LOCUS       NM_001013706            2470 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens perilipin 5 (PLIN5), mRNA.
ACCESSION   NM_001013706 XM_005259562 XM_496282
VERSION     NM_001013706.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2470)
  AUTHORS   Miner,G.E., So,C.M., Edwards,W., Ragusa,J.V., Wine,J.T., Wong
            Gutierrez,D., Airola,M.V., Herring,L.E., Coleman,R.A., Klett,E.L.
            and Cohen,S.
  TITLE     PLIN5 interacts with FATP4 at membrane contact sites to promote
            lipid droplet-to-mitochondria fatty acid transport
  JOURNAL   Dev Cell 58 (14), 1250-1265 (2023)
   PUBMED   37290445
  REMARK    GeneRIF: PLIN5 interacts with FATP4 at membrane contact sites to
            promote lipid droplet-to-mitochondria fatty acid transport.
REFERENCE   2  (bases 1 to 2470)
  AUTHORS   Ethem,I. and Hacioglu,C.
  TITLE     Effects of perilipin-5 on lipid metabolism and high-sensitivity
            cardiac troponin I
  JOURNAL   Rev Assoc Med Bras (1992) 68 (8), 1011-1016 (2022)
   PUBMED   36134829
  REMARK    GeneRIF: Effects of perilipin-5 on lipid metabolism and
            high-sensitivity cardiac troponin I.
REFERENCE   3  (bases 1 to 2470)
  AUTHORS   Fachada,V., Rahkila,P., Fachada,N., Turpeinen,T., Kujala,U.M. and
            Kainulainen,H.
  TITLE     Enlarged PLIN5-uncoated lipid droplets in inner regions of skeletal
            muscle type II fibers associate with type 2 diabetes
  JOURNAL   Acta Histochem 124 (3), 151869 (2022)
   PUBMED   35220055
  REMARK    GeneRIF: Enlarged PLIN5-uncoated lipid droplets in inner regions of
            skeletal muscle type II fibers associate with type 2 diabetes.
REFERENCE   4  (bases 1 to 2470)
  AUTHORS   Zhang,X., Xu,W., Xu,R., Wang,Z., Zhang,X., Wang,P., Peng,K., Li,M.,
            Li,J., Tan,Y., Wang,X. and Pei,H.
  TITLE     Plin5 Bidirectionally Regulates Lipid Metabolism in Oxidative
            Tissues
  JOURNAL   Oxid Med Cell Longev 2022, 4594956 (2022)
   PUBMED   35401929
  REMARK    GeneRIF: Plin5 Bidirectionally Regulates Lipid Metabolism in
            Oxidative Tissues.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2470)
  AUTHORS   Gemmink,A., Daemen,S., Brouwers,B., Hoeks,J., Schaart,G.,
            Knoops,K., Schrauwen,P. and Hesselink,M.K.C.
  TITLE     Decoration of myocellular lipid droplets with perilipins as a
            marker for in vivo lipid droplet dynamics: A super-resolution
            microscopy study in trained athletes and insulin resistant
            individuals
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1866 (2), 158852 (2021)
   PUBMED   33160079
  REMARK    GeneRIF: Decoration of myocellular lipid droplets with perilipins
            as a marker for in vivo lipid droplet dynamics: A super-resolution
            microscopy study in trained athletes and insulin resistant
            individuals.
REFERENCE   6  (bases 1 to 2470)
  AUTHORS   Wang,H. and Sztalryd,C.
  TITLE     Oxidative tissue: perilipin 5 links storage with the furnace
  JOURNAL   Trends Endocrinol Metab 22 (6), 197-203 (2011)
   PUBMED   21632259
  REMARK    GeneRIF: Perilipin 5 is the most recently established family
            member, highly expressed in oxidative tissues and could play an
            important role in regulating LD TAG hydrolysis in oxidative
            mammalian tissues. [Review]
            Review article
REFERENCE   7  (bases 1 to 2470)
  AUTHORS   Wang,H., Bell,M., Sreenivasan,U., Sreenevasan,U., Hu,H., Liu,J.,
            Dalen,K., Londos,C., Yamaguchi,T., Rizzo,M.A., Coleman,R., Gong,D.,
            Brasaemle,D. and Sztalryd,C.
  TITLE     Unique regulation of adipose triglyceride lipase (ATGL) by
            perilipin 5, a lipid droplet-associated protein
  JOURNAL   J Biol Chem 286 (18), 15707-15715 (2011)
   PUBMED   21393244
  REMARK    GeneRIF: interaction of ATGL with CGI-58 increased lipolysis,
            whereas interaction of ATGL with perilipin 5 decreased lipolysis.
            Erratum:[J Biol Chem. 2013 Apr 12;288(15):10952. Sreenevasan,
            Urmilla [corrected to Sreenivasan, Urmila]]
REFERENCE   8  (bases 1 to 2470)
  AUTHORS   Kimmel,A.R., Brasaemle,D.L., McAndrews-Hill,M., Sztalryd,C. and
            Londos,C.
