LOCUS       NM_001032392            3249 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens plasminogen like B1 (PLGLB1), mRNA.
ACCESSION   NM_001032392
VERSION     NM_001032392.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3249)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 3249)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 3249)
  AUTHORS   Weissbach,L. and Treadwell,B.V.
  TITLE     A plasminogen-related gene is expressed in cancer cells
  JOURNAL   Biochem Biophys Res Commun 186 (2), 1108-1114 (1992)
   PUBMED   1379800
REFERENCE   4  (bases 1 to 3249)
  AUTHORS   Ichinose,A.
  TITLE     Multiple members of the plasminogen-apolipoprotein(a) gene family
            associated with thrombosis
  JOURNAL   Biochemistry 31 (12), 3113-3118 (1992)
   PUBMED   1554698
REFERENCE   5  (bases 1 to 3249)
  AUTHORS   Ichinose,A., Espling,E.S., Takamatsu,J., Saito,H., Shinmyozu,K.,
            Maruyama,I., Petersen,T.E. and Davie,E.W.
  TITLE     Two types of abnormal genes for plasminogen in families with a
            predisposition for thrombosis
  JOURNAL   Proc Natl Acad Sci U S A 88 (1), 115-119 (1991)
   PUBMED   1986355
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1991 Apr 1;88(7):2967]
REFERENCE   6  (bases 1 to 3249)
  AUTHORS   Frank,S.L., Klisak,I., Sparkes,R.S. and Lusis,A.J.
  TITLE     A gene homologous to plasminogen located on human chromosome
            2q11-p11
  JOURNAL   Genomics 4 (3), 449-451 (1989)
   PUBMED   2714803
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125232.4 and AC111200.7.
            
            On Feb 11, 2020 this sequence version replaced NM_001032392.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070296.1, SRR5189664.93109.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155590, SAMN04284274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355705.4/ ENSP00000347933.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AC125232.4         3097-3206           c
            111-246             AC111200.7         183667-183802       c
            247-353             AC111200.7         182416-182522       c
            354-3249            AC111200.7         176338-179233       c
FEATURES             Location/Qualifiers
     source          1..3249
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..3249
                     /gene="PLGLB1"
                     /gene_synonym="PLGL; PLGP1; PRGB; PRP-B"
                     /note="plasminogen like B1"
                     /db_xref="GeneID:5343"
                     /db_xref="HGNC:HGNC:9072"
                     /db_xref="MIM:173340"
     exon            1..110
                     /gene="PLGLB1"
                     /gene_synonym="PLGL; PLGP1; PRGB; PRP-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..352
                     /gene="PLGLB1"
                     /gene_synonym="PLGL; PLGP1; PRGB; PRP-B"
                     /note="plasminogen-related protein B; type B plasminogen
                     related; plasminogen-like protein B"
                     /codon_start=1
                     /product="plasminogen-like protein B precursor"
                     /protein_id="NP_001027564.1"
                     /db_xref="CCDS:CCDS33238.1"
                     /db_xref="GeneID:5343"
                     /db_xref="HGNC:HGNC:9072"
                     /db_xref="MIM:173340"
                     /translation="MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGPSLFSVTKKQLGAG
                     SREECAAKCEEDKEFTCRAFQYHSKEQQCVIMAENRKSSIIIRMRDAVLFEK"
     exon            111..246
                     /gene="PLGLB1"
                     /gene_synonym="PLGL; PLGP1; PRGB; PRP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            247..353
                     /gene="PLGLB1"
                     /gene_synonym="PLGL; PLGP1; PRGB; PRP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            354..3249
                     /gene="PLGLB1"
                     /gene_synonym="PLGL; PLGP1; PRGB; PRP-B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      642..647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLGLB1"
                     /gene_synonym="PLGL; PLGP1; PRGB; PRP-B"
                     /note="hexamer: AATATA"
     polyA_site      664
                     /gene="PLGLB1"
                     /gene_synonym="PLGL; PLGP1; PRGB; PRP-B"
                     /note="major polyA site"
     regulatory      1145..1150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLGLB1"
                     /gene_synonym="PLGL; PLGP1; PRGB; PRP-B"
                     /note="hexamer: AATGAA"
     polyA_site      1167
