LOCUS       NM_014264               3838 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens polo like kinase 4 (PLK4), transcript variant 1, mRNA.
ACCESSION   NM_014264
VERSION     NM_014264.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3838)
  AUTHORS   Wang,B., Zhang,X., Li,Z.S., Wei,C., Yu,R.Z., Du,X.Z., He,Y.J.,
            Ren,Y., Zhen,Y.W. and Han,L.
  TITLE     Polo-like kinase 4 promotes tumorigenesis and glucose metabolism in
            glioma by activating AKT1 signaling
  JOURNAL   Cancer Lett 585, 216665 (2024)
   PUBMED   38290657
  REMARK    GeneRIF: Polo-like kinase 4 promotes tumorigenesis and glucose
            metabolism in glioma by activating AKT1 signaling.
REFERENCE   2  (bases 1 to 3838)
  AUTHORS   Grossmann,J., Kratz,A.S., Kordonsky,A., Prag,G. and Hoffmann,I.
  TITLE     CRL4DCAF1 ubiquitin ligase regulates PLK4 protein levels to prevent
            premature centriole duplication
  JOURNAL   Life Sci Alliance 7 (6), e202402668 (2024)
   PUBMED   38490717
  REMARK    GeneRIF: CRL4[DCAF1] ubiquitin ligase regulates PLK4 protein levels
            to prevent premature centriole duplication.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3838)
  AUTHORS   Han,Y.W., Xu,S.X., Zhang,J., Li,Y.F., Xu,P., Lee,S.C. and Zhao,J.Z.
  TITLE     Cadmium promotes the binding and centrosomal translocation of
            CCDC85C and PLK4 via ROS-GCLM pathway to trigger centrosome
            amplification in colon cancer cells
  JOURNAL   Toxicol Lett 392, 84-93 (2024)
   PUBMED   38185225
REFERENCE   4  (bases 1 to 3838)
  AUTHORS   Scott,P., Curinha,A., Gliech,C. and Holland,A.J.
  TITLE     PLK4 self-phosphorylation drives the selection of a single site for
            procentriole assembly
  JOURNAL   J Cell Biol 222 (12) (2023)
   PUBMED   37773039
  REMARK    GeneRIF: PLK4 self-phosphorylation drives the selection of a single
            site for procentriole assembly.
            Erratum:[J Cell Biol. 2024 Jan 1;223(1):e20230106912112023c. doi:
            10.1083/jcb.20230106912112023c.. PMID: 38095873]
REFERENCE   5  (bases 1 to 3838)
  AUTHORS   Sullenberger,C., Kong,D., Avazpour,P., Luvsanjav,D. and Loncarek,J.
  TITLE     Centrosomal organization of Cep152 provides flexibility in Plk4 and
            procentriole positioning
  JOURNAL   J Cell Biol 222 (12) (2023)
   PUBMED   37707473
  REMARK    GeneRIF: Centrosomal organization of Cep152 provides flexibility in
            Plk4 and procentriole positioning.
REFERENCE   6  (bases 1 to 3838)
  AUTHORS   Yamashita,Y., Kajigaya,S., Yoshida,K., Ueno,S., Ota,J., Ohmine,K.,
            Ueda,M., Miyazato,A., Ohya,K., Kitamura,T., Ozawa,K. and Mano,H.
  TITLE     Sak serine-threonine kinase acts as an effector of Tec tyrosine
            kinase
  JOURNAL   J Biol Chem 276 (42), 39012-39020 (2001)
   PUBMED   11489907
REFERENCE   7  (bases 1 to 3838)
  AUTHORS   Mayor,T., Stierhof,Y.D., Tanaka,K., Fry,A.M. and Nigg,E.A.
  TITLE     The centrosomal protein C-Nap1 is required for cell cycle-regulated
            centrosome cohesion
  JOURNAL   J Cell Biol 151 (4), 837-846 (2000)
   PUBMED   11076968
REFERENCE   8  (bases 1 to 3838)
  AUTHORS   Hudson,J.W., Chen,L., Fode,C., Binkert,C. and Dennis,J.W.
