LOCUS       NM_182943               3749 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
            (PLOD2), transcript variant 1, mRNA.
ACCESSION   NM_182943
VERSION     NM_182943.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3749)
  AUTHORS   Yue,W., Zhang,H., Gao,Y., Ding,J., Xue,R., Dong,C., Liu,F.,
            Yang,L., Yang,L. and Li,L.
  TITLE     Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes collagen
            cross-linking and ECM stiffening to induce liver fibrosis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167205 (2024)
   PUBMED   38696846
  REMARK    GeneRIF: Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes
            collagen cross-linking and ECM stiffening to induce liver fibrosis.
REFERENCE   2  (bases 1 to 3749)
  AUTHORS   Chen,Y., He,Y., Li,Z., Zhang,N., Zhou,C., He,X. and Xue,D.
  TITLE     METTL3 facilitates renal cell carcinoma progression by PLOD2
            m6A-methylation under prolonged hypoxia
  JOURNAL   Cell Death Dis 15 (1), 62 (2024)
   PUBMED   38233403
  REMARK    GeneRIF: METTL3 facilitates renal cell carcinoma progression by
            PLOD2 m[6]A-methylation under prolonged hypoxia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3749)
  AUTHORS   Liu,T., Xiang,W., Chen,Z., Wang,G., Cao,R., Zhou,F., Meng,Z.,
            Luo,Y. and Chen,L.
  TITLE     Hypoxia-induced PLOD2 promotes clear cell renal cell carcinoma
            progression via modulating EGFR-dependent AKT pathway activation
  JOURNAL   Cell Death Dis 14 (11), 774 (2023)
   PUBMED   38008826
  REMARK    GeneRIF: Hypoxia-induced PLOD2 promotes clear cell renal cell
            carcinoma progression via modulating EGFR-dependent AKT pathway
            activation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3749)
  AUTHORS   Glaser,S.F., Brezski,A., Baumgarten,N., Klangwart,M.,
            Heumuller,A.W., Maji,R.K., Leisegang,M.S., Guenther,S.,
            Zehendner,C.M., John,D., Schulz,M.H., Zarnack,K. and Dimmeler,S.
  TITLE     Circular RNA circPLOD2 regulates pericyte function by targeting the
            transcription factor KLF4
  JOURNAL   Cell Rep 42 (8), 112824 (2023)
   PUBMED   37481725
  REMARK    GeneRIF: Circular RNA circPLOD2 regulates pericyte function by
            targeting the transcription factor KLF4.
REFERENCE   5  (bases 1 to 3749)
  AUTHORS   Tong,Y., Qi,Y., Xiong,G., Li,J., Scott,T.L., Chen,J., He,D., Li,L.,
            Wang,C., Lane,A.N. and Xu,R.
  TITLE     The PLOD2/succinate axis regulates the epithelial-mesenchymal
            plasticity and cancer cell stemness
  JOURNAL   Proc Natl Acad Sci U S A 120 (20), e2214942120 (2023)
   PUBMED   37155842
  REMARK    GeneRIF: The PLOD2/succinate axis regulates the
            epithelial-mesenchymal plasticity and cancer cell stemness.
REFERENCE   6  (bases 1 to 3749)
  AUTHORS   Wang,C., Valtavaara,M. and Myllyla,R.
  TITLE     Lack of collagen type specificity for lysyl hydroxylase isoforms
  JOURNAL   DNA Cell Biol 19 (2), 71-77 (2000)
   PUBMED   10701773
REFERENCE   7  (bases 1 to 3749)
  AUTHORS   Yeowell,H.N. and Walker,L.C.
  TITLE     Tissue specificity of a new splice form of the human lysyl
            hydroxylase 2 gene
  JOURNAL   Matrix Biol 18 (2), 179-187 (1999)
   PUBMED   10372558
REFERENCE   8  (bases 1 to 3749)
  AUTHORS   Valtavaara,M., Szpirer,C., Szpirer,J. and Myllyla,R.
