LOCUS       NM_005817               2232 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens perilipin 3 (PLIN3), transcript variant 1, mRNA.
ACCESSION   NM_005817
VERSION     NM_005817.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2232)
  AUTHORS   Liang,W., Zhou,Z., Gao,Q., Zhu,Z., Zhu,J., Lin,J., Wen,Y., Qian,F.,
            Wang,L., Zhai,Y., Lv,J., Zhang,H., Zhong,F. and Du,H.
  TITLE     Tumor-derived Prevotella intermedia aggravates gastric cancer by
            enhancing Perilipin 3 expression
  JOURNAL   Cancer Sci 115 (4), 1141-1153 (2024)
   PUBMED   38287724
  REMARK    GeneRIF: Tumor-derived Prevotella intermedia aggravates gastric
            cancer by enhancing Perilipin 3 expression.
REFERENCE   2  (bases 1 to 2232)
  AUTHORS   He,Y., Liu,L., Dong,Y., Zhang,X., Song,Y., Jing,Y., Ni,Y., Wang,Y.,
            Wang,Z. and Ding,L.
  TITLE     Lipid droplets-related Perilipin-3: potential immune checkpoint and
            oncogene in oral squamous cell carcinoma
  JOURNAL   Cancer Immunol Immunother 73 (5), 78 (2024)
   PUBMED   38554152
  REMARK    GeneRIF: Lipid droplets-related Perilipin-3: potential immune
            checkpoint and oncogene in oral squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2232)
  AUTHORS   Stribny,J. and Schneiter,R.
  TITLE     Binding of perilipin 3 to membranes containing diacylglycerol is
            mediated by conserved residues within its PAT domain
  JOURNAL   J Biol Chem 299 (12), 105384 (2023)
   PUBMED   37898398
  REMARK    GeneRIF: Binding of perilipin 3 to membranes containing
            diacylglycerol is mediated by conserved residues within its PAT
            domain.
REFERENCE   4  (bases 1 to 2232)
  AUTHORS   Men,X. and Zhu,W.
  TITLE     Silencing of Perilipin 3 Inhibits Lung Adenocarcinoma Cell Immune
            Resistance by Regulating the Transcription of PD-L1 Through c-Myc
  JOURNAL   Immunol Invest 52 (7), 815-831 (2023)
   PUBMED   37578465
  REMARK    GeneRIF: Silencing of Perilipin 3 Inhibits Lung Adenocarcinoma Cell
            Immune Resistance by Regulating the Transcription of PD-L1 Through
            c-Myc.
REFERENCE   5  (bases 1 to 2232)
  AUTHORS   Chung,J., Park,J., Lai,Z.W., Lambert,T.J., Richards,R.C., Zhang,J.,
            Walther,T.C. and Farese,R.V. Jr.
  TITLE     The Troyer syndrome protein spartin mediates selective autophagy of
            lipid droplets
  JOURNAL   Nat Cell Biol 25 (8), 1101-1110 (2023)
   PUBMED   37443287
REFERENCE   6  (bases 1 to 2232)
  AUTHORS   Krise,J.P., Sincock,P.M., Orsel,J.G. and Pfeffer,S.R.
  TITLE     Quantitative analysis of TIP47-receptor cytoplasmic domain
            interactions: implications for endosome-to-trans Golgi network
            trafficking
  JOURNAL   J Biol Chem 275 (33), 25188-25193 (2000)
   PUBMED   10829017
REFERENCE   7  (bases 1 to 2232)
  AUTHORS   Than,N.G., Sumegi,B., Than,G.N., Kispal,G. and Bohn,H.
  TITLE     Cloning and sequencing of human oncodevelopmental soluble placental
            tissue protein 17 (PP17): homology with adipophilin and the mouse
            adipose differentiation-related protein
  JOURNAL   Tumour Biol 20 (4), 184-192 (1999)
   PUBMED   10393528
REFERENCE   8  (bases 1 to 2232)
  AUTHORS   Than,N.G., Sumegi,B., Than,G.N., Kispal,G. and Bohn,H.
  TITLE     Cloning and sequence analysis of cDNAs encoding human placental
            tissue protein 17 (PP17) variants
  JOURNAL   Eur J Biochem 258 (2), 752-757 (1998)
   PUBMED   9874244
REFERENCE   9  (bases 1 to 2232)
  AUTHORS   Diaz,E. and Pfeffer,S.R.
  TITLE     TIP47: a cargo selection device for mannose 6-phosphate receptor
            trafficking
  JOURNAL   Cell 93 (3), 433-443 (1998)
   PUBMED   9590177
REFERENCE   10 (bases 1 to 2232)
  AUTHORS   Bohn,H., Kraus,W. and Winckler,W.