  TITLE     Sak kinase gene structure and transcriptional regulation
  JOURNAL   Gene 241 (1), 65-73 (2000)
   PUBMED   10607900
REFERENCE   9  (bases 1 to 3838)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
REFERENCE   10 (bases 1 to 3838)
  AUTHORS   Schultz,S.J. and Nigg,E.A.
  TITLE     Identification of 21 novel human protein kinases, including 3
            members of a family related to the cell cycle regulator nimA of
            Aspergillus nidulans
  JOURNAL   Cell Growth Differ 4 (10), 821-830 (1993)
   PUBMED   8274451
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC036023.1, BU633758.1 and
            AI088969.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014264.4.
            
            Summary: This gene encodes a member of the polo family of
            serine/threonine protein kinases. The protein localizes to
            centrioles, complex microtubule-based structures found in
            centrosomes, and regulates centriole duplication during the cell
            cycle. Three alternatively spliced transcript variants that encode
            different protein isoforms have been found for this gene. [provided
            by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036023.1, SRR1803612.105680.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270861.10/ ENSP00000270861.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3211              BC036023.1         1-3211
            3212-3812           BU633758.1         16-616              c
            3813-3838           AI088969.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..3838
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q28.1"
     gene            1..3838
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /note="polo like kinase 4"
                     /db_xref="GeneID:10733"
                     /db_xref="HGNC:HGNC:11397"
                     /db_xref="MIM:605031"
     exon            1..272
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..3155
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /EC_number="2.7.11.21"
                     /note="isoform 1 is encoded by transcript variant 1; Snk
                     akin kinase; serine/threonine-protein kinase PLK4;
                     serine/threonine-protein kinase 18;
                     serine/threonine-protein kinase Sak"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PLK4 isoform 1"
                     /protein_id="NP_055079.3"
                     /db_xref="CCDS:CCDS3735.1"
                     /db_xref="GeneID:10733"
                     /db_xref="HGNC:HGNC:11397"
                     /db_xref="MIM:605031"
                     /translation="MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMID
                     KKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLK
                     NRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQ
                     LKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKN
                     TLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDL
                     GTVEDSIDSGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDF
                     SSSGDGNSFYTQWGNQETSNSGRGRVIQDAEERPHSRYLRRAYSSDRSGTSNSQSQAK
                     TYTMERCHSAEMLSVSKRSGGGENEERYSPTDNNANIFNFFKEKTSSSSGSFERPDNN
                     QALSNHLCPGKTPFPFADPTPQTETVQQWFGNLQINAHLRKTTEYDSISPNRDFQGHP
                     DLQKDTSKNAWTDTKVKKNSDASDNAHSVKQQNTMKYMTALHSKPEIIQQECVFGSDP
                     LSEQSKTRGMEPPWGYQNRTLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELV
                     KEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLADRPPSPTDNISRYSFDNLPEKY
