LOCUS       NM_001122               1897 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens perilipin 2 (PLIN2), transcript variant 1, mRNA.
ACCESSION   NM_001122
VERSION     NM_001122.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1897)
  AUTHORS   Chiariello,A., Rossetti,L., Valente,S., Pasquinelli,G.,
            Sollazzo,M., Iommarini,L., Porcelli,A.M., Tognocchi,M., Conte,G.,
            Santoro,A., Kwiatkowska,K.M., Garagnani,P., Salvioli,S. and
            Conte,M.
  TITLE     Downregulation of PLIN2 in human dermal fibroblasts impairs
            mitochondrial function in an age-dependent fashion and induces cell
            senescence via GDF15
  JOURNAL   Aging Cell 23 (5), e14111 (2024)
   PUBMED   38650174
  REMARK    GeneRIF: Downregulation of PLIN2 in human dermal fibroblasts
            impairs mitochondrial function in an age-dependent fashion and
            induces cell senescence via GDF15.
REFERENCE   2  (bases 1 to 1897)
  AUTHORS   Li,J., Zhang,Q., Guan,Y., Liao,D., Chen,H., Xiong,H., Sheng,Y.,
            Chen,X. and Pang,J.
  TITLE     TRIB3 promotes the progression of renal cell carcinoma by
            upregulating the lipid droplet-associated protein PLIN2
  JOURNAL   Cell Death Dis 15 (4), 240 (2024)
   PUBMED   38561354
  REMARK    GeneRIF: TRIB3 promotes the progression of renal cell carcinoma by
            upregulating the lipid droplet-associated protein PLIN2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1897)
  AUTHORS   Tzur,Y., Winek,K., Madrer,N., Dubnov,S., Bennett,E.R.,
            Greenberg,D.S., Hanin,G., Gammal,A., Tam,J., Arkin,I.T., Paldor,I.
            and Soreq,H.
  TITLE     Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis
            via beta-Klotho and perilipin 2
  JOURNAL   Mol Metab 79, 101856 (2024)
   PUBMED   38141848
  REMARK    GeneRIF: Lysine tRNA fragments and miR-194-5p co-regulate hepatic
            steatosis via beta-Klotho and perilipin 2.
REFERENCE   4  (bases 1 to 1897)
  AUTHORS   Han,J., Itoh,T., Shioya,A., Sakurai,M., Oyama,T., Kumagai,M.,
            Takamura,H., Okuro,M., Mukai,T., Kitakata,H., Inagaki,M.,
            Higashi,M., Guo,X. and Yamada,S.
  TITLE     The combination of the low immunohistochemical expression of
            peroxiredoxin 4 and perilipin 2 predicts longer survival in
            pancreatic ductal adenocarcinoma with peroxiredoxin 4 possibly
            playing a main role
  JOURNAL   Histol Histopathol 38 (12), 1415-1427 (2023)
   PUBMED   37787446
  REMARK    GeneRIF: The combination of the low immunohistochemical expression
            of peroxiredoxin 4 and perilipin 2 predicts longer survival in
            pancreatic ductal adenocarcinoma with peroxiredoxin 4 possibly
            playing a main role.
REFERENCE   5  (bases 1 to 1897)
  AUTHORS   Blot,G., Karadayi,R., Przegralek,L., Sartoris,T.M.,
            Charles-Messance,H., Augustin,S., Negrier,P., Blond,F.,
            Muniz-Ruvalcaba,F.P., Rivera-de la Parra,D., Vignaud,L.,
            Couturier,A., Sahel,J.A., Acar,N., Jimenez-Corona,A., Delarasse,C.,
            Garfias,Y., Sennlaub,F. and Guillonneau,X.
  TITLE     Perilipin 2-positive mononuclear phagocytes accumulate in the
            diabetic retina and promote PPARgamma-dependent vasodegeneration
  JOURNAL   J Clin Invest 133 (19), e161348 (2023)
   PUBMED   37781924
  REMARK    GeneRIF: Perilipin 2-positive mononuclear phagocytes accumulate in
            the diabetic retina and promote PPARgamma-dependent
            vasodegeneration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1897)
  AUTHORS   Schultz,C.J., Torres,E., Londos,C. and Torday,J.S.
  TITLE     Role of adipocyte differentiation-related protein in surfactant
            phospholipid synthesis by type II cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 283 (2), L288-L296 (2002)
   PUBMED   12114189
REFERENCE   7  (bases 1 to 1897)
  AUTHORS   Heid,H.W., Moll,R., Schwetlick,I., Rackwitz,H.R. and Keenan,T.W.
