LOCUS       NM_002666               2916 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens perilipin 1 (PLIN1), transcript variant 1, mRNA.
ACCESSION   NM_002666
VERSION     NM_002666.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2916)
  AUTHORS   Huang,J.H., Wei,Y., Fang,Z., Yu,C., Zhang,R., Feng,Z.B. and
            Zeng,L.P.
  TITLE     Clinical pathological significance and biological function of PLIN1
            in hepatocellular carcinoma: bioinformatics analysis and in vitro
            experiments
  JOURNAL   BMC Cancer 24 (1), 1073 (2024)
   PUBMED   39215210
  REMARK    GeneRIF: Clinical pathological significance and biological function
            of PLIN1 in hepatocellular carcinoma: bioinformatics analysis and
            in vitro experiments.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2916)
  AUTHORS   Desgrouas,C., Thalheim,T., Cerino,M., Badens,C. and
            Bonello-Palot,N.
  TITLE     Perilipin 1: a systematic review on its functions on lipid
            metabolism and atherosclerosis in mice and humans
  JOURNAL   Cardiovasc Res 120 (3), 237-248 (2024)
   PUBMED   38214891
  REMARK    GeneRIF: Perilipin 1: a systematic review on its functions on lipid
            metabolism and atherosclerosis in mice and humans.
REFERENCE   3  (bases 1 to 2916)
  AUTHORS   Wang,M., Cao,X., Shang,Y., Jiang,Y., Chen,P., Duan,C., Zhang,D.,
            Wang,P., Ji,J. and Gong,Z.
  TITLE     Correlational analysis of PLIN1 with inflammation in diabetic foot
            ulcer wounds
  JOURNAL   Diabetes Res Clin Pract 209, 111605 (2024)
   PUBMED   38453058
  REMARK    GeneRIF: Correlational analysis of PLIN1 with inflammation in
            diabetic foot ulcer wounds.
REFERENCE   4  (bases 1 to 2916)
  AUTHORS   Bajpeyi,S., Apaflo,J.N., Rosas,V., Sepulveda-Rivera,K.,
            Varela-Ramirez,A., Covington,J.D., Galgani,J.E. and Ravussin,E.
  TITLE     Effect of an acute long-duration exercise bout on skeletal muscle
            lipid droplet morphology, GLUT 4 protein, and perilipin protein
            expression
  JOURNAL   Eur J Appl Physiol 123 (12), 2771-2778 (2023)
   PUBMED   37368137
  REMARK    GeneRIF: Effect of an acute long-duration exercise bout on skeletal
            muscle lipid droplet morphology, GLUT 4 protein, and perilipin
            protein expression.
REFERENCE   5  (bases 1 to 2916)
  AUTHORS   de Luis,D., Izaola,O., Primo,D. and Aller,R.
  TITLE     RS2289487 variation in PERILIPIN gene is a predictor of weight loss
            and protection against impaired glucose metabolism after a
            meal-replacement diet in postmenopausal obese females
  JOURNAL   Eur Rev Med Pharmacol Sci 27 (19), 9355-9362 (2023)
   PUBMED   37843309
  REMARK    GeneRIF: RS2289487 variation in PERILIPIN gene is a predictor of
            weight loss and protection against impaired glucose metabolism
            after a meal-replacement diet in postmenopausal obese females.
REFERENCE   6  (bases 1 to 2916)
  AUTHORS   Wang,Y., Sullivan,S., Trujillo,M., Lee,M.J., Schneider,S.H.,
            Brolin,R.E., Kang,Y.H., Werber,Y., Greenberg,A.S. and Fried,S.K.
  TITLE     Perilipin expression in human adipose tissues: effects of severe
            obesity, gender, and depot
  JOURNAL   Obes Res 11 (8), 930-936 (2003)
   PUBMED   12917496
REFERENCE   7  (bases 1 to 2916)
  AUTHORS   Mottagui-Tabar,S., Ryden,M., Lofgren,P., Faulds,G., Hoffstedt,J.,
            Brookes,A.J., Andersson,I. and Arner,P.
