LOCUS       NM_001243079            2520 bp    mRNA    linear   PRI 19-DEC-2024
DEFINITION  Homo sapiens polo like kinase 5 (inactive) (PLK5), mRNA.
ACCESSION   NM_001243079
VERSION     NM_001243079.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2520)
  AUTHORS   Li,Z., Hao,P., Wu,Q., Li,F., Zhao,J., Wu,K., Qu,C., Chen,Y., Li,M.,
            Chen,X., Stucky,A., Zhong,J., Li,L. and Zhong,J.F.
  TITLE     Genetic mutations associated with metastatic clear cell renal cell
            carcinoma
  JOURNAL   Oncotarget 7 (13), 16172-16179 (2016)
   PUBMED   26908440
  REMARK    GeneRIF: we report a three-nucleotide deletion near the C-region of
            Plk5 that is specifically associated with the lymphatic metastasis
            in patients with clear cell renal cell carcinoma
REFERENCE   2  (bases 1 to 2520)
  AUTHORS   de Carcer,G., Escobar,B., Higuero,A.M., Garcia,L., Anson,A.,
            Perez,G., Mollejo,M., Manning,G., Melendez,B., Abad-Rodriguez,J.
            and Malumbres,M.
  TITLE     Plk5, a polo box domain-only protein with specific roles in neuron
            differentiation and glioblastoma suppression
  JOURNAL   Mol Cell Biol 31 (6), 1225-1239 (2011)
   PUBMED   21245385
  REMARK    GeneRIF: The human polo-like kinase 5 gene is significantly
            silenced in astrocytoma and glioblastoma multiforme by promoter
            hypermethylation, suggesting a tumor suppressor function for this
            gene.
REFERENCE   3  (bases 1 to 2520)
  AUTHORS   Andrysik,Z., Bernstein,W.Z., Deng,L., Myer,D.L., Li,Y.Q.,
            Tischfield,J.A., Stambrook,P.J. and Bahassi el,M.
  TITLE     The novel mouse Polo-like kinase 5 responds to DNA damage and
            localizes in the nucleolus
  JOURNAL   Nucleic Acids Res 38 (9), 2931-2943 (2010)
   PUBMED   20100802
REFERENCE   4  (bases 1 to 2520)
  AUTHORS   Zhang,Z.D., Frankish,A., Hunt,T., Harrow,J. and Gerstein,M.
  TITLE     Identification and analysis of unitary pseudogenes: historic and
            contemporary gene losses in humans and other primates
  JOURNAL   Genome Biol 11 (3), R26 (2010)
   PUBMED   20210993
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC027307.5, AK054808.1, AI651075.1 and BC100791.2.
            
            On May 17, 2019 this sequence version replaced NM_001243079.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.255346.1,
                                           SRR3476690.705705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000454744.7/ ENSP00000468376.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC027307.5         113900-113902
            4-455               AK054808.1         7-458
            456-518             AI651075.1         417-479
            519-529             AK054808.1         522-532
            530-1653            BC100791.2         97-1220
            1654-2520           AC027307.5         125003-125869
FEATURES             Location/Qualifiers
     source          1..2520
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2520
                     /gene="PLK5"
                     /gene_synonym="PLK-5; PLK5P; SgK384ps"
                     /note="polo like kinase 5 (inactive)"
                     /db_xref="GeneID:126520"
                     /db_xref="HGNC:HGNC:27001"
                     /db_xref="MIM:621048"
     exon            1..170
                     /gene="PLK5"
                     /gene_synonym="PLK-5; PLK5P; SgK384ps"
