LOCUS       NM_005030               2160 bp    mRNA    linear   PRI 02-MAR-2025
DEFINITION  Homo sapiens polo like kinase 1 (PLK1), mRNA.
ACCESSION   NM_005030
VERSION     NM_005030.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2160)
  AUTHORS   Geng,L., Liu,F., Yang,L., Liu,Y. and Wu,G.
  TITLE     USP18 promotes the proliferation, invasion, and migration of head
            and neck squamous cell carcinoma by deubiquitinating PLK1
  JOURNAL   Exp Cell Res 442 (2), 114284 (2024)
   PUBMED   39424095
  REMARK    GeneRIF: USP18 promotes the proliferation, invasion, and migration
            of head and neck squamous cell carcinoma by deubiquitinating PLK1.
REFERENCE   2  (bases 1 to 2160)
  AUTHORS   Iliaki,S., Kreike,M., Ferreras Moreno,N., De Meyer,F., Aidarova,A.,
            Braun,H., Libert,C., Afonina,I.S. and Beyaert,R.
  TITLE     Polo-like kinase 1 (PLK1) is a novel CARD14-binding protein in
            keratinocytes
  JOURNAL   Biochem Pharmacol 228, 116316 (2024)
   PUBMED   38797267
  REMARK    GeneRIF: Polo-like kinase 1 (PLK1) is a novel CARD14-binding
            protein in keratinocytes.
REFERENCE   3  (bases 1 to 2160)
  AUTHORS   Conti,D., Verza,A.E., Pesenti,M.E., Cmentowski,V., Vetter,I.R.,
            Pan,D. and Musacchio,A.
  TITLE     Role of protein kinase PLK1 in the epigenetic maintenance of
            centromeres
  JOURNAL   Science 385 (6713), 1091-1097 (2024)
   PUBMED   39236163
  REMARK    GeneRIF: Role of protein kinase PLK1 in the epigenetic maintenance
            of centromeres.
REFERENCE   4  (bases 1 to 2160)
  AUTHORS   Liu,R., Zhou,D., Yu,B. and Zhou,Z.
  TITLE     Phosphorylation of LZTS2 by PLK1 activates the Wnt pathway
  JOURNAL   Cell Signal 120, 111226 (2024)
   PUBMED   38740232
  REMARK    GeneRIF: Phosphorylation of LZTS2 by PLK1 activates the Wnt
            pathway.
REFERENCE   5  (bases 1 to 2160)
  AUTHORS   Liu,Z., Zhang,Y., Yu,L., Zhang,Z. and Li,G.
  TITLE     A miR-361-5p/ ORC6/ PLK1 axis regulates prostate cancer progression
  JOURNAL   Exp Cell Res 440 (1), 114130 (2024)
   PUBMED   38885805
  REMARK    GeneRIF: A miR-361-5p/ ORC6/ PLK1 axis regulates prostate cancer
            progression.
REFERENCE   6  (bases 1 to 2160)
  AUTHORS   Brauninger,A., Strebhardt,K. and Rubsamen-Waigmann,H.
  TITLE     Identification and functional characterization of the human and
            murine polo-like kinase (Plk) promoter
  JOURNAL   Oncogene 11 (9), 1793-1800 (1995)
   PUBMED   7478607
REFERENCE   7  (bases 1 to 2160)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
REFERENCE   8  (bases 1 to 2160)
  AUTHORS   Golsteyn,R.M., Schultz,S.J., Bartek,J., Ziemiecki,A., Ried,T. and
            Nigg,E.A.
  TITLE     Cell cycle analysis and chromosomal localization of human Plk1, a
            putative homologue of the mitotic kinases Drosophila polo and
            Saccharomyces cerevisiae Cdc5
  JOURNAL   J Cell Sci 107 (Pt 6), 1509-1517 (1994)
   PUBMED   7962193
REFERENCE   9  (bases 1 to 2160)
  AUTHORS   Hamanaka,R., Maloid,S., Smith,M.R., O'Connell,C.D., Longo,D.L. and
            Ferris,D.K.
