LOCUS       NM_006622               2786 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens polo like kinase 2 (PLK2), transcript variant 1, mRNA.
ACCESSION   NM_006622
VERSION     NM_006622.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2786)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 2786)
  AUTHORS   Li,J. and Ma,F.
  TITLE     Polo-Like Kinase 2 Is Identified in Hypertrophy, Extracellular
            Matrix Accumulation, and Oxidative Stress of Mesangial Cells in
            Diabetic Nephropathy through p38-MAPK Signaling
  JOURNAL   Ann Clin Lab Sci 53 (2), 192-199 (2023)
   PUBMED   37094847
  REMARK    GeneRIF: Polo-Like Kinase 2 Is Identified in Hypertrophy,
            Extracellular Matrix Accumulation, and Oxidative Stress of
            Mesangial Cells in Diabetic Nephropathy through p38-MAPK Signaling.
REFERENCE   3  (bases 1 to 2786)
  AUTHORS   Zong,Y., Miao,Y., Li,W., Zheng,M., Xu,Z., Gao,H., Feng,W., Xu,Z.,
            Zhao,J., Shen,L. and Lu,A.
  TITLE     Combination of FOXD1 and Plk2: A novel biomarker for predicting
            unfavourable prognosis of colorectal cancer
  JOURNAL   J Cell Mol Med 26 (12), 3471-3482 (2022)
   PUBMED   35579380
  REMARK    GeneRIF: Combination of FOXD1 and Plk2: A novel biomarker for
            predicting unfavourable prognosis of colorectal cancer.
REFERENCE   4  (bases 1 to 2786)
  AUTHORS   Ding,Y., Liu,H., Zhang,C., Bao,Z. and Yu,S.
  TITLE     Polo-like kinases as potential targets and PLK2 as a novel
            biomarker for the prognosis of human glioblastoma
  JOURNAL   Aging (Albany NY) 14 (5), 2320-2334 (2022)
   PUBMED   35256538
  REMARK    GeneRIF: Polo-like kinases as potential targets and PLK2 as a novel
            biomarker for the prognosis of human glioblastoma.
REFERENCE   5  (bases 1 to 2786)
  AUTHORS   Kunzel,S.R., Hoffmann,M., Weber,S., Kunzel,K., Kammerer,S.,
            Gunscht,M., Klapproth,E., Rausch,J.S.E., Sadek,M.S., Kolanowski,T.,
            Meyer-Roxlau,S., Piorkowski,C., Tugtekin,S.M., Rose-John,S.,
            Yin,X., Mayr,M., Kuhlmann,J.D., Wimberger,P., Grutzmann,K.,
            Herzog,N., Kupper,J.H., O'Reilly,M., Kabir,S.N., Sommerfeld,L.C.,
            Guan,K., Wielockx,B., Fabritz,L., Nattel,S., Ravens,U., Dobrev,D.,
            Wagner,M. and El-Armouche,A.
  TITLE     Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial
            Fibrillation
  JOURNAL   Circ Res 129 (8), 804-820 (2021)
   PUBMED   34433292
  REMARK    GeneRIF: Diminished PLK2 Induces Cardiac Fibrosis and Promotes
            Atrial Fibrillation.
REFERENCE   6  (bases 1 to 2786)
  AUTHORS   Shimizu-Yoshida,Y., Sugiyama,K., Rogounovitch,T., Ohtsuru,A.,
            Namba,H., Saenko,V. and Yamashita,S.
  TITLE     Radiation-inducible hSNK gene is transcriptionally regulated by p53
            binding homology element in human thyroid cells
  JOURNAL   Biochem Biophys Res Commun 289 (2), 491-498 (2001)
   PUBMED   11716500
REFERENCE   7  (bases 1 to 2786)
  AUTHORS   Liby,K., Wu,H., Ouyang,B., Wu,S., Chen,J. and Dai,W.
  TITLE     Identification of the human homologue of the early-growth response
            gene Snk, encoding a serum-inducible kinase
  JOURNAL   DNA Seq 11 (6), 527-533 (2001)
   PUBMED   11696980
REFERENCE   8  (bases 1 to 2786)
  AUTHORS   Holtrich,U., Wolf,G., Yuan,J., Bereiter-Hahn,J., Karn,T.,
            Weiler,M., Kauselmann,G., Rehli,M., Andreesen,R., Kaufmann,M.,
            Kuhl,D. and Strebhardt,K.
