LOCUS       NM_001395068            4154 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens pleckstrin homology domain containing S1 (PLEKHS1),
            transcript variant 5, mRNA.
ACCESSION   NM_001395068 XM_005270162
VERSION     NM_001395068.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4154)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4154)
  AUTHORS   Jung,C.K., Jung,S.H., Jeon,S., Jeong,Y.M., Kim,Y., Lee,S., Bae,J.S.
            and Chung,Y.J.
  TITLE     Risk Stratification Using a Novel Genetic Classifier Including
            PLEKHS1 Promoter Mutations for Differentiated Thyroid Cancer with
            Distant Metastasis
  JOURNAL   Thyroid 30 (11), 1589-1600 (2020)
   PUBMED   32326836
  REMARK    GeneRIF: Risk Stratification Using a Novel Genetic Classifier
            Including PLEKHS1 Promoter Mutations for Differentiated Thyroid
            Cancer with Distant Metastasis.
REFERENCE   3  (bases 1 to 4154)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4154)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4154)
  AUTHORS   Pignot,G., Le Goux,C., Vacher,S., Schnitzler,A., Radvanyi,F.,
            Allory,Y., Lallemand,F., Delongchamps,N.B., Zerbib,M., Terris,B.,
            Damotte,D. and Bieche,I.
  TITLE     PLEKHS1: A new molecular marker predicting risk of progression of
            non-muscle-invasive bladder cancer
  JOURNAL   Oncol Lett 18 (4), 3471-3480 (2019)
   PUBMED   31516565
REFERENCE   6  (bases 1 to 4154)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 4154)
  AUTHORS   Kotoh,J., Sasaki,D., Matsumoto,K. and Maeda,A.
  TITLE     Plekhs1 and Prdx3 are candidate genes responsible for mild
            hyperglycemia associated with obesity in a new animal model of
            F344-fa-nidd6 rat
  JOURNAL   J Vet Med Sci 78 (11), 1683-1691 (2016)
   PUBMED   27523322
  REMARK    GeneRIF: this gene is involved in the mild elevation of blood
            glucose levels and insulin resistance in obesity.
REFERENCE   8  (bases 1 to 4154)
  AUTHORS   Grossmann,A., Benlasfer,N., Birth,P., Hegele,A., Wachsmuth,F.,
            Apelt,L. and Stelzl,U.
  TITLE     Phospho-tyrosine dependent protein-protein interaction network
  JOURNAL   Mol Syst Biol 11 (3), 794 (2015)
   PUBMED   25814554
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592546.7.
            
            On Jun 1, 2021 this sequence version replaced XM_005270162.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA1968832 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000694986.1/ ENSP00000511629.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AL592546.7         122822-122901       c
            81-127              AL592546.7         119278-119324       c
            128-216             AL592546.7         108084-108172       c
            217-323             AL592546.7         107865-107971       c
            324-458             AL592546.7         107104-107238       c
            459-534             AL592546.7         105693-105768       c
            535-651             AL592546.7         104683-104799       c
            652-771             AL592546.7         102494-102613       c
            772-878             AL592546.7         100250-100356       c
            879-1088            AL592546.7         99548-99757         c
            1089-1190           AL592546.7         98717-98818         c
            1191-1326           AL592546.7         97324-97459         c
            1327-4154           AL592546.7         91154-93981         c
FEATURES             Location/Qualifiers
     source          1..4154
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.3"
     gene            1..4154
                     /gene="PLEKHS1"
                     /gene_synonym="C10orf81; HEL185"
                     /note="pleckstrin homology domain containing S1"
                     /db_xref="GeneID:79949"
                     /db_xref="HGNC:HGNC:26285"
     exon            1..80
                     /gene="PLEKHS1"
                     /gene_synonym="C10orf81; HEL185"
                     /inference="alignment:Splign:2.1.0"
     exon            81..127
                     /gene="PLEKHS1"
                     /gene_synonym="C10orf81; HEL185"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1506
                     /gene="PLEKHS1"
                     /gene_synonym="C10orf81; HEL185"
                     /note="isoform 4 is encoded by transcript variant 5; PH