  TITLE     Cloning and characterization of human and murine homologues of the
            Drosophila polo serine-threonine kinase
  JOURNAL   Cell Growth Differ 5 (3), 249-257 (1994)
   PUBMED   8018557
REFERENCE   10 (bases 1 to 2160)
  AUTHORS   Lake,R.J. and Jelinek,W.R.
  TITLE     Cell cycle- and terminal differentiation-associated regulation of
            the mouse mRNA encoding a conserved mitotic protein kinase
  JOURNAL   Mol Cell Biol 13 (12), 7793-7801 (1993)
   PUBMED   7902533
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC300189.1 and BC014846.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005030.5.
            
            Summary: The Ser/Thr protein kinase encoded by this gene belongs to
            the CDC5/Polo subfamily. It is highly expressed during mitosis and
            elevated levels are found in many different types of cancer.
            Depletion of this protein in cancer cells dramatically inhibited
            cell proliferation and induced apoptosis; hence, it is a target for
            cancer therapy. [provided by RefSeq, Sep 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002369.2, U01038.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300093.9/ ENSP00000300093.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                DC300189.1         118-155
            39-2160             BC014846.1         1-2122
FEATURES             Location/Qualifiers
     source          1..2160
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.2"
     gene            1..2160
                     /gene="PLK1"
                     /gene_synonym="PLK; STPK13"
                     /note="polo like kinase 1"
                     /db_xref="GeneID:5347"
                     /db_xref="HGNC:HGNC:9077"
                     /db_xref="MIM:602098"
     exon            1..452
                     /gene="PLK1"
                     /gene_synonym="PLK; STPK13"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1856
                     /gene="PLK1"
                     /gene_synonym="PLK; STPK13"
                     /EC_number="2.7.11.21"
                     /note="polo (Drosophia)-like kinase; cell cycle regulated
                     protein kinase; PLK-1; serine/threonine-protein kinase 13"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PLK1"
                     /protein_id="NP_005021.2"
                     /db_xref="CCDS:CCDS10616.1"
                     /db_xref="GeneID:5347"
                     /db_xref="HGNC:HGNC:9077"
                     /db_xref="MIM:602098"
                     /translation="MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVL
                     VDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEI
                     SIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQI
                     VLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYI
                     APEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINP
                     VAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDP
                     SNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSER
                     GLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDS
                     LQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARL
                     PYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSL
                     LEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS"
     exon            453..621
                     /gene="PLK1"
                     /gene_synonym="PLK; STPK13"
                     /inference="alignment:Splign:2.1.0"
     exon            622..766
                     /gene="PLK1"
                     /gene_synonym="PLK; STPK13"
                     /inference="alignment:Splign:2.1.0"
     exon            767..860
                     /gene="PLK1"
                     /gene_synonym="PLK; STPK13"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1080
