LOCUS       NP_001013728             463 aa            linear   PRI 28-APR-2025
DEFINITION  perilipin-5 [Homo sapiens].
ACCESSION   NP_001013728 XP_005259619 XP_496282
VERSION     NP_001013728.2
DBSOURCE    REFSEQ: accession NM_001013706.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 463)
  AUTHORS   Miner,G.E., So,C.M., Edwards,W., Ragusa,J.V., Wine,J.T., Wong
            Gutierrez,D., Airola,M.V., Herring,L.E., Coleman,R.A., Klett,E.L.
            and Cohen,S.
  TITLE     PLIN5 interacts with FATP4 at membrane contact sites to promote
            lipid droplet-to-mitochondria fatty acid transport
  JOURNAL   Dev Cell 58 (14), 1250-1265 (2023)
   PUBMED   37290445
  REMARK    GeneRIF: PLIN5 interacts with FATP4 at membrane contact sites to
            promote lipid droplet-to-mitochondria fatty acid transport.
REFERENCE   2  (residues 1 to 463)
  AUTHORS   Ethem,I. and Hacioglu,C.
  TITLE     Effects of perilipin-5 on lipid metabolism and high-sensitivity
            cardiac troponin I
  JOURNAL   Rev Assoc Med Bras (1992) 68 (8), 1011-1016 (2022)
   PUBMED   36134829
  REMARK    GeneRIF: Effects of perilipin-5 on lipid metabolism and
            high-sensitivity cardiac troponin I.
REFERENCE   3  (residues 1 to 463)
  AUTHORS   Fachada,V., Rahkila,P., Fachada,N., Turpeinen,T., Kujala,U.M. and
            Kainulainen,H.
  TITLE     Enlarged PLIN5-uncoated lipid droplets in inner regions of skeletal
            muscle type II fibers associate with type 2 diabetes
  JOURNAL   Acta Histochem 124 (3), 151869 (2022)
   PUBMED   35220055
  REMARK    GeneRIF: Enlarged PLIN5-uncoated lipid droplets in inner regions of
            skeletal muscle type II fibers associate with type 2 diabetes.
REFERENCE   4  (residues 1 to 463)
  AUTHORS   Zhang,X., Xu,W., Xu,R., Wang,Z., Zhang,X., Wang,P., Peng,K., Li,M.,
            Li,J., Tan,Y., Wang,X. and Pei,H.
  TITLE     Plin5 Bidirectionally Regulates Lipid Metabolism in Oxidative
            Tissues
  JOURNAL   Oxid Med Cell Longev 2022, 4594956 (2022)
   PUBMED   35401929
  REMARK    GeneRIF: Plin5 Bidirectionally Regulates Lipid Metabolism in
            Oxidative Tissues.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 463)
  AUTHORS   Gemmink,A., Daemen,S., Brouwers,B., Hoeks,J., Schaart,G.,
            Knoops,K., Schrauwen,P. and Hesselink,M.K.C.
  TITLE     Decoration of myocellular lipid droplets with perilipins as a
            marker for in vivo lipid droplet dynamics: A super-resolution
            microscopy study in trained athletes and insulin resistant
            individuals
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1866 (2), 158852 (2021)
   PUBMED   33160079
  REMARK    GeneRIF: Decoration of myocellular lipid droplets with perilipins
            as a marker for in vivo lipid droplet dynamics: A super-resolution
            microscopy study in trained athletes and insulin resistant
            individuals.
REFERENCE   6  (residues 1 to 463)
  AUTHORS   Wang,H. and Sztalryd,C.
  TITLE     Oxidative tissue: perilipin 5 links storage with the furnace
  JOURNAL   Trends Endocrinol Metab 22 (6), 197-203 (2011)
   PUBMED   21632259
  REMARK    GeneRIF: Perilipin 5 is the most recently established family
            member, highly expressed in oxidative tissues and could play an
            important role in regulating LD TAG hydrolysis in oxidative
            mammalian tissues. [Review]
            Review article
REFERENCE   7  (residues 1 to 463)
  AUTHORS   Wang,H., Bell,M., Sreenivasan,U., Sreenevasan,U., Hu,H., Liu,J.,
            Dalen,K., Londos,C., Yamaguchi,T., Rizzo,M.A., Coleman,R., Gong,D.,
            Brasaemle,D. and Sztalryd,C.
  TITLE     Unique regulation of adipose triglyceride lipase (ATGL) by
            perilipin 5, a lipid droplet-associated protein
  JOURNAL   J Biol Chem 286 (18), 15707-15715 (2011)
   PUBMED   21393244
  REMARK    GeneRIF: interaction of ATGL with CGI-58 increased lipolysis,
            whereas interaction of ATGL with perilipin 5 decreased lipolysis.