  TITLE     Primary structure, tissue distribution, and chromosomal
            localization of a novel isoform of lysyl hydroxylase (lysyl
            hydroxylase 3)
  JOURNAL   J Biol Chem 273 (21), 12881-12886 (1998)
   PUBMED   9582318
  REMARK    Erratum:[J Biol Chem 2000 Jul 7;275(27):20956]
REFERENCE   9  (bases 1 to 3749)
  AUTHORS   Szpirer,C., Szpirer,J., Riviere,M., Vanvooren,P., Valtavaara,M. and
            Myllyla,R.
  TITLE     Localization of the gene encoding a novel isoform of lysyl
            hydroxylase
  JOURNAL   Mamm Genome 8 (9), 707-708 (1997)
   PUBMED   9271685
REFERENCE   10 (bases 1 to 3749)
  AUTHORS   Valtavaara,M., Papponen,H., Pirttila,A.M., Hiltunen,K., Helander,H.
            and Myllyla,R.
  TITLE     Cloning and characterization of a novel human lysyl hydroxylase
            isoform highly expressed in pancreas and muscle
  JOURNAL   J Biol Chem 272 (11), 6831-6834 (1997)
   PUBMED   9054364
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM724669.1, BC037169.1 and
            AC107021.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_182943.2.
            
            Summary: The protein encoded by this gene is a membrane-bound
            homodimeric enzyme that is localized to the cisternae of the rough
            endoplasmic reticulum. The enzyme (cofactors iron and ascorbate)
            catalyzes the hydroxylation of lysyl residues in collagen-like
            peptides. The resultant hydroxylysyl groups are attachment sites
            for carbohydrates in collagen and thus are critical for the
            stability of intermolecular crosslinks. Some patients with
            Ehlers-Danlos syndrome type VIB have deficiencies in lysyl
            hydroxylase activity. Mutations in the coding region of this gene
            are associated with Bruck syndrome. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1, also known as LH2b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037169.1, SRR1803612.117327.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282903.10/ ENSP00000282903.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BM724669.1         441-469
            30-2508             BC037169.1         12-2490
            2509-2509           AC107021.4         83377-83377         c
            2510-3749           BC037169.1         2492-3731
FEATURES             Location/Qualifiers
     source          1..3749
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q24"
     gene            1..3749
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /note="procollagen-lysine,2-oxoglutarate 5-dioxygenase 2"
                     /db_xref="GeneID:5352"
                     /db_xref="HGNC:HGNC:9082"
                     /db_xref="MIM:601865"
     exon            1..304
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..2472
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /EC_number="1.14.11.4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; lysine hydroxylase 2; telopeptide lysyl
                     hydroxylase; lysyl hydroxylase 2; lysyl hydroxlase 2;
                     procollagen-lysine 5-dioxygenase; telopeptidyl lysyl
                     hydroxylase; procollagen lysyl hydroxylase 2"
                     /codon_start=1
                     /product="procollagen-lysine,2-oxoglutarate 5-dioxygenase
                     2 isoform 1 precursor"
                     /protein_id="NP_891988.1"
                     /db_xref="CCDS:CCDS3132.1"
                     /db_xref="GeneID:5352"
                     /db_xref="HGNC:HGNC:9082"
                     /db_xref="MIM:601865"
                     /translation="MGGCTVKPQLLLLALVLHPWNPCLGADSEKPSSIPTDKLLVITV