  TITLE     Adipophilin is a specific marker of lipid accumulation in diverse
            cell types and diseases
  JOURNAL   Cell Tissue Res 294 (2), 309-321 (1998)
   PUBMED   9799447
REFERENCE   8  (bases 1 to 1897)
  AUTHORS   Heid,H.W., Schnolzer,M. and Keenan,T.W.
  TITLE     Adipocyte differentiation-related protein is secreted into milk as
            a constituent of milk lipid globule membrane
  JOURNAL   Biochem J 320 (Pt 3) (Pt 3), 1025-1030 (1996)
   PUBMED   9003395
REFERENCE   9  (bases 1 to 1897)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
REFERENCE   10 (bases 1 to 1897)
  AUTHORS   Jiang,H.P. and Serrero,G.
  TITLE     Isolation and characterization of a full-length cDNA coding for an
            adipose differentiation-related protein
  JOURNAL   Proc Natl Acad Sci U S A 89 (17), 7856-7860 (1992)
   PUBMED   1518805
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN277218.1, BC005127.2 and
            BI494696.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001122.3.
            
            Summary: The protein encoded by this gene belongs to the perilipin
            family, members of which coat intracellular lipid storage droplets.
            This protein is associated with the lipid globule surface membrane
            material, and maybe involved in development and maintenance of
            adipose tissue. However, it is not restricted to adipocytes as
            previously thought, but is found in a wide range of cultured cell
            lines, including fibroblasts, endothelial and epithelial cells, and
            tissues, such as lactating mammary gland, adrenal cortex, Sertoli
            and Leydig cells, and hepatocytes in alcoholic liver cirrhosis,
            suggesting that it may serve as a marker of lipid accumulation in
            diverse cell types and diseases. Alternatively spliced transcript
            variants have been found for this gene. [provided by RefSeq, Mar
            2011].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005127.2, SRR5189664.128091.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276914.7/ ENSP00000276914.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                CN277218.1         117-136
            21-1888             BC005127.2         1-1868
            1889-1897           BI494696.1         199-207
FEATURES             Location/Qualifiers
     source          1..1897
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p22.1"
     gene            1..1897
                     /gene="PLIN2"
                     /gene_synonym="ADFP; ADRP"
                     /note="perilipin 2"
                     /db_xref="GeneID:123"
                     /db_xref="HGNC:HGNC:248"
                     /db_xref="MIM:103195"
     exon            1..74
                     /gene="PLIN2"
                     /gene_synonym="ADFP; ADRP"
                     /inference="alignment:Splign:2.1.0"
     exon            75..126
                     /gene="PLIN2"
                     /gene_synonym="ADFP; ADRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1410
                     /gene="PLIN2"
                     /gene_synonym="ADFP; ADRP"
                     /note="adipose differentiation-related protein;
                     adipophilin"
                     /codon_start=1
                     /product="perilipin-2"
                     /protein_id="NP_001113.2"
                     /db_xref="CCDS:CCDS6490.1"
                     /db_xref="GeneID:123"
                     /db_xref="HGNC:HGNC:248"
                     /db_xref="MIM:103195"
                     /translation="MASVAVDPQPSVVTRVVNLPLVSSTYDLMSSAYLSTKDQYPYLK
                     SVCEMAENGVKTITSVAMTSALPIIQKLEPQIAVANTYACKGLDRIEERLPILNQPST
                     QIVANAKGAVTGAKDAVTTTVTGAKDSVASTITGVMDKTKGAVTGSVEKTKSVVSGSI
                     NTVLGSRMMQLVSSGVENALTKSELLVEQYLPLTEEELEKEAKKVEGFDLVQKPSYYV
                     RLGSLSTKLHSRAYQQALSRVKEAKQKSQQTISQLHSTVHLIEFARKNVYSANQKIQD
                     AQDKLYLSWVEWKRSIGYDDTDESHCAEHIESRTLAIARNLTQQLQTTCHTLLSNIQG
                     VPQNIQDQAKHMGVMAGDIYSVFRNAASFKEVSDSLLTSSKGQLQKMKESLDDVMDYL
