LOCUS       NM_001084               2821 bp    mRNA    linear   PRI 03-JUN-2024
DEFINITION  Homo sapiens procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
            (PLOD3), mRNA.
ACCESSION   NM_001084
VERSION     NM_001084.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2821)
  AUTHORS   Ding,M., Wang,C., Hu,J., She,J., Shi,R., Liu,Y., Sun,Q., Xu,H.,
            Zhou,G., Wu,W. and Xia,H.
  TITLE     PLOD3 facilitated T cell activation in the colorectal tumor
            microenvironment and liver metastasis by the TNF-alpha/ NF-kappaB
            pathway
  JOURNAL   J Transl Med 22 (1), 30 (2024)
   PUBMED   38184566
  REMARK    GeneRIF: PLOD3 facilitated T cell activation in the colorectal
            tumor microenvironment and liver metastasis by the TNF-alpha/
            NF-kappaB pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2821)
  AUTHORS   Ishikawa,Y., Taga,Y., Coste,T., Tufa,S.F., Keene,D.R., Mizuno,K.,
            Tournier-Lasserve,E. and Gould,D.B.
  TITLE     Lysyl hydroxylase 3-mediated post-translational modifications are
            required for proper biosynthesis of collagen alpha1alpha1alpha2(IV)
  JOURNAL   J Biol Chem 298 (12), 102713 (2022)
   PUBMED   36403858
  REMARK    GeneRIF: Lysyl hydroxylase 3-mediated post-translational
            modifications are required for proper biosynthesis of collagen
            alpha1alpha1alpha2(IV).
REFERENCE   3  (bases 1 to 2821)
  AUTHORS   Li,W.H., Huang,K., Wen,F.B., Cui,G.H., Guo,H.Z. and Zhao,S.
  TITLE     PLOD3 regulates the expression of YAP1 to affect the progression of
            non-small cell lung cancer via the PKCdelta/CDK1/LIMD1 signaling
            pathway
  JOURNAL   Lab Invest 102 (4), 440-451 (2022)
   PUBMED   35039611
  REMARK    GeneRIF: PLOD3 regulates the expression of YAP1 to affect the
            progression of non-small cell lung cancer via the
            PKCdelta/CDK1/LIMD1 signaling pathway.
REFERENCE   4  (bases 1 to 2821)
  AUTHORS   Shi,J., Bao,M., Wang,W., Wu,X., Li,Y., Zhao,C. and Liu,W.
  TITLE     Integrated Profiling Identifies PLOD3 as a Potential Prognostic and
            Immunotherapy Relevant Biomarker in Colorectal Cancer
  JOURNAL   Front Immunol 12, 722807 (2021)
   PUBMED   34646265
  REMARK    GeneRIF: Integrated Profiling Identifies PLOD3 as a Potential
            Prognostic and Immunotherapy Relevant Biomarker in Colorectal
            Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2821)
  AUTHORS   Gong,S., Duan,Y., Wu,C., Osterhoff,G., Schopow,N. and
            Kallendrusch,S.
  TITLE     A Human Pan-Cancer System Analysis of Procollagen-Lysine,
            2-Oxoglutarate 5-Dioxygenase 3 (PLOD3)
  JOURNAL   Int J Mol Sci 22 (18), 9903 (2021)
   PUBMED   34576068
  REMARK    GeneRIF: A Human Pan-Cancer System Analysis of Procollagen-Lysine,
            2-Oxoglutarate 5-Dioxygenase 3 (PLOD3).
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2821)
  AUTHORS   Ruotsalainen,H., Vanhatupa,S., Tampio,M., Sipila,L., Valtavaara,M.
            and Myllyla,R.
  TITLE     Complete genomic structure of mouse lysyl hydroxylase 2 and lysyl
            hydroxylase 3/collagen glucosyltransferase
  JOURNAL   Matrix Biol 20 (2), 137-146 (2001)
   PUBMED   11334715
REFERENCE   7  (bases 1 to 2821)
  AUTHORS   Heikkinen,J., Risteli,M., Wang,C., Latvala,J., Rossi,M.,
            Valtavaara,M. and Myllyla,R.
  TITLE     Lysyl hydroxylase 3 is a multifunctional protein possessing
            collagen glucosyltransferase activity
  JOURNAL   J Biol Chem 275 (46), 36158-36163 (2000)
   PUBMED   10934207
REFERENCE   8  (bases 1 to 2821)
  AUTHORS   Rautavuoma,K., Passoja,K., Helaakoski,T. and Kivirikko,K.I.
  TITLE     Complete exon-intron organization of the gene for human lysyl
            hydroxylase 3 (LH3)
  JOURNAL   Matrix Biol 19 (1), 73-79 (2000)
   PUBMED   10686427
REFERENCE   9  (bases 1 to 2821)
  AUTHORS   Passoja,K., Rautavuoma,K., Ala-Kokko,L., Kosonen,T. and
            Kivirikko,K.I.