                     /gene="PLK1"
                     /gene_synonym="PLK; STPK13"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1236
                     /gene="PLK1"
                     /gene_synonym="PLK; STPK13"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1314
                     /gene="PLK1"
                     /gene_synonym="PLK; STPK13"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1469
                     /gene="PLK1"
                     /gene_synonym="PLK; STPK13"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1652
                     /gene="PLK1"
                     /gene_synonym="PLK; STPK13"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..2160
                     /gene="PLK1"
                     /gene_synonym="PLK; STPK13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2140..2145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLK1"
                     /gene_synonym="PLK; STPK13"
                     /note="hexamer: ATTAAA"
     polyA_site      2160
                     /gene="PLK1"
                     /gene_synonym="PLK; STPK13"
                     /note="major polyA site"
ORIGIN      
        1 ggaggctctg ctcggatcga ggtctgcagc gcagcttcgg gagcatgagt gctgcagtga
       61 ctgcagggaa gctggcacgg gcaccggccg accctgggaa agccggggtc cccggagttg
      121 cagctcccgg agctccggcg gcggctccac cggcgaaaga gatcccggag gtcctagtgg
      181 acccacgcag ccggcggcgc tatgtgcggg gccgcttttt gggcaagggc ggctttgcca
      241 agtgcttcga gatctcggac gcggacacca aggaggtgtt cgcgggcaag attgtgccta
      301 agtctctgct gctcaagccg caccagaggg agaagatgtc catggaaata tccattcacc
      361 gcagcctcgc ccaccagcac gtcgtaggat tccacggctt tttcgaggac aacgacttcg
      421 tgttcgtggt gttggagctc tgccgccgga ggtctctcct ggagctgcac aagaggagga
      481 aagccctgac tgagcctgag gcccgatact acctacggca aattgtgctt ggctgccagt
      541 acctgcaccg aaaccgagtt attcatcgag acctcaagct gggcaacctt ttcctgaatg
      601 aagatctgga ggtgaaaata ggggattttg gactggcaac caaagtcgaa tatgacgggg
      661 agaggaagaa gaccctgtgt gggactccta attacatagc tcccgaggtg ctgagcaaga
      721 aagggcacag tttcgaggtg gatgtgtggt ccattgggtg tatcatgtat accttgttag
      781 tgggcaaacc accttttgag acttcttgcc taaaagagac ctacctccgg atcaagaaga
      841 atgaatacag tattcccaag cacatcaacc ccgtggccgc ctccctcatc cagaagatgc
      901 ttcagacaga tcccactgcc cgcccaacca ttaacgagct gcttaatgac gagttcttta
      961 cttctggcta tatccctgcc cgtctcccca tcacctgcct gaccattcca ccaaggtttt
     1021 cgattgctcc cagcagcctg gaccccagca accggaagcc cctcacagtc ctcaataaag
     1081 gcttggagaa ccccctgcct gagcgtcccc gggaaaaaga agaaccagtg gttcgagaga
     1141 caggtgaggt ggtcgactgc cacctcagtg acatgctgca gcagctgcac agtgtcaatg
     1201 cctccaagcc ctcggagcgt gggctggtca ggcaagagga ggctgaggat cctgcctgca
     1261 tccccatctt ctgggtcagc aagtgggtgg actattcgga caagtacggc cttgggtatc
     1321 agctctgtga taacagcgtg ggggtgctct tcaatgactc aacacgcctc atcctctaca
     1381 atgatggtga cagcctgcag tacatagagc gtgacggcac tgagtcctac ctcaccgtga
     1441 gttcccatcc caactccttg atgaagaaga tcaccctcct taaatatttc cgcaattaca
     1501 tgagcgagca cttgctgaag gcaggtgcca acatcacgcc gcgcgaaggt gatgagctcg
     1561 cccggctgcc ctacctacgg acctggttcc gcacccgcag cgccatcatc ctgcacctca
     1621 gcaacggcag cgtgcagatc aacttcttcc aggatcacac caagctcatc ttgtgcccac
     1681 tgatggcagc cgtgacctac atcgacgaga agcgggactt ccgcacatac cgcctgagtc
     1741 tcctggagga gtacggctgc tgcaaggagc tggccagccg gctccgctac gcccgcacta
     1801 tggtggacaa gctgctgagc tcacgctcgg ccagcaaccg tctcaaggcc tcctaatagc
     1861 tgccctcccc tccggactgg tgccctcctc actcccacct gcatctgggg cccatactgg
     1921 ttggctcccg cggtgccatg tctgcagtgt gccccccagc cccggtggct gggcagagct
     1981 gcatcatcct tgcaggtggg ggttgctgta taagttattt ttgtacatgt tcgggtgtgg
     2041 gttctacagc cttgtccccc tccccctcaa ccccaccata tgaattgtac agaatatttc
     2101 tattgaattc ggaactgtcc tttccttggc tttatgcaca ttaaacagat gtgaatattc
//