                     /inference="alignment:Splign:2.1.0"
     exon            171..284
                     /gene="PLK5"
                     /gene_synonym="PLK-5; PLK5P; SgK384ps"
                     /inference="alignment:Splign:2.1.0"
     exon            285..401
                     /gene="PLK5"
                     /gene_synonym="PLK-5; PLK5P; SgK384ps"
                     /inference="alignment:Splign:2.1.0"
     exon            402..531
                     /gene="PLK5"
                     /gene_synonym="PLK-5; PLK5P; SgK384ps"
                     /inference="alignment:Splign:2.1.0"
     exon            532..619
                     /gene="PLK5"
                     /gene_synonym="PLK-5; PLK5P; SgK384ps"
                     /inference="alignment:Splign:2.1.0"
     exon            620..715
                     /gene="PLK5"
                     /gene_synonym="PLK-5; PLK5P; SgK384ps"
                     /inference="alignment:Splign:2.1.0"
     CDS             714..1724
                     /gene="PLK5"
                     /gene_synonym="PLK-5; PLK5P; SgK384ps"
                     /EC_number="2.7.11.21"
                     /note="polo-like kinase 5, pseudogene"
                     /codon_start=1
                     /product="inactive serine/threonine-protein kinase PLK5"
                     /protein_id="NP_001230008.1"
                     /db_xref="CCDS:CCDS59328.1"
                     /db_xref="GeneID:126520"
                     /db_xref="HGNC:HGNC:27001"
                     /db_xref="MIM:621048"
                     /translation="MYTVLTGTPPFMASPLSEMYQNIREGHYPEPAHLSANARRLIVH
                     LLAPNPAERPSLDHLLQDDFFTQGFTPDRLPAHSCHSPPIFAIPPPLGRIFRKVGQRL
                     LTQCRPPCPFTPKEASGPGEGGPDPDSMEWDGESSLSAKEVPCLEGPIHLVAQGTLQS
                     DLAGPEGSRRPEVEAALRHLQLCLDVGPPATQDPLGEQQPILWAPKWVDYSSKYGFGY
                     QLLDGGRTGRHPHGPATPRREGTLPTPVPPAGPGLCLLRFLASEHALLLLFSNGMVQV
                     SFSGVPAQLVLSGEGEGLQLTLWEQGSPGTSYSLDVPRSHGCAPTTGQHLHHALRMLQ
                     SI"
     exon            716..914
                     /gene="PLK5"
                     /gene_synonym="PLK-5; PLK5P; SgK384ps"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1041
                     /gene="PLK5"
                     /gene_synonym="PLK-5; PLK5P; SgK384ps"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1118
                     /gene="PLK5"
                     /gene_synonym="PLK-5; PLK5P; SgK384ps"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1203
                     /gene="PLK5"
                     /gene_synonym="PLK-5; PLK5P; SgK384ps"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1281
                     /gene="PLK5"
                     /gene_synonym="PLK-5; PLK5P; SgK384ps"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1427
                     /gene="PLK5"
                     /gene_synonym="PLK-5; PLK5P; SgK384ps"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1538
                     /gene="PLK5"
                     /gene_synonym="PLK-5; PLK5P; SgK384ps"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..2520
                     /gene="PLK5"
                     /gene_synonym="PLK-5; PLK5P; SgK384ps"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1907..1912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLK5"
                     /gene_synonym="PLK-5; PLK5P; SgK384ps"