  TITLE     Purification and characterization of two new soluble placental
            tissue proteins (PP13 and PP17)
  JOURNAL   Oncodev Biol Med 4 (5), 343-350 (1983)
   PUBMED   6856484
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312740.1, BQ057849.1,
            AK225045.1 and BC019278.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005817.4.
            
            Summary: Mannose 6-phophate receptors (MPRs) deliver lysosomal
            hydrolase from the Golgi to endosomes and then return to the Golgi
            complex. The protein encoded by this gene interacts with the
            cytoplasmic domains of both cation-independent and cation-dependent
            MPRs, and is required for endosome-to-Golgi transport. This protein
            also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS
            oncogene family. The interaction with RAB9 has been shown to
            increase the affinity of this protein for its cargo. Multiple
            transcript variants encoding different isoforms have been found for
            this gene.[provided by RefSeq, Aug 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019278.1, AK226088.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221957.9/ ENSP00000221957.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AK312740.1         28-56
            30-631              BQ057849.1         18-619
            632-1804            AK225045.1         599-1771
            1805-2232           BC019278.1         1795-2222
FEATURES             Location/Qualifiers
     source          1..2232
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2232
                     /gene="PLIN3"
                     /gene_synonym="M6PRBP1; PP17; TIP47"
                     /note="perilipin 3"
                     /db_xref="GeneID:10226"
                     /db_xref="HGNC:HGNC:16893"
                     /db_xref="MIM:602702"
     exon            1..59
                     /gene="PLIN3"
                     /gene_synonym="M6PRBP1; PP17; TIP47"
                     /inference="alignment:Splign:2.1.0"
     exon            60..142
                     /gene="PLIN3"
                     /gene_synonym="M6PRBP1; PP17; TIP47"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1381
                     /gene="PLIN3"
                     /gene_synonym="M6PRBP1; PP17; TIP47"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tail-interacting protein, 47 kD; testicular tissue protein
                     Li 114; cargo selection protein TIP47; placental protein
                     17; 47 kDa MPR-binding protein; mannose-6-phosphate
                     receptor-binding protein 1"
                     /codon_start=1
                     /product="perilipin-3 isoform 1"
                     /protein_id="NP_005808.3"
                     /db_xref="CCDS:CCDS12137.1"
                     /db_xref="GeneID:10226"
                     /db_xref="HGNC:HGNC:16893"
                     /db_xref="MIM:602702"
                     /translation="MSADGAEADGSTQVTVEEPVQQPSVVDRVASMPLISSTCDMVSA
                     AYASTKESYPHIKTVCDAAEKGVRTLTAAAVSGAQPILSKLEPQIASASEYAHRGLDK
                     LEENLPILQQPTEKVLADTKELVSSKVSGAQEMVSSAKDTVATQLSEAVDATRGAVQS
                     GVDKTKSVVTGGVQSVMGSRLGQMVLSGVDTVLGKSEEWADNHLPLTDAELARIATSL
                     DGFDVASVQQQRQEQSYFVRLGSLSERLRQHAYEHSLGKLRATKQRAQEALLQLSQVL
                     SLMETVKQGVDQKLVEGQEKLHQMWLSWNQKQLQGPEKEPPKPEQVESRALTMFRDIA
                     QQLQATCTSLGSSIQGLPTNVKDQVQQARRQVEDLQATFSSIHSFQDLSSSILAQSRE
                     RVASAREALDHMVEYVAQNTPVTWLVGPFAPGITEKAPEEKK"
     exon            143..341
                     /gene="PLIN3"
                     /gene_synonym="M6PRBP1; PP17; TIP47"
                     /inference="alignment:Splign:2.1.0"
     exon            342..424
                     /gene="PLIN3"
                     /gene_synonym="M6PRBP1; PP17; TIP47"
