LOCUS       NM_002665               3016 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens plasminogen like B2 (PLGLB2), mRNA.
ACCESSION   NM_002665
VERSION     NM_002665.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3016)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 3016)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 3016)
  AUTHORS   Tateno,T. and Ichinose,A.
  TITLE     Expression of plasminogen-related gene B varies among normal
            tissues and increases in cancer tissues
  JOURNAL   FEBS Lett 445 (1), 31-35 (1999)
   PUBMED   10069369
REFERENCE   4  (bases 1 to 3016)
  AUTHORS   Lewis,V.O., Gehrmann,M., Weissbach,L., Hyman,J.E., Rielly,A.,
            Jones,D.G., Llinas,M. and Schaller,J.
  TITLE     Homologous plasminogen N-terminal and plasminogen-related gene A
            and B peptides. Characterization of cDNAs and recombinant fusion
            proteins
  JOURNAL   Eur J Biochem 259 (3), 618-625 (1999)
   PUBMED   10092845
REFERENCE   5  (bases 1 to 3016)
  AUTHORS   Kida,M., Wakabayashi,S. and Ichinose,A.
  TITLE     Characterization of the 5'-flanking regions of plasminogen-related
            genes A and B
  JOURNAL   FEBS Lett 404 (1), 95-99 (1997)
   PUBMED   9074645
REFERENCE   6  (bases 1 to 3016)
  AUTHORS   Magnaghi,P., Citterio,E., Malgaretti,N., Acquati,F., Ottolenghi,S.
            and Taramelli,R.
  TITLE     Molecular characterisation of the human apo(a)-plasminogen gene
            family clustered on the telomeric region of chromosome 6 (6q26-27)
  JOURNAL   Hum Mol Genet 3 (3), 437-442 (1994)
   PUBMED   8012354
REFERENCE   7  (bases 1 to 3016)
  AUTHORS   Weissbach,L. and Treadwell,B.V.
  TITLE     A plasminogen-related gene is expressed in cancer cells
  JOURNAL   Biochem Biophys Res Commun 186 (2), 1108-1114 (1992)
   PUBMED   1379800
REFERENCE   8  (bases 1 to 3016)
  AUTHORS   Ichinose,A.
  TITLE     Multiple members of the plasminogen-apolipoprotein(a) gene family
            associated with thrombosis
  JOURNAL   Biochemistry 31 (12), 3113-3118 (1992)
   PUBMED   1554698
REFERENCE   9  (bases 1 to 3016)
  AUTHORS   Ichinose,A., Espling,E.S., Takamatsu,J., Saito,H., Shinmyozu,K.,
            Maruyama,I., Petersen,T.E. and Davie,E.W.
  TITLE     Two types of abnormal genes for plasminogen in families with a
            predisposition for thrombosis
  JOURNAL   Proc Natl Acad Sci U S A 88 (1), 115-119 (1991)
   PUBMED   1986355
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1991 Apr 1;88(7):2967]
REFERENCE   10 (bases 1 to 3016)
  AUTHORS   Frank,S.L., Klisak,I., Sparkes,R.S. and Lusis,A.J.
  TITLE     A gene homologous to plasminogen located on human chromosome
            2q11-p11
  JOURNAL   Genomics 4 (3), 449-451 (1989)
   PUBMED   2714803
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093616.5 and BC005379.1.
            
            On Jan 20, 2007 this sequence version replaced NM_002665.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M93143.2, BC005379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2152719
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359481.9/ ENSP00000352458.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC093616.5         92843-92846
            5-1154              BC005379.1         1-1150
            1155-3016           AC093616.5         102371-104232
FEATURES             Location/Qualifiers
     source          1..3016
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..3016
                     /gene="PLGLB2"
                     /gene_synonym="PLGLA; PLGLA1; PLGP1; PLGP2; PRGA"
                     /note="plasminogen like B2"
                     /db_xref="GeneID:5342"
                     /db_xref="HGNC:HGNC:9073"
     exon            1..116
                     /gene="PLGLB2"
                     /gene_synonym="PLGLA; PLGLA1; PLGP1; PLGP2; PRGA"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..358
                     /gene="PLGLB2"
                     /gene_synonym="PLGLA; PLGLA1; PLGP1; PLGP2; PRGA"
                     /note="plasminogen pseudogene 1; type B plasminogen
                     related; plasminogen-related protein B; plasminogen-like
                     protein B; Plasminogen-like protein A; Plasminogen-like
                     protein A1; plasminogen-related protein A"
                     /codon_start=1
                     /product="plasminogen-like protein B precursor"
                     /protein_id="NP_002656.1"
                     /db_xref="CCDS:CCDS1999.1"
                     /db_xref="GeneID:5342"
                     /db_xref="HGNC:HGNC:9073"
