LOCUS       NM_004073               2340 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens polo like kinase 3 (PLK3), mRNA.
ACCESSION   NM_004073
VERSION     NM_004073.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2340)
  AUTHORS   Wen,J., Wang,Q., Zhang,W. and Wang,W.
  TITLE     TUBA1A licenses APC/C-mediated mitotic progression to drive
            glioblastoma growth by inhibiting PLK3
  JOURNAL   FEBS Lett 597 (24), 3072-3086 (2023)
   PUBMED   37873730
  REMARK    GeneRIF: TUBA1A licenses APC/C-mediated mitotic progression to
            drive glioblastoma growth by inhibiting PLK3.
REFERENCE   2  (bases 1 to 2340)
  AUTHORS   Yu,S., Lv,L., Li,Y., Ning,Q., Liu,T. and Hu,T.
  TITLE     PLK3 promotes the proneural-mesenchymal transition in glioblastoma
            via transcriptional regulation of C5AR1
  JOURNAL   Mol Biol Rep 50 (10), 8249-8258 (2023)
   PUBMED   37568042
  REMARK    GeneRIF: PLK3 promotes the proneural-mesenchymal transition in
            glioblastoma via transcriptional regulation of C5AR1.
REFERENCE   3  (bases 1 to 2340)
  AUTHORS   Barton,O., Naumann,S.C., Diemer-Biehs,R., Kunzel,J., Steinlage,M.,
            Conrad,S., Makharashvili,N., Wang,J., Feng,L., Lopez,B.S.,
            Paull,T.T., Chen,J., Jeggo,P.A. and Lobrich,M.
  TITLE     Polo-like kinase 3 regulates CtIP during DNA double-strand break
            repair in G1
  JOURNAL   J Cell Biol 206 (7), 877-894 (2014)
   PUBMED   25267294
  REMARK    GeneRIF: Plk3 binds to CtIP phosphorylated at S327 via its Polo box
            domains, which is necessary for robust damage-induced CtIP
            phosphorylation at S327 and subsequent CtIP phosphorylation at
            T847.
REFERENCE   4  (bases 1 to 2340)
  AUTHORS   Salvi,M., Trashi,E., Cozza,G., Franchin,C., Arrigoni,G. and
            Pinna,L.A.
  TITLE     Investigation on PLK2 and PLK3 substrate recognition
  JOURNAL   Biochim Biophys Acta 1824 (12), 1366-1373 (2012)
   PUBMED   22828320
  REMARK    GeneRIF: have identified and validated as in vitro PLK2 and PLK3
            substrates HSP90, GRP-94, beta-tubulin, calumenin, and 14-3-3
            epsilon
REFERENCE   5  (bases 1 to 2340)
  AUTHORS   Lopez-Sanchez,I., Sanz-Garcia,M. and Lazo,P.A.
  TITLE     Plk3 interacts with and specifically phosphorylates VRK1 in Ser342,
            a downstream target in a pathway that induces Golgi fragmentation
  JOURNAL   Mol Cell Biol 29 (5), 1189-1201 (2009)
   PUBMED   19103756
  REMARK    GeneRIF: The Plk3-VRK1 kinase module might represent two
            consecutive steps of a signaling cascade that participates in the
            regulation of Golgi fragmentation.
REFERENCE   6  (bases 1 to 2340)
  AUTHORS   Bahassi el,M., Conn,C.W., Myer,D.L., Hennigan,R.F., McGowan,C.H.,
            Sanchez,Y. and Stambrook,P.J.
  TITLE     Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein
            involved in stress response pathways
  JOURNAL   Oncogene 21 (43), 6633-6640 (2002)
   PUBMED   12242661
  REMARK    GeneRIF: Plk3 is a multifunctional protein that associates with
            multiple complexes and that contributes to response to stress
            incurred by DNA damage and mitotic spindle disruption, albeit via
            different pathways.
REFERENCE   7  (bases 1 to 2340)
  AUTHORS   Wang,Q., Xie,S., Chen,J., Fukasawa,K., Naik,U., Traganos,F.,
            Darzynkiewicz,Z., Jhanwar-Uniyal,M. and Dai,W.
  TITLE     Cell cycle arrest and apoptosis induced by human Polo-like kinase 3
            is mediated through perturbation of microtubule integrity
  JOURNAL   Mol Cell Biol 22 (10), 3450-3459 (2002)
   PUBMED   11971976
  REMARK    GeneRIF: Results suggest that Plk3 plays an important role in the
            regulation of microtubule dynamics and centrosomal function in the
            cell and that deregulated expression of Plk3 results in cell cycle
            arrest and apoptosis.
REFERENCE   8  (bases 1 to 2340)
  AUTHORS   Ouyang,B., Pan,H., Lu,L., Li,J., Stambrook,P., Li,B. and Dai,W.
