LOCUS       NM_032129               3176 bp    mRNA    linear   PRI 20-DEC-2024
DEFINITION  Homo sapiens pleckstrin homology domain containing N1 (PLEKHN1),
            transcript variant 1, mRNA.
ACCESSION   NM_032129
VERSION     NM_032129.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3176)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3176)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3176)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3176)
  AUTHORS   Kuriyama,S., Tsuji,T., Sakuma,T., Yamamoto,T. and Tanaka,M.
  TITLE     PLEKHN1 promotes apoptosis by enhancing Bax-Bak
            hetro-oligomerization through interaction with Bid in human colon
            cancer
  JOURNAL   Cell Death Discov 4, 11 (2018)
   PUBMED   29531808
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3176)
  AUTHORS   Yu,X., Noll,R.R., Romero Duenas,B.P., Allgood,S.C., Barker,K.,
            Caplan,J.L., Machner,M.P., LaBaer,J., Qiu,J. and Neunuebel,M.R.
  TITLE     Legionella effector AnkX interacts with host nuclear protein
            PLEKHN1
  JOURNAL   BMC Microbiol 18 (1), 5 (2018)
   PUBMED   29433439
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3176)
  AUTHORS   Maeda,A., Uchida,M., Nishikawa,S., Nishino,T. and Konishi,H.
  TITLE     Role of N-myristoylation in stability and subcellular localization
            of the CLPABP protein
  JOURNAL   Biochem Biophys Res Commun 495 (1), 1249-1256 (2018)
   PUBMED   29180010
REFERENCE   7  (bases 1 to 3176)
  AUTHORS   Nishino,T., Matsunaga,R., Jikihara,H., Uchida,M., Maeda,A., Qi,G.,
            Abe,T., Kiyonari,H., Tashiro,S., Inagaki-Ohara,K., Shimamoto,F. and
            Konishi,H.
  TITLE     Antagonizing effect of CLPABP on the function of HuR as a regulator
            of ARE-containing leptin mRNA stability and the effect of its
            depletion on obesity in old male mouse
  JOURNAL   Biochim Biophys Acta 1861 (11), 1816-1827 (2016)
   PUBMED   27616329
REFERENCE   8  (bases 1 to 3176)
  AUTHORS   Sano,E., Shono,S., Tashiro,K., Konishi,H., Yamauchi,E. and
            Taniguchi,H.
  TITLE     Novel tyrosine phosphorylated and cardiolipin-binding protein
            CLPABP functions as mitochondrial RNA granule
  JOURNAL   Biochim Biophys Acta 1783 (6), 1036-1047 (2008)
   PUBMED   18191643
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645608.30.
            
            On Dec 7, 2018 this sequence version replaced NM_032129.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136730.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968540,
                                           SAMEA2142586 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379410.8/ ENSP00000368720.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AL645608.30        90332-90464
            134-233             AL645608.30        90554-90653
            234-380             AL645608.30        94127-94273
            381-461             AL645608.30        94371-94451
            462-534             AL645608.30        94536-94608
            535-662             AL645608.30        94729-94856
            663-758             AL645608.30        94963-95058
            759-839             AL645608.30        95174-95254
            840-915             AL645608.30        95925-96000
            916-1052            AL645608.30        96138-96274
            1053-1202           AL645608.30        96711-96860
            1203-1343           AL645608.30        97036-97176
            1344-1484           AL645608.30        97350-97490
            1485-1703           AL645608.30        97683-97901
            1704-1752           AL645608.30        98166-98214
            1753-3176           AL645608.30        98292-99715
FEATURES             Location/Qualifiers