  TITLE     Cloning and characterization of a third human lysyl hydroxylase
            isoform
  JOURNAL   Proc Natl Acad Sci U S A 95 (18), 10482-10486 (1998)
   PUBMED   9724729
REFERENCE   10 (bases 1 to 2821)
  AUTHORS   Valtavaara,M., Szpirer,C., Szpirer,J. and Myllyla,R.
  TITLE     Primary structure, tissue distribution, and chromosomal
            localization of a novel isoform of lysyl hydroxylase (lysyl
            hydroxylase 3)
  JOURNAL   J Biol Chem 273 (21), 12881-12886 (1998)
   PUBMED   9582318
  REMARK    Erratum:[J Biol Chem 2000 Jul 7;275(27):20956]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC011674.2, AC004876.2 and
            AL049952.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001084.4.
            
            Summary: The protein encoded by this gene is a membrane-bound
            homodimeric enzyme that is localized to the cisternae of the rough
            endoplasmic reticulum. The enzyme (cofactors iron and ascorbate)
            catalyzes the hydroxylation of lysyl residues in collagen-like
            peptides. The resultant hydroxylysyl groups are attachment sites
            for carbohydrates in collagen and thus are critical for the
            stability of intermolecular crosslinks. Some patients with
            Ehlers-Danlos syndrome type VIB have deficiencies in lysyl
            hydroxylase activity. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011674.2, AF068229.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000223127.8/ ENSP00000223127.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               BC011674.2         7-232
            227-227             AC004876.2         113390-113390       c
            228-2819            BC011674.2         234-2825
            2820-2821           AL049952.1         1394-1395
FEATURES             Location/Qualifiers
     source          1..2821
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2821
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /note="procollagen-lysine,2-oxoglutarate 5-dioxygenase 3"
                     /db_xref="GeneID:8985"
                     /db_xref="HGNC:HGNC:9083"
                     /db_xref="MIM:603066"
     exon            1..416
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..2524
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /EC_number="1.14.11.4"
                     /EC_number="2.4.1.50"
                     /EC_number="2.4.1.66"
                     /note="lysyl hydroxylase 3; lysine hydroxylase 3; lysyl
                     hydroxlase 3; multifunctional procollagen lysine
                     hydroxylase and glycosyltransferase LH3"
                     /codon_start=1
                     /product="multifunctional procollagen lysine hydroxylase
                     and glycosyltransferase LH3 precursor"
                     /protein_id="NP_001075.1"
                     /db_xref="CCDS:CCDS5715.1"
                     /db_xref="GeneID:8985"
                     /db_xref="HGNC:HGNC:9083"
                     /db_xref="MIM:603066"
                     /translation="MTSSGPGPRFLLLLPLLLPPAASASDRPRGRDPVNPEKLLVITV
                     ATAETEGYLRFLRSAEFFNYTVRTLGLGEEWRGGDVARTVGGGQKVRWLKKEMEKYAD
                     REDMIIMFVDSYDVILAGSPTELLKKFVQSGSRLLFSAESFCWPEWGLAEQYPEVGTG
                     KRFLNSGGFIGFATTIHQIVRQWKYKDDDDDQLFYTRLYLDPGLREKLSLNLDHKSRI
                     FQNLNGALDEVVLKFDRNRVRIRNVAYDTLPIVVHGNGPTKLQLNYLGNYVPNGWTPE
                     GGCGFCNQDRRTLPGGQPPPRVFLAVFVEQPTPFLPRFLQRLLLLDYPPDRVTLFLHN
                     NEVFHEPHIADSWPQLQDHFSAVKLVGPEEALSPGEARDMAMDLCRQDPECEFYFSLD
                     ADAVLTNLQTLRILIEENRKVIAPMLSRHGKLWSNFWGALSPDEYYARSEDYVELVQR
                     KRVGVWNVPYISQAYVIRGDTLRMELPQRDVFSGSDTDPDMAFCKSFRDKGIFLHLSN
                     QHEFGRLLATSRYDTEHLHPDLWQIFDNPVDWKEQYIHENYSRALEGEGIVEQPCPDV
                     YWFPLLSEQMCDELVAEMEHYGQWSGGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWL
                     QLLRTYVGPMTESLFPGYHTKARAVMNFVVRYRPDEQPSLRPHHDSSTFTLNVALNHK
                     GLDYEGGGCRFLRYDCVISSPRKGWALLHPGRLTHYHEGLPTTWGTRYIMVSFVDP"
     exon            417..508
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            509..645
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            646..809
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            810..922
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            923..986
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1084
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1186