                     /inference="alignment:Splign:2.1.0"
     exon            425..710
                     /gene="PLIN3"
                     /gene_synonym="M6PRBP1; PP17; TIP47"
                     /inference="alignment:Splign:2.1.0"
     exon            711..910
                     /gene="PLIN3"
                     /gene_synonym="M6PRBP1; PP17; TIP47"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1036
                     /gene="PLIN3"
                     /gene_synonym="M6PRBP1; PP17; TIP47"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..2232
                     /gene="PLIN3"
                     /gene_synonym="M6PRBP1; PP17; TIP47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2210..2215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLIN3"
                     /gene_synonym="M6PRBP1; PP17; TIP47"
                     /note="hexamer: AATAAA"
     polyA_site      2232
                     /gene="PLIN3"
                     /gene_synonym="M6PRBP1; PP17; TIP47"
                     /note="major polyA site"
ORIGIN      
        1 ggtttccaag ctggttttga agtcgcggca gctgttcctg ggacgtccgg ttgaccgcgc
       61 gtctgctgca gagaccatgt ctgccgacgg ggcagaggct gatggcagca cccaggtgac
      121 agtggaagaa ccggtacagc agcccagtgt ggtggaccgt gtggccagca tgcctctgat
      181 cagctccacc tgcgacatgg tgtccgcagc ctatgcctcc accaaggaga gctacccgca
      241 catcaagact gtctgcgacg cagcagagaa gggagtgagg accctcacgg cggctgctgt
      301 cagcggggct cagccgatcc tctccaagct ggagccccag attgcatcag ccagcgaata
      361 cgcccacagg gggctggaca agttggagga gaacctcccc atcctgcagc agcccacgga
      421 gaaggtcctg gcggacacca aggagcttgt gtcgtctaag gtgtcggggg cccaagagat
      481 ggtgtctagc gccaaggaca cggtggccac ccaattgtcg gaggcggtgg acgcgacccg
      541 cggtgctgtg cagagcggcg tggacaagac aaagtccgta gtgaccggcg gcgtccaatc
      601 ggtcatgggc tcccgcttgg gccagatggt gttgagtggg gtcgacacgg tgctggggaa
      661 gtcggaggag tgggcggaca accacctgcc ccttacggat gccgaactgg cccgcatcgc
      721 cacatccctg gatggctttg acgtcgcgtc cgtgcagcag cagcggcagg aacagagcta
      781 cttcgtacgt ctgggctccc tgtcggagag gctgcggcag cacgcctatg agcactcgct
      841 gggcaagctt cgagccacca agcagagggc acaggaggct ctgctgcagc tgtcgcaggt
      901 cctaagcctg atggaaactg tcaagcaagg cgttgatcag aagctggtgg aaggccagga
      961 gaagctgcac cagatgtggc tcagctggaa ccagaagcag ctccagggcc ccgagaagga
     1021 gccgcccaag ccagagcagg tcgagtcccg ggcgctcacc atgttccggg acattgccca
     1081 gcaactgcag gccacctgta cctccctggg gtccagcatt cagggcctcc ccaccaatgt
     1141 gaaggaccag gtgcagcagg cccgccgcca ggtggaggac ctccaggcca cgttttccag
     1201 catccactcc ttccaggacc tgtccagcag cattctggcc cagagccgtg agcgtgtcgc
     1261 cagcgcccgc gaggccctgg accacatggt ggaatatgtg gcccagaaca cacctgtcac
     1321 gtggctcgtg ggaccctttg cccctggaat cactgagaaa gccccggagg agaagaagta
     1381 gggggagagg agaggactca gcgggccccg tctctataat gcagctgtgc tctggagtcc
     1441 tcaacccggg gctcatttca aacttatttt ctagccactc ctcccagctc ttctgtgctg
     1501 tccacttggg aagctaaggc tctcaaaacg ggcatcaccc agttgaccca tctctcagcc
     1561 tctctgagct tggaagaagc ctgttctgag cctcacccta tcagtcagta gagagagatg
     1621 tccagaaaaa atatctttca ggaaagttct cccctgcaga attttttttc cttgttaaat
     1681 atcaggaata taggccgggt gcggtggctc acacctgtaa tcccagcact ttgggaggct
     1741 gaggcgggcg gaacacctga ggtcaggtgt tcgagaccag ccaggccaac atggtgaaac
     1801 cccgtctcta ctaaaaatac aaaaaaaaat gagccgggca tggtagcagg tgtctgttat
     1861 cccagttagg aggctgaggc aagagaatct cttgaacctg agaggcggag gttgcagtga
     1921 gccaagatcg cgccattgca ctccagcctg ggggacaaga gtgagactta gtctcaaaaa
     1981 aaaaaaaaaa gaaaaaaaaa tcagggatat agttcatatc ccacttcttt gtttacaccg
     2041 atgtccctga atatcagcct gtagctaatg gacttgggat ttctggtcta agtgggcctc
     2101 ctggggatgg ggtggtacac tgagcttctg agcctcattg tagagtagaa aggtactggg
     2161 gcctgtgtgg taagccttgt tgaaatgctc tggtattcag tattgcctta ataaacttca
     2221 cccacaactg ca
//