                     domain-containing protein C10orf81; epididymis luminal
                     protein 185; PH domain-containing family S member 1;
                     pleckstrin homology domain-containing family S member 1;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family S
                     member 1 isoform 4"
                     /protein_id="NP_001381997.1"
                     /db_xref="CCDS:CCDS91351.1"
                     /db_xref="GeneID:79949"
                     /db_xref="HGNC:HGNC:26285"
                     /translation="MEPKPQKSPGKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKK
                     RFFILSKAGEKSFSLSYYKDHHHRGSIEIDQNSSVEVGISSQEKMQSVQKMFKCHPDE
                     VMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSS
                     PLLGPSSTSEAVGSSSPRNGLQDKHLMEQSSPGFRQTHLQDLSEATQDVKEENHYLTP
                     RSVLLELDNIIASSDSGESIETDGPDQVSGRIECHYEPMESYFFKETSHESVDSSKEE
                     PQTLPETQDGDLHLQEQGSGIDWCLSPADVEAQTTNDQKGSASLTVVQLSILINNIPD
                     ESQVEKLNVFLSPPDVINYLALTEATGRICVSQWEGPPRLGCIFCHGDHLLAVNDLKP
                     QSLEEVSLFLTRSIQKEKLKLTIGRIPNSETFHAASCMCPSKCQSAAPSQLDKPRLNR
                     APKRSPAIKKSQQKGARE"
     exon            128..216
                     /gene="PLEKHS1"
                     /gene_synonym="C10orf81; HEL185"
                     /inference="alignment:Splign:2.1.0"
     exon            217..323
                     /gene="PLEKHS1"
                     /gene_synonym="C10orf81; HEL185"
                     /inference="alignment:Splign:2.1.0"
     exon            324..458
                     /gene="PLEKHS1"
                     /gene_synonym="C10orf81; HEL185"
                     /inference="alignment:Splign:2.1.0"
     exon            459..534
                     /gene="PLEKHS1"
                     /gene_synonym="C10orf81; HEL185"
                     /inference="alignment:Splign:2.1.0"
     exon            535..651
                     /gene="PLEKHS1"
                     /gene_synonym="C10orf81; HEL185"
                     /inference="alignment:Splign:2.1.0"
     exon            652..771
                     /gene="PLEKHS1"
                     /gene_synonym="C10orf81; HEL185"
                     /inference="alignment:Splign:2.1.0"
     exon            772..878
                     /gene="PLEKHS1"
                     /gene_synonym="C10orf81; HEL185"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1088
                     /gene="PLEKHS1"
                     /gene_synonym="C10orf81; HEL185"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1190
                     /gene="PLEKHS1"
                     /gene_synonym="C10orf81; HEL185"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1326
                     /gene="PLEKHS1"
                     /gene_synonym="C10orf81; HEL185"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..4154
                     /gene="PLEKHS1"
                     /gene_synonym="C10orf81; HEL185"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3132..3137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHS1"
                     /gene_synonym="C10orf81; HEL185"
                     /note="hexamer: ATTAAA"
     polyA_site      3150
                     /gene="PLEKHS1"
                     /gene_synonym="C10orf81; HEL185"
     regulatory      4130..4135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHS1"
                     /gene_synonym="C10orf81; HEL185"
                     /note="hexamer: AATAAA"
     polyA_site      4154
                     /gene="PLEKHS1"
                     /gene_synonym="C10orf81; HEL185"
                     /note="major polyA site"
ORIGIN      
        1 agagtcagca ggagtgagtt caggaatcct cgggacaagg cactttcctg agcactggac
       61 cagcgacctc ttggcttcca gggaggacac acagccatca tggaacccaa acctcagaag
      121 agtccaggca aacaatttac attttcttat gaaaatgaag tctgcaaaca agattacttt
      181 attaaatcac caccttctca gctgttctcc tctgtgacct cttggaaaaa gcggtttttc
      241 atcctgtcaa aggctgggga aaagagcttt agtctttcct attataaaga ccatcatcac
      301 cgaggttcca ttgaaattga tcaaaattcc agtgtagaag ttggcataag tagccaggaa
      361 aagatgcaat ctgtgcagaa gatgtttaaa tgccaccctg atgaggtcat gtccatcaga
      421 accactaaca gggaatactt cctcattggc cacgacaggg agaagattaa agactgggtc
      481 tccttcatgt catcatttcg ccaggatata aaagcaacac agcagaacac agaggaggaa
      541 ctctcattgg gtaataaaag aaccctcttc tactccagcc ctctccttgg cccttccagc