                     ATKESDGFHRFMQSAKYFNYTVKVLGQGEEWRGGDGINSIGGGQKVRLMKEVMEHYAD
                     QDDLVVMFTECFDVIFAGGPEEVLKKFQKANHKVVFAADGILWPDKRLADKYPVVHIG
                     KRYLNSGGFIGYAPYVNRIVQQWNLQDNDDDQLFYTKVYIDPLKREAINITLDHKCKI
                     FQTLNGAVDEVVLKFENGKARAKNTFYETLPVAINGNGPTKILLNYFGNYVPNSWTQD
                     NGCTLCEFDTVDLSAVDVHPNVSIGVFIEQPTPFLPRFLDILLTLDYPKEALKLFIHN
                     KEVYHEKDIKVFFDKAKHEIKTIKIVGPEENLSQAEARNMGMDFCRQDEKCDYYFSVD
                     ADVVLTNPRTLKILIEQNRKIIAPLVTRHGKLWSNFWGALSPDGYYARSEDYVDIVQG
                     NRVGVWNVPYMANVYLIKGKTLRSEMNERNYFVRDKLDPDMALCRNAREMTLQREKDS
                     PTPETFQMLSPPKGVFMYISNRHEFGRLLSTANYNTSHYNNDLWQIFENPVDWKEKYI
                     NRDYSKIFTENIVEQPCPDVFWFPIFSEKACDELVEEMEHYGKWSGGKHHDSRISGGY
                     ENVPTDDIHMKQVDLENVWLHFIREFIAPVTLKVFAGYYTKGFALLNFVVKYSPERQR
                     SLRPHHDASTFTINIALNNVGEDFQGGGCKFLRYNCSIESPRKGWSFMHPGRLTHLHE
                     GLPVKNGTRYIAVSFIDP"
     exon            305..396
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     exon            397..533
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     exon            534..697
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     exon            698..810
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     exon            811..874
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     exon            875..972
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1074
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1200
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1322
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1427
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1553
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1695
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1758
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1872
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1938
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2043
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2190
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2316
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..3749
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3551..3556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /note="hexamer: TATAAA"
     polyA_site      3574
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /note="major polyA site"
     regulatory      3731..3736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
                     /note="hexamer: AATAAA"
     polyA_site      3749
                     /gene="PLOD2"
                     /gene_synonym="BRKS2; LH2; TLH"
ORIGIN      
        1 gctgctccgt gcctccaccg acgacctcac tcagctgcgt tacgcgccgc tccggctgcc
       61 ggccgcgcgc cttgcccgcc ggctcccgcc cgcaatcggc ggctcagggc ggacccgggt
      121 ctctgcgttc tcgcgagaag cgcggcgctg cggggccgtg ggcgcctgag cccgcgcggc
      181 cctcgagggc cgaatatggg gggatgcacg gtgaagcctc agctgctgct cctggcgctc
      241 gtcctccacc cctggaatcc ctgtctgggt gcggactcgg agaagccctc gagcatcccc
      301 acagataaat tattagtcat aactgtagca acaaaagaaa gtgatggatt ccatcgattt
      361 atgcagtcag ccaaatattt caattatact gtgaaggtcc ttggtcaagg agaagaatgg
      421 agaggtggtg atggaattaa tagtattgga gggggccaga aagtgagatt aatgaaagaa
      481 gtcatggaac actatgctga tcaagatgat ctggttgtca tgtttactga atgctttgat
      541 gtcatatttg ctggtggtcc agaagaagtt ctaaaaaaat tccaaaaggc aaaccacaaa
      601 gtggtctttg cagcagatgg aattttgtgg ccagataaaa gactagcaga caagtatcct
      661 gttgtgcaca ttgggaaacg ctatctgaat tcaggaggat ttattggcta tgctccatat
      721 gtcaaccgta tagttcaaca atggaatctc caggataatg atgatgatca gctcttttac
      781 actaaagttt acattgatcc actgaaaagg gaagctatta acatcacatt ggatcacaaa