                     /translation="MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGPSLFSVTKKQLGAG
                     SREECAAKCEEDKEFTCRAFQYHSKEQQCVIMAENRKSSIIIRMRDAVLFEK"
     exon            117..252
                     /gene="PLGLB2"
                     /gene_synonym="PLGLA; PLGLA1; PLGP1; PLGP2; PRGA"
                     /inference="alignment:Splign:2.1.0"
     exon            253..359
                     /gene="PLGLB2"
                     /gene_synonym="PLGLA; PLGLA1; PLGP1; PLGP2; PRGA"
                     /inference="alignment:Splign:2.1.0"
     exon            360..3016
                     /gene="PLGLB2"
                     /gene_synonym="PLGLA; PLGLA1; PLGP1; PLGP2; PRGA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctcatgtaa gtcaacaaca tcctgggatt gggacacact ttctgggcac tgctggccag
       61 tcccaaaatg gaacataagg aagtggttct tctacttctt ttatttctga aatcaggtca
      121 aggagagccc ctggatgact atgtgaatac ccaggggcct tcactgttca gtgtcactaa
      181 gaagcagctg ggggcaggaa gcagagaaga atgtgcagca aaatgtgaag aggacaaaga
      241 attcacctgc agggcattcc aatatcacag taaagagcaa caatgtgtga taatggctga
      301 aaacaggaag tcctccataa tcattaggat gagagatgca gttttatttg aaaagtaaat
      361 gtatctttca gagtgcaaga ctgggaatgg aaagaactac agagggacga tgtccaaaac
      421 aaaaaatggc atcacctgtc aaaaatggag ttccacttct ccccgcagac ctaggtcaga
      481 cttttccttt catctttgtg ttcatctact gtaaagtgtc cgtctgtgtc tgtgagggat
      541 tggttccagg acccctgtgg ctaccaaaat ccatgcttct caagtccctt atgtaaaatg
      601 gtgcagtatt tgcatataac ctacatacct tctcttgtgc aatccctaat ataatgtaaa
      661 tgctatgtaa tcgttgttat actgtattgt ttttatttgt attatgtttt attgtcatat
      721 tgttattttc tctcatcttt ttcaagtctt ttccatccac agttggttga atttgtggat
      781 gtggaaccca tggatacaga gggccaactg tatttaggat aatttcatca cttttaattc
      841 aaaccagaat atgtgaataa gcagacagaa agaatctttt tgatgtcgat gttcaactat
      901 ttttggcacc atagtagaac atggttgctt tctatttttt cttgggtatg gaggtttctt
      961 gaagacctag aacatagaag aatgcctagt taaaaaaaaa aatcaatgaa actacgagtt
     1021 ttaggccaaa tctgagaaaa gaccaaagat gactatgttt gggactgaag taaacatatc
     1081 aagttagaac tctcatcaca tgtttgactc aaattgtgga gcaaaatagt aaataaaata
     1141 taaaaatgaa aatgaagata cgtgaaattc aaatgtcaca acttgcctat tatttatttt
     1201 agtgcatttt tttgtgcttt tcccagtttg gtgttaggtg gccttaagtt ctcagtaatg
     1261 acacttatca aataggaact tagtgttact cacctttatc cattccccca acactcaaca
     1321 aattgccttt gctatatccc tatgagatga gcagatcaaa tattccccgt gagttaatga
     1381 aaactgattc aaccaaatgg cgaagtcaga gactatcggg ggccatggag acactctggg
     1441 ccatttttat gaggtagtct aggctcatct tcatgaggga actgaggtct tggggggtgg
     1501 gggttaccca aataggttca cagaagaacc agaaataaaa cctgcctttc tagactgtaa
     1561 gtcttgtgat tgtcatctaa atggttgtct ctatacagca actcatctct agaactgaaa
     1621 ataagtttaa atccctcctc catccccaat aattcaagct gcatttcaga gaaaaccagg
     1681 actttggaat cagacagatc aactttgaat tcttgatctg cttcttcata gctatttatg
     1741 cttaggcaag ttttgttttg ttttgtttta cgttgccact cagtcttctc atctgtaaaa
     1801 cagggataat aacaccttcc tcaaatggtt ttttttatta ggactaaaag agagaatgtg
     1861 tggaaagatg ttagtggaat tcctggcaca tagttcacat ggacaaaatg gtgttaacta
     1921 cgaaaatttt tacagagaaa agggcaactg acaaaagcag gtgtttggaa tgaattaaga
     1981 ccatggcagg cttttgaggc ctttatattt ctcctgactg tgcaataaaa atattttggc
     2041 tctctgtcta agacttggct gtcacagtag caatggtaat attagctact gtgccagaag
     2101 cagcctatca atagagaaat tgaaaatctg accacacaaa tgctgcagca cccagctgaa
     2161 atgcatttgg atgacaatct cagatgggaa tcgagagcat ctccttctgc cttgctaata
     2221 gcaagctgat ttttagaata tagtctaagt gcttctcttc catcctcccc agattctcac
     2281 ctgctacaca cccctcagag ggactggagg aatccagaca acgatgcgca ggggccctgg
     2341 tgctatacta ctgatccaga acagagatat gactactgcg acattcctga gtgtgaaggg
     2401 caggagtggc tctagaaaat gttttcattt ctgcccttca cctgtaaaat aatttgttgt
     2461 aaagcccctt cccacaggga tattattaat aattgcgtaa cgtgttcacc tctcggaaag
     2521 gagcaaaact ttgctcagat cccagaatta acctgatttt tttttttttt tctgagacag
     2581 aattttgctc tcattgccca ggctagagtg caatggtgcg atctcagctc accacaacct
     2641 ccgcctccgg gttcaagcga ttctcctacc tcagcctccc aagtagctgg aattacatgc
     2701 atgtgccacc atgcctggct aattttacat ttttagtaga gacagggttt ctccatgttg
     2761 gtcaggctgg tcttgaactc tcgacctcag gtgagccgcc cgcctcagcc tcccaaagtg
     2821 ctgggattac aggcatgagc caccatgccc agcagacctg aattattatt attaaaatgt
     2881 tacatcaaca tgtacaaata taaaactaca tctaaactct aagtacagac ttcttatgct
     2941 taaaactctt acacagtgtt aaccccaaga cagatttgca attaagtagt taaaataaga
     3001 caacaaagtc aataaa
//