  TITLE     Adhesion induced expression of the serine/threonine kinase Fnk in
            human macrophages
  JOURNAL   Oncogene 19 (42), 4832-4839 (2000)
   PUBMED   11039900
REFERENCE   9  (bases 1 to 2786)
  AUTHORS   Ouyang,B., Li,W., Pan,H., Meadows,J., Hoffmann,I. and Dai,W.
  TITLE     The physical association and phosphorylation of Cdc25C protein
            phosphatase by Prk
  JOURNAL   Oncogene 18 (44), 6029-6036 (1999)
   PUBMED   10557092
REFERENCE   10 (bases 1 to 2786)
  AUTHORS   Kauselmann,G., Weiler,M., Wulff,P., Jessberger,S., Konietzko,U.,
            Scafidi,J., Staubli,U., Bereiter-Hahn,J., Strebhardt,K. and Kuhl,D.
  TITLE     The polo-like protein kinases Fnk and Snk associate with a Ca(2+)-
            and integrin-binding protein and are regulated dynamically with
            synaptic plasticity
  JOURNAL   EMBO J 18 (20), 5528-5539 (1999)
   PUBMED   10523297
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AA954432.1, AK027851.1,
            BC013879.2 and N66865.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006622.3.
            
            Summary: The protein encoded by this gene is a member of the polo
            family of serine/threonine protein kinases that have a role in
            normal cell division. This gene is most abundantly expressed in
            testis, spleen and fetal tissues, and its expression is inducible
            by serum, suggesting that it may also play an important role in
            cells undergoing rapid cell division. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.174219.1, AF059617.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274289.8/ ENSP00000274289.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AA954432.1         191-213             c
            24-374              AK027851.1         22-372
            375-2244            BC013879.2         361-2230
            2245-2781           AK027851.1         2242-2778
            2782-2786           N66865.1           12-16               c
FEATURES             Location/Qualifiers
     source          1..2786
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..2786
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /note="polo like kinase 2"
                     /db_xref="GeneID:10769"
                     /db_xref="HGNC:HGNC:19699"
                     /db_xref="MIM:607023"
     exon            1..397
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..2185
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /EC_number="2.7.11.21"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serum-inducible kinase; serine/threonine-protein kinase
                     PLK2; PLK-2; serine/threonine-protein kinase SNK"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PLK2 isoform 1"
                     /protein_id="NP_006613.2"
                     /db_xref="CCDS:CCDS3974.1"
                     /db_xref="GeneID:10769"
                     /db_xref="HGNC:HGNC:19699"
                     /db_xref="MIM:607023"
                     /translation="MELLRTITYQPAASTKMCEQALGKGCGADSKKKRPPQPPEESQP
                     PQSQAQVPPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDL
                     TNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLE
                     YCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAME
                     LKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLG
                     RPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFF
                     LQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKED
                     EDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVR
                     GTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWV
                     DYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFI
                     SQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVN
                     FYHDHTKIIICSQNEEYLLTYINEDRISTTFRLTTLLMSGCSSELKNRMEYALNMLLQ
                     RCN"
     exon            398..505
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /inference="alignment:Splign:2.1.0"
     exon            506..622
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /inference="alignment:Splign:2.1.0"
     exon            623..752
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /inference="alignment:Splign:2.1.0"
     exon            753..840
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /inference="alignment:Splign:2.1.0"
     exon            841..936