      841 tgcaaaattt tccagacctt aaatggagct gtagatgaag ttgttttaaa atttgaaaat
      901 ggcaaagcca gagctaagaa tacattttat gaaacattac cagtggcaat taatggaaat
      961 ggacccacca agattctcct gaattatttt ggaaactatg tacccaattc atggacacag
     1021 gataatggct gcactctttg tgaattcgat acagtcgact tgtctgcagt agatgtccat
     1081 ccaaacgtat caataggtgt ttttattgag caaccaaccc cttttctacc tcggtttctg
     1141 gacatattgt tgacactgga ttacccaaaa gaagcactta aactttttat tcataacaaa
     1201 gaagtttatc atgaaaagga catcaaggta ttttttgata aagctaagca tgaaatcaaa
     1261 actataaaaa tagtaggacc agaagaaaat ctaagtcaag cggaagccag aaacatggga
     1321 atggactttt gccgtcagga tgaaaagtgt gattattact ttagtgtgga tgcagatgtt
     1381 gttttgacaa atccaaggac tttaaaaatt ttgattgaac aaaacagaaa gatcattgct
     1441 cctcttgtaa ctcgtcatgg aaagctgtgg tccaatttct ggggagcatt gagtcctgat
     1501 ggatactatg cacgatctga agattatgtg gatattgttc aagggaatag agtaggagta
     1561 tggaatgtcc catatatggc taatgtgtac ttaattaaag gaaagacact ccgatcagag
     1621 atgaatgaaa ggaactattt tgttcgtgat aaactggatc ctgatatggc tctttgccga
     1681 aatgctagag aaatgacttt acaaagggaa aaagactccc ctactccgga aacattccaa
     1741 atgctcagcc ccccaaaggg tgtatttatg tacatttcta atagacatga atttggaagg
     1801 ctattatcca ctgctaatta caatacttcc cattataaca atgacctctg gcagattttt
     1861 gaaaatcctg tggactggaa ggaaaagtat ataaaccgtg attattcaaa gattttcact
     1921 gaaaatatag ttgaacagcc ctgtccagat gtcttttggt tccccatatt ttctgaaaaa
     1981 gcctgtgatg aattggtaga agaaatggaa cattacggca aatggtctgg gggaaaacat
     2041 catgatagcc gtatatctgg tggttatgaa aatgtcccaa ctgatgatat ccacatgaag
     2101 caagttgatc tggagaatgt atggcttcat tttatccggg agttcattgc accagttaca
     2161 ctgaaggtct ttgcaggcta ttatacgaag ggatttgcac tactgaattt tgtagtaaaa
     2221 tactcccctg aacgacagcg ttctcttcgt cctcatcatg atgcttctac atttaccata
     2281 aacattgcac ttaataacgt gggagaagac tttcagggag gtggttgcaa atttctaagg
     2341 tacaattgct ctattgagtc accacgaaaa ggctggagct tcatgcatcc tgggagactc
     2401 acacatttgc atgaaggact tcctgttaaa aatggaacaa gatacattgc agtgtcattt
     2461 atagatccct aagttattta cttttcattg aattgaaatt tattttggat gaatgactgg
     2521 catgaacacg tctttgaagt tgtggctgag aagatgagag gaatatttaa ataacatcaa
     2581 cagaacaact tcactttggg ccaaacattt gaaaaacttt ttataaaaaa ttgtttgata
     2641 tttcttaatg tctgctctga gccttaaaac acagattgaa gaagaaaaga aagaaaaaac
     2701 ttaaatattt atttctatgc tttgttgcct ctgagaataa tgacaattta tgaatttgtg
     2761 tttcaaattg ataaaatatt taggtacaaa taacaagact aataatattt tcttatttaa
     2821 aaaaagcatg ggaagatttt tatttatcaa aatatagagg aaatgtagac aaaatggata
     2881 taaatgaaaa ttaccatgtt gtaaaacctt gaaaatcaga ttctaactgg atttgtatgc
     2941 aactaagtat ttttctgaac acctatgcag gtcttattta cagtagttac taagggaaca
     3001 cacaaagaat tacacaacgt tttcctcaag aaaatggtac aaaacacaac cgaggagcgt
     3061 atacagttga aaacattttt gttttgattg gaaggcagat tattttatat tagtattaaa
     3121 aatcaaaccc tatgtttctt tcagatgaat cttccaaagt ggattatatt aagcaggtat
     3181 tagatttagg aaaacctttc catttcttaa agtattatca agtgtcaaga tcagcaagtg
     3241 tccttaagtc aaacaggttt tttttgttgt tgtttttgct ttgtttcctt ttttagaaag
     3301 ttctagaaaa taggaaaacg aaaaatttca ttgagatgag tagtgcattt aattattttt
     3361 taaaaaactt tttaagtact tgaattttat atcaggaaaa caaagttgtt gagccttgct
     3421 tcttccgttt tgccctttgt ctcgctcctt attctttttt tggggggagg gttatttgct
     3481 tttttatctt cctggcataa tttccatttt attcttctga gtgtctatgt taacttccct
     3541 ctatcccgct tataaaaaaa ttctccaaca aaaatacttg ttgacttgat gttttatcac
     3601 ttctctaagt aaggttgaaa tatccttatt gtagctactg tttttaatgt aaaggttaaa
     3661 cttgaaaaga aattcttaat cacggtgcca aaattcattt tctaacacca tgtgttagaa
     3721 aattataaaa aataaaataa ttttagaaa
//