                     /gene="PLGLB1"
                     /gene_synonym="PLGL; PLGP1; PRGB; PRP-B"
                     /note="major polyA site"
     regulatory      3228..3233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLGLB1"
                     /gene_synonym="PLGL; PLGP1; PRGB; PRP-B"
                     /note="hexamer: AATAAA"
     polyA_site      3249
                     /gene="PLGLB1"
                     /gene_synonym="PLGL; PLGP1; PRGB; PRP-B"
                     /note="major polyA site"
ORIGIN      
        1 gtaagtcaac aacatcctgg gattgggaca cactttctgg gcactgctgg ccagtcccaa
       61 aatggaacat aaggaagtgg ttcttctact tcttttattt ctgaaatcag gtcaaggaga
      121 gcccctggat gactatgtga atacccaggg gccttcactg ttcagtgtca ctaagaagca
      181 gctgggggca ggaagcagag aagaatgtgc agcaaaatgt gaagaggaca aagaattcac
      241 ctgcagggca ttccaatatc acagtaaaga gcaacaatgt gtgataatgg ctgaaaacag
      301 gaagtcctcc ataatcatta ggatgagaga tgcagtttta tttgaaaagt aaatgtatct
      361 ttcagagtgc aagactggga atggaaagaa ctacagaggg acgatgtcca aaacaaaaaa
      421 tggcatcacc tgtcaaaaat ggagttccac ttctccccgc aaacctaggt cagacttttc
      481 ctttcatctt tgtgttcatc tactgtaaag tgtccgtctg tgtctgtgag ggattggttc
      541 caggacccct gtggctacca aaatccatgc ttctcaagtc ccttatgtaa aatggtgcag
      601 tatttgcata taacctacat accttctctt gtgcaatccc taatataatg taaatgctat
      661 gtaatcgttg ttatactgta ttgtttttat ttgtattatg ttttattgtc atattgttat
      721 tttctctcat ctttttcaag tcttttccat ccacagttgg ttgaatttgt ggatgtggaa
      781 cccatggata cagagggcca actgtattta ggataatttc atcactttta attcaaacca
      841 gaatatgtga ataagcagac agaaagaatc tttttgatgt cgatgttcaa ctatttttgg
      901 caccatagta gaacatggtt gctttctatt ttttcttggg tatggaggtt tcttgaagac
      961 ctagaacata gaagaatgcc tagttaaaaa aaaaaatcaa tgaaactacg agttttaggc
     1021 caaatctgag aaaagaccaa agatgactat gtttgggact gaagtaaaca tatcaagtta
     1081 gaactctcat cacatgtttg actcaaattg tggagcaaaa tagtaaataa aatataaaaa
     1141 tgaaaatgaa gatacgtgaa attcaaatgt cacaacttgc ctattattta ttttagtgca
     1201 tttttttgtg cttttcccag tttggtgtta ggtggcctta agttctcagt aatgacactt
     1261 atcaaatagg aacttagtgt tactcacctt tatccattcc cccaacactc aacaaattgc
     1321 ctttgctata tccctatgag atgagcagat caaatattcc ccgtgagtta atgaaaactg
     1381 attcaaccaa atggcgaagt cagagactat cgggggccat ggagacactc tgggccattt
     1441 ttatgaggta gtctaggctc atcttcatga gggaactgag gtcttggggg gtgggggtta
     1501 cccaaatagg ttcacagaag aaccagaaat aaaacctgcc tttctagact gtaagtcttg
     1561 tgattgtcat ctaaatggtt gtctctatac agcaactcat ctctagaact gaaaataagt
     1621 ttaaatccct cctccatccc caataattca agctgcattt cagagaaaac caggactttg
     1681 gaatcagaca gatcaacttt gacttcttga tctgcttctt catagctatt tatgcttagg
     1741 caagttttgt tttgttttgt tttacgttgc cactcagtct tctcatctgt aaaacaggga
     1801 taataacacc ttcctcaaat ggtttttttt attaggacta aaagagagaa tgtgtggaaa
     1861 gatgttagtg gaattcctgg cacatagttc acatggacaa aatggtgtta actacgaaaa
     1921 tttttacaga gaaaagggca actgacaaaa gcaggtgttt ggaatgaatt aagaccatgg
     1981 caggcttttg aggcctttat atttctcctg actgtgcaat aaaaatattt tggctctctg
     2041 tctaagactt ggctgtcaca gtagcaatgg taatattagc tactgtgcca gaagcagcct
     2101 atcaatagag aaattgaaaa tctgaccaca caaatgctgc agcacccagc tgaaatgcat
     2161 ttggatgaca atctcagatg ggaatcgaga gcatctcctt ctgccttgct aatagcaagc
     2221 tgatttttag aatatagtct aagtgcttct cttccatcct ccccagattc tcacctgcta
     2281 cacacccctc agagggactg gaggaatcca gacaacgatg cgcaggggcc ctggtgctat
     2341 actactgatc cagaacagag agatgactac tgcgacattc ctgagtgtga agggcaggag
     2401 tggctctaga aaatgttttc atttctgccc ttcacctgta aaataatttg ttgtaaagcc
     2461 ccttcccaca gggatattat taataattgc gtaacgtgtt cacctctcgg aaaggagcaa
     2521 aactttgctc agatcccaga attaacctga tttttttttt ttttctgaga cagaattttg
     2581 ctctcattgc ccaggctaga gtgcaatggt gcgatctcag ctcaccacaa cctccgcctc
     2641 cgggttcaag cgattctcct acctcagcct cccaagtagc tggaattaca tgcatgtgcc
     2701 accatgcctg gctaatttta catttttagt agagacaggg tttctccatg ttggtcaggc
     2761 tggtcttgaa ctctcgacct caggtgagcc gcccgcctca gcctcccaaa gtgctgggat
     2821 tacaggcatg agccaccatg cccagcagac ctgaattatt attattaaaa tgttacatca
     2881 acatgtacaa atataaaact acatctaaac tctaagtaca gacttcttat gcttaaaact
     2941 cttacacagt gttaacccca agacagattt gcaattaagt agttaaaata agacaacaaa
     3001 gtcaataaaa atcaaataaa caatatacat ttaatgtggt agactttgct gttttgctga
     3061 agctaagcaa ggaaccagtt tttaaatcag caatccgtta ttttaatgga ctgagcaatt
     3121 taatagtgca cctcaaaggt caatgataaa aactaaaaaa aaaaaatacc tactgaaaaa
     3181 actgtcatcg tttcacattt ctggctacgt tagtgcaaaa gggaataaat aaaggtgaga
     3241 tttgtgtga
//