                     /note="hexamer: ATTAAA"
     polyA_site      1931
                     /gene="PLK5"
                     /gene_synonym="PLK-5; PLK5P; SgK384ps"
                     /note="major polyA site"
ORIGIN      
        1 agagcggccc cggagcggcc gcagcgcggt ggtctcggcc cggctgcgcc agagtccgcg
       61 cgatggagcc ccggccgcgg cggcggcgca ggagtcgccc cctggtcgcc gccttcctgc
      121 gagacccggg ctcgggccgc gtgtacaggc gcgggaagct gatcggcaag ggcgccttca
      181 gccgctgcta caagctgaca gacatgtcca ccagcgccgt gttcgccctc aaggtggtgc
      241 cgtgtggcgg ggctggggcc gggtggcttc gcccgcaggg aaaggtggag cgtgagattg
      301 ccctgcatag ccgcctgcga ccccgcaaca tcgtggcttt ccacggacac tttgctgacc
      361 gcgaccacgt gtacatggtg ctggagtact gcagccgcca gtctttggcc cacgtgctga
      421 gggcgcggca gatcctgacg gagccagaag tgcgcgacta cctgcggggc ctggtcagcg
      481 gcctgcgcta cctgcaccag cggtgcatcc tgcaccgcga cctgaagctc agtaacttct
      541 tccttaacaa gaacatggag gtgaagattg gagacctggg actggcggcc aaggtggggc
      601 cagggggccg ctgccacaga gtactctgtg ggacccctaa cttcctggac cctgaggttg
      661 tctccagaaa cggtcactcc tgccagtagg acatctgggc tctgggctgc atcatgtaca
      721 cggtgctgac tggcacccca cccttcatgg cctcacccct gtcggagatg taccaaaaca
      781 tccgtgaggg ccactacccc gaacccgctc acctgtctgc caatgcgcgc cgcctcatcg
      841 tgcacctcct agcacccaac ccggccgagc ggcccagcct ggaccacctg ctgcaggacg
      901 acttcttcac acagggtttc actccagacc ggctgccggc ccactcctgc cacagtcccc
      961 ccatcttcgc catacccccg cctctgggca ggatcttccg gaaggtgggc cagcggctgc
     1021 tcacccagtg ccggccaccc tgccccttca cgcctaaaga ggcctcgggt ccaggagaag
     1081 gtgggccaga ccctgactcc atggagtggg acggcgagag ctccctgtct gcgaaagagg
     1141 ttccctgcct ggaaggcccc atccacctgg tcgcacaagg gaccctgcag agtgacctgg
     1201 ccgggcccga ggggagccgg cggccagagg tggaggcggc cctcagacac ctgcagctgt
     1261 gcctggatgt aggccccccg gccacacagg accccctggg agagcagcag cccatcctct
     1321 gggcccccaa atgggtggat tattccagca aatacggctt tggctaccag ctcttggacg
     1381 gggggcgcac gggacggcac ccacatggcc ctgcgacccc ccggagggag gggaccctcc
     1441 ccacacctgt gccacctgct ggacccggcc tctgcctcct gcgcttcctg gcctctgagc
     1501 acgccctgct gctgctgttc agcaatggga tggtgcaggt gagcttcagt ggagtcccgg
     1561 cccaactggt gctgagtggc gagggtgagg gtttgcagct caccctctgg gagcaggggt
     1621 cccctggcac ctcctactcc ctggacgtcc cgcggagcca cggctgcgcc cccaccaccg
     1681 gacagcacct tcaccacgcc ctccgcatgc tgcagagtat ctagtgcccc tgagggtcag
     1741 agtggacccc tgcatggtag tgccagggac ccaggctcca tttccattcc tgtggctccc
     1801 ccagaggggc tgtcctgggg gagggctggg gggcacacgg gaggtgggtt cttgccttgt
     1861 ggcatgactg ttcaacccag actttgctgg gatctcttcc tttttcatta aagacaattt
     1921 gaaatgctgt aggccatggt ctgcctctct ttgggggaaa gcgtttgagg agctttggca
     1981 aagaaacgtt gaccccacgt gacgttgcat cctccctgtt tctcttagtg gcagaggtgg
     2041 gttacatttt cactaatgca gacattagca ccagaggcca gtgtagtggc tcatgcctgg
     2101 aatcccagca ctttgggagg ccaaggcagg aggatcgctt gggcccagga gtttgagacc
     2161 agcctgggca acatggcaag accccatctc tacaaaaaat tagctgggca tggtggcacg
     2221 tgcctgtagt cccagctact tgggaggctg agatgggagg atggcgtgag catgggaggt
     2281 tgaggctgca gtgagctgtg attgcaccac tgcactccag cctgggcgac agaacaaaga
     2341 ccctgtctca acaacaacaa aagtagtacc agaagtgggg ttctgccata actccaaatc
     2401 taaaacatgg gacagttgct taatgggtgg acaggaaaga agccgacact gaggctggaa
     2461 agatggctgg ctatgctccg ggacacagtt ggcacaaccg tcacctgtgc tgccctgggg
//