      601 acatcagagg ctgttggctc cagctcacca agaaatggtc tccaagacaa gcatttaatg
      661 gaacaaagtt ctccaggatt taggcaaact cacctacaag atttatcaga agccactcaa
      721 gatgtgaagg aagagaatca ttatcttact cctcgaagtg ttcttttaga gttggataat
      781 atcattgctt ccagtgattc tggtgaatcc attgaaactg atggtccaga ccaggtctct
      841 ggaagaattg agtgtcatta tgagccaatg gaatcctatt ttttcaaaga gacatcccat
      901 gagtctgtgg atagcagcaa agaggaaccc cagacccttc cagagaccca ggatggggac
      961 ctccacctgc aagaacaagg ctcaggaatt gattggtgtc tttcccctgc cgatgtggaa
     1021 gcacagacca caaatgacca aaaggggtcg gcctcactaa ctgttgtgca attgtctata
     1081 ttaatcaata atatccccga tgaaagccaa gtggagaaac tgaacgtttt cctttctcct
     1141 cctgatgtca tcaactatct tgctctcaca gaagccacag gacggatatg tgtgtctcag
     1201 tgggaaggcc ccccacgttt gggatgcata ttttgccacg gagatcatct tctggcagtg
     1261 aatgacctga aaccccagag cctggaggag gtctccctgt ttcttacccg gtccatccag
     1321 aaggagaaat taaagcttac catcggcagg atcccaaatt cagagacatt ccatgctgca
     1381 tcctgtatgt gtccctcaaa atgccaaagt gctgcacctt ctcagctgga taagcctaga
     1441 ctgaacagag ctcccaagag gagtccggcc attaaaaaga gccagcagaa aggagccagg
     1501 gagtaacgca ccccagaccc atggcagcag aaccaggatg gagctgggac tgtccagctc
     1561 tgccccctgc tgctgccatg tgataggaga cagtcggcac ccccctctga atttctgcat
     1621 ctgcatctta acaatgggga tgactatccc ctctctggtt attgtatcag agatgctaag
     1681 agggtcatgt ggcatgattg gagaacctgg gggaattgga aggccttatt atctcagcta
     1741 ttgtcccaaa caccacagac acagattggg tcagtccttc atgtaataca tgctgtgttc
     1801 tgtgaggatg tggtccacac aattccttct ttgttaaggg acatacagtt gcaaatactc
     1861 actgcatgaa ggcaagattc ccaagggaga tgtgatagct gatcaggctt cccagacacc
     1921 tccttcccaa acacctcctt cccaacacct ccttccccaa catccttccc aacacctcct
     1981 tcccaacacc tccttcccaa acacctcctt cccaaacacc tccttcccaa cacctccttc
     2041 cccaacacct ccttcccaaa cacctctttc ccaaacacct ccttcccaga cacctccttc
     2101 ccaacacctc cttcccaaca cctccttccc aaacccctct ttcccaaaca cctccttccc
     2161 caacacctcc ttcccaacac ctccttcccc cttccccaac acctccttcc ccaacacctc
     2221 cttcccaaca cctccttccc aaacccctcc ttccccaaca tccttcccaa cacctccttc
     2281 ccaacacctc cttcccaaac acctccttcc caaacacctc cttcccaaca cctccttccc
     2341 caacacctcc ttcccaaaca cctctttccc aaacacctcc ttcccagaca cctccttccc
     2401 aacaccgcct tcccaacacc tccttcccaa acccctcttt cccaaacacc tccttcccca
     2461 acacctcctt ccccaacacc tccttcccaa cacctccttc ccccttcccc aacaactcct
     2521 tccccaacac ctccttccca aacatcccct tcccaaacac ctgcctctct tcaaccccac
     2581 aggccagagt gctgagacag agtggccttt tggattcaat aagtatcttg ttctcttaaa
     2641 gactcagcaa cgattttaga agtcgcagca gttttacatc acatgcagcc aagatcagct
     2701 tgctctacaa gcaataacag aactacttag cacttcaagg ttgaaagttc ttcactaatg
     2761 gatccattga ctaattgatc ctggaaggcc aaaggaataa aattctttta tataaatagg
     2821 aaaacaaagg cagagagcta aagcactaat caaatcgggg ggtgttagag caaaaacagg
     2881 cttcagaaag agtattttac catgcttcac atggaaaaaa tcgagccccg gagcgatgaa
     2941 aggcatattt tctttgtttc tccaagtttc ataaccgttc agttgcagaa ccaagaatct
     3001 aaaaccagct ctgggaaaca aatgtccaga tgccagcctc atagttgaac ttggatttga
     3061 aaataccttc agcacttaga agagacattc aaatacattt catttcctgt tacccagatt
     3121 gttcggaaag tattaaaaat ttttcattta catgctgata cggtttggat ctgtgtccct
     3181 aacaaatccc atgtcgagct gtggtccccg gtgttggaga tggagcctgg tgggaggcag
     3241 ctggatcgtg aggtcgtggg ggtggagttc tcacgaagga gttagcatca tccccttggc
     3301 gctgttctcg tgatagtaag ttctcgtgag atctggttgt ttaaaagtgt gcagcacctc
     3361 tccgctcact ctcttcctcc tgctcctgcc gtgtaagatg cctgctctgt ctgccacaag
     3421 tgaaagcttc ctgaggtctc cccggaagca gatgctgcca cgcttcctgt acagcctgca
     3481 gaactgtgga ccaatcaaac ctcttttctt ataaattacc tggtcttggg gatttcttta
     3541 tttaatgtga gaacgcatgc ccttttggat ctgctgtttc tacttttata aatttatcat
     3601 gcagaaatac acaaatacac aaagatacat gtaaaaaaag tagtttactg cagtactgtt
     3661 tgtaataata aaaaatcagg ctggacgtgg tggttcatgc ctataattcc aaccctttgg
     3721 gaggccggga caggtggatc acctgaggtc tggagctcga gaacaacctg accaacatgg
     3781 agaaaccctg tctctactaa aaatacaaaa ctagctgggc attgtggcac atgcctgcaa
     3841 tcccagctac ttgagaggct ggggcaggag aatcactaga accgggaggc ggaagttgca
     3901 gtgagccaag atcatgccat tgcactccag cctgggcaac aagaggaaaa cccagtctca
     3961 aaaaaaaaaa aaaaatcatg tgggtattgc ttaattctga tttcatatca ttgaacactg
     4021 tagatattaa aatgttcagc aggcacagtt ctgtaaaatt gttcgtgata cattaagaat
     4081 gaaagaatca agttgtataa taaggataac atcatcccac ttttgtacaa ataaatgttt
     4141 ggtgtttgtg tgta
//