  TITLE     Evidence for an important role of perilipin in the regulation of
            human adipocyte lipolysis
  JOURNAL   Diabetologia 46 (6), 789-797 (2003)
   PUBMED   12802495
  REMARK    GeneRIF: Perilipin could be a factor behind impaired lipolysis in
            insulin-resistants sconditions.
REFERENCE   8  (bases 1 to 2916)
  AUTHORS   Hagstrom-Toft,E., Qvisth,V., Nennesmo,I., Ryden,M., Bolinder,H.,
            Enoksson,S., Bolinder,J. and Arner,P.
  TITLE     Marked heterogeneity of human skeletal muscle lipolysis at rest
  JOURNAL   Diabetes 51 (12), 3376-3383 (2002)
   PUBMED   12453889
REFERENCE   9  (bases 1 to 2916)
  AUTHORS   Souza,S.C., Muliro,K.V., Liscum,L., Lien,P., Yamamoto,M.T.,
            Schaffer,J.E., Dallal,G.E., Wang,X., Kraemer,F.B., Obin,M. and
            Greenberg,A.S.
  TITLE     Modulation of hormone-sensitive lipase and protein kinase
            A-mediated lipolysis by perilipin A in an adenoviral reconstituted
            system
  JOURNAL   J Biol Chem 277 (10), 8267-8272 (2002)
   PUBMED   11751901
REFERENCE   10 (bases 1 to 2916)
  AUTHORS   Nishiu,J., Tanaka,T. and Nakamura,Y.
  TITLE     Isolation and chromosomal mapping of the human homolog of perilipin
            (PLIN), a rat adipose tissue-specific gene, by differential display
            method
  JOURNAL   Genomics 48 (2), 254-257 (1998)
   PUBMED   9521880
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB266707.1, AB005293.1,
            AC013787.15, CB266260.1, BC031084.1, CA427560.1 and BQ003487.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002666.4.
            
            Summary: The protein encoded by this gene coats lipid storage
            droplets in adipocytes, thereby protecting them until they can be
            broken down by hormone-sensitive lipase. The encoded protein is the
            major cAMP-dependent protein kinase substrate in adipocytes and,
            when unphosphorylated, may play a role in the inhibition of
            lipolysis. Alternatively spliced transcript variants varying in the
            5' UTR, but encoding the same protein, have been found for this
            gene. [provided by RefSeq, Feb 2009].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Transcript variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031084.1, AB005293.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154125 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300055.10/ ENSP00000300055.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                CB266707.1         61-106
            47-710              AB005293.1         40-703
            711-711             AC013787.15        147082-147082       c
            712-1243            AB005293.1         705-1236
            1244-1254           CB266260.1         111-121
            1255-2150           BC031084.1         1248-2143
            2151-2548           CA427560.1         15-412              c
            2549-2916           BQ003487.1         14-381              c
FEATURES             Location/Qualifiers
     source          1..2916
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..2916
                     /gene="PLIN1"
                     /gene_synonym="FPLD4; PERI; PLIN"
                     /note="perilipin 1"
                     /db_xref="GeneID:5346"
                     /db_xref="HGNC:HGNC:9076"
                     /db_xref="MIM:170290"