                     VNNTPLNWLVGPFYPQLTESQNAQDQGAEMDKSSQETQRSEHKTH"
     exon            127..322
                     /gene="PLIN2"
                     /gene_synonym="ADFP; ADRP"
                     /inference="alignment:Splign:2.1.0"
     exon            323..405
                     /gene="PLIN2"
                     /gene_synonym="ADFP; ADRP"
                     /inference="alignment:Splign:2.1.0"
     exon            406..691
                     /gene="PLIN2"
                     /gene_synonym="ADFP; ADRP"
                     /inference="alignment:Splign:2.1.0"
     exon            692..873
                     /gene="PLIN2"
                     /gene_synonym="ADFP; ADRP"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1008
                     /gene="PLIN2"
                     /gene_synonym="ADFP; ADRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1897
                     /gene="PLIN2"
                     /gene_synonym="ADFP; ADRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1715..1720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLIN2"
                     /gene_synonym="ADFP; ADRP"
                     /note="hexamer: AATAAA"
     polyA_site      1748
                     /gene="PLIN2"
                     /gene_synonym="ADFP; ADRP"
                     /note="major polyA site"
     regulatory      1868..1873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLIN2"
                     /gene_synonym="ADFP; ADRP"
                     /note="hexamer: AATAAA"
     polyA_site      1897
                     /gene="PLIN2"
                     /gene_synonym="ADFP; ADRP"
                     /note="major polyA site"
ORIGIN      
        1 gctttgaccg ggtcgtggca gccggagtcg tcttcgggac gcgcctgctc ttcgcctttc
       61 gctgcagtcc gtcgatttct ttctccagga agaaaaatgg catccgttgc agttgatcca
      121 caaccgagtg tggtgactcg ggtggtcaac ctgcccttgg tgagctccac gtatgacctc
      181 atgtcctcag cctatctcag tacaaaggac cagtatccct acctgaagtc tgtgtgtgag
      241 atggcagaga acggtgtgaa gaccatcacc tccgtggcca tgaccagtgc tctgcccatc
      301 atccagaagc tagagccgca aattgcagtt gccaatacct atgcctgtaa ggggctagac
      361 aggattgagg agagactgcc tattctgaat cagccatcaa ctcagattgt tgccaatgcc
      421 aaaggcgctg tgactggggc aaaagatgct gtgacgacta ctgtgactgg ggccaaggat
      481 tctgtggcca gcacgatcac aggggtgatg gacaagacca aaggggcagt gactggcagt
      541 gtggagaaga ccaagtctgt ggtcagtggc agcattaaca cagtcttggg gagtcggatg
      601 atgcagctcg tgagcagtgg cgtagaaaat gcactcacca aatcagagct gttggtagaa
      661 cagtacctcc ctctcactga ggaagaacta gaaaaagaag caaaaaaagt tgaaggattt
      721 gatctggttc agaagccaag ttattatgtt agactgggat ccctgtctac caagcttcac
      781 tcccgtgcct accagcaggc tctcagcagg gttaaagaag ctaagcaaaa aagccaacag
      841 accatttctc agctccattc tactgttcac ctgattgaat ttgccaggaa gaatgtgtat
      901 agtgccaatc agaaaattca ggatgctcag gataagctct acctctcatg ggtagagtgg
      961 aaaaggagca ttggatatga tgatactgat gagtcccact gtgctgagca cattgagtca
     1021 cgtactcttg caattgcccg caacctgact cagcagctcc agaccacgtg ccacaccctc
     1081 ctgtccaaca tccaaggtgt accacagaac atccaagatc aagccaagca catgggggtg
     1141 atggcaggcg acatctactc agtgttccgc aatgctgcct cctttaaaga agtgtctgac
     1201 agcctcctca cttctagcaa ggggcagctg cagaaaatga aggaatcttt agatgacgtg
     1261 atggattatc ttgttaacaa cacgcccctc aactggctgg taggtccctt ttatcctcag
     1321 ctgactgagt ctcagaatgc tcaggaccaa ggtgcagaga tggacaagag cagccaggag
     1381 acccagcgat ctgagcataa aactcattaa acctgcccct atcactagtg catgctgtgg
     1441 ccagacagat gacacctttt gttatgttga aattaacttg ctaggcaacc ctaaattggg
     1501 aagcaagtag ctagtataaa ggccctcaat tgtagttgtt tccagctgaa ttaagagctt
     1561 taaagtttct ggcattagca gatgatttct gttcacctgg taagaaaaga atgataggct
     1621 tgtcagagcc tatagccaga actcagaaaa aattcaaatg cacttatgtt ctcattctat
     1681 ggccattgtg ttgcctctgt tactgtttgt attgaataaa aacatcttca tgtgggctgg
     1741 ggtagaaact ggtgtctgct ctggtgtgat ctgaaaaggc gtcttcactg ctttatctca
     1801 tgatgcttgc ttgtaaaact tgattttagt ttttcatttc tcaaatagga atactacctt
     1861 tgaattcaat aaaattcact gcaggataga ccagtta
//