            Erratum:[J Biol Chem. 2013 Apr 12;288(15):10952. Sreenevasan,
            Urmilla [corrected to Sreenivasan, Urmila]]
REFERENCE   8  (residues 1 to 463)
  AUTHORS   Kimmel,A.R., Brasaemle,D.L., McAndrews-Hill,M., Sztalryd,C. and
            Londos,C.
  TITLE     Adoption of PERILIPIN as a unifying nomenclature for the mammalian
            PAT-family of intracellular lipid storage droplet proteins
  JOURNAL   J Lipid Res 51 (3), 468-471 (2010)
   PUBMED   19638644
  REMARK    Review article
REFERENCE   9  (residues 1 to 463)
  AUTHORS   Minnaard,R., Schrauwen,P., Schaart,G., Jorgensen,J.A., Lenaers,E.,
            Mensink,M. and Hesselink,M.K.
  TITLE     Adipocyte differentiation-related protein and OXPAT in rat and
            human skeletal muscle: involvement in lipid accumulation and type 2
            diabetes mellitus
  JOURNAL   J Clin Endocrinol Metab 94 (10), 4077-4085 (2009)
   PUBMED   19602560
  REMARK    GeneRIF: Results indicate involvement of OXPAT and ADRP in muscular
            lipid accumulation and type 2 diabetes.
REFERENCE   10 (residues 1 to 463)
  AUTHORS   Dalen,K.T., Dahl,T., Holter,E., Arntsen,B., Londos,C., Sztalryd,C.
            and Nebb,H.I.
  TITLE     LSDP5 is a PAT protein specifically expressed in fatty acid
            oxidizing tissues
  JOURNAL   Biochim Biophys Acta 1771 (2), 210-227 (2007)
   PUBMED   17234449
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011498.7, BC033570.1, DQ839131.1, AW445065.1 and BX105717.1.
            
            On or before Aug 31, 2013 this sequence version replaced
            XP_005259619.1, NP_001013728.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ839131.1, ERR279830.7446.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381848.7/ ENSP00000371272.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     Protein         1..463
                     /product="perilipin-5"
                     /note="lipid storage droplet protein 5"
                     /calculated_mol_wt=50660
     Region          1..173
                     /region_name="Essential for lipid droplet targeting.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00G26.2)"
     Region          1..108
                     /region_name="Interaction with LIPE.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00G26.2)"
     Site            2
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8BVZ1; propagated from
                     UniProtKB/Swiss-Prot (Q00G26.2)"
     Region          16..382
                     /region_name="Perilipin"
                     /note="Perilipin family; pfam03036"
                     /db_xref="CDD:460784"
     Site            148
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8BVZ1; propagated from
                     UniProtKB/Swiss-Prot (Q00G26.2)"
     Region          185..463
                     /region_name="Interaction with PNPLA2 and ABHD5.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00G26.2)"
     Site            322
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (Q00G26.2)"
     Region          444..463
                     /region_name="Recruits mitochondria at the lipid droplet
                     surface. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00G26.2)"
     CDS             1..463
                     /gene="PLIN5"
                     /gene_synonym="LSDA5; LSDP5; MLDP; OXPAT"
                     /coded_by="NM_001013706.3:82..1473"
                     /db_xref="CCDS:CCDS42473.1"
                     /db_xref="GeneID:440503"
                     /db_xref="HGNC:HGNC:33196"
                     /db_xref="MIM:613248"
ORIGIN      
        1 mseeeaaqip rssvweqdqq nvvqrvvalp lvratctavc dvysaakdrh pllgsacrla
       61 encvcglttr aldhaqplle hlqpqlatmn slacrgldkl eeklpflqqp setvvtsakd
      121 vvassvtgvv dlarrgrrws velkrsvsha vdvvleksee lvdhflpmte eelaalaaea
      181 egpevgsved qrrqqgyfvr lgslsarirh layehsvgkl rqskhraqdt laqlqetlel
      241 idhmqcgvtp tapacpgkvh elwgewgqrp pesrrrsqae letlvlsrsl tqelqgtvea
      301 lessvrglpa gaqekvaevr rsvdalqtaf adarcfrdvp aaalaegrgr vahahacvde
      361 llelvvqavp lpwlvgpfap ilverpeplp dladlvdevi ggpdprwahl dwpaqqrawe
      421 aehrdgsgng dgdrmgvagd iceqepetps cpvkhtlmpe ldf
//