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1312
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1434
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1539
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1665
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1807
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1921
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..1990
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2095
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2242
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2368
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2821
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2803..2808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /note="hexamer: AATAAA"
     polyA_site      2821
                     /gene="PLOD3"
                     /gene_synonym="BCARD; LH3"
                     /note="major polyA site"
ORIGIN      
        1 acatgtgtca agcggctggc tcagcccaga gtccctgtct cccgcccgcc ggcccgagcc
       61 gccgcccctc ccccgcctcc cgtgcgcccg ggacaatcct cgccttgtct gtggcgccgg
      121 catctggagc tttctgtagc ctccggatac gccttttttt cagggcgtag ccccagccaa
      181 gctgctcccc gcggcggccg cacagcagcc cgagcgcccc ctttccagag ctcccctccg
      241 gagctgggat ccaggcgcgt agcggagatc ccaggatcct gggtgctgtc tgggcccgct
      301 ccccaccatg acctcctcgg ggcctggacc ccggttcctg ctgctgctgc cgctgctgct
      361 gccccctgcg gcctcagcct ccgaccggcc ccggggccga gacccggtca acccagagaa
      421 gctgctggtg atcactgtgg ccacagctga aaccgagggg tacctgcgtt tcctgcgctc
      481 tgcggagttc ttcaactaca ctgtgcggac cctgggcctg ggagaggagt ggcgaggggg
      541 tgatgtggct cgaacagttg gtggaggaca gaaggtccgg tggttaaaga aggaaatgga
      601 gaaatacgct gaccgggagg atatgatcat catgtttgtg gatagctacg acgtgattct
      661 ggccggcagc cccacagagc tgctgaagaa gttcgtccag agtggcagcc gcctgctctt
      721 ctctgcagag agcttctgct ggcccgagtg ggggctggcg gagcagtacc ctgaggtggg
      781 cacggggaag cgcttcctca attctggtgg attcatcggt tttgccacca ccatccacca
      841 aatcgtgcgc cagtggaagt acaaggatga tgacgacgac cagctgttct acacacggct
      901 ctacctggac ccaggactga gggagaaact cagccttaat ctggatcata agtctcggat
      961 ctttcagaac ctcaacgggg ctttagatga agtggtttta aagtttgatc ggaaccgtgt
     1021 gcgtatccgg aacgtggcct acgacacgct ccccattgtg gtccatggaa acggtcccac
     1081 taagctgcag ctcaactacc tgggaaacta cgtccccaat ggctggactc ctgagggagg
     1141 ctgtggcttc tgcaaccagg accggaggac actcccgggg gggcagcctc ccccccgggt
     1201 gtttctggcc gtgtttgtgg aacagcctac tccgtttctg ccccgcttcc tgcagcggct
     1261 gctactcctg gactatcccc ccgacagggt cacccttttc ctgcacaaca acgaggtctt
     1321 ccatgaaccc cacatcgctg actcctggcc gcagctccag gaccacttct cagctgtgaa
     1381 gctcgtgggg ccggaggagg ctctgagccc aggcgaggcc agggacatgg ccatggacct
     1441 gtgtcggcag gaccccgagt gtgagttcta cttcagcctg gacgccgacg ctgtcctcac
     1501 caacctgcag accctgcgta tcctcattga ggagaacagg aaggtgatcg cccccatgct
     1561 gtcccgccac ggcaagctgt ggtccaactt ctggggcgcc ctgagccccg atgagtacta
     1621 cgcccgctcc gaggactacg tggagctggt gcagcggaag cgagtgggtg tgtggaatgt
     1681 accatacatc tcccaggcct atgtgatccg gggtgatacc ctgcggatgg agctgcccca
     1741 gagggatgtg ttctcgggca gtgacacaga cccggacatg gccttctgta agagctttcg
     1801 agacaagggc atcttcctcc atctgagcaa tcagcatgaa tttggccggc tcctggccac
     1861 ttccagatac gacacggagc acctgcaccc cgacctctgg cagatcttcg acaaccccgt
     1921 cgactggaag gagcagtaca tccacgagaa ctacagccgg gccctggaag gggaaggaat
     1981 cgtggagcag ccatgcccgg acgtgtactg gttcccactg ctgtcagaac aaatgtgtga
     2041 tgagctggtg gcagagatgg agcactacgg ccagtggtca ggcggccggc atgaggattc
     2101 aaggctggct ggaggctacg agaatgtgcc caccgtggac atccacatga agcaggtggg
     2161 gtacgaggac cagtggctgc agctgctgcg gacgtatgtg ggccccatga ccgagagcct
     2221 gtttcccggt taccacacca aggcgcgggc ggtgatgaac tttgtggttc gctaccggcc
     2281 agacgagcag ccgtctctgc ggccacacca cgactcatcc accttcaccc tcaacgttgc
     2341 cctcaaccac aagggcctgg actatgaggg aggtggctgc cgcttcctgc gctacgactg
     2401 tgtgatctcc tccccgagga agggctgggc actcctgcac cccggccgcc tcacccacta
     2461 ccacgagggg ctgccaacga cctggggcac acgctacatc atggtgtcct ttgtcgaccc
     2521 ctgacactca accactctgc caaacctgcc ctgccattgt gcctttttag ggggcctggc
     2581 ccccgtcctg ggagttgggg gatgggtctc tctgtctccc cacttcctga gttcatgttc
     2641 cgcgtgcctg aactgaatat gtcaccttgc tcccaagaca cggccctctc aggaagctcc
     2701 cggagtcccc gcctctctcc tccgcccaca ggggttcgtg ggcacagggc ttctggggac
     2761 tccccgcgtg ataaattatt aatgttccgc agtctcactc tgaataaagg acagtttgta
     2821 a
//