                     WRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPGADFEVWFYDGVKIHKTEDFI
                     QVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICLALESIISEEERKTRSAPF
                     FPIIIGRKPGSTSSPKALSPPPSVDSNYPTRERASFNRMVMHSAASPTQAPILNPSMV
                     TNEGLGLTTTASGTDISSNSLKDCLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDG
                     SQLVVQAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILLMFSNPTPNFH"
     exon            273..368
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /inference="alignment:Splign:2.1.0"
     exon            369..464
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /inference="alignment:Splign:2.1.0"
     exon            465..579
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /inference="alignment:Splign:2.1.0"
     exon            580..1600
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1701
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..2072
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2177
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2280
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2430
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2564
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2656
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2804
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2945
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3052
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3838
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3184..3189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /note="hexamer: AATAAA"
     polyA_site      3211
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /note="major polyA site"
     regulatory      3665..3670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /note="hexamer: AATAAA"
     polyA_site      3685
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /note="major polyA site"
     regulatory      3707..3712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /note="hexamer: ATTAAA"
     polyA_site      3729
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
     regulatory      3736..3741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /note="hexamer: AGTAAA"
     polyA_site      3758
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
     regulatory      3811..3816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
                     /note="hexamer: AATACA"
     polyA_site      3838
                     /gene="PLK4"
                     /gene_synonym="MCCRP2; SAK; STK18"
ORIGIN      
        1 accaccagcc tagctcggac ggcaagcggc gggagatttt caaaatggga gcccagaggc
       61 accgcccagg cctcggaagg tgtcagggag aactttccgt ggtttcagcg tcgtcgcctg
      121 gagcggcggt ttagagagcc gagcctgatg ggcgccaagg ccggctggct gcttggagcg
      181 ctgcctcgaa gggactgcgt gaaggaagct aatccggaga acccaggcca gagcctggaa
      241 atatggcgac ctgcatcggg gagaagatcg aggattttaa agttggaaat ctgcttggta
      301 aaggatcatt tgctggtgtc tacagagctg agtccattca cactggtttg gaagttgcaa
      361 tcaaaatgat agataagaaa gccatgtaca aagcaggaat ggtacagaga gtccaaaatg
      421 aggtgaaaat acattgccaa ttgaaacatc cttctatctt ggagctttat aactattttg
      481 aagatagcaa ttatgtgtat ctggtattag aaatgtgcca taatggagaa atgaacaggt
      541 atctaaagaa tagagtgaaa cccttctcag aaaatgaagc tcgacacttc atgcaccaga
      601 tcatcacagg gatgttgtat cttcattctc atggtatact acaccgggac ctcacacttt
      661 ctaacctcct actgactcgt aatatgaaca tcaagattgc tgattttggg ctggcaactc
      721 aactgaaaat gccacatgaa aagcactata cattatgtgg aactcctaac tacatttcac
      781 cagaaattgc cactcgaagt gcacatggcc ttgaatctga tgtttggtcc ctgggctgta
      841 tgttttatac attacttatc gggagaccac ccttcgacac tgacacagtc aagaacacat