     exon            1..117
                     /gene="PLIN1"
                     /gene_synonym="FPLD4; PERI; PLIN"
                     /inference="alignment:Splign:2.1.0"
     exon            118..176
                     /gene="PLIN1"
                     /gene_synonym="FPLD4; PERI; PLIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1700
                     /gene="PLIN1"
                     /gene_synonym="FPLD4; PERI; PLIN"
                     /note="lipid droplet-associated protein"
                     /codon_start=1
                     /product="perilipin-1"
                     /protein_id="NP_002657.3"
                     /db_xref="CCDS:CCDS10353.1"
                     /db_xref="GeneID:5346"
                     /db_xref="HGNC:HGNC:9076"
                     /db_xref="MIM:170290"
                     /translation="MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTST
                     KEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKI
                     PALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDT
                     AEFAANTRAGRLASGGADLALGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSL
                     LSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLSSLAQWGASVAMQAVSRRR
                     SEVRVPWLHSLAAAQEEDHEDQTDTEGEDTEEEEELETEENKFSEVAALPGPRGLLGG
                     VAHTLQKTLQTTISAVTWAPAAVLGMAGRVLHLTPAPAVSSTKGRAMSLSDALKGVTD
                     NVVDTVVHYVPLPRLSLMEPESEFRDIDNPPAEVERREAERRASGAPSAGPEPAPRLA
                     QPRRSLRSAQSPGAPPGPGLEDEVATPAAPRPGFPAVPREKPKRRVSDSFFRPSVMEP
                     ILGRTHYSQLRKKS"
     exon            177..381
                     /gene="PLIN1"
                     /gene_synonym="FPLD4; PERI; PLIN"
                     /inference="alignment:Splign:2.1.0"
     exon            382..464
                     /gene="PLIN1"
                     /gene_synonym="FPLD4; PERI; PLIN"
                     /inference="alignment:Splign:2.1.0"
     exon            465..729
                     /gene="PLIN1"
                     /gene_synonym="FPLD4; PERI; PLIN"
                     /inference="alignment:Splign:2.1.0"
     exon            730..902
                     /gene="PLIN1"
                     /gene_synonym="FPLD4; PERI; PLIN"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1094
                     /gene="PLIN1"
                     /gene_synonym="FPLD4; PERI; PLIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1340
                     /gene="PLIN1"
                     /gene_synonym="FPLD4; PERI; PLIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..2916
                     /gene="PLIN1"
                     /gene_synonym="FPLD4; PERI; PLIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2896..2901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLIN1"
                     /gene_synonym="FPLD4; PERI; PLIN"
                     /note="hexamer: AATAAA"
     polyA_site      2916
                     /gene="PLIN1"
                     /gene_synonym="FPLD4; PERI; PLIN"
                     /note="major polyA site"
ORIGIN      
        1 actctgcagc ctgggctctg tgagactgag gtggcggtca gccggagtga gtgttggggt
       61 cctggggcac ctgccttaca tggcttgttt atgaacatta aagggaagaa gttgaagctt
      121 gaggagcgag gatggcagtc aacaaaggcc tcaccttgct ggatggagac ctccctgagc
      181 aggagaatgt gctgcagcgg gtcctgcagc tgccggtggt gagtggcacc tgcgaatgct