     source          1..3176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..3176
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /note="pleckstrin homology domain containing N1"
                     /db_xref="GeneID:84069"
                     /db_xref="HGNC:HGNC:25284"
                     /db_xref="MIM:621052"
     exon            1..133
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1886
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /note="isoform a is encoded by transcript variant 1;
                     pleckstrin homology domain-containing family N member 1;
                     PH domain-containing family N member 1; cardiolipin and
                     phosphatidic acid-binding protein"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family N
                     member 1 isoform a"
                     /protein_id="NP_115505.2"
                     /db_xref="CCDS:CCDS4.1"
                     /db_xref="GeneID:84069"
                     /db_xref="HGNC:HGNC:25284"
                     /db_xref="MIM:621052"
                     /translation="MGNSHCVPQAPRRLRASFSRKPSLKGNREDSARMSAGLPGPEAA
                     RSGDAAANKLFHYIPGTDILDLENQRENLEQPFLSVFKKGRRRVPVRNLGKVVHYAKV
                     QLRFQHSQDVSDCYLELFPAHLYFQAHGSEGLTFQGLLPLTELSVCPLEGSREHAFQI
                     TGPLPAPLLVLCPSRAELDRWLYHLEKQTALLGGPRRCHSAPPQRRLTRLRTASGHEP
                     GGSAVCASRVKLQHLPAQEQWDRLLVLYPTSLAIFSEELDGLCFKGELPLRAVHINLE
                     EKEKQIRSFLIEGPLINTIRVVCASYEDYGHWLLCLRAVTHREGAPPLPGAESFPGSQ
                     VMGSGRGSLSSGGQTSWDSGCLAPPSTRTSHSLPESSVPSTVGCSSQHTPDQANSDRA
                     SIGRRRTELRRSGSSRSPGSKARAEGRGPVTPLHLDLTQLHRLSLESSPDAPDHTSET
                     SHSPLYADPYTPPATSHRRVTDVRGLEEFLSAMQSARGPTPSSPLPSVPVSVPASDPR
                     SCSSGPAGPYLLSKKGALQSRAAQRHRGSAKDGGPQPPDAPQLVSSAREGSPEPWLPL
                     TDGRSPRRSRDPGYDHLWDETLSSSHQKCPQLGGPEASGGLVQWI"
     exon            134..233
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /inference="alignment:Splign:2.1.0"
     exon            234..380
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /inference="alignment:Splign:2.1.0"
     exon            381..461
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /inference="alignment:Splign:2.1.0"
     exon            462..534
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /inference="alignment:Splign:2.1.0"
     exon            535..662
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /inference="alignment:Splign:2.1.0"
     exon            663..758
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /inference="alignment:Splign:2.1.0"
     exon            759..839
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /inference="alignment:Splign:2.1.0"
     exon            840..915
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1052
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1202
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1343
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1484
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1703
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1752
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..3176
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3156..3161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /note="hexamer: AGTAAA"
     polyA_site      3176
                     /gene="PLEKHN1"
                     /gene_synonym="CLPABP"
                     /note="major polyA site"
ORIGIN      
        1 aggaggctgt ggacagggac ccagacttgc cgacctgtac gactctggcc atggggaaca
       61 gccactgtgt ccctcaggcc cccaggaggc tccgggcctc cttctccaga aagccctcgc
      121 tgaagggaaa cagagaggac agcgcgcgga tgtcggccgg cctgccgggc cccgaggctg
