LOCUS       NM_018465                981 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens plasminogen receptor with a C-terminal lysine
            (PLGRKT), mRNA.
ACCESSION   NM_018465
VERSION     NM_018465.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 981)
  AUTHORS   Miles,L.A., Krajewski,S., Baik,N., Parmer,R.J. and Mueller,B.M.
  TITLE     Plg-RKT Expression in Human Breast Cancer Tissues
  JOURNAL   Biomolecules 12 (4), 503 (2022)
   PUBMED   35454092
  REMARK    GeneRIF: Plg-RKT Expression in Human Breast Cancer Tissues.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 981)
  AUTHORS   Samad,F., Bai,H., Baik,N., Haider,P., Zhang,Y., Rega-Kaun,G.,
            Kaun,C., Prager,M., Wojta,J., Bui,Q., Chakrabarty,S., Wang,J.,
            Parmer,R.J. and Miles,L.A.
  TITLE     The plasminogen receptor Plg-RKT regulates adipose function and
            metabolic homeostasis
  JOURNAL   J Thromb Haemost 20 (3), 742-754 (2022)
   PUBMED   34897983
  REMARK    GeneRIF: The plasminogen receptor Plg-RKT regulates adipose
            function and metabolic homeostasis.
REFERENCE   3  (bases 1 to 981)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 981)
  AUTHORS   Whyte,C.S., Morrow,G.B., Baik,N., Booth,N.A., Jalal,M.M.,
            Parmer,R.J., Miles,L.A. and Mutch,N.J.
  TITLE     Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT,
            on activated human and murine platelets
  JOURNAL   Blood 137 (2), 248-257 (2021)
   PUBMED   32842150
  REMARK    GeneRIF: Exposure of plasminogen and a novel plasminogen receptor,
            Plg-RKT, on activated human and murine platelets.
REFERENCE   5  (bases 1 to 981)
  AUTHORS   Vago,J.P., Sugimoto,M.A., Lima,K.M., Negreiros-Lima,G.L., Baik,N.,
            Teixeira,M.M., Perretti,M., Parmer,R.J., Miles,L.A. and Sousa,L.P.
  TITLE     Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate
            Macrophage Phenotypic, and Functional Changes
  JOURNAL   Front Immunol 10, 1458 (2019)
   PUBMED   31316511
  REMARK    GeneRIF: Plasminogen and the Plasminogen Receptor, Plg-RKT,
            Regulate Macrophage Phenotypic, and Functional Changes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 981)
  AUTHORS   Lighvani,S., Baik,N., Diggs,J.E., Khaldoyanidi,S., Parmer,R.J. and
            Miles,L.A.
  TITLE     Regulation of macrophage migration by a novel plasminogen receptor
            Plg-R KT
  JOURNAL   Blood 118 (20), 5622-5630 (2011)
   PUBMED   21940822
  REMARK    GeneRIF: Plg-R(KT) plays a key role in the plasminogen-dependent
            regulation of macrophage invasion, chemotactic migration, and
            recruitment in the inflammatory response.
REFERENCE   7  (bases 1 to 981)
  AUTHORS   Bai,H., Baik,N., Kiosses,W.B., Krajewski,S., Miles,L.A. and
            Parmer,R.J.
  TITLE     The novel plasminogen receptor, plasminogen receptor(KT)
            (Plg-R(KT)), regulates catecholamine release
  JOURNAL   J Biol Chem 286 (38), 33125-33133 (2011)
   PUBMED   21795689
  REMARK    GeneRIF: Plg-R(KT) was highly expressed in bovine adrenomedullary
            chromaffin cells, human pheochromocytoma tissue, PC12
            pheochromocytoma cells, and murine hippocampus.
REFERENCE   8  (bases 1 to 981)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 981)
  AUTHORS   Andronicos,N.M., Chen,E.I., Baik,N., Bai,H., Parmer,C.M.,
            Kiosses,W.B., Kamps,M.P., Yates,J.R. 3rd, Parmer,R.J. and
            Miles,L.A.