  TITLE     Adoption of PERILIPIN as a unifying nomenclature for the mammalian
            PAT-family of intracellular lipid storage droplet proteins
  JOURNAL   J Lipid Res 51 (3), 468-471 (2010)
   PUBMED   19638644
  REMARK    Review article
REFERENCE   9  (bases 1 to 2470)
  AUTHORS   Minnaard,R., Schrauwen,P., Schaart,G., Jorgensen,J.A., Lenaers,E.,
            Mensink,M. and Hesselink,M.K.
  TITLE     Adipocyte differentiation-related protein and OXPAT in rat and
            human skeletal muscle: involvement in lipid accumulation and type 2
            diabetes mellitus
  JOURNAL   J Clin Endocrinol Metab 94 (10), 4077-4085 (2009)
   PUBMED   19602560
  REMARK    GeneRIF: Results indicate involvement of OXPAT and ADRP in muscular
            lipid accumulation and type 2 diabetes.
REFERENCE   10 (bases 1 to 2470)
  AUTHORS   Dalen,K.T., Dahl,T., Holter,E., Arntsen,B., Londos,C., Sztalryd,C.
            and Nebb,H.I.
  TITLE     LSDP5 is a PAT protein specifically expressed in fatty acid
            oxidizing tissues
  JOURNAL   Biochim Biophys Acta 1771 (2), 210-227 (2007)
   PUBMED   17234449
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011498.7, BC033570.1, DQ839131.1, AW445065.1 and BX105717.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001013706.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ839131.1, ERR279830.7446.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381848.7/ ENSP00000371272.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC011498.7         166850-166877       c
            29-33               BC033570.1         1-5
            34-843              DQ839131.1         1-810
            844-1108            AW445065.1         1-265               c
            1109-1915           DQ839131.1         1076-1882
            1916-1971           AC011498.7         154683-154738       c
            1972-2470           BX105717.1         35-533
FEATURES             Location/Qualifiers
     source          1..2470
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2470
                     /gene="PLIN5"
                     /gene_synonym="LSDA5; LSDP5; MLDP; OXPAT"
                     /note="perilipin 5"
                     /db_xref="GeneID:440503"
                     /db_xref="HGNC:HGNC:33196"
                     /db_xref="MIM:613248"
     exon            1..60
                     /gene="PLIN5"
                     /gene_synonym="LSDA5; LSDP5; MLDP; OXPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            61..141
                     /gene="PLIN5"
                     /gene_synonym="LSDA5; LSDP5; MLDP; OXPAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1473
                     /gene="PLIN5"
                     /gene_synonym="LSDA5; LSDP5; MLDP; OXPAT"
                     /note="lipid storage droplet protein 5"
                     /codon_start=1
                     /product="perilipin-5"
                     /protein_id="NP_001013728.2"
                     /db_xref="CCDS:CCDS42473.1"
                     /db_xref="GeneID:440503"
                     /db_xref="HGNC:HGNC:33196"
                     /db_xref="MIM:613248"
                     /translation="MSEEEAAQIPRSSVWEQDQQNVVQRVVALPLVRATCTAVCDVYS
                     AAKDRHPLLGSACRLAENCVCGLTTRALDHAQPLLEHLQPQLATMNSLACRGLDKLEE
                     KLPFLQQPSETVVTSAKDVVASSVTGVVDLARRGRRWSVELKRSVSHAVDVVLEKSEE
                     LVDHFLPMTEEELAALAAEAEGPEVGSVEDQRRQQGYFVRLGSLSARIRHLAYEHSVG
                     KLRQSKHRAQDTLAQLQETLELIDHMQCGVTPTAPACPGKVHELWGEWGQRPPESRRR
                     SQAELETLVLSRSLTQELQGTVEALESSVRGLPAGAQEKVAEVRRSVDALQTAFADAR
                     CFRDVPAAALAEGRGRVAHAHACVDELLELVVQAVPLPWLVGPFAPILVERPEPLPDL
                     ADLVDEVIGGPDPRWAHLDWPAQQRAWEAEHRDGSGNGDGDRMGVAGDICEQEPETPS
                     CPVKHTLMPELDF"
     exon            142..337
                     /gene="PLIN5"
                     /gene_synonym="LSDA5; LSDP5; MLDP; OXPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            338..420
                     /gene="PLIN5"
                     /gene_synonym="LSDA5; LSDP5; MLDP; OXPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            421..601