  TITLE     Human Prk is a conserved protein serine/threonine kinase involved
            in regulating M phase functions
  JOURNAL   J Biol Chem 272 (45), 28646-28651 (1997)
   PUBMED   9353331
REFERENCE   9  (bases 1 to 2340)
  AUTHORS   Peng,C.Y., Graves,P.R., Thoma,R.S., Wu,Z., Shaw,A.S. and
            Piwnica-Worms,H.
  TITLE     Mitotic and G2 checkpoint control: regulation of 14-3-3 protein
            binding by phosphorylation of Cdc25C on serine-216
  JOURNAL   Science 277 (5331), 1501-1505 (1997)
   PUBMED   9278512
REFERENCE   10 (bases 1 to 2340)
  AUTHORS   Li,B., Ouyang,B., Pan,H., Reissmann,P.T., Slamon,D.J., Arceci,R.,
            Lu,L. and Dai,W.
  TITLE     Prk, a cytokine-inducible human protein serine/threonine kinase
            whose expression appears to be down-regulated in lung carcinomas
  JOURNAL   J Biol Chem 271 (32), 19402-19408 (1996)
   PUBMED   8702627
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC013899.2 and BC013960.2.
            
            On Nov 22, 2018 this sequence version replaced NM_004073.3.
            
            Summary: The protein encoded by this gene is a member of the highly
            conserved polo-like kinase family of serine/threonine kinases.
            Members of this family are characterized by an amino-terminal
            kinase domain and a carboxy-terminal bipartite polo box domain that
            functions as a substrate-binding motif and a cellular localization
            signal. Polo-like kinases are important regulators of cell cycle
            progression. This gene has also been implicated in stress responses
            and double-strand break repair. In human cell lines, this protein
            is reported to associate with centrosomes in a
            microtubule-dependent manner, and during mitosis, the protein
            becomes localized to the mitotic apparatus. Expression of a
            kinase-defective mutant results in abnormal cell morphology caused
            by changes in microtubule dynamics and mitotic arrest followed by
            apoptosis. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013899.2, AJ293866.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372201.5/ ENSP00000361275.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1557              BC013899.2         14-1570
            1558-2340           BC013960.2         1436-2218
FEATURES             Location/Qualifiers
     source          1..2340
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..2340
                     /gene="PLK3"
                     /gene_synonym="CNK; FNK; PLK-3; PRK"
                     /note="polo like kinase 3"
                     /db_xref="GeneID:1263"
                     /db_xref="HGNC:HGNC:2154"
                     /db_xref="MIM:602913"
     exon            1..297
                     /gene="PLK3"
                     /gene_synonym="CNK; FNK; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..2028
                     /gene="PLK3"
                     /gene_synonym="CNK; FNK; PLK-3; PRK"
                     /EC_number="2.7.11.21"
                     /note="proliferation-related kinase; FGF-inducible kinase;
                     cytokine-inducible serine/threonine-protein kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PLK3"
                     /protein_id="NP_004064.2"
                     /db_xref="CCDS:CCDS515.1"
                     /db_xref="GeneID:1263"
                     /db_xref="HGNC:HGNC:2154"
                     /db_xref="MIM:602913"
                     /translation="MEPAAGFLSPRPFQRAAAAPAPPAGPGPPPSALRGPELEMLAGL
                     PTSDPGRLITDPRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPH
                     QREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEP
                     EVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKK
                     TICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVH
                     YTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDL
                     TPPNPARSLFAKVTKSLFGRKKKSKNHAQERDEVSGLVSGLMRTSVGHQDARPEAPAA
                     SGPAPVSLVETAPEDSSPRGTLASSGDGFEEGLTVATVVESALCALRNCIAFMPPAEQ
                     NPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNP
                     TSTKHFSFSVGAVPRALQPQLGILRYFASYMEQHLMKGGDLPSVEEVEVPAPPLLLQW
                     VKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEPLLVTFVARNRSACTYLASHLRQLG
                     CSPDLRQRLRYALRLLRDRSPA"
     exon            298..405
                     /gene="PLK3"
                     /gene_synonym="CNK; FNK; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            406..522
                     /gene="PLK3"
                     /gene_synonym="CNK; FNK; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            523..652
                     /gene="PLK3"