  TITLE     Proteomics-based discovery of a novel, structurally unique, and
            developmentally regulated plasminogen receptor, Plg-RKT, a major
            regulator of cell surface plasminogen activation
  JOURNAL   Blood 115 (7), 1319-1330 (2010)
   PUBMED   19897580
REFERENCE   10 (bases 1 to 981)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM693747.1, AK027594.1 and AA919015.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018465.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.327824.1,
                                           SRR5189655.195401.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159368 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000223864.7/ ENSP00000223864.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BM693747.1         13-61
            50-979              AK027594.1         1-930
            980-981             AA919015.1         28-29               c
FEATURES             Location/Qualifiers
     source          1..981
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.1"
     gene            1..981
                     /gene="PLGRKT"
                     /gene_synonym="AD025; C9orf46; MDS030; Plg-R(KT); PLG-RKT"
                     /note="plasminogen receptor with a C-terminal lysine"
                     /db_xref="GeneID:55848"
                     /db_xref="HGNC:HGNC:23633"
                     /db_xref="MIM:618444"
     exon            1..137
                     /gene="PLGRKT"
                     /gene_synonym="AD025; C9orf46; MDS030; Plg-R(KT); PLG-RKT"
                     /inference="alignment:Splign:2.1.0"
     exon            138..263
                     /gene="PLGRKT"
                     /gene_synonym="AD025; C9orf46; MDS030; Plg-R(KT); PLG-RKT"
                     /inference="alignment:Splign:2.1.0"
     exon            264..350
                     /gene="PLGRKT"
                     /gene_synonym="AD025; C9orf46; MDS030; Plg-R(KT); PLG-RKT"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..713
                     /gene="PLGRKT"
                     /gene_synonym="AD025; C9orf46; MDS030; Plg-R(KT); PLG-RKT"
                     /note="5033414D02Rik; transmembrane protein C9orf46;
                     plasminogen receptor, C-terminal lysine transmembrane
                     protein"
                     /codon_start=1
                     /product="plasminogen receptor (KT)"
                     /protein_id="NP_060935.2"
                     /db_xref="CCDS:CCDS6463.1"
                     /db_xref="GeneID:55848"
                     /db_xref="HGNC:HGNC:23633"
                     /db_xref="MIM:618444"
                     /translation="MGFIFSKSMNESMKNQKEFMLMNARLQLERQLIMQSEMRERQMA
                     MQIAWSREFLKYFGTFFGLAAISLTAGAIKKKKPAFLVPIVPLSFILTYQYDLGYGTL
                     LERMKGEAEDILETEKSKLQLPRGMITFESIEKARKEQSRFFIDK"
     exon            351..481
                     /gene="PLGRKT"
                     /gene_synonym="AD025; C9orf46; MDS030; Plg-R(KT); PLG-RKT"
                     /inference="alignment:Splign:2.1.0"
     exon            482..591
                     /gene="PLGRKT"
                     /gene_synonym="AD025; C9orf46; MDS030; Plg-R(KT); PLG-RKT"
                     /inference="alignment:Splign:2.1.0"
     exon            592..981
                     /gene="PLGRKT"
                     /gene_synonym="AD025; C9orf46; MDS030; Plg-R(KT); PLG-RKT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      957..962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLGRKT"
                     /gene_synonym="AD025; C9orf46; MDS030; Plg-R(KT); PLG-RKT"
                     /note="hexamer: AATAAA"
     polyA_site      981
                     /gene="PLGRKT"
                     /gene_synonym="AD025; C9orf46; MDS030; Plg-R(KT); PLG-RKT"
                     /note="major polyA site"
ORIGIN      
        1 gaggtgcgtc atctactgtg tctgggcgcc aatcccgacg ctgggcggag cgaggcccgg
       61 tccctgcagc gggcgaaagg agcccgggcc tggaggtttg cgtaccggtc gcctggtccc
      121 ggcaccagcg ccgcccagtg tggtttccca taaggaagct cttcttcctg cttggcttcc
      181 acctttaacc cttccacctg ggagcgtcct ctaacacatt cagactacaa gtccagaccc
      241 aggagagcaa ggcccagaaa gaggtcaaaa tggggtttat attttcaaaa tctatgaatg
      301 aaagcatgaa aaatcaaaag gagttcatgc ttatgaatgc tcgacttcag ctggaaaggc
      361 agctcatcat gcagagtgaa atgagggaaa gacaaatggc catgcagatt gcgtggtctc
      421 gggaattcct caaatatttt ggaacttttt ttggccttgc agccatctct ttaacagctg
      481 gagcgattaa aaaaaagaag ccagccttcc tggtcccgat tgttccatta agctttatcc
      541 tcacctacca gtatgacttg ggctatggaa cccttttaga aagaatgaaa ggtgaagctg
      601 aggacatact ggaaacagaa aagagtaaat tgcagctgcc aagaggaatg atcacttttg
      661 aaagcattga aaaagccaga aaggaacaga gtagattctt catagacaaa tgaaatcatg
      721 cttaccaatc aaatctcaaa gcacagaatt attgacttga atcatggttt ttacagtttt
      781 ttaaatgctc aagattttga tattatagat tttattttaa aatattaaaa tgcaagatag
      841 ttttgagcta ttttaaaata aaatttataa cattcaacac aaaatcatgg aggtgctcta
      901 aataactttt agatttcctc tctctgtgtg cattaccaat atctaagtgt aaaattaata
      961 aattgttttg aattcctgga a
//