                     /gene="PLIN5"
                     /gene_synonym="LSDA5; LSDP5; MLDP; OXPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            602..801
                     /gene="PLIN5"
                     /gene_synonym="LSDA5; LSDP5; MLDP; OXPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            802..915
                     /gene="PLIN5"
                     /gene_synonym="LSDA5; LSDP5; MLDP; OXPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            916..2470
                     /gene="PLIN5"
                     /gene_synonym="LSDA5; LSDP5; MLDP; OXPAT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2445..2450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLIN5"
                     /gene_synonym="LSDA5; LSDP5; MLDP; OXPAT"
                     /note="hexamer: AATAAA"
     polyA_site      2470
                     /gene="PLIN5"
                     /gene_synonym="LSDA5; LSDP5; MLDP; OXPAT"
                     /note="major polyA site"
ORIGIN      
        1 gtggagactc gagcctgggg tcggcggaga cagctggtgt ctgaagccgc tcgcgcccag
       61 ggtgaccctg tttgcagcac gatgtctgaa gaagaggcgg ctcagatccc cagatccagt
      121 gtgtgggagc aggaccagca gaacgtggtg cagcgtgtgg tggctctgcc cctggtcagg
      181 gccacgtgca ccgcggtctg cgatgtttac agtgcagcca aggacaggca cccgctgctg
      241 ggctccgcct gccgcctggc tgagaactgc gtgtgcggcc tgaccacccg tgccctggac
      301 cacgcccagc cgctgctcga gcacctgcag ccccagctgg ccactatgaa cagcctcgcc
      361 tgcaggggcc tggacaagct ggaagagaag cttccctttc tccagcaacc ttcggagacg
      421 gtggtgacct cagccaagga cgtggtggcc agcagtgtca cgggtgtggt ggacctggcc
      481 cggaggggcc ggcgctggag cgtggagctg aagcgctccg tgagccatgc tgtggatgtt
      541 gtactggaaa aatcagagga gctggtggat cacttcctgc ccatgacgga ggaagagctc
      601 gcggcactgg cggctgaggc tgaaggccct gaagtgggtt cggtggagga tcagaggaga
      661 cagcagggct actttgtgcg cctcggctcc ctgtcagcac ggatccgcca cctggcctac
      721 gagcactctg tggggaaact gaggcagagc aaacaccgtg cccaggacac cctggcccag
      781 ctgcaggaga cgctggagct gatagaccac atgcagtgtg gggtgacccc caccgccccg
      841 gcctgccctg ggaaggtgca cgagctgtgg ggggaatggg gccagcgccc tccggagagc
      901 cgccgccgga gccaggcaga gctggagacg ctggtgctgt cccgcagcct gacccaggag
      961 ctgcagggca cggtagaggc tctggagtcc agcgtgcggg gcctgcccgc cggcgcccag
     1021 gagaaggtgg ctgaggtgcg gcgcagtgtg gatgccctgc agaccgcctt cgctgatgcc
     1081 cgctgcttca gggacgtgcc agcggccgcg ctggccgagg gccggggtcg cgtggcccac
     1141 gcgcacgcct gcgtggacga gctgctggag ctggtggtgc aggccgtgcc gctgccctgg
     1201 ctggtgggac ccttcgcgcc catccttgtg gagcgacccg agcccctgcc cgacctggcg
     1261 gacctggtgg acgaggtcat cgggggccct gacccccgct gggcgcacct ggactggccg
     1321 gcccagcaga gagcctggga ggcagagcac agggacggga gtgggaatgg ggatggggac
     1381 aggatgggtg ttgccgggga catctgcgag caggaacccg agacccccag ctgcccggtc
     1441 aagcacaccc tgatgcccga gctggacttc tgacccatgg gccagtggag gcggggagga
     1501 aaggccacct gcacaccccg atccctgctg ccccctggtg gccacacgta agctcgaggc
     1561 cttggccttg acccttcttt ggaatcaggc ccaactccgg atctctgacc acctttttgg
     1621 tattggactc tcccattttt tccttgaaca catggacaaa gaggcccggg ggagcagggc
     1681 ctcgaaccct attcaggcca acttgagcca caagctgggt tcttcaccta tgtcctgctc
     1741 cctggctcca tgaagcgaat ccaaatcttt ccaagaggct gggcacagtg gctcacgcct
     1801 gtaatcccag cactttggga gtctgaggca ggtggatcat ctgaagtcag gagttcggga
     1861 tcatcctggc caacatgatg aaaccctgtc tctacttaga aagaaagaaa aaaaaaaaaa
     1921 aagccaggtg tggtggtgtg cacctgtagt cccagctagt tgtgaggctg acgcagaaga
     1981 attgcttaaa cccgagaggc gcggagcttg cagtgagcag agatcgcgcc actgcacacc
     2041 agcctgggtg acagagcgag actccatcta acaaaaaata atagtaacag cctcccgaag
     2101 aaatacacat tttgcccaat gccttctgtt tggggctttg aaaagtgagc cctgactggg
     2161 tgtggtggtt gacacctgtt atcacagcac tttgggaggc caaggtggga ggactgcttg
     2221 agcccaggag ttggaggctg cagtgagcca tgatcttgcc cctgcgctct cgcctgggtg
     2281 acagagcaag actctatctc aaaaatgttt ttaaaaaata cttcctaggg aaacacacat
     2341 tttgccctat ttggaacttt gaaaagtgag ccctcctctg cccatgggcc gtgctgctca
     2401 gcctgccata ctcgcttgct ttgctgtttg ggatttgcct ccagaataaa ggtccttttt
     2461 gttgttgaaa
//