                     /gene_synonym="CNK; FNK; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            653..740
                     /gene="PLK3"
                     /gene_synonym="CNK; FNK; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            741..836
                     /gene="PLK3"
                     /gene_synonym="CNK; FNK; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1035
                     /gene="PLK3"
                     /gene_synonym="CNK; FNK; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1159
                     /gene="PLK3"
                     /gene_synonym="CNK; FNK; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1251
                     /gene="PLK3"
                     /gene_synonym="CNK; FNK; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1345
                     /gene="PLK3"
                     /gene_synonym="CNK; FNK; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1429
                     /gene="PLK3"
                     /gene_synonym="CNK; FNK; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1592
                     /gene="PLK3"
                     /gene_synonym="CNK; FNK; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1722
                     /gene="PLK3"
                     /gene_synonym="CNK; FNK; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1836
                     /gene="PLK3"
                     /gene_synonym="CNK; FNK; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..2340
                     /gene="PLK3"
                     /gene_synonym="CNK; FNK; PLK-3; PRK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2322..2327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLK3"
                     /gene_synonym="CNK; FNK; PLK-3; PRK"
                     /note="hexamer: AATAAA"
     polyA_site      2340
                     /gene="PLK3"
                     /gene_synonym="CNK; FNK; PLK-3; PRK"
                     /note="major polyA site"
ORIGIN      
        1 gcagcgtagc aaatccaggc agcgccacgc gcggccgggg ccgggcggaa ccgagaagcc
       61 gggaccgcgc tgcgacgcgc cggccgcatg gagcctgccg ccggtttcct gtctccgcgc
      121 cccttccagc gtgcggccgc cgcgcccgct cccccggccg ggcccgggcc gcctccgagt
      181 gccttgcgcg gacctgagct ggagatgctg gccgggctac cgacgtcaga ccccgggcgc
      241 ctcatcacgg acccgcgcag cggccgcacc tacctcaaag gccgcttgtt gggcaagggg
      301 ggcttcgccc gctgctacga ggccactgac acagagactg gcagcgccta cgctgtcaaa
      361 gtcatcccgc agagccgcgt cgccaagccg catcagcgcg agaagatcct aaatgagatt
      421 gagctgcacc gagacctgca gcaccgccac atcgtgcgtt tttcgcacca ctttgaggac
      481 gctgacaaca tctacatttt cttggagctc tgcagccgaa agtccctggc ccacatctgg
      541 aaggcccggc acaccctgtt ggagccagaa gtgcgctact acctgcggca gatcctttct
      601 ggcctcaagt acttgcacca gcgcggcatc ttgcaccggg acctcaagtt gggaaatttt
      661 ttcatcactg agaacatgga actgaaggtg ggggattttg ggctggcagc ccggttggag
      721 cctccggagc agaggaagaa gaccatctgt ggcaccccca actatgtggc tccagaagtg
      781 ctgctgagac agggccacgg ccctgaggcg gatgtatggt cactgggctg tgtcatgtac
      841 acgctgctct gcgggagccc tccctttgag acggctgacc tgaaggagac gtaccgctgc
      901 atcaagcagg ttcactacac gctgcctgcc agcctctcac tgcctgcccg gcagctcctg
      961 gccgccatcc ttcgggcctc accccgagac cgcccctcta ttgaccagat cctgcgccat
     1021 gacttcttta ccaagggcta cacccccgat cgactcccta tcagcagctg cgtgacagtc
     1081 ccagacctga caccccccaa cccagctagg agtctgtttg ccaaagttac caagagcctc
     1141 tttggcagaa agaagaagag taagaatcat gcccaggaga gggatgaggt ctccggtttg
     1201 gtgagcggcc tcatgcgcac atccgttggc catcaggatg ccaggccaga ggctccagca
     1261 gcttctggcc cagcccctgt cagcctggta gagacagcac ctgaagacag ctcaccccgt
     1321 gggacactgg caagcagtgg agatggattt gaagaaggtc tgactgtggc cacagtagtg
     1381 gagtcagccc tttgtgctct gagaaattgt atagccttca tgcccccagc ggaacagaac
     1441 ccggcccccc tggcccagcc agagcctctg gtgtgggtca gcaagtgggt tgactactcc
     1501 aataagttcg gctttgggta tcaactgtcc agccgccgtg tggctgtgct cttcaacgat
     1561 ggcacacata tggccctgtc ggccaacaga aagactgtgc actacaatcc caccagcaca
     1621 aagcacttct ccttctccgt gggtgctgtg ccccgggccc tgcagcctca gctgggtatc
     1681 ctgcggtact tcgcctccta catggagcag cacctcatga agggtggaga tctgcccagt
     1741 gtggaagagg tagaggtacc tgctccgccc ttgctgctgc agtgggtcaa gacggatcag
     1801 gctctcctca tgctgtttag tgatggcact gtccaggtga acttctacgg ggaccacacc
     1861 aagctgattc tcagtggctg ggagcccctc cttgtgactt ttgtggcccg aaatcgtagt
     1921 gcttgtactt acctcgcttc ccaccttcgg cagctgggct gctctccaga cctgcggcag
     1981 cgactccgct atgctctgcg cctgctccgg gaccgcagcc cagcctagga cccaagccct
     2041 gaggcctgag gcctgtgcct gtcaggctct ggcccttgcc tttgtggcct tcccccttcc
     2101 tttggtgcct cactgggggc tttgggccga atcccccagg gaatcaggga ccagctttac
     2161 tggagttggg ggcggcttgt cttcgctggc tcctacccca tctccaagat aagcctgagc
     2221 cttagctccc agctaggggg cgttatttat ggaccacttt tatttattgt cagacactta
     2281 tttattggga tgtgagcccc aggggggcct cctcctagga taataaacaa ttttgcagaa
//