      901 taaataaagt agtattggca gattatgaaa tgccatcttt tttgtcaata gaggccaagg
      961 accttattca ccagttactt cgtagaaatc cagcagatcg tttaagtctg tcttcagtat
     1021 tggaccatcc ttttatgtcc cgaaattctt caacaaaaag taaagattta ggaactgtgg
     1081 aagactcaat tgatagtggg catgccacaa tttctactgc aattacagct tcttccagta
     1141 ccagtataag tggtagttta tttgacaaaa gaagactttt gattggtcag ccactcccaa
     1201 ataaaatgac tgtatttcca aagaataaaa gttcaactga tttttcttct tcaggagatg
     1261 gaaacagttt ttatactcag tggggaaatc aagaaaccag taatagtgga aggggaagag
     1321 taattcaaga tgcagaagaa aggccacatt ctcgatacct tcgtagagct tattcctctg
     1381 atagatctgg cacttctaat agtcagtctc aagcaaaaac atatacaatg gaacgatgtc
     1441 actcagcaga aatgctttca gtgtccaaaa gatcaggagg aggtgaaaat gaagagaggt
     1501 actcacccac agacaacaat gccaacattt ttaacttctt taaagaaaag acatccagta
     1561 gttctggatc ttttgaaaga cctgataaca atcaagcact ctccaatcat ctttgtccag
     1621 gaaaaactcc ttttccattt gcagacccga cacctcagac tgaaaccgta caacagtggt
     1681 ttgggaatct gcaaataaat gctcatttaa gaaaaactac tgaatatgac agcatcagcc
     1741 caaaccggga cttccagggc catccagatt tgcagaagga cacatcaaaa aatgcctgga
     1801 ctgatacaaa agtcaaaaag aactctgatg cttctgataa tgcacattct gtaaaacagc
     1861 aaaataccat gaaatatatg actgcacttc acagtaaacc tgagataatc caacaagaat
     1921 gtgtttttgg ctcagatcct ctttctgaac agagcaagac taggggtatg gagccaccat
     1981 ggggttatca gaatcgtaca ttaagaagca ttacatctcc gttggttgct cacaggttaa
     2041 aaccaatcag acagaaaacc aaaaaggctg tggtgagcat acttgattca gaggaggtgt
     2101 gtgtggagct tgtaaaggag tatgcatctc aagaatatgt gaaagaagtt cttcagatat
     2161 ctagtgatgg aaatacgatc actatttatt atccaaatgg tggtagaggt tttcctcttg
     2221 ctgatagacc accctcacct actgacaaca tcagtaggta cagctttgac aatttaccag
     2281 aaaaatactg gcgaaaatat caatatgctt ccaggtttgt acagcttgta agatctaaat
     2341 ctcccaaaat cacttatttt acaagatatg ctaaatgcat tttgatggag aattctcctg
     2401 gtgctgattt tgaggtttgg ttttatgatg gggtaaaaat acacaaaaca gaagatttca
     2461 ttcaggtgat tgaaaagaca gggaagtctt acactttaaa aagtgaaagt gaagttaata
     2521 gcttgaaaga ggagataaaa atgtatatgg accatgctaa tgagggtcat cgtatttgtt
     2581 tagcactgga atccataatt tcagaagagg aaaggaaaac taggagtgct ccctttttcc
     2641 caataatcat aggaagaaaa cctggtagta ctagttcacc taaggcctta tcacctcctc
     2701 cttctgtgga ttcaaattac ccaacgagag agagagcatc tttcaacaga atggtcatgc
     2761 atagtgctgc ttctccaaca caggcaccaa tccttaatcc ctctatggtt acaaatgaag
     2821 gacttggtct tacaactaca gcttctggaa cagacatctc ttctaatagt ctaaaagatt
     2881 gtcttcctaa atcagcacaa cttttgaaat ctgtttttgt gaaaaatgtt ggttgggcta
     2941 cacagttaac tagtggagct gtgtgggttc agtttaatga tgggtcccag ttggttgtgc
     3001 aggcaggagt gtcttctatc agttatacct caccaaatgg tcaaacaact aggtatggag
     3061 aaaatgaaaa attaccagac tacatcaaac agaaattaca gtgtctgtct tccatccttt
     3121 tgatgttttc taatccgact cctaattttc attgattaaa actcctttca gacatataag
     3181 tttaataaat aacttttttg ttgactttca agtaaagtga ttttttttaa tttaacataa
     3241 agtcttcaga aagcctttct atgaaagaat tttaacctat aatgtaaagg atgtattctg
     3301 agagaacaaa gcagaatgaa acttgagtca cttactaaat atagtggata taaaatagaa
     3361 cacctgactt tgctcttaga ccataacccc cgaacttact atgttcatat atttgtattg
     3421 aacaatcttt taaaagcaaa aatgtaaatg atgtgtagtt tatttgtgct tttattgttt
     3481 tccctgcgtc tcagacatgt tgagaatcat ggacaaaacc tgctggaatt ttggaatttt
     3541 tgaagatgta aataatgtgt atttatgtta taagtaacat atgtaaacat gtatatttgt
     3601 tttatattta tttttgtaac accagtgtct gatgaaacat ttttgcaaat gcattttata
     3661 aaaaaataaa tatagtgata agttacatta tcttttgatt catttaatta aatacttatt
     3721 tttaaataac ttaccagtaa actcactttt taaattttgt tgcctgttga ggagccaatt
     3781 aaattttaaa tattaatttt gcaaatgtta aatacattgt ttctctatta tctgaaaa
//
