LOCUS       NM_015993               1497 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens plasmolipin (PLLP), mRNA.
ACCESSION   NM_015993
VERSION     NM_015993.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1497)
  AUTHORS   Azzaz,F., Mazzarino,M., Chahinian,H., Yahi,N., Scala,C.D. and
            Fantini,J.
  TITLE     Structure of the Myelin Sheath Proteolipid Plasmolipin (PLLP) in a
            Ganglioside-Containing Lipid Raft
  JOURNAL   Front Biosci (Landmark Ed) 28 (8), 157 (2023)
   PUBMED   37664934
  REMARK    GeneRIF: Structure of the Myelin Sheath Proteolipid Plasmolipin
            (PLLP) in a Ganglioside-Containing Lipid Raft.
REFERENCE   2  (bases 1 to 1497)
  AUTHORS   Zheng,P., Sun,S., Wang,J., Cheng,Z.J., Lei,K.C., Xue,M., Zhang,T.,
            Huang,H., Zhang,X.D. and Sun,B.
  TITLE     Integrative omics analysis identifies biomarkers of idiopathic
            pulmonary fibrosis
  JOURNAL   Cell Mol Life Sci 79 (1), 66 (2022)
   PUBMED   35015148
  REMARK    GeneRIF: Integrative omics analysis identifies biomarkers of
            idiopathic pulmonary fibrosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1497)
  AUTHORS   Cacho-Navas,C., Reglero-Real,N., Colas-Algora,N., Barroso,S., de
            Rivas,G., Stamatakis,K., Feito,J., Andres,G., Fresno,M., Kremer,L.,
            Correas,I., Alonso,M.A. and Millan,J.
  TITLE     Plasmolipin regulates basolateral-to-apical transcytosis of ICAM-1
            and leukocyte adhesion in polarized hepatic epithelial cells
  JOURNAL   Cell Mol Life Sci 79 (1), 61 (2022)
   PUBMED   34999972
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1497)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1497)
  AUTHORS   Yaffe,Y., Hugger,I., Yassaf,I.N., Shepshelovitch,J., Sklan,E.H.,
            Elkabetz,Y., Yeheskel,A., Pasmanik-Chor,M., Benzing,C.,
            Macmillan,A., Gaus,K., Eshed-Eisenbach,Y., Peles,E. and
            Hirschberg,K.
  TITLE     The myelin proteolipid plasmolipin forms oligomers and induces
            liquid-ordered membranes in the Golgi complex
  JOURNAL   J Cell Sci 128 (13), 2293-2302 (2015)
   PUBMED   26002055
  REMARK    GeneRIF: These data support a model in which PLLP functions in
            myelin biogenesis through organization of myelin liquid-ordered
            membranes in the Golgi complex.
REFERENCE   6  (bases 1 to 1497)
  AUTHORS   Byrne,E.M., Gehrman,P.R., Medland,S.E., Nyholt,D.R., Heath,A.C.,
            Madden,P.A., Hickie,I.B., Van Duijn,C.M., Henders,A.K.,
            Montgomery,G.W., Martin,N.G. and Wray,N.R.
  CONSRTM   Chronogen Consortium
  TITLE     A genome-wide association study of sleep habits and insomnia
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 162B (5), 439-451 (2013)
   PUBMED   23728906
REFERENCE   7  (bases 1 to 1497)
  AUTHORS   Hamacher,M., Pippirs,U., Kohler,A., Muller,H.W. and Bosse,F.
  TITLE     Plasmolipin: genomic structure, chromosomal localization, protein
            expression pattern, and putative association with Bardet-Biedl
            syndrome
  JOURNAL   Mamm Genome 12 (12), 933-937 (2001)
   PUBMED   11707781
REFERENCE   8  (bases 1 to 1497)
  AUTHORS   Fischer,I. and Sapirstein,V.S.
  TITLE     Molecular cloning of plasmolipin. Characterization of a novel
            proteolipid restricted to brain and kidney
  JOURNAL   J Biol Chem 269 (40), 24912-24919 (1994)
   PUBMED   7929173
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA366260.1 and BC002760.2.