      181 ctcgaagcgg ggacgccgcc gccaacaagc tcttccacta catcccgggc acggacatcc
      241 tggacctgga gaaccagcga gaaaacctgg agcagccatt cctgagtgtg ttcaagaagg
      301 ggcggcggag ggtgcctgtg aggaacctgg gaaaagttgt gcattacgcc aaggtccagc
      361 tgcggttcca gcacagccag gatgtcagcg actgctacct ggagctattc cccgcccacc
      421 tgtacttcca ggcccacggc tcggaaggac tcacatttca ggggctgtta ccgctgacgg
      481 agctgagtgt ctgcccgctc gaggggtccc gagagcacgc cttccagatc acaggcccac
      541 tgcccgcacc cctcctggtg ctctgcccca gccgggccga gctggaccgc tggctttacc
      601 acctggagaa gcagacggcc ctcctcgggg ggccgcggcg ctgccactcg gcacccccac
      661 agcgccgtct aacccggctg cggacggcgt cagggcacga acccggcggc agtgctgtct
      721 gtgcctcgag ggtcaagctg cagcacctgc ccgcacagga gcagtgggac cggctcttgg
      781 tcctgtaccc aacgtccttg gccattttct ccgaggagct ggacgggctt tgcttcaagg
      841 gggagctccc actccgtgcc gtccacatca acctggagga gaaggagaag cagatccgct
      901 ccttcctgat tgaaggcccc ctcatcaaca ccatccgcgt ggtgtgcgcc agctacgagg
      961 actacggtca ctggctgctg tgccttcgcg ctgtcaccca cagggagggg gccccgccgc
     1021 tgcctggtgc cgagagcttc ccagggtcgc aggttatggg cagtggccga ggctcactct
     1081 cctcaggcgg acagaccagc tgggactcgg ggtgcttggc gcccccctcc acccgcacca
     1141 gccactccct gcctgagtcc tcagtgccat ccaccgtggg ctgctcctcc cagcacacac
     1201 cggaccaggc caactctgac cgtgccagca ttggccgacg gaggaccgag ctgagacgca
     1261 gtggcagcag ccggtcaccc gggagcaagg cccgggcaga gggccgcggc cctgtcaccc
     1321 cactgcacct ggacctgacc cagctgcaca ggctgagcct ggagagcagc ccagatgccc
     1381 ctgaccacac ttcggaaaca tcacactcgc ccctctatgc cgacccctac acaccacccg
     1441 ccacctccca ccgcagggtc acagatgtcc ggggcctgga ggagttcctc agtgccatgc
     1501 agagtgcacg tggacccacg ccctcgagcc cactcccctc ggtgcctgtg tctgtgcctg
     1561 cctctgaccc tcgctcctgc tcctccggcc ccgctggccc ctacttgctc tccaagaagg
     1621 gagccctgca gtccagagcc gctcagagac accggggctc agccaaggat ggggggccgc
     1681 agcccccaga cgcccctcag cttgtctcct ctgccaggga aggttcgccc gaaccctggc
     1741 tgcctctgac agatggtcgg tcccccagga ggagccggga ccccggctac gaccacctct
     1801 gggacgagac tttgtcttcc tcccaccaga agtgccccca gcttggaggg cctgaggcca
     1861 gtggggggct tgtgcagtgg atctgatggc cgcggtgagg tgggttctca ggaccaccct
     1921 cgccaagctc cagggtacct gcccctctaa cccacttcaa attacaagtc agggtctgaa
     1981 cccagtgtga tggggggagt ctctggggcc ctgagttcag agcccgtccc tcagctcctg
     2041 ttccttggtg ccagcagctg gggcagggaa gggtgggagg ggccccatcc aaaggatgcc
     2101 ctggccagcg aggctgggtc acaggtcagg gaggtcctgg ccgtccacag ggtcggccct
     2161 cagctcagcc cgccaggagt cagggaggag actcgctggg agtgggaggg cagcacgggc
     2221 gtgaaggtcg gaggacagag aaaggtcagc agggtcagag tatgtgaggt cagagggcat
     2281 gagggtcaca ggtcagcaag gtgtgaggag cacaagccag ggtgccccga ggaggagggt
     2341 gggtgggtcc ttgtgtggcc tggcgcgcac cacagggcag cacgggagac gttgacacca
     2401 ccggacgaga aagaaaaaag agagaagaga gagaggagaa gagagaaaag aagagaagag
     2461 agaagagaag agaaggaaag agagagagag aataagaaaa ggaagaaaga aaaagaaaag
     2521 atagaatttt attggtgctg catccatgtg ttctctgctc agcagccagg gtctcccaca
     2581 gtcttgagga cccccaccca gcacccagcc aggcagcccc cttcctctgc cacctcgggc
     2641 ccctcaccga ccttcccacc tcatctctga ctcctcttgg ctgtgggtcc ccagctgccc
     2701 cacaggagcc cccgggacaa ccccaggagc ccagccctcc atctgaggcc accgaattct
     2761 ccctctgcac ctgcacccag ggctcccggg gaggggctcg cggctctgcc acagaccccc
     2821 accctgcagg ggctgctgca ctggggaggg gcaggcagag ccttcgctgt ctcaggccag
     2881 agcccgcaga ggccttggcc acagtccttt gaggatcaag agtgatgggc cttggagccc
     2941 ttgccagccc agcccacctg tgaggaggct gcccatcccc tctttgaggc caccctgtgt
     3001 cctctcccct gcctctgccc agagctccag ccggagtgtc ttgctgctca gacccctccg
     3061 aggtccaagt cctgtcctgc cactcagctc cccctgcacc ccagaagaaa cgcagggtgc
     3121 ggttgcattt gatttcagat aaacaacaac ttcttagtaa aatgacctcc ccacta
//