      241 tccagaagac ctacaccagc actaaggaag cccaccccct ggtggcctct gtgtgcaatg
      301 cctatgagaa gggcgtgcag agcgccagta gcttggctgc ctggagcatg gagccggtgg
      361 tccgcaggct gtccacccag ttcacagctg ccaatgagct ggcctgccga ggcttggacc
      421 acctggagga aaagatcccc gccctccagt acccccctga aaagattgct tctgagctga
      481 aggacaccat ctccacccgc ctccgcagtg ccagaaacag catcagcgtt cccatcgcga
      541 gcacttcaga caaggtcctg ggggccgctt tggccgggtg cgagcttgcc tggggggtgg
      601 ccagagacac tgcggaattt gctgccaaca ctcgagctgg ccgactggct tctggagggg
      661 ccgacttggc cttgggcagc attgagaagg tggtggagta cctcctccct ccagacaagg
      721 aagagtcagc ccctgctcct ggacaccagc aagcccagaa gtctcccaag gccaagccaa
      781 gcctcttgag cagggttggg gctctgacca acaccctctc tcgatacacc gtgcagacca
      841 tggcccgggc cctggagcag ggccacaccg tggccatgtg gatcccaggc gtggtgcccc
      901 tgagcagcct ggcccagtgg ggtgcctcag tggccatgca ggcggtgtcc cggcggagga
      961 gcgaagtgcg ggtaccctgg ctgcacagcc tcgcagccgc ccaggaggag gatcatgagg
     1021 accagacaga cacggaggga gaggacacgg aggaggagga agaattggag actgaggaga
     1081 acaagttcag tgaggtagca gccctgccag gccctcgagg cctcctgggt ggtgtggcac
     1141 ataccctgca gaagaccctc cagaccacca tctcggctgt gacatgggca cctgcagctg
     1201 tgctgggcat ggcagggagg gtgctgcacc tcacaccagc ccctgctgtc tcctcaacca
     1261 aggggagggc catgtcccta tcagatgccc tgaagggcgt tactgacaac gtggtggaca
     1321 cagtggtgca ttacgtgccg ctccccaggc tgtcgctgat ggagcccgag agcgaattcc
     1381 gggacatcga caacccacca gccgaggtcg agcgccggga ggcggagcgc agagcgtctg
     1441 gggcgccgtc cgccggcccg gagcccgccc cgcgtctcgc acagccccgc cgcagcctgc
     1501 gcagcgcgca gagccccggc gcgccccccg gcccgggcct ggaggacgaa gtcgccacgc
     1561 ccgcagcgcc gcgcccgggc ttcccggccg tgccccgcga gaagccaaag cgcagggtca
     1621 gcgacagctt cttccggccc agcgtcatgg agcccatcct gggccgcacg cattacagcc
     1681 agctgcgcaa gaagagctga gtcgccgcac cagccgccgc gccccgggcc ggcgggtttc
     1741 tctaacaaat aaacagaacc cgcactgccc aggcgagcgt tgccactttc aaagtggtcc
     1801 cctggggagc tcagcctcat cctgatgatg ctgccaaggc gcacttttta tttttatttt
     1861 atttttattt tttttttagc atccttttgg ggcttcactc tcagagccag tttttaaggg
     1921 acaccagagc cgcagcctgc tctgattcta tggcttggtt gttactataa gagtaattgc
     1981 ctaacttgat ttttcatctc tttaaccaaa cttgtggcca aaagatattt gaccgtttcc
     2041 aaaattcaga ttctgcctct gcggataaat atttgccacg aatgagtaac tcctgtcacc
     2101 actctgaagg tccagacaga aggttttgac acattcttag cactgaactc ctctgtgatc
     2161 taggatgatc tgttccccct ctgatgaaca tcctctgatg atctaggctc ccagcaggct
     2221 actttgaagg gaacaatcag atgcaaaagc tcttgggtgt ttatttaaaa tactagtgtc
     2281 actttctgag tacccgccgc ttcacaggct gagtccaggc ctgtgtgctt tgtagagcca
     2341 gctgcttgct cacagccaca tttccatttg catcattact gccttcacct gcatagtcac
     2401 tcttttgatg ctggggaacc aaaatggtga tgatatatag actttatgta tagccacagt
     2461 tcatccccaa ccctagtctt cgaaatgtta atatttgata aatctagaaa atgcattcat
     2521 acaattacag aattcaaata ttgcaaaagg atgtgtgtct ttctccccga gctcccctgt
     2581 tccccttcat tgaaaaccac cacggtgcca tctcttgtgt atgcagggct atgcacctgc
     2641 aggcacgtgt gtatgcactc cccgcttgtg tttacacaag ctgtggggtg ttacgcatgc
     2701 ctgctttttt cacttaataa tacagcttgg agagattttt gtatcacatt ataaatccca
     2761 ctcgctcttt ttgatggcca cataataact actgcataat atggatacgc cttatttgat
     2821 ttaactagtt ccctaatgat ggacttttaa gttgtttcct ttttttttct tttttgctac
     2881 tgcaaacgat gctataataa atgtccttat caaaaa
//