            
            On Nov 23, 2018 this sequence version replaced NM_015993.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1100809.1,
                                           SRR3476690.131888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153733 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219207.10/ ENSP00000219207.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                DA366260.1         1-37
            38-1497             BC002760.2         1-1460
FEATURES             Location/Qualifiers
     source          1..1497
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q13"
     gene            1..1497
                     /gene="PLLP"
                     /gene_synonym="PMLP; TM4SF11"
                     /note="plasmolipin"
                     /db_xref="GeneID:51090"
                     /db_xref="HGNC:HGNC:18553"
                     /db_xref="MIM:600340"
     exon            1..267
                     /gene="PLLP"
                     /gene_synonym="PMLP; TM4SF11"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..681
                     /gene="PLLP"
                     /gene_synonym="PMLP; TM4SF11"
                     /note="transmembrane 4 superfamily member 11
                     (plasmolipin); plasma membrane proteolipid (plasmolipin)"
                     /codon_start=1
                     /product="plasmolipin"
                     /protein_id="NP_057077.1"
                     /db_xref="CCDS:CCDS10777.1"
                     /db_xref="GeneID:51090"
                     /db_xref="HGNC:HGNC:18553"
                     /db_xref="MIM:600340"
                     /translation="MAEFPSKVSTRTSSPAQGAEASVSALRPDLGFVRSRLGALMLLQ
                     LVLGLLVWALIADTPYHLYPAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPL
                     VLMIFNISATVLYITAFIACSAAVDLTSLRGTRPYNQRAAASFFACLVMIAYGVSAFF
                     SYQAWRGVGSNAATSQMAGGYA"
     exon            268..441
                     /gene="PLLP"
                     /gene_synonym="PMLP; TM4SF11"
                     /inference="alignment:Splign:2.1.0"
     exon            442..564
                     /gene="PLLP"
                     /gene_synonym="PMLP; TM4SF11"
                     /inference="alignment:Splign:2.1.0"
     exon            565..1497
                     /gene="PLLP"
                     /gene_synonym="PMLP; TM4SF11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1478..1483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLLP"
                     /gene_synonym="PMLP; TM4SF11"
                     /note="hexamer: AATAAA"
     polyA_site      1497
                     /gene="PLLP"
                     /gene_synonym="PMLP; TM4SF11"
                     /note="major polyA site"
ORIGIN      
        1 gacgcctcct gcagcgcctg gagccacaca gggatccgga gcctggggga aaagcggcgc
       61 gggagccggc acccaccgct ggaggggcgg cgacggcggc cgtagcgacc tcgggaggca
      121 agcggagccg ccatggccga gttcccgtcg aaagttagca cgcggaccag cagtcctgcg
      181 cagggcgccg aagcctcggt gtcggcgctg cgcccggacc tgggcttcgt gcgctcccgc
      241 ctcggggcgc tcatgctgct gcagctggtg ctggggctgc tggtgtgggc gctgattgcg
      301 gacaccccgt accacctgta tccggcctat ggctgggtga tgttcgtcgc tgtcttcctc
      361 tggctggtga caatcgtcct cttcaacctc tacctgtttc agctgcacat gaagttgtac
      421 atggttccct ggccactggt gttaatgatc tttaacatca gcgccaccgt tctctacatc
      481 accgccttca tcgcctgctc tgcggcagtt gacctgacat ccctgagggg cacccggcct
      541 tataaccagc gcgcggctgc ctcgttcttt gcgtgtttgg tgatgatcgc ctatggagtg
      601 agtgccttct tcagctacca ggcctggcga ggagtaggca gcaatgcggc caccagtcag
      661 atggctggcg gctatgccta aaccacctgt gccacggccc cctctggggc tgaagccgcc
      721 gctgggtcac agagcagggt caccctgcaa gcctgaagct ggggagccct gcgtggagtc
      781 agcccaacag ggactgcatt tgctcctctc tgcccgtcag acataagctc tcacagcgct
      841 aaggaagcag gcccaggctg gcaggcatct cggcttgcag gaggccaact gctgagacct
      901 cttctccatc ccccttattc agtggaagat gacgggggat ctgaggctgt gtctctgcct
      961 tgtctttaga ggacttcagc gtccaagact ggggcccacc cttctcacca gcactaaatg
     1021 cactaacaag gactccagac ctgcagcccc agacccgccg tagtataagc ctaacaagca
     1081 acacgtagca ccttagtctt tgttccagga gagctgagca agctggtgaa accactctcc
     1141 ttcctttaaa caccgtttca accaacctct ccctggagcc aacctgtaaa aagtgggttg
     1201 attgctgaca gcatggtctt ccctccctgc atttcagaca taccagttac tgaaagcaaa
     1261 tcagttttaa gtgatttctc agtgctgaaa agcctgtcca ggtttccttc cctttcccaa
     1321 gcctctctct gtaatactcc ctttgggcga agctaacatc ggtgcctccc cgaccttgct
     1381 gactaggcac atgggacgca aaggagggag ggaagcaagg ccttgcctgg cgagttgtca
     1441 tgtggttggt ggtgactgtt ttattttttt taataaaaat aaagatgaga gaaatta
//
