /db_xref="GeneID:5355"
                     /db_xref="HGNC:HGNC:9087"
                     /db_xref="MIM:300112"
                     /translation="MADSERLSAPGCWAACTNFSRTRKGILLFAEIILCLVILICFSA
                     STPGYSSLSVIEMILAAIFFVVYMCDLHTKIPFINWPWSDFFRTLIAAILYLITSIVV
                     LVERGNHSKIVAGVLGLIATCLFGYDAYVTFPVRQPRHTAAPTDPADGPV"
     exon            200..352
                     /gene="PLP2"
                     /gene_synonym="A4; A4LSB"
                     /inference="alignment:Splign:2.1.0"
     exon            353..448
                     /gene="PLP2"
                     /gene_synonym="A4; A4LSB"
                     /inference="alignment:Splign:2.1.0"
     exon            449..539
                     /gene="PLP2"
                     /gene_synonym="A4; A4LSB"
                     /inference="alignment:Splign:2.1.0"
     exon            540..1103
                     /gene="PLP2"
                     /gene_synonym="A4; A4LSB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      937..942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLP2"
                     /gene_synonym="A4; A4LSB"
                     /note="hexamer: AATAAA"
     polyA_site      957
                     /gene="PLP2"
                     /gene_synonym="A4; A4LSB"
                     /note="major polyA site"
     regulatory      966..971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLP2"
                     /gene_synonym="A4; A4LSB"
                     /note="hexamer: AATAAA"
     polyA_site      988
                     /gene="PLP2"
                     /gene_synonym="A4; A4LSB"
     regulatory      1080..1085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLP2"
                     /gene_synonym="A4; A4LSB"
                     /note="hexamer: ATTAAA"
     polyA_site      1103
                     /gene="PLP2"
                     /gene_synonym="A4; A4LSB"
ORIGIN      
        1 cttcccggcc agacggcggg caagacagct gggtgtacag cgtcctcgaa accacgagca
       61 agtgagcaga tcctccgagg caccagggac tccagcccat gccatggcgg attctgagcg
      121 cctctcggct cctggctgct gggccgcctg caccaacttc tcgcgcactc gaaagggaat
      181 cctcctgttt gctgagatta tattatgcct ggtgatcctg atctgcttca gtgcctccac
      241 accaggctac tcctccctgt cggtgattga gatgatcctt gctgctattt tctttgttgt
      301 ctacatgtgt gacctgcaca ccaagatacc attcatcaac tggccctgga gtgatttctt
      361 ccgaaccctc atagcggcaa tcctctacct gatcacctcc attgttgtcc ttgttgagag
      421 aggaaaccac tccaaaatcg tcgcaggggt actgggccta atcgctacgt gcctctttgg
      481 ctatgatgcc tatgtcacct tccccgttcg gcagccaaga catacagcag cccccactga
      541 ccccgcagat ggcccggtgt aggcgaactt ccctcatttc tctctgcaat ctgcaaataa
      601 ctcctccatt gaaataactc ctccccaccc caacaacaac attcccagca gaccaactcc
      661 caccccctct ttgaggtaaa agtgccttta ttgggagact tttgtcttcc agcctgccaa
      721 tcaaccctcc tgggtgtggc caccatatgt gtgtgcctag gtcctccttc tgcacgatcc
      781 aataggagac accagttctg actgaaccat gcccccacct aagtcacaaa atgagggaag
      841 tggggagtta gatttcagag tccaggccct aggttgggac ccactccaaa taatctcctc
      901 ggtgtgggtg gtggttctat agagggataa atgaataata aacattgtta aaatatacga
      961 taatgaataa agtaatcctt tcatcaaatg tgggtaaatt tcaagcatca ggagggggaa
     1021 atggagtgga aacagctggg gcaaggaggc aaagaagcca ggcctgtttt acaacaaata
     1081 ttaaattact tcaataatac aaa
//