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1135
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1283
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1381
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1511
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1752
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1882
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..1993
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2786
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2674..2679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /note="hexamer: AATAAA"
     polyA_site      2702
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /note="major polyA site"
     regulatory      2762..2767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /note="hexamer: AATAAA"
     polyA_site      2786
                     /gene="PLK2"
                     /gene_synonym="hPlk2; hSNK; SNK"
                     /note="major polyA site"
ORIGIN      
        1 gcacaagtgg accggggtgt tgggtgctag tcggcaccag aggcaagggt gcgaggacca
       61 cggccggctc ggacgtgtga ccgcgcctag ggggtggcag cgggcagtgc ggggcggcaa
      121 ggcgaccatg gagcttttgc ggactatcac ctaccagcca gccgccagca ccaaaatgtg
      181 cgagcaggcg ctgggcaagg gttgcggagc ggactcgaag aagaagcggc cgccgcagcc
      241 ccccgaggaa tcgcagccac ctcagtccca ggcgcaagtg cccccggcgg cccctcacca
      301 ccatcaccac cattcgcact cggggccgga gatctcgcgg attatcgtcg accccacgac
      361 tgggaagcgc tactgccggg gcaaagtgct gggaaagggt ggctttgcaa aatgttacga
      421 gatgacagat ttgacaaata acaaagtcta cgccgcaaaa attattcctc acagcagagt
      481 agctaaacct catcaaaggg aaaagattga caaagaaata gagcttcaca gaattcttca
      541 tcataagcat gtagtgcagt tttaccacta cttcgaggac aaagaaaaca tttacattct
      601 cttggaatac tgcagtagaa ggtcaatggc tcatattttg aaagcaagaa aggtgttgac
      661 agagccagaa gttcgatact acctcaggca gattgtgtct ggactgaaat accttcatga
      721 acaagaaatc ttgcacagag atctcaaact agggaacttt tttattaatg aagccatgga
      781 actaaaagtt ggggacttcg gtctggcagc caggctagaa cccttggaac acagaaggag
      841 aacgatatgt ggtaccccaa attatctctc tcctgaagtc ctcaacaaac aaggacatgg
      901 ctgtgaatca gacatttggg ccctgggctg tgtaatgtat acaatgttac tagggaggcc
      961 cccatttgaa actacaaatc tcaaagaaac ttataggtgc ataagggaag caaggtatac
     1021 aatgccgtcc tcattgctgg ctcctgccaa gcacttaatt gctagtatgt tgtccaaaaa
     1081 cccagaggat cgtcccagtt tggatgacat cattcgacat gacttttttt tgcagggctt
     1141 cactccggac agactgtctt ctagctgttg tcatacagtt ccagatttcc acttatcaag
     1201 cccagctaag aatttcttta agaaagcagc tgctgctctt tttggtggca aaaaagacaa
     1261 agcaagatat attgacacac ataatagagt gtctaaagaa gatgaagaca tctacaagct
     1321 taggcatgat ttgaaaaaga cttcaataac tcagcaaccc agcaaacaca ggacagatga
     1381 ggagctccag ccacctacca ccacagttgc caggtctgga acacccgcag tagaaaacaa
     1441 gcagcagatt ggggatgcta ttcggatgat agtcagaggg actcttggca gctgtagcag
     1501 cagcagtgaa tgccttgaag acagtaccat gggaagtgtt gcagacacag tggcaagggt
     1561 tcttcgggga tgtctggaaa acatgccgga agctgattgc attcccaaag agcagctgag
     1621 cacatcattt cagtgggtca ccaaatgggt tgattactct aacaaatatg gctttgggta
     1681 ccagctctca gaccacaccg tcggtgtcct tttcaacaat ggtgctcaca tgagcctcct
     1741 tccagacaaa aaaacagttc actattacgc agagcttggc caatgctcag ttttcccagc
     1801 aacagatgct cctgagcaat ttattagtca agtgacggtg ctgaaatact tttctcatta
     1861 catggaggag aacctcatgg atggtggaga tctgcctagt gttactgata ttcgaagacc
     1921 tcggctctac ctccttcagt ggctaaaatc tgataaggcc ctaatgatgc tctttaatga
     1981 tggcaccttt caggtgaatt tctaccatga tcatacaaaa atcatcatct gtagccaaaa
     2041 tgaagaatac cttctcacct acatcaatga ggataggata tctacaactt tcaggctgac
     2101 aactctgctg atgtctggct gttcatcaga attaaaaaat cgaatggaat atgccctgaa
     2161 catgctctta caaagatgta actgaaagac ttttcgaatg gaccctatgg gactcctctt
     2221 ttccactgtg agatctacag ggaagccaaa agaatgatct agagtatgtt gaagaagatg
     2281 gacatgtggt ggtacgaaaa caattcccct gtggcctgct ggactggttg gaaccagaac
     2341 aggctaaggc atacagttct tgactttgga caatccaaga gtgaaccaga atgcagtttt
     2401 ccttgagata cctgttttaa aaggtttttc agacaatttt gcagaaaggt gcattgattc
     2461 ttaaattctc tctgttgaga gcatttcagc cagaggactt tggaactgtg aatatacttc
     2521 ctgaagggga gggagaaggg aggaagctcc catgttgttt aaaggctgta attggagcag
     2581 cttttggctg cgtaactgtg aactatggcc atatataatt ttttttcatt aatttttgaa
     2641 gatacttgtg gctggaaaag tgcattcctt gttaataaac tttttattta ttacagccca
     2701 aagagcagta tttattatca aaatgtcttt ttttttatgt tgaccatttt aaaccgttgg
     2761 caataaagag tatgaaaacg cagaaa
//
